9 results about "Physical stability" patented technology

The present application discloses a sirolimus-albumin composition and a preparation method therefor. The preparation method of the present application incorporates an incubation step before solvent removal via evaporation of liquid having undergone high-pressure homogenization, thereby resulting in more uniform nanoparticles and further improving the physical stability of a nanosuspension and the chemical stability of a formulation without the need for any stabilizer. Compared with marketed products, the sirolimus-albumin composition of the present application can be completely dissolved within 1-3 min, the reconstitution operation is simpler, and a nanoparticle suspension after reconstitution remains stable at 30°C for 24 h, thereby offering greater convenience for clinical use. In addition, the composition of the present application can be stored at room temperature, is convenient to transport, and has a longer shelf life.

The present application provides a crystal form of a KAT6A / B inhibitor, and a preparation method therefor and a use thereof. The crystal form provided by the present application has good chemical stability and physical stability, and low moisture absorption, is less affected by heat, humidity, and light, and is convenient for storage and formulation development.

The invention discloses a composite coating as well as a preparation method and application of touch packaging paper, the composite coating comprises a waterproof coating and a touch coating: the waterproof coating comprises the following raw materials in parts by mass: 30-35 parts of first film-forming resin, 10-15 parts of a first ketone solvent, 40-50 parts of an aromatic hydrocarbon solvent, 4-6 parts of a second ketone solvent and 1-5 parts of a matting agent; the tactile paint comprises the following raw materials in parts by mass: 30-35 parts of second film-forming resin, 60-65 parts of a dispersing agent, 0.1-5 parts of a modifying agent and 0.1-5 parts of a sterilizing agent, and the waterproof paint and the tactile paint in the range are adopted to respectively form a waterproof layer and a tactile coating, so that on the premise of ensuring the processing feasibility, the tactile paint can be applied to the waterproof layer and the tactile coating. And excellent physical stability and high-end sensory quality are synchronously achieved, and the method is particularly suitable for electronic product inner packaging scenes with strict requirements for flatness, touch feeling and reliability.

The application discloses a sirolimus albumin composition and a preparation method thereof. The preparation method of the application adds an incubation step before evaporation and removal of a solvent from a material liquid after high-pressure homogenization, which not only makes nanoparticles more uniform, but also further improves the physical stability of a nanosuspension and the chemical stability of a preparation without adding any stabilizer. Compared with a marketed product, the sirolimus albumin composition disclosed by the application can be completely dissolved in 1-3 min, the reconstitution operation is more convenient, and the nanosuspension after reconstitution can be stable at 30 DEG C for 24 h, which is more convenient for clinical use. Moreover, the composition of the application can be stored at room temperature, is convenient for transportation, and has a longer effective period.

The invention discloses a treatment method for improving physical stability of a raw material medicine, and relates to the technical field of medicine solid chemistry and preparations, the treatment method comprises the following steps: contacting the raw material medicine in an amorphous state with an ethanol medium, dispersing, and inducing the amorphous state to be converted into a crystal form; and standing, separating the solid, and drying the solid product to obtain a final product with stable crystal form and stable particle size. The preparation method has the advantages that the defects of slow and uncontrollable amorphous state conversion of raw material medicines in the prior art are overcome, the metastable amorphous state can be actively and quickly converted into a thermodynamically stable target crystal form, the long-term stability of the particle size of the product is synchronously realized in the process, and the influence of particle size change on the preparation product is reduced; the added ethanol medium is not only a poor solvent, but also an efficient crystal crystallization inducer, and can permeate into a molecular grid of the amorphous drug, so that the energy barrier of molecular rearrangement is reduced, and the original spontaneous and slow solid phase change is converted into a rapid and directional technological process.

The present invention provides composite particles with improved chemical and physical stability, and multilayer ceramic capacitors containing these particles. [Solution] The composite particle according to one embodiment comprises a core containing Ni, and a shell located on the core and containing a compound comprising at least one of Al and Zr, wherein the content of Al or Zr is 0.001 to 5.0 moles per 100 moles of Ni.

The invention discloses an online three-dimensional boxing method and device with a physical stability verification function. The method comprises the steps that before the placing position of an object to be packed in a box body is selected, the object to be packed is loaded in the box body; comprising the following steps: carrying out physical stability verification according to a height map of a loaded object of each grid in a box body and the size of an object to be loaded so as to generate a feasibility mask of a candidate placement position, and enumerating and generating all possible candidate placement positions according to the height map of the loaded object; traversing each candidate placement position, and sequentially performing static centroid stability detection and centroid stability detection of mass distribution transmission to generate a feasibility mask, wherein the value of each element in the feasibility mask is 1 or 0 to represent whether the corresponding grid can be used as the candidate placement position of the object to be loaded. According to the method, the stability of online three-dimensional boxing is improved through physical stability verification, the problem that due to the stability problem, objects to be boxed collapse is solved, and the efficiency of online three-dimensional boxing is improved.

The invention discloses a preparation method of microcapsule essence particles, and relates to the technical field of microcapsule essence preparation, in particular to microcapsule granular essence and a preparation method thereof.The preparation method comprises the following steps that an oily essence base is embedded in a first wall material through a spray drying method, and microcapsule essence powder is prepared; carrying out melt extrusion granulation on the microcapsule essence powder obtained in the previous step and a second wall material; through the synergistic combination of two processes, the powdery essence which is easy to absorb moisture and raise dust is converted into a particle product which is high in physical stability and good in controlled release performance, the inherent defects of the traditional spray drying essence are effectively overcome, and the application range of the essence in the fields of foods, tobaccos and the like is widened.

This invention discloses an online 3D bin packing method and apparatus with physical stability verification. The method includes, before selecting a placement location for an item within a bin, performing physical stability verification based on the height map of the already packed items in each grid within the bin and the dimensions of the item to be packed to generate a feasibility mask for candidate placement locations. This includes enumerating all possible candidate placement locations based on the height map of the already packed items, and for each candidate placement location, iterating and sequentially performing static centroid stability detection and mass distribution transfer centroid stability detection to generate a feasibility mask. The value of each element in the feasibility mask is 1 or 0, indicating whether the corresponding grid is a candidate placement location for the item. This invention aims to improve the stability of online 3D bin packing by utilizing physical stability verification, preventing item collapse due to stability issues, and improving the efficiency of online 3D bin packing.