37 results about "Continuous infusion" patented technology

The invention provides a method for determining bovine protein turnover metabolism through combination of [2H2] tyrosine tracing and nitrogen equilibrium, and belongs to the technical field of protein turnover metabolism determination. Comprising the following steps: S1, a nitrogen balance determination method: determining the nitrogen content of cattle feed, excrement and urine samples; s2, an isotope tracing determination method: S21, putting an isotope injection tube and a blood collection tube into the bovine jugular vein treatment; s22, collecting a baseline blood sample, injecting [2H2] tyrosine with an initial dose, continuously infusing the [2H2] tyrosine, and collecting a test blood sample in the last period of time of infusing the [2H2] tyrosine; and S23, respectively centrifugally separating the two blood samples to obtain corresponding plasma, and then measuring the abundance of [2H2] tyrosine in the plasma of the blood samples. According to the method, the bovine protein turnover metabolism is creatively determined by combining [2H2] tyrosine tracing with nitrogen balance, and the determination method is efficient and low in cost.

The invention provides a high-stability high-concentration zinc-containing insulin preparation, and belongs to the field of pharmaceutical preparations, the concentration of human insulin in the preparation is greater than 500 IU / mL, the preparation further contains zinc ions, a preservative, an isotonic agent and a buffer agent, the pH value of the preparation is 7.0-7.8, and the content of the zinc ions in the preparation is greater than 1%. Compared with similar products known in the field, the preparation has great physical stability, the volume of injection liquid medicine can be reduced under the condition that the required amount of insulin is the same, the hardening and caking phenomena of tissues at an injection part are effectively relieved, and the preparation still can be kept in a basically non-aggregated state in a heat or mechanical pressure environment; the method is suitable for continuous infusion systems.

The invention discloses a precise control device for continuous infusion of a boron-loaded drug, which overcomes the defects of insufficient precise control, poor continuity and no dynamic closed loop in the existing boron neutron capture therapy. The device comprises a first shell and a second shell which are connected through a hinge, the device is further provided with an electromagnetic drive extrusion assembly, a fixing assembly and a rope ring, and the electromagnetic drive extrusion assembly comprises an electromagnet, a magnetic conductive block and a first elastic piece. The device further comprises a module which is specifically a data collecting and processing module and can collect liquid medicine parameters, pipeline parameters, physiological parameters and flow velocity data and remove abnormal data through filtering processing. And the influence factor calculation module can calculate a physiological state influence factor and an infusion resistance influence factor. Through electromagnetic pressure control, multi-factor calibration and multi-patient overall planning, the flow velocity precision meets the precision infusion requirement, the effective concentration of boron-loaded medicine in the body is stabilized in a treatment window, and the infusion interruption risk is greatly reduced.

The utility model provides an intraspinal and peripheral nerve block continuous administration infusion system which comprises an air bag, connecting catheters are symmetrically installed on the side wall of the air bag arranged in a skin layer, and a rubber isolation pad is installed in the middle of the interior of the air bag. One end of the connecting guide pipe is connected with a driving mechanism, the driving mechanism comprises a fixing shell, a micro pump and a storage battery are installed in the fixing shell, a switch is installed on the surface of the fixing shell, and the switch is electrically connected with the micro pump and the storage battery; the side wall of the micro pump is provided with two communicating pipes, and one communicating pipe is connected with the connecting guide pipe. The other communicating pipe is connected with an input catheter, and the input catheter penetrates through the skin layer and enters the epidural space from the space between the spinous protrusions. The intraspinal and peripheral nerve block continuous administration infusion system has the advantages of being simple in structure, small in size and convenient to use.

The invention belongs to the field of perfusion instruments, and particularly discloses a gastrointestinal surgery perfusion device which comprises a body, an inner cylinder, an outer cylinder arranged on the periphery of the inner cylinder and a four-way seat arranged between the inner cylinder and the outer cylinder. The liquid filling mechanism comprises a piston rod I arranged in the inner cylinder, a piston rod II arranged in the outer cylinder, and supplementing pieces arranged on the inner cylinder and the outer cylinder; the driving mechanism comprises a shell arranged at the rear end of the inner cylinder, a driving piece arranged in the shell and a conversion piece arranged on the driving piece; by means of the liquid filling mechanism, filling work of enema liquid in the auxiliary containing cavity can be automatically completed when liquid filling work is propelled, then continuous liquid filling work is achieved by circularly and alternately pushing the first piston rod and the second piston rod, continuous liquid filling can be achieved under the condition that the size of the device is not increased, and personnel use is facilitated.

The present invention provides regimens and methods for treating cancer, including continuous infusion of coenzyme Q10. Coenzyme Q10 can be administered as a monotherapy or in combination with other agents, such as anti-cancer agents, chemotherapeutic agents, or anti-angiogenic agents. Coenzyme Q10 can be administered at two or more different rates.

A method for treating ascites patients by administering the peptide drug terlipressin by continuous infusion. The patients include those whose ascites condition has not progressed to hepatorenal syndrome (HRS). Administration may be accomplished with a continuous infusion pump.

The utility model relates to the technical field of medical instruments, in particular to a pressure bag capable of automatically identifying pressurization. According to the technical scheme, the pressure bag comprises an infusion bag and a pressure bag body for pressurizing the infusion bag, a cavity is formed in the pressure bag body, a connecting belt is arranged on the inner wall of the bottom of the pressure bag body, a mounting groove is formed in the inner wall of one side of the pressure bag body, and a sliding mounting plate is detachably connected into the mounting groove; a sensor structure is installed on the side face of the sliding installation plate, and pressing rods located on the two sides of the sensor structure are further installed on the side face of the sliding installation plate. An air pump is fixedly installed below the connecting belt, and the output end of the air pump is connected with an air conveying pipe. The infusion apparatus is novel in structure, the sensor can be conveniently and rapidly replaced, disassembled and assembled, the sensor can be conveniently and repeatedly used, automatic pressurization is achieved, the workload of medical workers is reduced, and continuous infusion is guaranteed.

The technical solution of the present invention discloses a continuous infusion clampless indwelling needle, including a needle tube assembly, a hose and an infusion connector, wherein the infusion connector includes an infusion connector body and an infusion pump body, and the infusion pump body is equipped with a microfluidic component that can generate continuous positive pressure microflow, and the microfluidic component converts the liquid medicine injected from the inlet of the infusion pump body into a slow continuous positive pressure microflow and outputs it to the outlet of the infusion pump body. The infusion pump of the present invention realizes the microflow that can continuously generate positive pressure for more than 24 hours by arranging a microfluidic component internally, which can meet the needs of most patients for infusion every other day, so that during the intermittent period of infusion, the indwelling catheter is always flushed with saline or other liquid medicine to prevent the formation of thrombus in the blood vessel, and there is no need for medical staff to flush and seal the tube regularly, which effectively solves the problem of catheter blockage caused by blood reflux and coagulation in the indwelling catheter.

The present invention provides a [ 2 H2] A method for determining bovine protein turnover metabolism by tyrosine tracing combined with nitrogen balance, belonging to the technical field of protein turnover metabolism determination, comprising S1. Nitrogen balance determination method: determining the nitrogen content of bovine feed, feces, and urine samples; S2. Isotope tracing determination method: S21. inserting an isotope injection tube and a blood collection tube into the bovine jugular vein; S22. collecting a baseline blood sample, and then injecting an initial dose of [ 2 H2] tyrosine, then continuous infusion [ 2 H2] tyrosine, in the infusion [ 2 H2] tyrosine in the last period of time, collect the test blood sample; S23. Centrifuge the two blood samples to obtain the corresponding plasma, and then measure the [ 2 H2] tyrosine abundance. The present invention pioneered the use of [ 2 H2] Tyrosine tracing combined with nitrogen balance is used to determine bovine protein turnover metabolism, which is an efficient and low-cost method.

The present invention is directed to methods for treating or preventing neuroinflammation in a subject by administering an effective amount of a single-domain antibody (sdAb) comprising SEQ ID NO:1. The method is applicable to subjects with multiple sclerosis, including secondary progressive, primary progressive, and relapsing-remitting forms. Administration may be intravenous, subcutaneous, or intrathecal, with dosage regimens including daily administration, loading and maintenance doses, or continuous infusion. The method may be initiated upon first clinical signs of central nervous system demyelination and contin- ued for at least 14 days. The sdAb may be co-administered with a pharmaceutically acceptable excipient such as mannitol, sucrose, or polysorbate 80, and optionally combined with disease-modifying therapies including interferon-β, glatiramer acetate, fingolimod, or ocrelizumab. The invention provides a targeted approach for modulating neuroinflammatory processes in neurological disorders.

The present disclosure is drawn to a method of treating a patient in need of treatment, comprising identifying a patient in need of treatment for stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, or hypoxia / ischemia; administering a bolus of glyburide to the patient; and administering a continuous infusion of glyburide to the patient at from about 15 μg / hr and about 300 μg / hr, wherein the continuous infusion glyburide is administered for a period of time more than about 20 hours.

The present invention is directed to methods for treating or preventing neuroinflammation in a subject by administering an effective amount of a single-domain antibody (sdAb) comprising SEQ ID NO:1. The method is applicable to subjects with multiple sclerosis, including secondary progressive, primary progressive, and relapsing-remitting forms. Administration may be intravenous, subcutaneous, or intrathecal, with dosage regimens including daily administration, loading and maintenance doses, or continuous infusion. The method may be initiated upon first clinical signs of central nervous system demyelination and continued for at least 14 days. The sdAb may be co-administered with a pharmaceutically acceptable excipient such as mannitol, sucrose, or polysorbate 80, and optionally combined with disease-modifying therapies including interferon-β, glatiramer acetate, fingolimod, or ocrelizumab. The invention provides a targeted approach for modulating neuroinflammatory processes in neurological disorders.

A system (1) for performing a continuous infusion procedure using at least two infusion devices (10A, 10B), the system comprising: a first infusion device (10A) configured to deliver a fluid (F1) from a first medicament container (100A) in an adjustable manner; a second infusion device (10B) configured to deliver a fluid (F2) from a second medicament container (100B) in an adjustable manner; and a control system (11) configured to control the first and second infusion devices (10A, 10B) such that the first infusion device (10A) delivers a fluid (F1) for a first time period and the second infusion device (10B) delivers a fluid (F2) for a second time period. Wherein it is provided that the control system (11) comprises a memory (110) storing a plurality of predefined transition flow routines (R1 to R5), and the control system is configured to: select one predefined transition flow routine of the plurality of predefined transition flow routines (R1 to R5), and controlling the first and second infusion devices (10A, 10B) according to a transition period (TP) between the first and second time periods in accordance with the selected predefined transition flow routine (R1 to R5).

The invention relates to the technical field of animal models, and discloses a dog continuous infusion model device which comprises an injection pump, a fixed panel is arranged on the upper surface of the injection pump, an infusion extension tube is fixedly connected to the inner wall of the fixed panel, and an iron pack basket is fixedly connected to the outer wall of the infusion extension tube. A clamping groove is formed in the inner wall of the iron pack basket, a three-way valve is fixedly connected to the interior of the iron pack basket, an injection tube is fixedly connected to the outer wall of the right side of the three-way valve, a switch is arranged on the outer wall of the left side of the three-way valve, and venous intubation cloth is fixedly connected to the bottom end of the three-way valve. The animal wears the special waistcoat, the catheter in the dog body penetrates through the opening of the waistcoat to be connected with the bottom end of the three-way valve, and one end of the infusion extension tube is connected to the other opening of the three-way valve, so that the animal can be continuously instilled for multiple times for a long time in a waking state, can freely move in the waking state, does not influence diet and water drinking, and meets the requirement of animal welfare.

The utility model discloses a blood concentration controllable propofol continuous infusion administration device for intraoperative anesthesia. The device comprises an injection control structure; the two sets of injection clamping structures are both assembled on the injection control structure, and each set of injection clamping structure is provided with a sliding position driving clamping end and a retention clamping end; each of the basic injector structure and the supplementary injector structure is provided with an infusion pushing end and a needle cylinder limiting end; the two sets of infusion pushing ends are detachably and fixedly connected with the two sets of sliding position driving clamping ends correspondingly, and the two sets of needle cylinder limiting ends are detachably and fixedly connected with the two sets of fixing clamping ends correspondingly. The technical problems that in the prior art, when a pumping syringe needs to stop injection midway to supplement propofol medicine, corresponding continuous intravenous infusion based on blood concentration is likely to be interrupted, then dynamic deviation exists in the medicine infusion amount within a certain period of subsequent time, and smooth operation is affected are solved.

The invention provides an infusion heat preservation structure for operating room nursing, and belongs to the technical field of infusion heat preservation structures. Comprising supporting rods, a heat preservation box, a base, rollers, a heat preservation assembly, a limiting assembly and a transmission assembly. By arranging the heat preservation assembly, before infusion is conducted on a patient, an infusion bag is inserted between a plurality of auxiliary heat conduction plates and a main heat conduction plate to extrude the auxiliary heat conduction plates and the main heat conduction plate to be away from each other, but the auxiliary heat conduction plates and the main heat conduction plate are always kept to be attached to the infusion bag under the reset action of a plurality of springs, the infusion bag is gradually flat along with continuous infusion, and the infusion effect is good. The main heat conducting plate and the auxiliary heat conducting plate can still be attached to the infusion bag under the reset action of the spring, so that the heat preservation effect of the heat conducting plates acting on the infusion bag is guaranteed, when infusion medicine is bottled liquid medicine, heat transfer can still be conducted on a bottle body through the infusion heat preservation structure, and therefore the application range of the infusion heat preservation structure is widened.

The invention discloses an anesthesia pump flow velocity abnormity automatic alarm device and method for fluorouracil continuous infusion, and relates to the field of anesthesia pump flow velocity abnormity detection.The anesthesia pump flow velocity abnormity automatic alarm device comprises a detection protection mechanism used for detecting the flow velocity of a continuous infusion anesthesia pump, and the detection protection mechanism comprises a detection plate box; a mounting cavity is formed in the detection plate box, a plurality of telescopic elements are fixedly connected to the interior of the mounting cavity, and one end of each telescopic element is connected with an arc-shaped detection plate; according to the anesthesia pump abnormal flow speed automatic alarm device and method for fluorouracil continuous infusion, through the effect of a clamping and containing mechanism, after detection is completed, a first rotating plate and a second rotating plate can be contained in a first containing groove and a second containing groove correspondingly; through the flexible storage mode, the occupied space of the two sides of the detection plate box is greatly reduced, a worker can conveniently store the detection plate box, and the portability and practicability of the equipment are improved.

The application discloses a constant-speed infusion device and method, wherein the device comprises: an infusion module comprising an infusion bag and an infusion pipeline; a pressurizing module comprising a pressurizing air bag wrapped around the outer periphery of the infusion module, the pressurizing air bag being connected with an external high-pressure gas source through a gas inlet pipeline; a pressure regulating module comprising a first-stage pressure regulating mechanism, a second-stage pressure regulating mechanism and an automatic switching mechanism arranged on the gas inlet pipeline; and a detection module comprising a first air pressure detection mechanism for detecting the air pressure value in the pressurizing air bag in real time. The application simplifies the operation steps, realizes rapid and seamless continuous infusion, and can guarantee the stability and safety of the infusion process through real-time monitoring of the air pressure condition and rapid switching of the automatic switching mechanism.

The utility model provides an intrusive pump flow catheter and an intrusive pump flow catheter system.The intrusive pump flow catheter comprises a fluid pipe and a perfusion drainage assembly, an infusion pump is arranged in the fluid pipe, the perfusion drainage assembly comprises a pressure storage part, a perfusion one-way valve and a perfusion pipeline, and a pressure storage cavity is defined by the retraction wall face and the expansion wall face of a pressure storage body in the pressure storage part; the elastic film is arranged in the pressure storage cavity and protrudes towards the retraction wall face in the initial state, a first cavity used for storing preset pressure perfusate is defined by the elastic film and the retraction wall face, and a second cavity used for providing deformation space for the elastic film is defined by the elastic film and the expansion wall face. Due to the fact that the elastic film is arranged in the mode of protruding towards the retraction wall face in the initial state, the elastic film can push more perfusate to the infusion pump under the action of the elastic restoring force of the elastic film, the duration of continuous infusion of the perfusate is prolonged, the possibility of blood return of the intrusive pump flow catheter is reduced, and the intrusive pump flow catheter is more convenient to use. Therefore, the possibility that the infusion pump is influenced by blood return is reduced.

The application discloses a multifunctional thoracic surgery clinical medicine administration device, which comprises a main body structure, an exchange structure and an auxiliary structure, the exchange structure is fixedly arranged in the main body structure, and the auxiliary structure is detachably arranged on the main body structure. The application relates to the technical field of medical infusion devices, and has the advantages of convenient installation, fixing, flexible connection and switching, realization of the series connection of multiple infusion bottles, switching of medicines through the liquid inlet pipe and the liquid outlet pipe of the device, improvement of the flexibility and efficiency of infusion, especially for the scene requiring continuous infusion administration, automatic monitoring, replacement of infusion and medicine replacement, timely prompting and notification when there is no medicine in the infusion bottle, improvement of the efficiency and quality of medical care, and enhancement of the safety guarantee of patients.

There is described a device for delivering a fluid pharmaceutical composition by intracranial continuous infusion, the device comprising: a reservoir [117] containing a pharmaceutical composition; a pump [101] forcing the pharmaceutical composition through an infusion tube [103] into an OMARY reservoir [111], the pump in fluid communication with the OMARY reservoir, and wherein the pump in fluid communication with the reservoir through a reservoir tube [115]; a filter [105] in line with the infusion tube; and an access conduit [113] in fluid communication with the OMYER reservoir, wherein the access conduit is substantially linear and accesses a target region of the brain within the ventricle.

The invention relates to a control method and system for continuous infusion dressing change based on a multi-connected liquid medicine tank, and the method comprises the steps: U1, hanging the multi-connected liquid medicine tank on a support for infusion, obtaining the image data information of the liquid medicine tank in real time based on a camera on the support, obtaining the image data information of liquid medicine drops in real time based on the camera on the support, and obtaining the image data information of the liquid medicine drops; the number data information of dripping liquid medicine drops is obtained in real time based on a laser counting sensor on the support; and U2, based on the image data information of the liquid medicine tank and the image data information of the liquid medicine drop, performing feature extraction on the images of the liquid medicine tank and the liquid medicine drop by adopting an improved Shii-Tomasi corner detection algorithm to obtain image feature data information of the liquid medicine tank and image feature data information of the liquid medicine drop. The infusion process of the liquid medicine tank can be accurately controlled, manual medicine changing is not needed in the whole process, the infusion efficiency and stability are improved, and therefore the use experience of a patient is improved.

The present application relates to a kind of control method and system based on multi-liquid medicine tank's continuous infusion drug change, the method includes:U1.It is hung on bracket and carries out infusion, based on the image data information of camera on bracket real-time acquisition medicine tank, based on the image data information of camera on bracket real-time acquisition medicine drop, based on the quantity data information of laser counting sensor on bracket real-time acquisition medicine drop drop;U2.Based on the image data information of the medicine tank and the image data information of the medicine drop, using improved Shi-Tomasi corner detection algorithm, the image of medicine tank and medicine drop is extracted, and the image feature data information of medicine tank and the image feature data information of medicine drop are obtained.The present application not only can accurately control the infusion process of medicine tank, and the whole process, without manual drug change, improve the efficiency and stability of infusion, to improve the use experience of patient.

A device includes: a main body portion (10A) having an inner cavity (11A); a plug (40A) that is slidable in a liquid-tight manner in the inner cavity (11A); a pressing portion (30A) that is disposed on the upstream side of the plug (40A) in the inner cavity (11A) and presses the plug (40A) toward the downstream side; a substance (X) to be administered that is accommodated on the downstream side of the plug (40A) in the inner cavity (11A) and is released into the living body by sliding of the plug (40A) toward the downstream side; and a release portion (50A) that is disposed on the distal end side of the main body portion (10A), and releases the substance (X) to be administered pushed out by the plug (40A) into the living body, the device being indwelled in a living body for sustainably extendedly releasing the substance (X) to be administered, and including: a notification unit (60A) that performs a notification operation for notifying abnormality to the outside when an internal pressure of the inner cavity (11A) exceeds a predetermined threshold value due to stop of movement of the plug (40A).

The invention discloses medicine infusion equipment which comprises a base and a drainage assembly used for switching liquid medicine bottles. The drainage assembly comprises a disc body, a connecting rod, supporting rods and a ring sleeve, the connecting rod is fixedly connected to the disc body, the supporting rods are symmetrically and fixedly connected to the connecting rod, the other ends of the supporting rods are fixedly connected with the ring sleeve, the ring sleeve is in threaded connection with a bolt, the bolt is used for clamping a liquid medicine bottle, a plurality of ejector rods are hinged to the disc body, and the ejector rods are fixedly connected to the disc body. The ejector rod corresponds to the supporting rod, a needle head is fixedly connected to the ejector rod, a plurality of through holes are symmetrically formed in the side wall of the needle head, and the ejector rod is connected with the switching assembly; according to the invention, the liquid medicine bottle can be replaced for continuous infusion after being emptied.

The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2 wherein a GD2 positive cancer is treated in the patient. Furthermore, the invention relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein a preparation comprising an anti-GD2 antibody is administered to the patient as a continuous infusion, without concomitantly administering IL-2. The present invention further relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein the one or more anti-GD2 antibody treatment periods is / are preceded, accompanied, and / or followed by one or more treatment periods with a retinoid.

The invention discloses a continuous infusion micro pump front tube, and relates to the technical field of micro pump front tubes. Comprising a connector A, a pipeline is installed at the bottom end of the connector A, a tight ring A and a tight ring B are installed on the inner wall of the connector A, a conveying bin is installed on the outer wall of the connector A, and conveying cavities are formed in the side wall of the connector A and the interior of the tight ring A. According to the invention, through the arrangement of the top block, the abutting ring and the pressing reset assembly, slight looseness is generated at the joint of the micro pump and the front pipe, so that when the joint of the micro pump shifts in the joint A to form a gap, the joint of the micro pump can be corrected and reset at the joint A through the pressure generated by leakage of liquid medicine from the gap; the micro pump and the connector A are tightly connected again, vibration of the micro pump in the working process is avoided, the phenomenon that the connector A and the micro pump connector loosen again is avoided, and it is ensured that the micro pump connector and the connector A rapidly recover to be tightly connected after loosing.

The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2) wherein a GD2 positive cancer is treated in the patient. Furthermore, the invention relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein a preparation comprising an anti-GD2 antibody is administered to the patient as a continuous infusion, without concomitantly administering IL-2. The present invention further relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein the one or more anti-GD2 antibody treatment periods is / are preceded, accompanied, and / or followed by one or more treatment periods with a retinoid.

The invention relates to the technical field of infusion control systems, and provides a multi-channel intelligent infusion control system and method.In the multi-channel intelligent infusion control system, a central control unit cooperates with a liquid level detection module, an electric control switch valve and a dripping speed control module on each infusion channel; the technical problems that an existing infusion device cannot automatically recognize multiple bottles of liquid medicine, cannot conduct seamless switching in sequence and depends on manual intervention are effectively solved. The system can automatically identify the number and the positions of connected infusion bottles based on liquid level feedback, intelligently open a current channel and close other channels according to a preset sequence, cut off the current channel in time before liquid medicine is completely infused so as to prevent air from entering, and synchronously switch to a next infusion channel, so that unattended multi-bottle continuous infusion in the whole process is realized; the risk of air embolism is thoroughly avoided, the workload of frequent inspection and manual bottle replacement of nurses is remarkably relieved, and infusion safety, continuity and patient experience are improved.