24 results about "Continuous infusion" patented technology

The invention provides a method for determining bovine protein turnover metabolism through combination of [2H2] tyrosine tracing and nitrogen equilibrium, and belongs to the technical field of protein turnover metabolism determination. Comprising the following steps: S1, a nitrogen balance determination method: determining the nitrogen content of cattle feed, excrement and urine samples; s2, an isotope tracing determination method: S21, putting an isotope injection tube and a blood collection tube into the bovine jugular vein treatment; s22, collecting a baseline blood sample, injecting [2H2] tyrosine with an initial dose, continuously infusing the [2H2] tyrosine, and collecting a test blood sample in the last period of time of infusing the [2H2] tyrosine; and S23, respectively centrifugally separating the two blood samples to obtain corresponding plasma, and then measuring the abundance of [2H2] tyrosine in the plasma of the blood samples. According to the method, the bovine protein turnover metabolism is creatively determined by combining [2H2] tyrosine tracing with nitrogen balance, and the determination method is efficient and low in cost.

The invention discloses a precise control device for continuous infusion of a boron-loaded drug, which overcomes the defects of insufficient precise control, poor continuity and no dynamic closed loop in the existing boron neutron capture therapy. The device comprises a first shell and a second shell which are connected through a hinge, the device is further provided with an electromagnetic drive extrusion assembly, a fixing assembly and a rope ring, and the electromagnetic drive extrusion assembly comprises an electromagnet, a magnetic conductive block and a first elastic piece. The device further comprises a module which is specifically a data collecting and processing module and can collect liquid medicine parameters, pipeline parameters, physiological parameters and flow velocity data and remove abnormal data through filtering processing. And the influence factor calculation module can calculate a physiological state influence factor and an infusion resistance influence factor. Through electromagnetic pressure control, multi-factor calibration and multi-patient overall planning, the flow velocity precision meets the precision infusion requirement, the effective concentration of boron-loaded medicine in the body is stabilized in a treatment window, and the infusion interruption risk is greatly reduced.

The utility model provides an intraspinal and peripheral nerve block continuous administration infusion system which comprises an air bag, connecting catheters are symmetrically installed on the side wall of the air bag arranged in a skin layer, and a rubber isolation pad is installed in the middle of the interior of the air bag. One end of the connecting guide pipe is connected with a driving mechanism, the driving mechanism comprises a fixing shell, a micro pump and a storage battery are installed in the fixing shell, a switch is installed on the surface of the fixing shell, and the switch is electrically connected with the micro pump and the storage battery; the side wall of the micro pump is provided with two communicating pipes, and one communicating pipe is connected with the connecting guide pipe. The other communicating pipe is connected with an input catheter, and the input catheter penetrates through the skin layer and enters the epidural space from the space between the spinous protrusions. The intraspinal and peripheral nerve block continuous administration infusion system has the advantages of being simple in structure, small in size and convenient to use.

The invention belongs to the field of perfusion instruments, and particularly discloses a gastrointestinal surgery perfusion device which comprises a body, an inner cylinder, an outer cylinder arranged on the periphery of the inner cylinder and a four-way seat arranged between the inner cylinder and the outer cylinder. The liquid filling mechanism comprises a piston rod I arranged in the inner cylinder, a piston rod II arranged in the outer cylinder, and supplementing pieces arranged on the inner cylinder and the outer cylinder; the driving mechanism comprises a shell arranged at the rear end of the inner cylinder, a driving piece arranged in the shell and a conversion piece arranged on the driving piece; by means of the liquid filling mechanism, filling work of enema liquid in the auxiliary containing cavity can be automatically completed when liquid filling work is propelled, then continuous liquid filling work is achieved by circularly and alternately pushing the first piston rod and the second piston rod, continuous liquid filling can be achieved under the condition that the size of the device is not increased, and personnel use is facilitated.

The present invention provides regimens and methods for treating cancer, including continuous infusion of coenzyme Q10. Coenzyme Q10 can be administered as a monotherapy or in combination with other agents, such as anti-cancer agents, chemotherapeutic agents, or anti-angiogenic agents. Coenzyme Q10 can be administered at two or more different rates.

A method for treating ascites patients by administering the peptide drug terlipressin by continuous infusion. The patients include those whose ascites condition has not progressed to hepatorenal syndrome (HRS). Administration may be accomplished with a continuous infusion pump.

The utility model relates to the technical field of medical instruments, in particular to a pressure bag capable of automatically identifying pressurization. According to the technical scheme, the pressure bag comprises an infusion bag and a pressure bag body for pressurizing the infusion bag, a cavity is formed in the pressure bag body, a connecting belt is arranged on the inner wall of the bottom of the pressure bag body, a mounting groove is formed in the inner wall of one side of the pressure bag body, and a sliding mounting plate is detachably connected into the mounting groove; a sensor structure is installed on the side face of the sliding installation plate, and pressing rods located on the two sides of the sensor structure are further installed on the side face of the sliding installation plate. An air pump is fixedly installed below the connecting belt, and the output end of the air pump is connected with an air conveying pipe. The infusion apparatus is novel in structure, the sensor can be conveniently and rapidly replaced, disassembled and assembled, the sensor can be conveniently and repeatedly used, automatic pressurization is achieved, the workload of medical workers is reduced, and continuous infusion is guaranteed.

The present invention provides a [ 2 H2] A method for determining bovine protein turnover metabolism by tyrosine tracing combined with nitrogen balance, belonging to the technical field of protein turnover metabolism determination, comprising S1. Nitrogen balance determination method: determining the nitrogen content of bovine feed, feces, and urine samples; S2. Isotope tracing determination method: S21. inserting an isotope injection tube and a blood collection tube into the bovine jugular vein; S22. collecting a baseline blood sample, and then injecting an initial dose of [ 2 H2] tyrosine, then continuous infusion [ 2 H2] tyrosine, in the infusion [ 2 H2] tyrosine in the last period of time, collect the test blood sample; S23. Centrifuge the two blood samples to obtain the corresponding plasma, and then measure the [ 2 H2] tyrosine abundance. The present invention pioneered the use of [ 2 H2] Tyrosine tracing combined with nitrogen balance is used to determine bovine protein turnover metabolism, which is an efficient and low-cost method.

The present invention is directed to methods for treating or preventing neuroinflammation in a subject by administering an effective amount of a single-domain antibody (sdAb) comprising SEQ ID NO:1. The method is applicable to subjects with multiple sclerosis, including secondary progressive, primary progressive, and relapsing-remitting forms. Administration may be intravenous, subcutaneous, or intrathecal, with dosage regimens including daily administration, loading and maintenance doses, or continuous infusion. The method may be initiated upon first clinical signs of central nervous system demyelination and contin- ued for at least 14 days. The sdAb may be co-administered with a pharmaceutically acceptable excipient such as mannitol, sucrose, or polysorbate 80, and optionally combined with disease-modifying therapies including interferon-β, glatiramer acetate, fingolimod, or ocrelizumab. The invention provides a targeted approach for modulating neuroinflammatory processes in neurological disorders.

The present disclosure is drawn to a method of treating a patient in need of treatment, comprising identifying a patient in need of treatment for stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, or hypoxia / ischemia; administering a bolus of glyburide to the patient; and administering a continuous infusion of glyburide to the patient at from about 15 μg / hr and about 300 μg / hr, wherein the continuous infusion glyburide is administered for a period of time more than about 20 hours.

The present invention is directed to methods for treating or preventing neuroinflammation in a subject by administering an effective amount of a single-domain antibody (sdAb) comprising SEQ ID NO:1. The method is applicable to subjects with multiple sclerosis, including secondary progressive, primary progressive, and relapsing-remitting forms. Administration may be intravenous, subcutaneous, or intrathecal, with dosage regimens including daily administration, loading and maintenance doses, or continuous infusion. The method may be initiated upon first clinical signs of central nervous system demyelination and continued for at least 14 days. The sdAb may be co-administered with a pharmaceutically acceptable excipient such as mannitol, sucrose, or polysorbate 80, and optionally combined with disease-modifying therapies including interferon-β, glatiramer acetate, fingolimod, or ocrelizumab. The invention provides a targeted approach for modulating neuroinflammatory processes in neurological disorders.

The invention discloses an anesthesia pump flow velocity abnormity automatic alarm device and method for fluorouracil continuous infusion, and relates to the field of anesthesia pump flow velocity abnormity detection.The anesthesia pump flow velocity abnormity automatic alarm device comprises a detection protection mechanism used for detecting the flow velocity of a continuous infusion anesthesia pump, and the detection protection mechanism comprises a detection plate box; a mounting cavity is formed in the detection plate box, a plurality of telescopic elements are fixedly connected to the interior of the mounting cavity, and one end of each telescopic element is connected with an arc-shaped detection plate; according to the anesthesia pump abnormal flow speed automatic alarm device and method for fluorouracil continuous infusion, through the effect of a clamping and containing mechanism, after detection is completed, a first rotating plate and a second rotating plate can be contained in a first containing groove and a second containing groove correspondingly; through the flexible storage mode, the occupied space of the two sides of the detection plate box is greatly reduced, a worker can conveniently store the detection plate box, and the portability and practicability of the equipment are improved.

The application discloses a constant-speed infusion device and method, wherein the device comprises: an infusion module comprising an infusion bag and an infusion pipeline; a pressurizing module comprising a pressurizing air bag wrapped around the outer periphery of the infusion module, the pressurizing air bag being connected with an external high-pressure gas source through a gas inlet pipeline; a pressure regulating module comprising a first-stage pressure regulating mechanism, a second-stage pressure regulating mechanism and an automatic switching mechanism arranged on the gas inlet pipeline; and a detection module comprising a first air pressure detection mechanism for detecting the air pressure value in the pressurizing air bag in real time. The application simplifies the operation steps, realizes rapid and seamless continuous infusion, and can guarantee the stability and safety of the infusion process through real-time monitoring of the air pressure condition and rapid switching of the automatic switching mechanism.

The utility model provides an intrusive pump flow catheter and an intrusive pump flow catheter system.The intrusive pump flow catheter comprises a fluid pipe and a perfusion drainage assembly, an infusion pump is arranged in the fluid pipe, the perfusion drainage assembly comprises a pressure storage part, a perfusion one-way valve and a perfusion pipeline, and a pressure storage cavity is defined by the retraction wall face and the expansion wall face of a pressure storage body in the pressure storage part; the elastic film is arranged in the pressure storage cavity and protrudes towards the retraction wall face in the initial state, a first cavity used for storing preset pressure perfusate is defined by the elastic film and the retraction wall face, and a second cavity used for providing deformation space for the elastic film is defined by the elastic film and the expansion wall face. Due to the fact that the elastic film is arranged in the mode of protruding towards the retraction wall face in the initial state, the elastic film can push more perfusate to the infusion pump under the action of the elastic restoring force of the elastic film, the duration of continuous infusion of the perfusate is prolonged, the possibility of blood return of the intrusive pump flow catheter is reduced, and the intrusive pump flow catheter is more convenient to use. Therefore, the possibility that the infusion pump is influenced by blood return is reduced.

The application discloses a multifunctional thoracic surgery clinical medicine administration device, which comprises a main body structure, an exchange structure and an auxiliary structure, the exchange structure is fixedly arranged in the main body structure, and the auxiliary structure is detachably arranged on the main body structure. The application relates to the technical field of medical infusion devices, and has the advantages of convenient installation, fixing, flexible connection and switching, realization of the series connection of multiple infusion bottles, switching of medicines through the liquid inlet pipe and the liquid outlet pipe of the device, improvement of the flexibility and efficiency of infusion, especially for the scene requiring continuous infusion administration, automatic monitoring, replacement of infusion and medicine replacement, timely prompting and notification when there is no medicine in the infusion bottle, improvement of the efficiency and quality of medical care, and enhancement of the safety guarantee of patients.

The present application relates to a kind of control method and system based on multi-liquid medicine tank's continuous infusion drug change, the method includes:U1.It is hung on bracket and carries out infusion, based on the image data information of camera on bracket real-time acquisition medicine tank, based on the image data information of camera on bracket real-time acquisition medicine drop, based on the quantity data information of laser counting sensor on bracket real-time acquisition medicine drop drop;U2.Based on the image data information of the medicine tank and the image data information of the medicine drop, using improved Shi-Tomasi corner detection algorithm, the image of medicine tank and medicine drop is extracted, and the image feature data information of medicine tank and the image feature data information of medicine drop are obtained.The present application not only can accurately control the infusion process of medicine tank, and the whole process, without manual drug change, improve the efficiency and stability of infusion, to improve the use experience of patient.

The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2 wherein a GD2 positive cancer is treated in the patient. Furthermore, the invention relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein a preparation comprising an anti-GD2 antibody is administered to the patient as a continuous infusion, without concomitantly administering IL-2. The present invention further relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein the one or more anti-GD2 antibody treatment periods is / are preceded, accompanied, and / or followed by one or more treatment periods with a retinoid.

The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2) wherein a GD2 positive cancer is treated in the patient. Furthermore, the invention relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein a preparation comprising an anti-GD2 antibody is administered to the patient as a continuous infusion, without concomitantly administering IL-2. The present invention further relates to preparations and methods for the treatment of a GD2 positive cancer in a patient, wherein the one or more anti-GD2 antibody treatment periods is / are preceded, accompanied, and / or followed by one or more treatment periods with a retinoid.

The invention relates to the technical field of infusion control systems, and provides a multi-channel intelligent infusion control system and method.In the multi-channel intelligent infusion control system, a central control unit cooperates with a liquid level detection module, an electric control switch valve and a dripping speed control module on each infusion channel; the technical problems that an existing infusion device cannot automatically recognize multiple bottles of liquid medicine, cannot conduct seamless switching in sequence and depends on manual intervention are effectively solved. The system can automatically identify the number and the positions of connected infusion bottles based on liquid level feedback, intelligently open a current channel and close other channels according to a preset sequence, cut off the current channel in time before liquid medicine is completely infused so as to prevent air from entering, and synchronously switch to a next infusion channel, so that unattended multi-bottle continuous infusion in the whole process is realized; the risk of air embolism is thoroughly avoided, the workload of frequent inspection and manual bottle replacement of nurses is remarkably relieved, and infusion safety, continuity and patient experience are improved.

Methods of treating ascites patients by administering the polypeptide drug terlipressin via continuous infusion. The patients include those whose ascites conditions have not developed to hepatorenal syndrome (HRS). Administration may be effected with a continuous infusion pump.

The utility model discloses a medicine infusion equipment, including base, drainage component for switching liquid medicine bottle, the drainage component, including disc body, connecting rod, bracing piece and ring, the disc body is fixedly connected with connecting rod, a plurality of bracing pieces are fixedly connected with symmetry on the connecting rod, the other end of bracing piece is fixedly connected with ring, the ring is threadedly connected with bolt, the bolt is used for clamping liquid medicine bottle, a plurality of top rods are hinged on the disc body, the top rod corresponds with bracing piece, needle is fixedly connected on the top rod, a plurality of through -holes are arranged on needle side wall symmetry, the top rod is connected with switching assembly, the utility model discloses can even replace continuous infusion after liquid medicine bottle empties.

The enteral nutrition input device comprises a supporting rod and a conveying pipe, a heat preservation box is detachably and fixedly connected to the supporting rod, a heat preservation cover is matched with the top of the heat preservation box in a sealed mode, a partition plate is vertically arranged in the heat preservation box, and the conveying pipe is connected with the partition plate. The partition plate divides the interior of the heat preservation box into a first containing cavity and a second containing cavity. A three-way valve is installed at one end of the conveying pipe, the output end of the three-way valve communicates with the conveying pipe, and the two input ends of the three-way valve communicate with a first connecting pipe communicating with the first containing cavity and a second connecting pipe communicating with the second containing cavity correspondingly; a pushing and injecting assembly is slidably connected into the second containing cavity and used for pushing and injecting warm water into the conveying pipe. The problem that in the prior art, particulate matter and sediment are extremely prone to being attached and deposited on the inner wall of a lumen when flowing through a conveying tube and a nasointestinal tube in the continuous infusion process of a patient, and the lumen is gradually narrow until the lumen is completely blocked is solved.

A system (1) for performing a continuous infusion process using at least two infusion devices (10A, 10B) comprises: a first infusion device (10A) configured to adjustably deliver fluid (F1) from a first medication container (100A), a second infusion device (10B) configured to adjustably deliver fluid (F2) from a second medication container (100B), and a control system (11) configured to control the first and second infusion devices (10A, 10B) so that the first infusion device (10A) delivers fluid (F1) at a first time period and the second infusion device (10B) delivers fluid (F2) at a second time period. Therein, it is provided that the control system (11) comprises memory (110) storing a plurality of pre-defined transitional flow routines (R1-R5), and is configured to: select one of the plurality of pre-defined transitional flow routines (R1-R5) and control the first and second infusion devices (10A, 10B) in a transitional period (TP) between the first time period and the second time period in accordance with the selected pre-defined transitional flow routine (R1-R5).