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4 results about "Terlipressin" patented technology
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Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help.
Deamination and esterification impurity of terlipressin preparation for injection and application of deamination and esterification impurity
The invention belongs to the field of biological medicine, and particularly relates to a 12-bit deamination esterification impurity of terlipressin for injection and application. The deamination and esterification impurity is a terlipressin 12-site deamination and esterification compound generated by reaction of terlipressin 12-site amination glycine and mannitol, the molecular weight of a single isotope is 1391.5510, and the structural formula of the deamination and esterification impurity is shown as a formula I. The deamination and esterification impurity is a terlipressin 12-site deamination and esterification compound.
Owner:TIANJIN INST FOR DRUG CONTROL
Impurity detection method of terlipressin preparation for injection
The invention belongs to the field of biological medicine, and particularly relates to an impurity detection method of a terlipressin preparation for injection. The impurity is the deamination esterification impurity of terlipressin and mannitol found for the first time, the structure of the impurity is shown as a formula I and / or a formula II, and the synthesized impurity is used as a reference substance and is detected through ultra-high performance liquid chromatography.
Owner:TIANJIN INST FOR DRUG CONTROL
Esterification impurity of terlipressin and mannitol and application
The invention belongs to the field of biological medicine, and particularly relates to esterified impurities of terlipressin and mannitol and application of the esterified impurities. The alcohol esterification impurity is a terlipressin mannitol esterification compound generated by deamination and esterification reaction of the 8th asparagine of terlipressin and mannitol, the single isotope molecular weight of the alcohol esterification impurity is 1391.5510, and the structural formula of the alcohol esterification impurity is as shown in the formula I. The alcohol esterification impurity is a terlipressin mannitol esterification compound.
Owner:TIANJIN INST FOR DRUG CONTROL
A lyophilized formulation of teceleptin acetate and a method for preparing the same
The application discloses a lyophilized preparation of terlipressin acetate and a preparation method thereof. The lyophilized preparation of terlipressin acetate comprises terlipressin acetate, an excipient, a stabilizer and water. The weight ratio of the terlipressin acetate and the excipient is 1:(8-18), the weight ratio of the terlipressin acetate and the stabilizer is 1:(1-2), and the weight ratio of the terlipressin acetate and water is 1:(4000-6000). The excipient is modified dextran. The application aims at solving the technical problem of poor stability of terlipressin.
Owner:HAINAN HUALON PHARM