A method for purifying terlipressin

A terlipressin and antioxidant technology, which is applied in the field of polypeptide purification, can solve the problems of low purity and yield of terlipressin, cannot meet industrial production, restrict the application of terlipressin, etc., and achieves simple operation. Easy, high yield, high purity effect
CN102731625BActive Publication Date: 2014-10-15HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2014-10-15

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Abstract

The present invention relates to the field of polypeptide purification, and particularly to a method for purifying terli. According to the method, a terli crude product is pre-treated, and then purification and salt conversion are performed to obtain the terli with purity more than 99.5%. The method of the present invention has the following advantages that: the operation is simple and easy to perform; the terli prepared by the method of the present invention has characteristics of high purity (the purity can be more than 99.5%, and the maximum single impurity is less than 0.1%) and high yield (the purification yield can be more than 85%, and the total yield can be more than 50%); and the method meets requirements of industrialization, and more than 1000 g of the refined peptide can be obtained in one batch.
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Description

technical field

[0001] The invention relates to the field of polypeptide purification, in particular to a method for purifying terlipressin. Background technique

[0002] Liver cirrhosis (hepatic cirrhosis) is a common clinical chronic progressive liver disease, which is diffuse liver damage caused by long-term or repeated effects of one or more etiologies. In my country, most of them are post-hepatitis cirrhosis, and a small part are alcoholic cirrhosis and schistosome cirrhosis. Histopathologically, extensive liver cell necrosis, nodular regeneration of residual liver cells, connective tissue hyperplasia, and fibrous septum formation lead to structural destruction of hepatic lobules and formation of pseudolobules. The liver gradually deforms and hardens and develops into cirrhosis. In the early stage, there are no obvious symptoms due to the strong compensatory function of the liver. In the later stage, liver function damage and portal hypertension are the main manifestat...

Claims

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