496 results about "Hyperplasia" patented technology

The invention discloses a subcutaneous injection site detection and recommendation system based on an intelligent algorithm, and aims to improve the safety of long-term subcutaneous injection and the drug absorption efficiency and reduce the risk of related complications such as subcutaneous hemorrhage, subcutaneous induration and subcutaneous fat hyperplasia at the same time. Comprising a subcutaneous tissue detection module for acquiring subcutaneous vascular distribution, fat layer thickness and induration state of a target part through infrared imaging and ultrasonic technologies and generating subcutaneous tissue characteristic data; the data processing module analyzes the feature data by using an image recognition algorithm, and recognizes a blood vessel dense region, induration and a part where fat hyperplasia has occurred; the injection part recommendation module is used for evaluating an analysis result of the data processing module based on a machine learning algorithm in combination with personalized injection historical data of the patient, and generating an optimal injection part recommendation scheme avoiding a risk area; the intelligent imaging and data analysis technology is utilized, the subcutaneous injection part selection accuracy is improved, and the patient comfort and the treatment effect are improved.

The invention relates to the technical field of medical care, and provides a patient risk dynamic assessment system in medical care teaching, which comprises a data acquisition module used for acquiring multi-modal image data of a postoperative gastric organ anastomosis area of a patient; the data processing module is used for preprocessing the multi-modal image data, establishing a three-dimensional model of organs around the anastomotic stoma and analyzing edge features of the anastomotic stoma; and the risk assessment module is used for constructing an anastomotic stoma state assessment model and outputting comprehensive scores of an anastomotic stoma blood perfusion condition, a tissue metabolism abnormal probability, an anastomotic stoma leakage risk, anastomotic stoma scar hyperplasia and healing trend prediction. A quantum dot fluorescence image, a Raman spectrum image, a CT image and an intraoperative high-definition white light image are enhanced through the system and evaluated, a nursing scheme is obtained in combination with opinions of medical staff, and compared with manual evaluation of the medical staff, the accuracy is higher, the feasibility of the nursing scheme is higher, and medical nursing use is facilitated.

The invention discloses a new medicine application of a local injection acoustic response stent in enhancing ultrasound histotripsy. The acoustic response scaffold (ARS) comprises a scaffold material, fluorocarbon gas or liquid fluorocarbon particles with liquid-vapor phase change capacity, and microbubble cloud in the scaffold generates a strong cavitation ablation treatment effect in a target area under the action of low-frequency and low-sound-pressure ultrasound. Fluorocarbon gas or liquid fluorocarbon particles contained in the ARS form microbubble cloud and ideal cavitation nuclei under low-frequency low-sound-pressure ultrasonic excitation, inertia cavitation resonance is achieved under the ultrasonic action, and then cavitation mechanical damage with local tissue controllable strength is generated. The low-intensity ultrasonic histotripsy has the characteristics of low sound pressure, low sound intensity, high targeting property, small tissue damage outside a target region, simplicity in instrument manufacturing and the like, and the targeting property and the safety of treatment are improved. The method does not need very accurate ultrasonic focusing, reduces the operation difficulty, and has application prospects in multiple medical fields such as prostatic hyperplasia, tumor ablation and tumor immunotherapy.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses a compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands is prepared from an iron-based metal organic framework composite drug carrying system, dopamine hydrochloride, a blank gel matrix, ethyl oleate, menthol, a solubilizer, a wetting agent and water, the iron-based metal organic framework composite drug loading system is composed of traditional Chinese medicine dihydric alcohol plastid, iron-based metal organic framework nanoparticles and cinnamomum camphora essential oil. The traditional Chinese medicine dihydric alcohol plastid and the cinnamomum camphora essential oil are loaded in the iron-based metal organic framework nano particles, so that the transdermal absorption of the medicine is improved, the pH response release property is realized, the dosage of active ingredients permeating into a focus part and the lasting action time are effectively increased, and then a coating layer is formed by polydopamine, so that the anti-inflammatory effect is improved. The dispersibility and compatibility of the drug loading system in vivo are further enhanced, the drug effect can be fully exerted, and the treatment effect on the hyperplasia of mammary glands is remarkably improved.

The invention discloses a method for promoting skeletal muscle development and application, and belongs to the technical field of biology. The invention provides a method for promoting skeletal muscle development, an AMPK / p38MAPK pathway is regulated and controlled by activating PPARalpha, the way of activating the PPARalpha is to give a PPARalpha agonist GW7647, and the regulation and control of the AMPK / p38MAPK pathway is shown as reduction of AMPK and P38 phosphorylation levels. Experiments show that the expression of MyoD, MyoG and Pax7 in skeletal muscle can be remarkably improved by activating PPARalpha, the phosphorylation level of AMPK and P38 is inhibited, and therefore muscle fiber proliferation and myoblast proliferation are promoted. The technology can be applied to livestock breeding to improve meat yield or develop drugs for treating skeletal muscle atrophy, and has remarkable economic and clinical values.

The invention relates to a skin grafting material and a using method thereof. The skin grafting material is composed of compressed sponge and repairing liquid. The compressed sponge is selected from chitosan sponge, collagen sponge or polyvinyl formal sponge; the repairing liquid is selected from normal saline containing human epidermal growth factors and / or normal saline containing superoxide dismutase. The use method comprises the following steps: attaching the skin layer of the cut skin graft to the compressed sponge, then putting the compressed sponge into a medical skin rolling machine, and cutting the skin graft into micro skin graft; the cut miniature skin graft is soaked in the repairing liquid, is attached to the position to be subjected to skin grafting after fully absorbing the liquid and expanding, and is wrapped with gauze. The skin grafting material provided by the invention can reduce damage to newborn granulation when the skin grafting material is removed, has an antibacterial effect and improves scar hyperplasia contracture after a skin grafting wound operation; meanwhile, the sponge which absorbs the liquid and expands can slowly release the repairing liquid, so that skin cell regeneration is promoted, epithelization of a skin grafting area is accelerated, and wound healing is promoted; the healing effect is good, and the application prospect is wide.

This invention relates to a non-invasive predictive kit and method for the progression of benign prostatic hyperplasia (BPH) based on prostatic fluid. The invention provides the application of FGF9 as a non-invasive predictive biomarker for the progression of BPH based on prostatic fluid, wherein the concentration of FGF9 in prostatic fluid serves as an indicator of BPH progression. The invention also provides a method for detecting the concentration of FGF9 in prostatic fluid for non-disease diagnostic purposes. Compared with existing technologies, the non-invasive BPH detection method based on prostatic fluid of this invention has advantages such as non-invasiveness, accuracy, simplicity, practicality, and scalability, and is expected to be widely used in the clinical diagnosis and treatment of prostate diseases.

The invention relates to a burn glove pressure monitoring method and device, a storage medium and electronic equipment, and relates to the technical field of pressure monitoring, and the method comprises the following steps: when each actual pressure is normal, based on a target area in a burn hand and at least one corresponding target pressure interval when an actual action posture appears, determining the pressure of the burn glove according to the target area; determining whether the actual pressure of the wound area is adjusted and optimized or not; if yes, determining a to-be-optimized area needing pressure adjustment and optimization from each wound area; determining a first appropriate pressure of the to-be-optimized area, and adjusting the actual pressure of the to-be-optimized area to the first appropriate pressure; and when abnormal pressure exists in the actual pressures, determining the wound area corresponding to the abnormal pressure as an abnormal area, determining a second suitable pressure of the abnormal area, and adjusting the actual pressure of the abnormal area as the second suitable pressure. The effect of the burn gloves on inhibiting scar hyperplasia can be improved.

The invention discloses ganoderma tsugae polysaccharide with a colorectal cancer relieving effect and a preparation method and application thereof, and belongs to the technical field of biological medicine. The ganoderma tsugae polysaccharide is prepared from mannose, glucose, galactose and fucose, the molar ratio of the mannose to the glucose to the galactose to the fucose is 3.221 to 1.414 to 80.539 to 14.826, and the molecular weight of the ganoderma tsugae polysaccharide is 7.056 kDa. It is proved that the ganoderma tsugae polysaccharide can significantly reduce the number and size of colon tumors; the pathological symptoms such as colon weight index, bleeding, crypt budding, dysplasia and hyperplasia are relieved; compared with the prior art, the ganoderma tsugae polysaccharide provided by the invention has the advantages that the ganoderma tsugae polysaccharide can obviously inhibit the levels of IFN-gamma, TGF-beta and IL-17A in colon and also can obviously inhibit the levels of IFN-gamma, TGF-beta and IL-17A in colon, and meanwhile, the level of IL-4 is improved, so that the ganoderma tsugae polysaccharide provided by the invention has an outstanding action effect in the aspect of relieving colorectal cancer, and a theoretical support is provided for developing colorectal cancer medicines with effectiveness and biological safety.

The utility model discloses an intracavity negative pressure device for treating upper digestive tract fistula, which comprises a drainage catheter, and two ends of the drainage catheter are respectively a suction end and a negative pressure end connected with the negative pressure device; a liquid suction hole adjacent to the suction end is formed in the side wall of the drainage catheter, and a sponge body wrapping the liquid suction hole is arranged on the outer wall of the drainage catheter. The sponge body comprises a first sponge body and a second sponge body with the aperture larger than that of the first sponge body, the first sponge body wraps the suction end, and the second sponge body is arranged between the first sponge body and the negative pressure end. The two cavernous bodies with different pore diameters are arranged in a partitioned mode, the first cavernous body with the small pore diameter absorbs effusion at the wound of the upper digestive tract fistula in time, granulation tissue hyperplasia is promoted, recovery of a patient is facilitated, and the treatment period is shortened; the second sponge body with the large hole diameter enables secretions with large viscidity to be adsorbed in time, the sponge body and the drainage catheter are not prone to being blocked, the service life of the negative pressure device is prolonged, and the replacement frequency of the device is reduced.

To provide drug-coated balloon catheters for treating, preventing or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen, and methods of using the same.SOLUTION: A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism, which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.SELECTED DRAWING: Figure 5A

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for relieving pain, promoting blood circulation, diminishing swelling and removing blood stasis, application thereof and a blood stasis dispersing and pain relieving patch. The invention provides a traditional Chinese medicine composition for relieving pain, activating blood, diminishing swelling and removing stasis. The traditional Chinese medicine composition comprises the following components: lycopodium clavatum, radix clematidis, asarum, gentiana macrophylla, radix angelicae, rheum officinale, notopterygium root, roasted herba epimedii, radix achyranthis bidentatae, peach kernel, radix angelicae pubescentis, vinegar-processed rhizoma corydalis, vinegar-processed rhizoma cyperi, moutan bark, prepared kusnezoff monkshood root, prepared monkshood, vinegar-processed frankincense, Sinkiang lithospermum, vinegar-processed myrrh and sanguisorba officinalis. The blood stasis dispersing and pain relieving patch has the advantages of being good in curative effect, quick in effect taking, convenient to use, safe and reliable, can be used for treating traumatic injuries and pain caused by cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, lumbar vertebrae hyperosteogeny, spinal stenosis, sciatica, ankylosing spondylitis, arthritis and other diseases, and can achieve the effect of treating both symptoms and root causes.

The invention provides a traceable mitochondrial targeting nano system as well as a preparation method and application thereof, and belongs to the field of medicines. The traceable mitochondrial targeting nano system constructed by the invention can continuously release resveratrol and maintain the photochemical stability of resveratrol. The nano system shows efficient cellular uptake and accurate mitochondrial targeting ability, and promotes removal of mitochondrial ROS and adjustment of mitochondrial autophagy, so that vascular leakage and angiogenesis are relieved, in-vivo microvascular hyperplasia and retina degeneration are remarkably inhibited, and the curative effect is improved. The distribution of the compound in fundus can be monitored in real time through clinical ophthalmological diagnosis equipment, and the compound has a good application prospect in preparation of drugs for preventing and / or treating diabetic retinopathy.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis / marijuana, nicotine, and activities including gambling.Compounds are of general formulawith substituents as defined herein.

Minimally invasive treatment methods for benign prostatic hyperplasia (BPH) tissue are disclosed. A system includes a sustained release solid formulation comprising a cytostatic or cytotoxic drug, and an applicator or delivery system for local delivery of a composition comprising the sustained release solid formulation to the prostate.

The present invention discloses a polypeptide combination wound healing preparation with high permeability, specifically relating to a polypeptide combination of tripeptide-1, hexapeptide-9, and palmitoyl-modified peptide, and a new use for treating skin diseases such as wounds, ulcers, burns, scars, and keloids. While the polypeptide combination plays a significant synergistic effect in wound healing, it can effectively prevent and inhibit scar hyperplasia. In addition, the polypeptide combination wound healing preparation of the present invention utilizes the wound healing promoting activity of the composite polypeptide, and is compounded with specific penetration enhancers and antioxidants to be prepared into a gel with functions of moisturizing, promoting healing, reducing infection, and relieving pain, greatly increasing skin penetration, significantly enhancing the skin retention dose, and having significant antibacterial, anti-inflammatory, eschar-removing and muscle-generating, astringent healing, and scar hyperplasia inhibiting effects, being particularly suitable for wound healing and reducing scar residue.

The invention provides novel fusion proteins of Interleukin 15 and prodrugs, and compositions and methods of preparation thereof, useful in treating various diseases and disorders (e.g., hyperplasia, solid tumor or hematopoietic malignancy).

Devices are described, in particular in the form of stents, for transurethral applications having the function of facilitating the post-operative recovery phase in the treatment of benign prostatic hyperplasia.

The invention relates to the field of biological dressings, and discloses an artificial dermis dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: adding water into a container, and freezing until the water is frozen; then adding a collagen A solution, freezing and standing; continuing to add collagen B liquid, freezing and standing; continuing to add collagen A liquid, freezing and then freeze-drying; and cross-linking in a glutaraldehyde solution, and cleaning to obtain the artificial dermis dressing. The dressing provided by the invention can provide a good stent effect and promote cell migration and proliferation, and the healing rate is close to 100% after wound making. In the wound healing process, the dressing can inhibit collagen deposition, relieve inflammatory response, inhibit abnormal hyperplasia of blood vessels, inhibit excessive proliferation of fibroblasts and excessive formation of granulation tissues, and effectively prevent scar formation. The dressing can also effectively inhibit abnormal vascular hyperplasia in a wound area, and fibrosis and scar hyperplasia caused by excessive vascular hyperplasia are prevented.

The present invention relates to vaccines based on viral vectors for delivery of antigens against infectious diseases. In particular, the present invention relates to a recombinantly modified vaccinia virus Ankara (MVA) encoding EBV antigens that elicit infectious mononuclear hyperplasia (IM) and different cancer types. The invention also relates to medical application of the recombinant MVA in prevention of diseases caused by EBV (Epstein-Barr Virus).

The invention discloses a curcumin-containing polyurethane hydrogel for promoting healing of scalded wounds. The hydrogel is prepared by a one-step method under the condition of no solvent and no catalyst. The raw materials comprise biodegradable polyester polyol, polyethylene glycol, bio-based diisocyanate, an acidic response chain extender, a zwitterionic chain extender, curcumin, a biodegradable cross-linking agent and a notoginsenoside aqueous solution. The hydrogel disclosed by the invention has the effect of promoting healing of scalded wounds; in a hemostasis stage, the hydrogel can quickly stop bleeding and construct a physical barrier; in the inflammation stage, the quaternary ammonium salt in the hydrogel and the physically loaded curcumin have a synergistic effect to effectively kill bacteria; in wound remodeling and hyperplasia stages, notoginsenoside slowly released by the hydrogel can regulate inflammatory response, improve collagen deposition and promote granulation tissue hyperplasia and neovascularization. The hydrogel has good biocompatibility, controllable degradation performance and multifunctional biological activity, and can be used as an efficient special dressing for scalded wounds.

The invention belongs to the technical field of in-vitro diagnostic reagents, and particularly relates to application of a detection reagent for GDF15 protein in extracellular vesicles in preparation of a prostate cancer diagnosis and / or staging kit. According to the invention, enrichment and proteomics detection are carried out on plasma EVs of patients with prostatic cancer (PCa) and benign prostatic hyperplasia (BPH), and through bioinformatics analysis, a potential EV protein marker GDF15 which can be used for early diagnosis of PCa is screened for the first time. The GDF15 protein is verified in a plurality of groups of new clinical queues by further adopting an immunological technology and a targeted quantitative mass spectrometry technology, and the distinguishing ability of the GDF15 protein to PCa and BPH and the distinguishing ability of the GDF15 protein to different PCa stages are determined. The method is expected to promote noninvasive precise diagnosis of clinical PCa, and has a good application prospect.

A stent is disclosed that is configured to maintain patency of the prostatic urethra despite an enlarged prostate. The stent can include a handle that, in an undeflected position, is disposed outside of the flow path of the stent. When the handle is pulled, the handle can deflect to generally aligned with a central axis of the stent. A capture device is disclosed that includes a tapered tip to navigate a working channel of a delivery device and a hook that can capture the stent handle and be moved into a tube to retain the stent handle to facilitate maneuvering of the stent in and out of the working channel of the delivery device. A loading adapter with a tapered port is disclosed that can be disposed on the delivery device to distribute compressive forces applied by the port on the stent during loading into the working channel.

The invention provides a pharmaceutical composition and application thereof in preparation of a compound preparation, and belongs to the field of medicines. The pharmaceutical composition comprises a potassium ion channel opener, a 5 alpha-reductase inhibitor and a phosphodiesterase 5 inhibitor. The pharmaceutical composition can synergistically promote treatment of androgen dependent diseases or prevention of complications, and by taking the pharmaceutical composition of minoxidil, finasteride and tadalafil as an example, the effects in a benign prostatic hyperplasia rat model and an androgenic alopecia mouse model are verified, which indicates that the minoxidil, finasteride and tadalafil have a synergistic interaction effect, and the pharmaceutical composition can be used for treating the androgen dependent diseases or preventing the complications. Good clinical application prospects are realized.

The invention relates to a balloon catheter for transurethral use, having a proximal region (2) comprising an at least single-lumen catheter shaft (4) with an inflation lumen and an inflatable balloon (5) connected to the distal end of the inflation lumen in a fluid-permeable manner, and a distal region (3) comprising a distal shaft (7) and a distal tip (9). The balloon (5) is coated with a medication and a placement aid (10) is provided at least in the proximal region (2). The placement aid (10) is tubular at least in the region of the balloon (5), and the tubular section has a length at least equal to the length of the balloon (5). The balloon catheter according to the invention allows the conservative treatment of benign prostatic hyperplasia without the use of additional imaging techniques.

Minimally invasive treatment methods for benign prostatic hyperplasia (BPH) tissue are disclosed. A system includes a sustained release solid formulation comprising a cytostatic or cytotoxic drug, and an applicator or delivery system for local delivery of a composition comprising the sustained release solid formulation to the prostate.

The invention discloses a novel compound and application thereof in preparation of a medicine for treating systemic lupus erythematosus. In-vitro experiments show that the compound provided by the invention can further inhibit the secretion of anti-dsDNA IgG + B cell subtype mediated autoantibody by inhibiting the process that B cells are differentiated into plasmoblasts; in-vivo experiments show that the compound provided by the invention can effectively reduce the content of total IgG and anti-dsDNA-IgG in peripheral blood of a systemic lupus erythematosus model mouse, inhibit splenomegaly and peripheral lymph node hyperplasia of the mouse, slow down urine protein increment of the mouse, inhibit glomerular lesion and renal tubule lesion of the mouse and inhibit IFN-gamma generation of the mouse kidney; differentiation of spleen and peripheral lymph node plasmablasts of mice is inhibited, that is, differentiation and function development (antibody secretion) processes of B cells are directly acted. Therefore, the compound provided by the invention has a prospect of being developed into drugs for treating systemic lupus erythematosus.

The invention provides an airway stent, and relates to the technical field of airway stents. Ozone gas is contained in the storage bottle body, the internal space of the storage bottle body is in a circular ring shape, and a sealing bottle cap is buckled on the top of the storage bottle body; the memory metal support is located in the annular space in the storage bottle body. A rubber sealing ring is installed in the sealing bottle cap, the storage bottle body is sleeved with a movable sleeve shell, and the top of the movable sleeve shell is connected with the sealing bottle cap. A spring is connected into the movable sleeve shell and connected with the storage bottle body. When the memory metal stent is placed in the airway of a patient, the melt degradation film is degraded by body fluid, the inhibition medicine is slowly released from the slow release micropores, and granulation hyperplasia in the airway is inhibited for a long time. The problems that an existing medical airway stent mostly adopts a coating film drug-containing mode for adjuvant therapy, due to the fact that an outer side coating film is thin, the drug content is small, the drug contained in the coating film can be completely released in a short time, and the effect is not long enough are solved.