The invention relates to an ultrasound micro-needle composite transdermal drug delivery device which comprises an ultrasound transdermal drug delivery system and a porous micro-needle transdermal drug delivery system. The ultrasound transdermal drug delivery system comprises an ultrasonator, a control mechanism and an ultrasonic wave transmission dielectric layer arranged on the outer side of an end plate of a shell; the porous micro-needle transdermal drug delivery system comprises a drug storage pool, a liquid inlet pipe, a miniature peristaltic pump, a liquid outlet pipe, a drug inlet pool and poly-p-xylylene thin film, a plurality of micro needles are arranged on the poly-p-xylylene thin film, one end of each micro needle is communicated with the drug inlet pool, and the other end of each micro needle is used for being in contact with the skin for drug delivery. The ultrasound micro-needle composite transdermal drug delivery device solves the technical problems that irritabilities of patients are prone to being caused by an existing transdermal drug delivery device, the existing transdermal drug delivery device is low in drug delivery speed and poor in drug delivery effect, and the lengths of the micro needles cannot be adjusted when the existing transdermal drug delivery device acts on different parts of the human body so that the existing transdermal drug delivery device is limited in application range; the ultrasound micro-needle composite transdermal drug delivery device is high in drug delivery speed, good in drug delivery effect and suitable for application and popularization.