227results about How to "Improve drug delivery efficiency" patented technology

The present invention provides improved devices and methods for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled substance delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. The luminal delivery prosthesis comprises a scaffold which is implantable within a body lumen and means on the scaffold for releasing a substance from the scaffold. The substance is released over a predetermined time pattern comprising an initial phase wherein the substance delivery rate is below a threshold level and a subsequent phase wherein the substance delivery rate is above a threshold level.

A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation. Warming the air of an aerosol makes it possible to reduce the diameter of aerosol particles produced by an aerosol generation device. Additionally, warming the air forces the diameter of the aerosol particles to be in the range required for systemic drug delivery independent of ambient conditions. Smaller particles can be more precisely targeted to different areas of the respiratory tract.

The invention discloses a macromolecular soluble microneedle used for polypeptide and protein medicines. The macromolecular soluble microneedle comprises a base as well as a needle body on the base and a needle point on the needle body, wherein the base and the needle body are made of a mixture of a high polymer material and a stabilizer; and solid active peptide or protein medicines are embedded into the needle point. The concentration degree of the medicines embedded in the needle point of the macromolecular soluble microneedle is relatively high, and nearly no residual medicines exist on the bottom of the needle body, so that the administration efficiency and the administration accuracy are greatly improved; in addition, the part entering the subcutaneous tissue of the needle body can rapidly dissolve, and further degrade to be completely absorbed by the tissues without toxic or side effects, so that the possible needle breaking risk existing in the microneedle made of other materials such as metal, glass and silicon is avoided. The preparation method of the macromolecular soluble microneedle is carried out under simple technological conditions, is low in price, and suitable for volume production, and the macromolecular soluble microneedle can be widely applied to the field of cutaneous penetration of macromolecular medicines.

The invention discloses an automatic spiral-dressing type dressing changing device. The automatic spiral-dressing type dressing changing device comprises a sickbed body, and wound dressing devices symmetrically arranged on two sides of the sickbed body. Each wound dressing device comprises a support plate, a lifting mechanism slidably connected with the support plate, and a transmission mechanismarranged on the lifting mechanism. Each transmission mechanism comprises a rotating disc and a bandage winding device. Each bandage winding device comprises a screw, a casing sleeving the screw, and atraveling gear in meshed connection with the screw. A central shaft of each traveling gear extends to the outside of a limiting slot to be connected with a 'T'-shaped connecting rod. An elastic bandage fixing clip is connected to the bottom end of each connecting rod through a rotating mechanism. The automatic spiral-dressing type dressing changing device has the advantages that a spirally-reverse folding method is realized through the wound dressing devices to prevent deflection of bandages during dressing, uniformity and firmness in dressing are achieved, and the dressing efficiency is improved; the tensioning degree of the bandages can be automatically adjusted during dressing to avoid loosening of the bandages; the wound dressing devices are pushed below the sickbed body, and accordingly, the occupying space of the wound dressing devices is saved.

The invention relates to a scheduling method of a medical prescription allocation queue. The method comprises the following steps that 1) prescriptions after payments are allocated to pharmacy management systems of corresponding pharmacies; 2) the pharmacy management systems of the pharmacies allocate the prescriptions according to allocation terminals that are currently open of the pharmacies; and 3) the pharmacy management systems of the pharmacies send dispensing terminal information of prescription allocation to a charging system, the dispensing terminal information is displayed via a display device, and the charging system prints a medicine taking guidance. The step 2) further comprises that 2-1) the correspondence between the queue and the allocation and dispensing terminals is initialized; and 2-2) whether a special terminal exists is determined, if yes, whether the prescription needs to be allocated to a special queue to which the special terminal belongs is determined according to a preset special terminal rule, and if not needed or no special terminal exists, the prescription is allocated to a common queue according to a set prescription allocation rule. According to the method, a computer automatically allocates the prescription queue according to the preset rules, the speed is high, the prescriptions are prevented from missing, and the dispensing efficiency of the pharmacies can be improved.

The embodiment of the invention discloses a dispensing system, a control end and a dispensing method. The dispensing method comprises the following steps of: entering prescription information; controlling a first conveying device to propel receiving positions of prescription medicaments in a stepped way according to the queue order of the prescription information; and when a receiving position is in butt joint with a dispensing device, controlling the dispensing device to dispense a prescription medicament to a receiving position, so that each receiving position corresponds to a prescription. The dispensing device where the prescription medicament is positioned can be used for dispensing the prescription medicament to the receiving position when the receiving position is moved to a butt joint position, so that a plurality of prescription medicaments can be dispensed at different receiving positions simultaneously, labor force is saved, the dispensing speed of the prescription medicaments is increased, and the dispensing efficiency is increased greatly.

A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device. Additionally, warming the air forces the size of the aerosol particles to be in the range required for systemic drug delivery independent of ambient conditions. Smaller particles can be more precisely targeted to different areas of the respiratory tract.

The invention relates to an ultrasound micro-needle composite transdermal drug delivery device which comprises an ultrasound transdermal drug delivery system and a porous micro-needle transdermal drug delivery system. The ultrasound transdermal drug delivery system comprises an ultrasonator, a control mechanism and an ultrasonic wave transmission dielectric layer arranged on the outer side of an end plate of a shell; the porous micro-needle transdermal drug delivery system comprises a drug storage pool, a liquid inlet pipe, a miniature peristaltic pump, a liquid outlet pipe, a drug inlet pool and poly-p-xylylene thin film, a plurality of micro needles are arranged on the poly-p-xylylene thin film, one end of each micro needle is communicated with the drug inlet pool, and the other end of each micro needle is used for being in contact with the skin for drug delivery. The ultrasound micro-needle composite transdermal drug delivery device solves the technical problems that irritabilities of patients are prone to being caused by an existing transdermal drug delivery device, the existing transdermal drug delivery device is low in drug delivery speed and poor in drug delivery effect, and the lengths of the micro needles cannot be adjusted when the existing transdermal drug delivery device acts on different parts of the human body so that the existing transdermal drug delivery device is limited in application range; the ultrasound micro-needle composite transdermal drug delivery device is high in drug delivery speed, good in drug delivery effect and suitable for application and popularization.

The invention discloses a method for preparing a plane hollow microneedle for transdermal administration, which comprises the following steps of: defining a microneedle flow channel pattern on one surface of a first metal substrate to form a trench, and defining a microneedle pattern on the other surface to form a cutting sign, wherein the central axis of the flow channel pattern is aligned with that of the microneedle pattern; bonding a second metal substrate with a trench surface of the first metal substrate; thinning a non-bonding surface of the second metal substrate, and allowing the cutting sign on the first metal substrate to align with and transfer to the non-bonding surface of the second metal substrate; and thinning a non-bonding surface of the first metal substrate, and cutting by aligning with the cutting sign on the second metal substrate to form the plane hollow microneedle. Based on the micromachining technology and by combining the conventional technology of machining and cutting at the same time, the method reduces the process difficulty, increases the using reliability of the microneedle, and is favorable for quantity production.

The invention discloses an automatic medicine vending machine. A plurality of medicine storage units are arranged on a medicine shelf; medicine storage slots in the medicine storage units are obliquely distributed; each medicine storage slot comprises a bottom plate and two side baffle plates connected with the bottom plate, and the inner walls of the inner side of the two side baffle plates are provided with guide slots from top to bottom; medicine retaining curtains are arranged at the upper sides of the medicine storage slots along the guide slots and can slide up and down along the guide slots; the bottom plates, the side baffle plates and the medicine retaining curtains form medicine accommodating spaces; the upper ends of the outer sides of the medicine retaining curtains are convexly provided with pull plates; guide rails are arranged below the pull plates along the arrangement directions of the medicine storage slots and provided with pulley blocks; the pulley blocks are provided with gear and rack mechanisms; gear-driven motors are in drive connection with gears of the gear and rack mechanisms so as to drive the racks to perform vertical linear motion; the top ends of the racks are provided with shifting forks clamped together with the pull plates; the outer sides of the guide rails are provided with synchronous belts; the pulley blocks are connected with the synchronous belts; the synchronous belts drive the pulley blocks to perform linear motion so as to drive the racks to move. The volume of the medicine vending machine is reduced, and the automatic medicine vending machine is capable of ensuring smooth vending of medicines and improving the medicine distribution efficiency.

The invention discloses an automatic medicine dispensing device. The device comprises a control module used for obtaining medicine information in prescriptions, generating at least one medicine output control signal according to the medicine information, outputting the signals to a medicine storage sending mechanism, controlling the medicine storage sending mechanism to output corresponding medicines and controlling the movement of a first conveying mechanism; the medicine storage sending mechanism is used for storing the medicines in classification, being connected with the control module, responding to the medicine output control signal output by the control module, and outputting the medicines belonging to the prescriptions; the first conveying mechanism is used for collecting all medicines belonging to one prescription sent by the medicine storage sending mechanism so as to output the collected medicines to a second conveying mechanism; and the second conveying mechanism is provided with a plurality of independent medicine containers, one of the plurality of the independent medicine containers receives the medicines belonging to the one prescription output by the first conveying mechanism and outputs the medicines to a medicine outlet. According to the automatic medicine dispensing device, the medicine dispensing waiting time is reduced, and the medicine dispensing efficiency is improved.

The invention relates to a preparation method of a polydopamine microcapsule oral insulin administration carrier. The preparation method comprises the following steps: dissolving insulin powder in an acidic solution, adding sodium chloride, and preparing insulin micro / nano particles by a salting-out process; dispersing the insulin micro / nano particles in a dopamine weakly-alkaline solution, and reacting under oscillation conditions to obtain a polydopamine-coated insulin core-shell structure; and finally, dispersing the polydopamine-coated insulin core-shell structure in a functional molecule solution, and modifying functional molecules on the surface, thereby obtaining the biocompatible polydopamine microcapsule oral insulin administration carrier capable of overcoming the intestinal tract barrier. The polydopamine microcapsule oral insulin administration carrier has the p-responsive insulin release behavior, has the advantages of favorable cell compatibility and the like, can overcome the intestinal tract barrier, and can be used for treating diabetes.

The invention discloses a traditional Chinese medicine for preventing and curing chicken respiratory diseases, which is prepared from the following raw materials: 2-10g of ephedra, 3-10g of semen armeniacae amarae, 3-10g of liquorice, 15-60g of gypsum, 10-15g of chrysanthemum, 5-10g of folium mori, 6-15g of fructus forsythiae, 3-6g of mint, 3-10g of Platycodon grandiflorum, 10-15g of honeysuckle, 10-30g of dandelion, 15-30g of Houttuynia cordata, 10-15g of folium isatidis, 3-10g of Scutellaria baicalensis, 10-15g of Radix Ophiopogonis and 0.015-0.03g of venenum bufonis. The invention adopts pure traditional Chinese medicine preparation, has the functions of diminishing inflammation, sterilizing and relieving cough and asthma, and has good prevention and cure effect on chicken respiratory diseases.

The invention discloses a method for preparing an off-plane hollow microneedle array for use in transdermal medicament administration, which comprises: growing a mask film on one side of a metal substrate, defining a microneedle array pattern to form a mask film pattern, and forming a perforation mark which is aligned with the mask film pattern on the other side of the metal substrate; protectingthe side with the perforation mark, and etching the metal substrate till the mask film falls off to form the off-plane microneedle array; and removing the protection of the side with the perforation mark, and performing perforation according to the perforation mark to form the off-plane hollow microneedle array. In the invention, based on a micromechanical process and a positioning perforation technique, the off-plane microneedle array preparation is realized, the process is simple, the processing process of the metal substrate body of off-plane hollow microneedles is made possible, he manufacturing level of the off-plane hollow microneedles is improved greatly, and the reliability and insertion property of the microneedle array are improved.

The invention discloses a drug distribution system and an automatic drug selling machine. The drug distribution system comprises at least one drug frame and a dispensing device movably arranged between a drug taking position and a drug discharging position, the dispensing device comprises a drug taking mechanism, a material box and a pouring mechanism, wherein the drug taking mechanism puts takendrugs into the material box, the pouring mechanism comprises a driving unit and a pouring transmission unit, the pouring transmission unit is connected with one end of the material box in a pivoted mode, and the pouring transmission unit is driven by the driving unit and drives the material box to rotate around a pivot point. The dispensing device reciprocates between the drug taking position andthe drug discharging position; when the drug taking mechanism is at the drug taking position, the drug taking mechanism realizes the drug taking action of the drugs in the drug frames and puts the drugs into the material box to realize the temporary storage of the drugs; and when the dispensing device moves to the drug discharging position, the material box is driven to rotate through the pouringmechanism, and thus the drugs in the material box are poured out along a discharging opening to realize automated drug distribution.

The invention provides a soluble micro-needle patch drug delivery device which comprises a main component and a micro-needle drug leading-in component connected with the main component. The micro-needle drug leading-in component comprises a micro-needle drug delivery accelerated dissolution portion and a micro-needle drug delivery pressure sensing portion, one end of the micro-needle drug deliveryaccelerated dissolution portion is connected with the main component, the other end of the micro-needle drug delivery accelerated dissolution portion is connected with the micro-needle drug deliverypressure sensing portion, the micro-needle drug delivery pressure sensing portion comprises a pressure sensing layer and a pressure sensor connected with the pressure sensing layer, the micro-needle drug delivery pressure sensing portion is used for placing a micro-needle patch on the pressure sensing layer, drugs are delivered to a drug delivery area through the micro-needle patch, and a drug delivery pressure value is acquired by the pressure sensor. According to the device, transdermal drug delivery is achieved by the soluble micro-needle patch through compression strength suitable for skins of a user, the drug delivery efficiency is improved in application process, drug components carried by a micro-needle is really absorbed by the skins, and user experience is improved.

The invention discloses a traditional Chinese medicine prescription automatic dispensing and medicine fetching method and a storage medium. The method comprises a prescription distribution step: obtaining a plurality of prescriptions, querying medicine warehouses according to a medicine list of each prescription to determine the storage positions of medicine, and distributing all prescriptions oneby one; a prescription dispensing step: acquiring medicine chest information required to be retrieved by a prescription required to be dispensed currently by an operating and dispensing table; sending the medicine chest information to a control device of the medicine warehouse to make a medicine chest grabbing mechanism of the medicine warehouse grab the corresponding medicine chests to a conveying belt and conveying the medicine chests to corresponding operating and dispensing tables; judging whether the medicine chests in the operating and dispensing tables finish medicine fetching; and ifyes, controlling discharging mechanisms of the operating and dispensing tables to convey the current medicine chests back to the conveying belt so as to convey the medicine chests back to the medicinewarehouses correspondingly. According to the method, the needed medicine can be automatically conveyed to the operating and dispensing tables to allow medicine fetching personnel to obtain, so that it is not needed to spend time in finding the medicine positions one by one, and the medicine fetching efficiency is improved.

A composition comprising cyclosporin A and a nonaqueous, physiologically acceptable liquid carrier, said composition being suitable for topical administration to an eye of a mammal is disclosed herein. Methods of treating disease related thereto are also disclosed.

The invention relates to a miniature injection needle and an integrated device thereof. The miniature needle comprises a needle and a body, wherein the needle comprises a slant part with the outer slant wall, a perfectly straight part with the outer perfectly-straight wall and a groove with the certain depth along the outer slant wall or the outer perfectly-straight wall; the body is coupled to the needle to move or support the needle, the body comprises a cylindrical part and a conical part the body connected to the needle part with the reduced diameter, and a plurality of V-shaped grooves are formed in the surface of the cylindrical part of the body in an etched mode in the axial direction of the body, The invention also relates to a miniature needle head and miniature needle device which are integrated with the miniature needle. The miniature needle and integrated device thereof have the advantages shown in the specification.

The invention discloses a prescription medicine conveying system. The prescription medicine conveying system comprises a prescription medicine information recipient, a central processing unit, a basket dispatching machine, a window distribution unit, a medicine basket conveying device, a medicine basket information storage card, a card reader, a principal computer and a display device. The basket dispatching machine, the prescription medicine information recipient and the window distribution unit are all in communication connection with the central processing unit. A medicine basket is installed on the basket dispatching machine. The medicine basket information storage card is installed on the medicine basket. The medicine basket information storage card is in communication connection with the card reader. The card reader is in communication connection with the central processing unit. The central processing unit is in unidirectional communication connection with the principal computer. The display device is in communication connection with the principal computer. The prescription medicine conveying system is capable of automatically sorting and conveying prescription medicine to corresponding windows, so that automatic medicine dispatching is achieved. The prescription medicine dispatching efficiency is improved. The labor is reduced. The cost is reduced.

The invention discloses a manufacturing method of a porous microneedle array based on metal sintering. The manufacturing method comprises the following steps that firstly, base mixed liquor is prepared and poured into a base mold, and the bottom of the base mold is provided with multiple conical holes used for manufacturing microneedles; secondly, the base mold with the base mixed liquor poured in the first step is aerated and dried, and a microneedle array obtained after drying and molding are conducted is taken out of the base mold; and thirdly, the microneedle array obtained in the second step is sintered, so that the metal porous microneedle array is obtained. By the adoption of the manufacturing method of the porous microneedle array based on metal sintering, the technology is simple, the structure is stable and the metal strength is high.

The invention is applied to the technical field of pharmacy automation, and provides a method for automatic dosing by means of a manipulator. The method includes the steps that a dosing instruction is received; according to the dosing instruction, medicine lack information that dosing operations need to be carried out is found through display equipment; medicine lack information of the first kind of medicines needing to be added is determined; according to the medicine lack information of the first kind of medicines, the first kind of medicines is added to the manipulator, and added medicine information is input to a database control center; the received first kind of medicines is delivered by the manipulator to a first dosing area which is set in advance and corresponds to an area where the first kind of medicines to be added is placed; the first kind of medicines is added to a first dosing tank by the manipulator according to the number of the medicines lacking in the first dosing tank corresponding to the first dosing area; the received number of the first kind of medicines is fed back to the database control center through the first dosing tank, and the database control center updates medicine lack information of a system. According to the method, accuracy of dosing of the manipulator is guaranteed, dosing efficiency is improved, and the method is practical.

The invention discloses a dressing change rack for nursing. The dressing change rack comprises a fixed base, a lifting mechanism and a binding device; the lifting mechanism is arranged on the fixed base; the binding device is fixed on the lifting mechanism; the binding device comprises a fixed disc, a circular slide block, a foot fixing device and a bandage winding device; the circular slide blockand the foot fixing device are arranged on the fixed disc; the bandage winding device is arranged on the circular slide block; the bandage winding device comprises a screw rod, a bearing sleeve, a T-shaped connecting rod and a bandage retaining clip; the screw rod is in threaded connection with a threaded circular hole; the bearing sleeve is fixed on one end of the screw rod; the T-shaped connecting rod is fixed on the bearing sleeve; the bandage retaining clip is elastic and is fixed on the bottom end of the connecting rod through a rotating mechanism; a tensioning mechanism is arranged on the bandage retaining clip. The dressing change rack for nursing is capable of realizing an automatic wound binding function, taking a spiral inverse folding method as a binding manner, uniformly and firmly binding, avoiding the problem of bacterial infection caused by the contact between the wound periphery of a patient and the outside, increasing the dressing efficiency, automatically adjusting the tensioning degree of the bandage while binding and avoiding the phenomenon of binding loosening.

The invention provides a target PEG (Polyethylene Glycol) modified gold nanorod and AlpcS4 coupled combination, preparation and application thereof, and an antitumor composition. The combination comprises AlPcS4 and PEG modified gold nanorods, wherein the PEG modified gold nanorods are gold nanorods modified by HS-PEG-COOH; carboxyl of HS-PEG-COOH is connected with polypeptides or target oligopeptides through amido bonds; AlPcS4 is adsorbed to the surfaces of the gold nanorods through electrostatic adsorption; and the surface plasmon resonance peak of the PEG modified gold nanorods is 750-850 nm. By adopting the combination, the medicine transmission efficiency of AlPcS4 can be improved by virtue of passive targeting capability of the gold nanorods or active targeting capability of target molecules, and the problems that an AlpcS4 medicine is low in transmission efficiency, limited in photodynamic effect and limited in tumor tissue selectivity and enrichment capacity are solved.

The invention relates to a glycyrrhetinic acid prodrug micelle for jointly carrying chemotherapy drug and a preparation method thereof. The micelle uses polyethylene glycol-glycyrrhetinic acidpolymerprodrug as a carrier; the chemotherapy drug is physically embedded and carried in the glycyrrhetinic acid prodrug micelle. The chemotherapeutic medicine and glycyrrhetinic acid are combined; a nanometer technology is used for building a chemotherapy drug carrying prodrug micelle co-delivery system; by regulating and controlling the bridging molecule number of lysine and glycyrrhetinic acid in polyethylene glycol-glycyrrhetinic acid prodrug, the jointly carrying proportion of the glycyrrhetinic acid and chemotherapeutic medicine can be regulated and controlled; the optimum combined chemotherapyproportioning ratio of the combined use drug is realized. Compared with the carrying of two kinds of drug jointly in a physical mode, the glycyrrhetinic acid prodrug micelle uses the jointly drug carrying mode of combining physical joint carrying and chemical bonding, the carrying quantity of the combined use drug can be obviously improved; the medicine delivery efficiency of the polymer prodrugmicelle can be improved.

The invention provides a preparation method and a purpose of oxidation-reduction response chitosan-lipidosome. The method is characterized in that disulfide disuccinimidyl substituted ester is used for synthesizing oxidation-reduction response disulfide bond connected double-aliphatic-chain substituent group phosphatidyl ethanolamine-s-s-chitosan. The synthesized double-aliphatic-chain substituent group phosphatidyl ethanolamine chitosan is used for modifying lipidosome by a back insertion self assembly method; the double-aliphatic-chain substituent group phosphatidyl ethanolamine chitosan-lipidosome medicine carrier with oxidation-reduction response chitosan brushes on the surface is formed through assembly. The assembled chitosan-lipidosome has strong cell adhesion performance and antiserum capability, has the environment response performance at the same time, and is applicable to intravenous injection. The invention also provides application of superparamagnetic ferroferric oxide nanometer particles coated by the chitosan-lipidosome to medicine delivery. High medicine delivery efficiency and high biocompatibility are realized; wide application prospects are realized.

The invention provides a pharmaceutical composition for treating viral infection of respiratory system. The pharmaceutical composition contains chloroquine and a sputum-removing drug. The sputum-removing drug is selected from at least one of acetylcysteine, ambroxol or ammonium chloride. The invention provides a preparation method of the pharmaceutical composition for preventing and treating diseases caused by virus infection of a human respiratory system. The medicine composition of the chloroquine and sputum-removing drug is prepared into a spray, an aerosol or an inhalation preparation forpreventing and treating the diseases caused by the virus infection of the human respiratory system.

The invention, which relates to the technical field of traditional Chinese medicine formula particle regulation, discloses a smart pharmacy system for a hospital. The system is composed of a hospitalinformation system and a pharmacy management system; and communication connection is established between the hospital information system and the pharmacy management system. According to the application, communication connection is established between the hospital information system and the pharmacy management system; and information transmission and interaction between the hospital information system and the pharmacy management system are realized through the communication connection; patient's prescription information can be stored, so that the prescription information is invoked convenientlyand the illness state of the patient is analyzed conveniently when the patient gets medicines next time; the dispensing accuracy and efficiency of the hospital pharmacy are improved effectively; thedrug inventory information is stored and managed conveniently by the hospital; and effective management and statistics are carried out on the dispensing state of the pharmacy.