11results about How to "Good biological stability" patented technology

The invention provides a green, stable and long-life RTP-coated IPA material and a preparation method and application thereof.The method comprises the steps that 1, lignin is catalytically degraded through ternary DES comprising a hydrogen bond acceptor, a hydrogen bond donor and an enhancer, and lignin degraded through DES is obtained; wherein in the DES, the hydrogen bond acceptor is choline chloride or allyltrimethylammonium chloride, the hydrogen bond donor is lactic acid, and the enhancer is ethylene glycol or manganese chloride; (2) carrying out carbonization reaction on the lignin degraded by the DES and boric acid to obtain CDs doped with an element B; (3) crosslinking the CDs with a polymer matrix to obtain an RTP material; and (4) carrying out a cross-linking reaction on the RTP material and isophthalic acid to obtain the green, stable and long-life RTP-coated IPA material. The green, stable and long-life RTP-coated IPA material disclosed by the invention has excellent phosphorescence life and stability in a solvent, and has important application potential.

This invention relates to a cyclic polypeptide molecular probe targeting neurocilia protein-1 (NRP-1), its preparation method, and its applications. The cyclic polypeptide molecular probe comprises the structure shown in Formula I or Formula II, where R1 is the structure shown in Formula III or Formula IV; and R2 is a radiolabeled nuclide or a radiolabeled nuclide including a bifunctional chelating group. The technical solution of this invention exhibits excellent targeting specificity and high sensitivity for NRP-1 protein, enabling visualization of NRP-1-highly expressing tumors (such as fibrosarcoma, lung cancer, pancreatic cancer, or breast cancer) and NRP-1-positive lesions (such as metabolic diseases, sclerotic lesions, or autoimmune diseases) on positron emission tomography (PET). It shows great promise in the early diagnosis of NRP-1-highly expressing malignant tumors and in guiding clinical NRP-1 monoclonal antibody treatment regimens.

The present invention relates to a UV-absorbing polymer composition comprising a polyolefin and a UV-absorbing agent, wherein the polyolefin contains at least one benzo-cyclobutene (BCB) pendant group, the UV-absorbing agent contains at least one dienophilic group, the polyolefin is capable of forming a cross-linked polyolefin by reaction between the BCB pendant groups, and the polyolefin and the UV-absorbing agent are covalently linked by reaction between the BCB pendant groups and the dienophilic groups. The present invention also relates to a process for the preparation of a UV-absorbing polymer and to a UV-absorbing polymer prepared thereby and to the use thereof.

This invention belongs to the field of biomedical materials technology, and relates to a signal probe that simultaneously possesses CT and MRI imaging capabilities, its preparation method, and its application. The preparation method includes the following steps: dissolving bismuth citrate and iron salt in water, adjusting the pH of the solution to <7, adding polyvinylpyrrolidone, then adding gallic acid, adjusting the pH of the mixed solution to >7, and after the reaction is complete, filtering through a membrane to remove impurities, dialysis, and drying to obtain bismuth-iron nanoparticles; mixing citric acid with the bismuth-iron nanoparticle solution, stirring and reacting to obtain citric acid-treated bismuth-iron nanoparticles; further activating to obtain an activated bismuth-iron nanoparticle solution; adding RGDfk and amino-terminated polyethylene glycol to the activated bismuth-iron nanoparticle solution, stirring and reacting in the dark, dialysis, and drying to obtain a signal probe that simultaneously possesses CT and MRI imaging capabilities. The signal probe prepared by this invention has a small particle size and simultaneously possesses CT and MRI imaging functions.

The present application relates to a kind of carboprost tromethamine injection and its preparation method.The injection uses meglumine as pH regulator, not only stable to CO2 in environment, and it is beneficial to improve the stability of carboprost tromethamine;At the same time, pre-charged needle injection is also avoided the operation of ampoule sealing, so that the prepared carboprost tromethamine injection can be stored at 2~20 ℃, storage and transportation and clinical use are more convenient.

The invention belongs to the technical field of biological material engineering and tissue engineering, and discloses a preparation method and application of fiber hydrogel capable of regulating and controlling cell aggregation and collective migration. According to the invention, carboxylated cellulose nanofibers are compounded with matrigel, and ionic crosslinking is carried out under the action of Ca < 2 + > to form the fiber hydrogel. The carboxylated cellulose nanofibers are crosslinked with Ca < 2 + > through fiber entanglement to construct a mechanical skeleton of the hydrogel. The obtained fiber hydrogel has the characteristics of fiber architecture, viscoelasticity, mechanical plasticity, abundant bioactive ligands and the like, and can regulate and control cell aggregation, morphological recombination and collective migration behaviors through a mechanical signal transduction pathway. The material provides a controllable, bionic and high-fidelity three-dimensional experimental platform for mechanical and biological research in the processes of cancer metastasis, embryonic development, immune response, tissue regeneration and the like.

This invention discloses a pollen-loaded quercetin-iron ion-puerarin nanoparticle, its preparation method, and its applications. The method involves obtaining pollen cavity microcarriers by removing the pollen cell wall from natural pollen. Iron ions mediate the coordination self-assembly of quercetin and puerarin, forming nanoparticles in situ within and on the surface of the pollen cavity, thus creating a pollen-loaded drug-containing composite nanoparticle system. The pollen-loaded drug-containing nanoparticles prepared by this invention can be used to prepare drugs for treating androgenetic alopecia. They utilize the natural structure of the pollen cavity to achieve efficient drug loading and sustained release. Iron ions, in conjunction with quercetin and puerarin, promote microcirculation in hair follicle blood vessels, inhibit 5α-reductase activity, reduce androgen receptor expression, and activate hair follicle stem cells, thereby reversing the process of androgenetic alopecia through multiple pathways and promoting hair growth. This invention uses natural raw materials, employs a simple and easy pollen processing method, exhibits good biocompatibility, multiple functions, significant therapeutic effects, and has a wide range of applications.

This invention discloses a medical material for the prevention and treatment of oral ulcers, its preparation method, and its application. The medical material of this invention comprises a two-dimensional sheet-like nanomaterial composed of an organic matrix and metallic elements. The two-dimensional sheet-like nanomaterial of this invention possesses advantages such as high crystallinity, favorable material transport, high healing rate, reduced recurrence risk, excellent biocompatibility, mild preparation process, scalability, ease of use, and low cost, and has broad application prospects in the field of oral ulcer prevention and treatment.

The application provides a multi-layer penetration controlled-release acid preparation and a preparation method thereof, and belongs to the field of cosmetics. The preparation is composed of Aspergillus oryzae fermentation substrate freeze-dried powder, composite alpha-hydroxy acid, salicylic acid, poloxamer 407, polyhydric alcohol and non-ionic surfactant. The freeze-dried powder is obtained by co-fermenting olea europaea leaves and curcuma and refining through ultrafiltration. A temperature-sensitive phase change system is constructed by using poloxamer, so that the product is changed from a liquid state to a gel state at body temperature, and the synergistic controlled release of acid components and bioactive substances is realized. The preparation process adopts low-temperature swelling and vacuum freeze-drying technology, so that the stability of the system and the efficiency of the active substances are ensured. The application significantly reduces the irritation of high-concentration acid, improves the black suppression and repair effect, and is suitable for precise improvement of hyperpigmentation problems such as chloasma.

The invention provides a green long-life RTP material and a preparation method and application thereof.The method comprises the steps that 1, lignin is catalytically degraded through ternary DES comprising a hydrogen bond acceptor, a hydrogen bond donor and an enhancer, and lignin degraded through DES is obtained; wherein in the DES, the hydrogen bond acceptor is choline chloride or allyltrimethylammonium chloride, the hydrogen bond donor is lactic acid, and the enhancer is ethylene glycol or manganese chloride; (2) carrying out carbonization reaction on the lignin degraded by the DES and boric acid to obtain CDs doped with an element B; and (3) crosslinking the CDs and a polymer matrix to obtain the green long-life RTP material. The green long-life RTP material has excellent phosphorescence life, and the preparation method of the green long-life RTP material is environmentally friendly, safe and high in economical efficiency.