21results about How to "Good biological stability" patented technology

The invention belongs to the technical field of tobaccos, and discloses a preparation method of a tobacco endogenous biomass-based material, which comprises the following steps: S1, carrying out dipping treatment and solid-liquid separation on a tobacco waste raw material, then carrying out defibering, and then carrying out alkali pretreatment and alkali liquor cooking treatment to obtain tobacco slurry; s2, bleaching and decolorizing the tobacco pulp to obtain bleached tobacco pulp; s3, carrying out enzyme treatment on the bleached tobacco pulp; s4, the tobacco pulp obtained after enzyme treatment is subjected to pulp grinding and high-pressure homogenization treatment, and the tobacco endogenous biomass-based material is obtained. The invention further discloses the tobacco endogenous biomass-based material and application thereof.

The invention relates to the field of marine food manufacturing, in particular to high-protein-content soy sauce and a preparation method thereof, and the high-protein-content soy sauce comprises the following raw materials: laminarin, modified anthocyanin, compound protein, docosahexaenoic acid, astaxanthin, taurine, carrageenan, beta-amylase, soybeans, salt and purified water. The laminarin, the modified anthocyanin and the compound protein play a role through a synergistic effect, the compound protein in the soy sauce is wrapped by the modified anthocyanin to form a compound, a laminarin film is tightly attached to the outer layer of the compound formed by the modified anthocyanin, and the wrapping capacity and the structural stability of the compound are further enhanced; meanwhile, the oxidation process of fat and protein in the soy sauce is slowed down, the modified anthocyanin and a laminarin film interact to maintain the protein content in the soy sauce, laminarin, the modified anthocyanin and compound protein form a dynamic balance system, the nutritional value and quality of the soy sauce are improved, and the soy sauce with high protein content is provided.

The present invention proposes an acid-reducing and fertilizing improver for red soil rice fields, a preparation method and an improvement method thereof, and belongs to the technical field of soil improvement. After the straw is carbonized, it is added to a urea solution, sodium alginate and carboxymethyl chitosan are added, and an injection pump is dripped into a calcium chloride solution drop by drop to obtain a gel ball, the surface of which is modified by a silane coupling agent, hydrolyzed, added to a solution containing microorganisms and biological enzymes, and freeze-dried to obtain an acid-reducing and fertilizing improver for red soil rice fields. The acid-reducing and fertilizing improver for red soil rice fields prepared by the present invention can not only effectively increase the soil pH value, improve soil fertility, improve soil structure, and promote the downward leaching of salt-damaging ions, but the straw powder can also improve the soil CO2 bias, soil air, and soil quality, and has a good slow-release effect and broad application prospects.

The invention provides a green, stable and long-life RTP-coated IPA material and a preparation method and application thereof.The method comprises the steps that 1, lignin is catalytically degraded through ternary DES comprising a hydrogen bond acceptor, a hydrogen bond donor and an enhancer, and lignin degraded through DES is obtained; wherein in the DES, the hydrogen bond acceptor is choline chloride or allyltrimethylammonium chloride, the hydrogen bond donor is lactic acid, and the enhancer is ethylene glycol or manganese chloride; (2) carrying out carbonization reaction on the lignin degraded by the DES and boric acid to obtain CDs doped with an element B; (3) crosslinking the CDs with a polymer matrix to obtain an RTP material; and (4) carrying out a cross-linking reaction on the RTP material and isophthalic acid to obtain the green, stable and long-life RTP-coated IPA material. The green, stable and long-life RTP-coated IPA material disclosed by the invention has excellent phosphorescence life and stability in a solvent, and has important application potential.

The invention provides an aloe capsule and a preparation method thereof, the capsule comprises purified aloe gel powder, an aloe polysaccharide extract, composite prebiotics, an antioxidant plant extract, vitamin E, dietary fibers, glycerin and other components, and has the effects of relaxing bowel, enhancing immunity and the like. The preparation method comprises the steps of ultrafiltration, ultrasonic treatment, freeze drying and the like, so that the high purity of the aloe gel powder and the retention of active components are ensured. In addition, the invention further provides a preparation process of airflow mixing granulation filling, nitrogen or carbon dioxide is used as mixed gas, and uniformity and stability of capsule components are guaranteed. The aloe capsule prepared by the method has the characteristics of definite components, remarkable effect, easiness in absorption and the like, and is suitable for people who need to improve intestinal health and enhance the antioxidant capacity of organisms.

This invention relates to a cyclic polypeptide molecular probe targeting neurocilia protein-1 (NRP-1), its preparation method, and its applications. The cyclic polypeptide molecular probe comprises the structure shown in Formula I or Formula II, where R1 is the structure shown in Formula III or Formula IV; and R2 is a radiolabeled nuclide or a radiolabeled nuclide including a bifunctional chelating group. The technical solution of this invention exhibits excellent targeting specificity and high sensitivity for NRP-1 protein, enabling visualization of NRP-1-highly expressing tumors (such as fibrosarcoma, lung cancer, pancreatic cancer, or breast cancer) and NRP-1-positive lesions (such as metabolic diseases, sclerotic lesions, or autoimmune diseases) on positron emission tomography (PET). It shows great promise in the early diagnosis of NRP-1-highly expressing malignant tumors and in guiding clinical NRP-1 monoclonal antibody treatment regimens.

The invention relates to the technical field of lipidomics and human health, in particular to screening and application of a pregnancy maternal lipid biomarker with fetal growth limitation, and the lipid biomarker is selected from one or any combination of DG 14: 0 / 18: 2, DG 16: 0 / 20: 4, TG 14: 0 / 16: 0 / 18: 1, TG 14: 0 / 16: 0 / 18: 2, TG 16: 0 / 16: 0 / 18: 0 and TG 16: 0 / 16: 0 / 18: 1. The lipid biomarker provided by the invention can accurately diagnose the pathogenesis of the fetal growth restriction, and provides a specific and noninvasive diagnosis means for the fetal growth restriction.

This invention discloses a method, product, and application for the separation of astatine-211 in an aqueous phase based on valence state regulation. The method includes: passing a solution of astatine-211 containing a strong oxidizing acid through a sulfur-containing solid support, causing specific adsorption of positively valence astatine-211; eluting with a water-soluble reducing agent to reduce astatine-211 to astatine anions, obtaining an aqueous astatine-211 eluent. The entire process is carried out in the aqueous phase, requiring no organic solvents and avoiding radionuclide volatilization loss due to heating and evaporation. This invention also provides an eluent composition prepared by this method, sodium astatide injection, astatine-211-labeled radiotargeting drugs and their preparation methods, as well as the application of this eluent composition in the preparation of drugs for treating NIS-positive diseases. This invention achieves highly selective separation and mild, rapid elution of astatine-211, and the product exhibits excellent biocompatibility and radiation stability, and can be used directly or after simple activation to prepare targeted α-therapy drugs.

The present invention relates to a UV-absorbing polymer composition comprising a polyolefin and a UV-absorbing agent, wherein the polyolefin contains at least one benzo-cyclobutene (BCB) pendant group, the UV-absorbing agent contains at least one dienophilic group, the polyolefin is capable of forming a cross-linked polyolefin by reaction between the BCB pendant groups, and the polyolefin and the UV-absorbing agent are covalently linked by reaction between the BCB pendant groups and the dienophilic groups. The present invention also relates to a process for the preparation of a UV-absorbing polymer and to a UV-absorbing polymer prepared thereby and to the use thereof.

This invention belongs to the field of biomedical materials technology, and relates to a signal probe that simultaneously possesses CT and MRI imaging capabilities, its preparation method, and its application. The preparation method includes the following steps: dissolving bismuth citrate and iron salt in water, adjusting the pH of the solution to <7, adding polyvinylpyrrolidone, then adding gallic acid, adjusting the pH of the mixed solution to >7, and after the reaction is complete, filtering through a membrane to remove impurities, dialysis, and drying to obtain bismuth-iron nanoparticles; mixing citric acid with the bismuth-iron nanoparticle solution, stirring and reacting to obtain citric acid-treated bismuth-iron nanoparticles; further activating to obtain an activated bismuth-iron nanoparticle solution; adding RGDfk and amino-terminated polyethylene glycol to the activated bismuth-iron nanoparticle solution, stirring and reacting in the dark, dialysis, and drying to obtain a signal probe that simultaneously possesses CT and MRI imaging capabilities. The signal probe prepared by this invention has a small particle size and simultaneously possesses CT and MRI imaging functions.

The present invention relates to a bioadhesive composition and a preparation method thereof. The bioadhesive composition comprises: mussel adhesion protein; and at least one of polyacrylic acid and polymethacrylic acid. The mussel adhesion protein is connected to at least one of the polyacrylic acid and polymethacrylic acid through an amide bond. The bioadhesive composition has a three-dimensional network structure.

The present application relates to a kind of carboprost tromethamine injection and its preparation method.The injection uses meglumine as pH regulator, not only stable to CO2 in environment, and it is beneficial to improve the stability of carboprost tromethamine;At the same time, pre-charged needle injection is also avoided the operation of ampoule sealing, so that the prepared carboprost tromethamine injection can be stored at 2~20 ℃, storage and transportation and clinical use are more convenient.

The invention belongs to the technical field of biological material engineering and tissue engineering, and discloses a preparation method and application of fiber hydrogel capable of regulating and controlling cell aggregation and collective migration. According to the invention, carboxylated cellulose nanofibers are compounded with matrigel, and ionic crosslinking is carried out under the action of Ca < 2 + > to form the fiber hydrogel. The carboxylated cellulose nanofibers are crosslinked with Ca < 2 + > through fiber entanglement to construct a mechanical skeleton of the hydrogel. The obtained fiber hydrogel has the characteristics of fiber architecture, viscoelasticity, mechanical plasticity, abundant bioactive ligands and the like, and can regulate and control cell aggregation, morphological recombination and collective migration behaviors through a mechanical signal transduction pathway. The material provides a controllable, bionic and high-fidelity three-dimensional experimental platform for mechanical and biological research in the processes of cancer metastasis, embryonic development, immune response, tissue regeneration and the like.

The invention discloses a breast cancer antibody drug conjugate based on a targeted HER2 receptor and application of the breast cancer antibody drug conjugate in the technical field of antibody drug conjugates, the breast cancer antibody drug conjugate comprises a monoclonal antibody, the monoclonal antibody is coupled with a cytotoxic drug through a polymer, the monoclonal antibody is trastuzumab, and the monoclonal antibody is an HER2 receptor. The cytotoxic drug is maytansine DM1 with a tubulin synthesis inhibition effect, the polymer comprises a polyaspartic acid chain, a plurality of maleimide groups are grafted on side branch carboxyl of the polyaspartic acid chain, and Fc-III-4C peptide in the polymer is combined with an Fc segment of trastuzumab through a high affinity effect, so that the polymer can be used for inhibiting microtubulin synthesis. And the monoclonal antibody-polymer-cytotoxic drug conjugate T-NPLA-DM1 is formed by using the monoclonal antibody-polymer-cytotoxic drug conjugate. The antibody drug conjugate is novel and effective, and the drug loading capacity of a single drug molecule is improved by using the polyamino acid as the drug conjugate, so that the drug-antibody ratio of the antibody drug conjugate is improved, and the lethality of an anti-tumor drug to HER2 positive breast cancer tumor cells is enhanced.

This invention discloses a pollen-loaded quercetin-iron ion-puerarin nanoparticle, its preparation method, and its applications. The method involves obtaining pollen cavity microcarriers by removing the pollen cell wall from natural pollen. Iron ions mediate the coordination self-assembly of quercetin and puerarin, forming nanoparticles in situ within and on the surface of the pollen cavity, thus creating a pollen-loaded drug-containing composite nanoparticle system. The pollen-loaded drug-containing nanoparticles prepared by this invention can be used to prepare drugs for treating androgenetic alopecia. They utilize the natural structure of the pollen cavity to achieve efficient drug loading and sustained release. Iron ions, in conjunction with quercetin and puerarin, promote microcirculation in hair follicle blood vessels, inhibit 5α-reductase activity, reduce androgen receptor expression, and activate hair follicle stem cells, thereby reversing the process of androgenetic alopecia through multiple pathways and promoting hair growth. This invention uses natural raw materials, employs a simple and easy pollen processing method, exhibits good biocompatibility, multiple functions, significant therapeutic effects, and has a wide range of applications.

The invention provides a medicine carrying system for treating corneal scars based on Tbeta4 and EISA hydrogel, the medicine carrying system is formed by covalently connecting the Tbeta4 and an EISA hydrogel skeleton, the Tbeta4 is a peptide fragment TB500 with an active function, the EISA hydrogel skeleton selects a YYY hydrogel skeleton Nap-YYY-G, and the formed medicine carrying system is YYY-TB500. By combining the anti-fibrosis effect of the Tbeta4 and the drug delivery advantage of the EISA polypeptide hydrogel, the delivery efficiency and drug effect of the Tbeta4 can be effectively improved, so that the repair process after corneal injury is improved, scar formation is reduced, and a new thought and treatment means are provided for treatment of corneal injury and scar.

The invention relates to a rigidity-adjustable nano-liposome hydrogel composite system and a preparation method thereof. According to the composite system, a shell is formed by DOPC and beta-sitosterol, and a core is prepared from sodium alginate or sodium alginate and Ca < 2 + >. According to the method, the rigidity of the liposome is controlled by controlling the crosslinking degree of sodium alginate and Ca < 2 + > of the core of the composite nano-liposome, so that the application stability of the composite liposome and the cell absorption efficiency of the medicine are improved. The preparation process is efficient, simple and convenient, and compared with traditional lipidosome, the liposome has good stability and biocompatibility and can be widely applied to transport carriers of drugs and nutrients.

This invention discloses a medical material for the prevention and treatment of oral ulcers, its preparation method, and its application. The medical material of this invention comprises a two-dimensional sheet-like nanomaterial composed of an organic matrix and metallic elements. The two-dimensional sheet-like nanomaterial of this invention possesses advantages such as high crystallinity, favorable material transport, high healing rate, reduced recurrence risk, excellent biocompatibility, mild preparation process, scalability, ease of use, and low cost, and has broad application prospects in the field of oral ulcer prevention and treatment.

The application provides a multi-layer penetration controlled-release acid preparation and a preparation method thereof, and belongs to the field of cosmetics. The preparation is composed of Aspergillus oryzae fermentation substrate freeze-dried powder, composite alpha-hydroxy acid, salicylic acid, poloxamer 407, polyhydric alcohol and non-ionic surfactant. The freeze-dried powder is obtained by co-fermenting olea europaea leaves and curcuma and refining through ultrafiltration. A temperature-sensitive phase change system is constructed by using poloxamer, so that the product is changed from a liquid state to a gel state at body temperature, and the synergistic controlled release of acid components and bioactive substances is realized. The preparation process adopts low-temperature swelling and vacuum freeze-drying technology, so that the stability of the system and the efficiency of the active substances are ensured. The application significantly reduces the irritation of high-concentration acid, improves the black suppression and repair effect, and is suitable for precise improvement of hyperpigmentation problems such as chloasma.

The invention provides a green long-life RTP material and a preparation method and application thereof.The method comprises the steps that 1, lignin is catalytically degraded through ternary DES comprising a hydrogen bond acceptor, a hydrogen bond donor and an enhancer, and lignin degraded through DES is obtained; wherein in the DES, the hydrogen bond acceptor is choline chloride or allyltrimethylammonium chloride, the hydrogen bond donor is lactic acid, and the enhancer is ethylene glycol or manganese chloride; (2) carrying out carbonization reaction on the lignin degraded by the DES and boric acid to obtain CDs doped with an element B; and (3) crosslinking the CDs and a polymer matrix to obtain the green long-life RTP material. The green long-life RTP material has excellent phosphorescence life, and the preparation method of the green long-life RTP material is environmentally friendly, safe and high in economical efficiency.