407results about How to "Good biological stability" patented technology

The invention belongs to the technical field of medicaments, and in particular relates to a hetero-aromatic ring shown by a general formula (I) as well as a derivative type tyrosine kinase inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, wherein X, Z, W, R1, R2, R3, L1, L2, a, b, c, d, e, p, q, A and B are as defined in the specification. The invention also relates to preparation methods of these compounds, a pharmaceutical preparation containing these compounds, and important functions of these compounds in preparation of medicaments for treating B cell related leukemia (such as B cell chronic lymphocytic carcinoma and non-hodgkin lymphoma) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus and the like).

A biostable porous polyether or polycarbonate polyurethane implant is manufactured from diphenyl methane diisocyanate, difunctional polytetramethylene ether glycol or a polycarbonate polyol, a trimerisation catalyst, a chain extender, water, a cross-linking agent, a blowing and / or gelling catalyst and a surfactant. The porous biomaterial has isocyanurate linkages and avoid content in excess of 85%. The implant may be used as an occluder or a tissue bridge.

The invention discloses a multi-effect semi-synthetic cutting solution. The solution is prepared by uniformly mixing the following raw material components in percentage by total mass of 100%: 10 to 14% of monoethanolamine for industrial use, 0.1 to 0.2% of benzotriazole for industrial use, 10 to 13% of boric acid for industrial use, 4 to 6% of phosphate-borate-containing water-based lubricant, 4 to 7% of tall oil fatty acid for industrial use, 8 to 12% of naphthenic oil K22, 2 to 4% of petroleum sodium sulfonate No.55, 0.5 to 1.5% of oleic acid polyoxyethylene ester for industrial use, 1.5 to 2% of 1,3,5-tri(2-hydroxyethyl)-hexahydrotriazine for industrial use, 0.1 to 0.2% of organic silicon defoamer for industrial use and the balance of water. The solution has high lubrication extreme pressure performance and is biodegradable and environment-friendly.

The invention belongs to the technical field of medicines and particularly relates to a phosphodiesterase-4 inhibitor as shown in a general formula (I) and a pharmaceutically acceptable salt, a stereoisomer or a solvent compound thereof. In the formula, R1, R2, R3, R4, R5, R6, R7, R8, R9, R7', R8', R9', L and a ring A are as defined in the specification. The invention further relates to a preparation method for the compound, a pharmaceutical composition with the compound, and an application of the compound and the pharmaceutical composition to preparation of drugs for treating and / or preventing inflammatory diseases, disease symptoms and disease conditions characterized by or related with undesired inflammatory immune reaction and all diseases induced by or related with TNF-alpha (tumor necrosis factor-alpha) and PDE-4 (phosphodiesterase-4) hypersecretion.

The invention provides an amino-functionalization magnetic silicon dioxide-ferroferric oxide composite nanomaterial. The material is characterized in that a microsphere structure is formed as magnetic ferroferric oxide is used as an inner core, silicon dioxide is used as an outer-layer coating material, amino groups with positive charges are used as functionalization modifying groups. The invention also provides a preparation method of the material, and an application of the material in water environment pollutant trace chemistry detection. The material is simple in preparation method, low in cost, high in extraction efficiency and high in adsorptive property, has selectivity on complex organic pollutants, is a reproducible environment-friendly novel material, and can be applied in trace chemistry analysis of a plurality of kinds of complex organic pollutants (particularly pollutants with negative charges) in a water environment.

The said polyurethane is prepared through preparing polymer with diisocyanate, hydroxyl-containing oligomer, chain expander with active hydrogen radical and chain expander with carboxylic radical, neutralizer with alkali radical, blocking agent, cross-linking agent and optional catalyst in certain proportion; and subsequent reaction in water to obtain polymer. The polyurethane features the blocking diisocyanate radical and hydroxyl radical and thus shape converting temperature of -30 deg.c to 100 deg.c. In temperature higher than the shape converting temperature, the polyurethane may have its shape converted; in temperature lower than the shape converting temperature, the polyurethane is unchanged in shape; and the polyurethane heated to the temperature higher than the shape converting temperature will restore original shape.

The invention relates to a hyaluronic acid-modified amphipathic chitosan derivative carrier with tumor microenvironment specificity drug release effect. The hyaluronic acid-modified amphipathic chitosan derivative carrier is characterized in that firstly, a hydrophilic group is introduced into a chitosan skeleton; then, a hydrophobic group is introduced into a specifically degradable link arm containing disulfide bonds, so as to realize the amphipathic function; the amphipathic derivative is assembled into nanomicelle by self in a waterborne medium, and is further modified by a charge adsorbing principle to target the molecular hyaluronic acid; the nanomicelle can effectively load an anti-tumor drug, and the hyaluronic acid is targeted to the tumor microstructure and then is degraded by hyaluronic acid enzyme in focus cells, so that the drug can be quickly released from the nanomicelle to act on the focal part, thereby obviously improving the concentration, therapy effect and biological utilization degree of free drug on the focal part. The hyaluronic acid-modified amphipathic chitosan derivative carrier has the advantages that the carrier which carries pharmaceutical activity or pharmacological activity molecules can be applied to internal injection of blood vessels or muscles or oral administration, so as to obviously improve the anti-tumor activity of drug; the preparation method is simple, the technology is matured, and the preparation method is suitable for large-scale production.

The present invention relates to anti-PD1 and anti-CD19 bispecific antibody and applications thereof, wherein the anti-PD1 and anti-CD19 bispecific antibody, or a variant, or a functional fragment thereof comprises: a domain capable of specifically recognizing and binding an immune cell surface antigen PD-1, wherein the domain comprises the heavy chain variable region (anti-PD-1 VH) of an anti-PD-1 specific antibody; and a domain capable of specifically recognizing and binding CD19, wherein the domain comprises the heavy chain variable region (anti-CD19 VH) of an anti-CD19 specific antibody. According to the present invention, the bispecific antibody has the whole human sequence, such that the occurrence of HAMA in clinical treatment application is effectively avoided, the occurrence of drug resistance can be effectively reduced, and the utilization efficiency and the treatment effect of the medicine can be improved; and the anti-PD-1 and anti-CD19 bispecific antibody can well mediate T cells to efficiently and specifically kill B-lymphocyte derived tumor cells compared to the existing anti-PD-1 specific antibody and the existing anti-CD19 specific antibody.

The invention relates to a polyhydroxyl polymer embolized microsphere, which is formed by cross-linking polymerization of biocompatible functional macromolecules. The embolized microsphere is characterized in that the functional macromolecule comprises a polymer, wherein at least two acetal structures containing acrylic acid or derivative radicals thereof connected on the main chain or at least two crosslinkable micro-molecules which are connected in a covalent bond mode and have acrylic acid or derivative structures thereof; the acetal structures or crosslinkable micro-molecules can form a hydrogel unsaturated functional group through free radical polymerization crosslinking; a functional group by using organic carboxylate as a negative charge carrier is contained inside the microsphere. The invention also provides a preparation process of the polyhydroxyl polymer embolized microsphere. The embolized microsphere has excellent biocompatibility and stability, large elastic stretching rate and recoverability, is uniform and controllable in granularity, excellent in dispersion, simple in use and operation and strong in targeting property, has excellent adsorption capability to bioactive substances, and can be used for various minimally invasive treatment.

The invention belongs to the technical field of medicine, particularly relates to a heterocyclic nitrogen compound which acts as a tyrosine kinase inhibitor and is represented by a general formula (I) as well as a deuterated material, pharmaceutically acceptable salt or stereisomer thereof. In the general formula (I), X, W, R1, R2, R3, L1, L2, a, b, c, d, e, p, q, a ring A and a ring B are defined in specification. The invention further relates to a preparation method of the compounds, a pharmaceutic preparation containing the compounds, and important actions of the compounds in treatment of leukemia (such as B cell chronic lymphocytic carcinoma and non-hodgkin lymphoma) related to B cell, and autoimmune diseases (such as rheumatoid arthritis and systemic lupus erythematosus).

The invention relates to a litchi vinegar drink and a preparation method of the litchi vinegar drink. The preparation method comprises the following steps: crushing pulp of fresh litchi fruits after removing fruit shells and seeds, juicing, adding acid and pectinase, standing to improve clarity at low temperature, filtering the supernatant with a cross flow filter and then storing in a freezing tank at low temperature; warming the clear juice to 20-25 DEG C, inoculating wine active dry yeast to perform alcoholic fermentation; adding lactose and inoculating active dry Lactobacillus bulgaricus to perform lactic acid fermentation at 20-25 DEG C, inoculating acetic acid bacteria to perform surface acetic fermentation at 20-25 DEG C, and removing microorganism in fermented mash with a cross flow filter to obtain original litchi vinegar; mixing the original litchi vinegar, clear litchi juice, honey, isomaltooligosaccharide, citric acid, tartaric acid, malic acid and pure water in a certain ratio; clarifying, filtering, deoxidizing, membrane filtering and filling to obtain the litchi vinegar drink. The method of the invention is unique in that the fermentation process employs multiple microbial strains, low temperature and long period, so that the litchi vinegar drink prepared by the method has rich fruity flavor of litchi and strong taste, integrates the nutritional and health care functions, and is a novel nourishing, skin caring and pollution-free green drink.

The present invention belongs to the technical field of medicine, and particularly relates to a CDK kinase inhibitor represented by a general formula (I), a pharmaceutically acceptable salt of the CDK kinase inhibitor, an ester of the CDK kinase inhibitor, a solvate of the CDK kinase inhibitor and stereoisomers of the CDK kinase inhibitor, the pharmaceutically acceptable salt, the ester and the solvate, wherein R1, R2, R3, R4, R5 and n are defined in the specification. The present invention further relates to preparation methods of the compounds, pharmaceutical formulations containing the compounds, pharmaceutical compositions containing the compounds, and applications of the compound, the pharmaceutically acceptable salt, the ester, the solvate and the stereoisomers in preparation of treatment and / or preparation of CDK kinase-mediated cancer associated diseases. The formula (I) is defined in the specification.

A polyurethane material containing F in side chain is prepared through alternative polymerization between the flexible chain segment consisting of polyether diol and / or polycarbonate diol and the rigid chain segment consisting of diisocyanate and chain-enlarging agent. Its advantages are high biologic stability and compatibility and high elasticity, strength and resistance to oxidizing and hydrolysis. It can be used for preparing artificial blood vessel, heart valve, etc.

The invention discloses a multifunctional semi-synthetic metal processing liquid and preparation method thereof. The multifunctional semi-synthetic metal processing liquid comprises, by weight, 5-20 parts of base oil, 8-10 parts of polyisobutylene succinic anhydride or the derivative of the same, 8-15 parts of borate, 2.5-8 parts of fatty acid methyl ester, 2 to 4 parts of rust inhibitor, 35 to 52 parts of water, 1 to 1.5 parts of amine, 0.5 to 0.8 part anti-hardening agent, 0.2 to 4.5 parts of copper corrosion inhibitor, 2 to 3 parts of aluminum corrosion inhibitor, 5 to 6 parts of coupling agents, 3 to 4 parts of fungicides and 0.2 to 0.3 part of defoaming agent. The metal processing liquid provided by the invention not only has excellent cooling effects, very good lubricating effects and extreme pressure property, excellent high temperature stability and low temperature stability, but also generates little foam. The processing liquid is an environment friendly product which can be used for the cutting and grinding operation with medium and high difficulties in the high-speed cutting and large piece cutting.

The invention discloses amphipathic polyurethane resin based on polysiloxane and a preparation method of the amphipathic polyurethane resin, as well as an anti-bacterial anti-protein performance of the amphipathic polyurethane resin. The preparation method comprises the following steps: carrying out a reaction between tert-Butyl bromoacetate and N-methyldiethanolamine under a certain condition to obtain a quaternary ammonium diol; carrying out cross-link between the quaternary ammonium diol and hydroxymethyl-terminated polydimethylsiloxane; carrying out hydrolysis to obtain the amphipathic polyurethane of which a molecular chain segment has not only a hydrophilic ingredient but also a hydrophobic ingredient. The amphipathic polyurethane has all of the relatively high hydrophilicity of zwitter ions, the low surface energy and dirt discharging superiority of polysiloxane, and the stability of polyurethane, thereby having an excellent practical application value in the anti-bacterial and anti-protein field.

This invention relates to a preparation method for poly-asparagic acid resin, which takes poly-pyrrolidine dione as the raw material to make crosslink poly-pyrrolidine dione with method of non-even phase suspended emulsion crosslink or non-even phase suspension crosslink and processes poly-asparagic acid resin by hydrolyzation characterizing that the crosslink poly-pyrrolidine dione is prepared by multi-section crosslink reaction, in which, the crosslinker is fed in for 2-4 times in equal volume and equal time interval, the crosslink poly-pyrrolidine dione and the resin are aged and crystallized and quickly dried, A ageing and crystallization process for 1-10 days under room temperature, B, quick drying process is carried out under -54-40deg.C.

The invention relates to a compound shown as formula (I), a pharmaceutically acceptable salt, ester or stereoisomer thereof. R1, R2, R3, R4, m, n, W, A, Z, E, F, X and Y are defined as the specification. The invention also relates to a preparation method of the compounds, pharmaceutical preparations and application in drugs for treatment and / or prevention of FXR (farnesoid X receptor) mediated nonalcoholic fatty liver diseases, primary biliary cirrhosis, lipid metabolism disorders, diabetic complications, malignant tumors and other related diseases. (formula (I)).

The invention relates to a compound shown as formula (I), a pharmaceutically acceptable salt, ester or stereoisomer thereof. R1, R2, R3, R4, m, n, W, A, Z, E, F, X and Y are defined as the specification. The invention also relates to a preparation method of the compounds, pharmaceutical preparations and application in drugs for treatment and / or prevention of FXR (farnesoid X receptor) mediated nonalcoholic fatty liver diseases, primary biliary cirrhosis, lipid metabolism disorders, diabetic complications, malignant tumors and other related diseases. (formula (I)).

The invention provides a new compound which has certain agonist activity on a Farnesoid X receptor (FXR) and is used for treating FXR mediated diseases and / or symptoms such as liver disease and gastrointestinal disease. (The formula is shown in the description.).

The invention belongs to the biological regenerative medicine field, and particularly relates to a preparation method of a tissue-regeneration-promoting controlled-release multiple-growth-factor self-assembled coating. The preparation method is as follows: using an organic polymer membrane and a three-dimensional scaffold as templates, and loading bone morphogenetic protein-2 (BMP2), dentin non-collagenous proteins (DNCPs), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and other bioactive factors with tissue regeneration promotion effects by a supramolecular layer by layer self-assembly technique to form a certain layers of supramolecular biological film coating structure simultaneously embedding with different growth factors on the template surface. The tissue-regeneration-promoting functional coating prepared by the preparation method has good biological compatibility and stability, can improve the surface properties of materials, and can induce tissue regeneration by adjusting the release of the loaded growth factors.

The invention is concerned with a method to remove sulfur dioxide of gas and smoke through bio-trickling filter tower with bamboo-carbon filler. The nutrient source spray on the filling inside the tower form the top of bio-trickling filter tower and run into the filling from up to down and enter the circulation gutter on the bottom of tower, then go back to the top of tower by circulation gutter. Meanwhile the gas and smoke with sulfur dioxide enter form the bottom of tower, during the rising process, it is cleaned by the bio-film with fixed desulfuration bacteria and discharged form the top of tower. The filling is the pretreatment bamboo-carbon and it is fit for getting Ferrous Sulfate desulfuration byproduct. The bamboo-carbon owns developed holes and strong adsorption ability to form steady and high active bio-film and to remove the sulfur dioxide. It has wide application future to callback sulfur with low cost.

The invention relates to a method for preparing immobilized enzyme by taking a bacterial cellulose bead / membrane as a vector. The method comprises the following steps of: fermenting to prepare the bacterial cellulose bead or the bacterial cellulose membrane; treating the bacterial cellulose bead or the bacterial cellulose membrane in a water bath with 0.1 percent NaOH at the temperature of between 80 and 90 DEG C for 30 to 120 minutes; rinsing the mixture with deionized water; collecting the solution; neutralizing residual alkali liquor with 0.1 percent acetic acid; standing the solution; rinsing the mixture with deionized water; taking the bead or the membrane out; absorbing surface moisture; freezing the bead or the membrane; performing freeze drying on the bead or the membrane for layer use; and preparing the immobilized enzyme by a physical adsorption method or an adsorption crosslinking method. The bacterial cellulose bead / membrane can efficiently adsorb biological enzyme, maintains the activity of the enzyme to the greatest extent and is safe and environmental friendly; and the method is simple, is easy to operate and has high controllability.

This invention provides a method for preparing agricultural nutritious high absorption resin. The method adds nutritious substances such as diammonium hydrogen phosphate to the polymerization system, and forms composite in the presence of initiator and crosslinker, the water absorption rate of the agricultural nutritious high absorption resin is 200-500 times, and that of physiological saline is 30-80 times. The agricultural nutritious high absorption resin has has both water absorption and nutritious functions.

The invention relates to a novel coronavirus advantage epitope fusion protein, a diagnosis reagent and an application, and belongs to a viral diagnosis reagent. The novel coronavirus advantage epitopefusion protein comprises an N protein advantage epitope peptide and an S protein advantage epitope peptide which are connected through a connecting arm, and an E protein advantage epitope peptide, wherein the N protein advantage epitope peptide comprises one or two or above of an advantage epitope peptide N1, an advantage epitope peptide N2, an advantage epitope peptide N3 and an advantage epitope peptide N4. The novel coronavirus advantage epitope fusion protein is high in specificity, high in sensitivity (higher in positive detection rate), high in biocompatibility, high in solubility and good in stability, and is favorable for preparation of a corresponding detection reagent. The detection reagent prepared from the fusion protein is high in sensitivity and good in specificity, and early screening of novel coronaviruses can be realized.

The invention discloses a method for immobilizing white-rot fungi by utilizing a bacterial cellulose membrane as a carrier, which includes the following steps: the separation of the white-rot fungi and the preparation of spore solution of the white-rot fungi; the preparation of the bacterial cellulose membrane; the modification treatment of the bacterial cellulose membrane and the preparation of immobilized cells. After the bacterial cellulose membrane is processed by epoxy chloropropane, absolute ethyl alcohol, perchloric acid and the like, the modified bacterial cellulose membrane obtained is adopted as a carrier and reacts with a 25-percent glutaric dialdehyde solution and mixed with the spore solution of the white-rot fungi after the treatment of repetitive washing and the like, and then the solution is sealed and stays overnight at the temperature of 4 DEG C, and repetitively washed to obtain a bacterial cellulose membrane immobilized white-rot fungi. Three continuous batches of treatment tests for organics and chroma of xylitol production wastewater show that the treatment effects of immobilized white-rot fungi are not found to be obviously reduced and the immobilized white-rot fungi has obvious stability.

The invention belongs to the technical field of medicines, in particular to an aryl kinase inhibitor represented by the general formula (I), pharmaceutically acceptable salts or stereisomers thereof, wherein R1, R2, R3, m, n, R5, Y, W, M, L or Q are defined in the specification. The invention further relates to a preparation method of the compounds, pharmaceutical preparations or pharmaceutical compositions comprising the compounds, and an application of the compounds for preparing medicines for treating and / or preventing ALK or c-Met mediated cancer related diseases.

The invention provides a preparation method of a Bi2Te3 dimensional nano tablet. The preparation method comprises a step of subjecting a Bi2Te3 nano material, water, and functional ligand molecules to ultrasonic exfoliation so as to obtain the Bi2Te3 dimensional nano tablet; wherein the functional ligand molecule is polyvinylpyrrolidone, cytochrome C, or bovine serum albumin. In the preparation method, the functional ligand molecule is taken as the stripping agent to carry out ultrasonic exfoliation on a Bi2Te3 nano material so as to obtain a functional ligand molecule-Bi2Te3 dimensional nano tablet with high water solubility; and the dimensional nano tablet has the advantages of uniform particle size, controllable morphology, high water solubility, good biocompatibility, and high photo-thermal conversion efficiency, is a good photo-thermal agent, and can be applied to tumor photo-thermal therapy. The provided preparation method can synthesize massive water-soluble Bi2Te3 with a photo-thermal property, the preparation process is simple, the cost is low, and the preparation method is suitable for industrial production.

The invention relates to the technical field of bio-medical engineering, and particularly relates to a nerve stimulator. The nerve stimulator comprises a substrate provided with a plurality of through holes, a plurality of microelectrodes arranged on the substrate through being filled in the through holes, a stimulus chip and a shell. One side of each microelectrode, leaks out of the substrate, serves as the stimulus part of the microelectrode, while the other side of the microelectrode serves as the connection part of the microelectrode. The connection parts of the microelectrodes are directly inverted and welded onto the stimulus chip. The shell is hermetically connected with the substrate. The manufacturing method of the nerve stimulator is composed of the laser drilling step, the through hole plating step and other machining steps, and the packaging manner thereof is realized through the laser welding step. According to the technical scheme of the invention, the microelectrodes are connected with the stimulus chip through the flip-chip bonding process, so that the tissue damage caused during the implantation process of the nerve stimulator can be greatly reduced. The manufacturing method is simple in process, and short in period. Based on the method, a high-density and orderly-arranged three-dimensional microelectrode array can be implemented. Meanwhile, the high-density selective stimulating and recording function can be realized. Therefore, the nerve stimulator and the manufacturing method thereof have a good application prospect.

The invention relates to a method for preparing an artificial vessel and the application thereof. The preparation method comprises the following steps: (1) in the preparation of membrane liquid, polymer that is 7 to 30 percent by weight proportion is added into organic solvent the weight proportion of which is 70 to 93 percent, so that casting solution is obtained through swelling and solution under the temperature between 40 DEG C and 80 DEG C; (2) in the preparation of the artificial vessel, a hollow fibre membrane is formed through the filtration and deaeration of the membrane liquid, serosity is squeezed out from a spinneret composed of two concentric tubes, the serosity which enters into precipitating bath through dry spinning then is processed through a post treatment process to obtain the artificial vessel. The method includes the application that the artificial vessel is transplanted to a physical organ or any organs which need quantities of vascular tissues to transport aliment, gas and waste. The artificial vessel obtained by using the preparation method has good adaptability, penetrability and biocompatibility, matches the self vessels, and has controllable outside diameter and wall thickness of the materials.

The invention discloses a high-efficiency safe environment-friendly all-synthetic cutting fluid and a preparation method thereof. The cutting fluid consists of the following components in percentage by weight: 20-30% of synthetic ester, 4-8% of surfactant, 5-15% of antirust agent, 2-10% of pH regulator, 0-3% of corrosion inhibitor and the balance of deionized water. The preparation method comprises the following specific steps: adding the pH regulator into part of the deionized water and stirring uniformly; adding the corrosion inhibitor and the antirust agent in turn and stirring until solid powder is completely dissolved; after uniformly mixing and stirring the synthetic ester, adding the surfactant of the proportion and stirring for 15 minutes till uniformity; pouring a semi-finished product into the reaction system and stirring uniformly; repeatedly flushing the preparation container with the rest deionized water, and completely beating the flushing liquid back into the reaction system; and continuously stirring the reaction system until the solution is uniform and transparent to obtain a finished product. In the invention, the prepared all-synthetic cutting fluid has excellent lubricating and antirust and corrosion inhibition properties as well as good stability at high and low temperature to avoid color change, and avoids stimulation to the skin of a human body; and moreover, the all-synthetic cutting fluid has good biological stability and is safe, environment-friendly and non-irritant.