70results about How to "Good biological stability" patented technology

The invention relates to a natural plant extract food antioxidant additive and a preparation method thereof, the natural plant extract food antioxidant additive comprises a core material and a wall material, and the core material comprises the following components by mass: 10-20 parts of a polyphenol compound, 10-15 parts of a polysaccharide compound and 20-30 parts of a flavonoid compound. The preparation method comprises the following steps: mixing sodium alginate and a polysaccharide compound to prepare a polysaccharide microcapsule; mixing a polyphenol compound, a flavonoid compound and the polysaccharide micro-capsule, and dispersing with an emulsifier to obtain an emulsified dispersion liquid; and mixing a chitosan solution and a polylysine solution to obtain a mixed wall material solution, adding the mixed wall material solution into the emulsified dispersion liquid to prepare a microcapsule product, washing, and freeze-drying to obtain the food antioxidant additive of the natural plant extract. The additive has the effect of improving the anti-oxidation performance, can provide long-acting and lasting anti-oxidation protection, and has a certain health-care effect.

The invention discloses a gene engineering exosome and a slow release method and application thereof, the gene engineering exosome is derived from human adipose-derived stem cells, si-tgfbr2 is loaded in the gene engineering exosome, the si-tgfbr2 is specific siRNA aiming at a Tgfbr2 gene, and the gene engineering exosome can regulate and control proliferation of VSMCs, inhibit transformation of the VSMCs from a contraction phenotype to a synthetic phenotype when the VSMCs are stimulated, and inhibit the growth of the VSMCs. According to the present invention, the gene engineering exosome can be used to maintain the normal structure and the function of the blood vessel, and the sustained release effect of the content in the gene engineering exosome can be achieved by wrapping the gene engineering exosome in the PHA biodegradable material, such that the local treatment concentration can be easily stabilized, the drug administration frequency can be easily reduced, the lasting time of the treatment effect can be easily prolonged, and the treatment gene can be effectively delivered to the target cell; the treatment effect is improved; when being used for modifying a small-caliber artificial blood vessel, the small-caliber artificial blood vessel can be improved in biocompatibility and functionality, and can be prevented from being implanted into the blood vessel for remodeling unbenign hyperplasia stenosis; the invention not only provides a new thought and method for the treatment of vascular diseases, but also has important clinical application value and popularization prospect.

The invention discloses an ROS-responsive edible antibacterial preservative film and a preparation method thereof. The invention discloses a ROS (reactive oxygen species)-responsive antibacterial agent which is composed of sodium alginate (SA), carboxymethyl chitosan (CS), an ROS response group (TK-NH2) and antibacterial micromolecules (AB), TK-SA with ROS response characteristics is obtained through acylation reaction of TK-NH2 and SA through EDC, the antibacterial micromolecules (AB) are loaded into TK-SA through acylation reaction of EDC, and AB-TK-SA with antibacterial activity is obtained; aB-TK-SA and CS are mixed, sprayed to a clean glass plate and dried at the room temperature. The ROS-responsive edible antibacterial preservative film (AB-TK-SA / CS) provided by the invention has the characteristics of safety, low toxicity and ROS-responsive release, and can effectively inhibit the growth of staphylococcus aureus; the method is simple and convenient in preparation process, low in cost and good in reproducibility, and has a good application prospect in the field of related food preservation.

The invention belongs to the technical field of oral preparations, and particularly relates to a collagen composition for brightening skin and a preparation method thereof. The collagen composition is prepared from the following raw materials in parts by weight: 40 to 60 parts of fish collagen peptide, 2 to 5 parts of arbutin extract, 0.1 to 0.5 part of black pepper extract, 3 to 6 parts of glutathione, 1 to 3 parts of ellagic acid, 1 to 2 parts of shea butter, 3 to 5 parts of antioxidant, 1 to 2 parts of squalane, 1 to 2 parts of ceramide, 0.5 to 1 part of sodium bicarbonate, 5 to 10 parts of beta-cyclodextrin, 1 to 3 parts of lecithin and 0.5 to 1 part of silicon dioxide. According to the invention, the polyethylene glycol grafted aminated nano cellulose magnetic carrier is used for immobilizing the enzyme, so that the thermal stability and denaturation resistance of the enzyme are improved, the crosslinking is optimized, the enzyme activity is retained, the recovery process is simplified, the cost is reduced, the yield and quality of the collagen peptide are improved, active ingredients are protected through nanocrystallization and embedding technologies, and the absorption efficiency and the product stability are enhanced.

The invention belongs to the technical field of tobaccos, and discloses a preparation method of a tobacco endogenous biomass-based material, which comprises the following steps: S1, carrying out dipping treatment and solid-liquid separation on a tobacco waste raw material, then carrying out defibering, and then carrying out alkali pretreatment and alkali liquor cooking treatment to obtain tobacco slurry; s2, bleaching and decolorizing the tobacco pulp to obtain bleached tobacco pulp; s3, carrying out enzyme treatment on the bleached tobacco pulp; s4, the tobacco pulp obtained after enzyme treatment is subjected to pulp grinding and high-pressure homogenization treatment, and the tobacco endogenous biomass-based material is obtained. The invention further discloses the tobacco endogenous biomass-based material and application thereof.

The invention relates to the field of marine food manufacturing, in particular to high-protein-content soy sauce and a preparation method thereof, and the high-protein-content soy sauce comprises the following raw materials: laminarin, modified anthocyanin, compound protein, docosahexaenoic acid, astaxanthin, taurine, carrageenan, beta-amylase, soybeans, salt and purified water. The laminarin, the modified anthocyanin and the compound protein play a role through a synergistic effect, the compound protein in the soy sauce is wrapped by the modified anthocyanin to form a compound, a laminarin film is tightly attached to the outer layer of the compound formed by the modified anthocyanin, and the wrapping capacity and the structural stability of the compound are further enhanced; meanwhile, the oxidation process of fat and protein in the soy sauce is slowed down, the modified anthocyanin and a laminarin film interact to maintain the protein content in the soy sauce, laminarin, the modified anthocyanin and compound protein form a dynamic balance system, the nutritional value and quality of the soy sauce are improved, and the soy sauce with high protein content is provided.

The invention discloses a preparation method and application of a porous GelMA microneedle for delivering AIE molecules based on HSF derived exosome. The preparation method comprises the following steps: S1, preparing TTMN molecules; s2, dispersing DPPC and Chol in chloroform, performing water bath evaporation at 50 DEG C to form a thin film, hydrating the thin film in PBS, incubating to enable DPPC and Chol to form a liposome structure again, and uniformly dispersing TTMN molecules in the liposome structure to obtain TL; s3, extracting an exosome from the HSF cells; s4, loading the TL into the exosome by utilizing an electroporation technology, so as to obtain TE; s5, preparing the GelMA; and S6, mixing the GelMA with the TE, so that the TE is uniformly dispersed in the GelMA to obtain a mixed solution, injecting the mixed solution into a microneedle mold, and irradiating with 405nm laser to obtain the porous GelMA microneedle. According to the invention, high-efficiency treatment of hypertrophic scars is realized, and the system has a remarkable drug delivery effect, an innovative photodynamic therapy, a high-efficiency scar tissue remodeling effect and good biological safety and stability, and has important clinical application value and market prospect.

The invention discloses 3D printing biological material ink based on a drug sustained-release polycitrate material and a preparation method and a printing method of the 3D printing biological material ink, and relates to the technical field of 3D printing biologication.The 3D printing biological material ink is prepared from a medical polycitrate polymer, nano-hydroxyapatite and an active drug ingredient; the addition amount of the hydroxyapatite is 5-65% of the total mass of the obtained biological material ink; the active pharmaceutical ingredients are gastrodin, notoginsenoside, recombinant wnt3a protein and LL-37 peptide; when the active medicines are gastrodin and notoginsenoside, the addition amount of the active medicines is 4-12% of the total mass of the obtained biological material ink; when the used active drugs are recombinant wnt3a protein and LL-37 peptide, the addition amount of the active drugs is 0.001-0.002% of the total mass of the obtained biological material ink; and the particle size of the nano hydroxyapatite is 60-80 nm. According to the method, 3D printing process parameters are selected, post-treatment is adopted to adjust a cross-linked network structure of a poly-citrate polymer, biological material scaffolds with different mechanical properties and degradation properties are obtained, and stable and long-acting release of carried drugs is ensured.

The invention discloses a magnesium boride nanosheet / inulin composite hydrogel and application thereof in treating inflammatory bowel diseases and complicated mental diseases, and the composite hydrogel is synthesized by doping magnesium boride nanosheets into inulin and carrying out hot melting and cooling to form gel. The composite hydrogel has good oxidation resistance and biocompatibility, reducing hydrogen can be generated through a hydrolysis reaction to be used for reducing active oxygen and inflammatory factors of the enteritis part, intestinal flora can be adjusted, meanwhile, the composite hydrogel can be prevented from being affected by gastric acid and reach the intestinal part through the addition of inulin, and the enteritis treatment effect is improved. Therefore, the inflammatory bowel disease and related anxiety and depression symptoms thereof are effectively treated.

The invention discloses a microbial soil conditioner for fragrant-flowered garlic planting, a use method and a fragrant-flowered garlic planting method, and belongs to the technical field of fragrant-flowered garlic planting moth prevention. The microbial soil conditioner for Chinese chive planting comprises carbohydrates, and 50-60 parts by weight of yeast zinc, 30-50 parts by weight of yeast iron, 2-5 parts by weight of oligosaccharin and 3-5 parts by weight of bacillus subtilis are added into every 200 parts by weight of carbohydrates. The microbial soil conditioner for planting the Chinese chives can promote healthy growth of the Chinese chives and improve natural moth resistance of the Chinese chives.

The invention relates to the technical field of biomedical materials, in particular to non-metal bioartificial aggregate not prone to collapse and application. The non-metal bioartificial aggregate has a gradient three-layer scaffold structure, the obtained non-metal bioartificial aggregate uses a self-assembly technology, collagen molecules in ECM are used as a template, a calcium ion-containing solution and a phosphate ion-containing solution are added, hydroxyapatite grows on the molecular template in an in-situ mineralization manner, and the non-metal bioartificial aggregate is obtained. The structure and composition of a natural compact bone and a cancellous bone are simulated, the bionic structure, composition and function of the stent material are realized, the stent material can well absorb stress after being implanted into a body due to the structural design, and the biomechanical property of the material is improved. Meanwhile, cell permeation and nutrient substance conveying are also facilitated, the growth and proliferation speed of osteoblasts is remarkably increased, and the vascularization level and the speed of conversion from a stent material to a living body bone are increased.

The invention discloses a high-mechanical-property orthokeratology lens material copolymer and a preparation method thereof, and relates to the technical field of high polymer materials. The used raw materials comprise a fluorosilicone material, a hydrophilic monomer, an initiator and a cross-linking agent; the method comprises the following steps: mixing a monomer and an initiator according to a preset ratio, degassing, and carrying out two-stage heating polymerization reaction in a mold. After the polymerization reaction is finished, the copolymer in the mold is taken out, and the required orthokeratology lens material copolymer with the high mechanical property can be obtained through cleaning and drying treatment. The process is simple in reaction step and short in reaction time, the reaction rate can be controlled, and the production cost of the orthokeratology lens is reduced. The copolymer has high oxygen permeability and excellent optical performance, and meanwhile, compared with common like products, the copolymer shows good mechanical performance. The composition is especially suitable for preparing myopia lenses, orthokeratology lenses (OK lenses) or rigid breathable contact lenses (RGP lenses), can provide excellent visual effects and wearing comfort, and reduces irritation to eyes.

The invention belongs to the technical field of biological materials, and particularly relates to a nerve repair scaffold and a preparation method thereof.The nerve repair scaffold is of a hollow double-shell fiber structure, the outer layer of the double-shell fiber structure is composed of PCL nanofiber filaments, the inner layer of the double-shell fiber structure comprises PCL-dECM fiber filaments, and the outer layer of the double-shell fiber structure is composed of PCL nanofiber filaments. The PCL-dECM cellosilk is a PCL cellosilk loaded with dECM, the PCL-dECM cellosilk of the inner layer is arranged in the axial direction of the double-shell fiber structure, and after the nerve repair stent is implanted, the nerve function recovery can be improved, and the biocompatibility is improved.

The invention provides a high-efficiency paricalcitol injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the high-efficiency paricalcitol injection comprises an oil phase substance containing paricalcitol and a water phase substance containing chitosan; the preparation method comprises the following steps: simultaneously pouring a water-phase substance and an oil-phase substance into a container of a high-speed shearing emulsifying machine, carrying out ultrasonic emulsification, filtering, carrying out high-pressure homogenization, centrifuging, taking supernate to obtain the paricalcitol injection, enabling the paricalcitol injection to pass through a pretreated cation exchange resin column, collecting effluent, recording data, and determining the content of the paricalcitol. And enabling the effluent after cation exchange to pass through a pretreated anion exchange resin column, collecting the effluent, filtering, and sterilizing to obtain the efficient paricalcitol injection.

The invention relates to the technical field of cosmetics, and particularly discloses a three-type collagen freeze-drying flocculant containing serum albumin, fibronectin and polypeptide as well as a preparation method and application of the three-type collagen freeze-drying flocculant. The three-type collagen freeze-dried flocculus containing serum albumin, fibronectin and polypeptide is successfully prepared through the preparation method with scientific proportioning and careful design, the synergistic effect of all the components is achieved, and the three-type collagen freeze-dried flocculus has good biocompatibility and stability, can remarkably promote cell adhesion, proliferation and differentiation, and has good application prospects. The three-type collagen freeze-drying floccule can be used for accelerating the tissue repair process, has a remarkable repair effect, and also has a remarkable moisturizing effect and a remarkable anti-wrinkle effect. And the preparation method of the three-type collagen freeze-dried floccules is simple and easy to implement, is suitable for large-scale production, and has relatively high application value and market prospect.

The invention discloses a preparation method of an injectable dextran / poly (L-lactic acid) interpenetrating network microsphere composite hydrogel filler, comprising the following preparation steps: (1) synthesis of a polymerizable poly (L-lactic acid-dextran) copolymer; (2) preparation of a polymerizable dextran; (3) preparation of poly (L-lactic acid-dextran) interpenetrating network microspheres; (4) preparation of dextran microspheres; (5) preparation of an injectable poly (L-lactic acid-dextran) interpenetrating network microsphere and dextran microsphere composite hydrogel filler. The preparation method disclosed in the invention has the following beneficial effects: mild processing conditions, suitable for large-scale production, and the obtained injectable poly (L-lactic acid-dextran) interpenetrating network microsphere and dextran microsphere composite hydrogel filler has good biocompatibility and degradability, and is suitable for the field of soft tissue filling.

The invention provides an aviation aluminum alloy cutting fluid. The cutting fluid comprises the following components in parts by weight: 40-50 parts of base oil, 5-15 parts of an emulsifier, 5-15 parts of an oiliness agent, 2-8 parts of an antirust agent, 20-30 parts of distilled water, 2-8 parts of a base number retention agent, 1-5 parts of a hard water resistant agent, 0.5-2 parts of a corrosion inhibitor, 2-5 parts of a bactericide, 0.1-1 part of a coupling agent and 0.05-0.2 part of a defoaming agent, wherein the hard water resistant agent comprises alcohol ether carboxylic acid. The invention further provides a preparation method of the aviation aluminum alloy cutting fluid. The aviation aluminum alloy cutting fluid prepared from the components meets the machining requirements of cutting, milling, cutting and the like, the aluminum corrosion inhibition performance and the emulsion stability are good, and meanwhile the cutting fluid is good in biological stability and long in service life.

The present invention proposes an acid-reducing and fertilizing improver for red soil rice fields, a preparation method and an improvement method thereof, and belongs to the technical field of soil improvement. After the straw is carbonized, it is added to a urea solution, sodium alginate and carboxymethyl chitosan are added, and an injection pump is dripped into a calcium chloride solution drop by drop to obtain a gel ball, the surface of which is modified by a silane coupling agent, hydrolyzed, added to a solution containing microorganisms and biological enzymes, and freeze-dried to obtain an acid-reducing and fertilizing improver for red soil rice fields. The acid-reducing and fertilizing improver for red soil rice fields prepared by the present invention can not only effectively increase the soil pH value, improve soil fertility, improve soil structure, and promote the downward leaching of salt-damaging ions, but the straw powder can also improve the soil CO2 bias, soil air, and soil quality, and has a good slow-release effect and broad application prospects.

The invention relates to the technical field of drug research and development, and discloses a cell membrane bionic polymer nano-drug and a preparation method and application thereof.The nano-drug comprises a cell membrane and polymer nanoparticles, and the polymer nanoparticles are composed of polymers, positively charged metal peroxide nanoparticles and chemotherapeutic drugs; the structural formula of the polymer is as follows: # imgabs0 #, wherein the polyethyleneimine in the polymer is polyethyleneimine with the weight-average molecular weight of 1000 to 10000, and n is equal to 3 to 30; the polyethylene glycol in the polymer is polyethylene glycol with the weight-average molecular weight of 2000-10000, and m is equal to 50-250. The nano-drug obtained by the invention can be enriched at a tumor site, and the tumor cell membrane is damaged by generating hydrogen peroxide in situ on the surface of the tumor cell membrane, so that the biological barrier of the tumor cell membrane, which hinders drug transport, is broken through, and the anti-tumor drug effect of the chemotherapeutic drug is enhanced.

The invention provides a green, stable and long-life RTP-coated IPA material and a preparation method and application thereof.The method comprises the steps that 1, lignin is catalytically degraded through ternary DES comprising a hydrogen bond acceptor, a hydrogen bond donor and an enhancer, and lignin degraded through DES is obtained; wherein in the DES, the hydrogen bond acceptor is choline chloride or allyltrimethylammonium chloride, the hydrogen bond donor is lactic acid, and the enhancer is ethylene glycol or manganese chloride; (2) carrying out carbonization reaction on the lignin degraded by the DES and boric acid to obtain CDs doped with an element B; (3) crosslinking the CDs with a polymer matrix to obtain an RTP material; and (4) carrying out a cross-linking reaction on the RTP material and isophthalic acid to obtain the green, stable and long-life RTP-coated IPA material. The green, stable and long-life RTP-coated IPA material disclosed by the invention has excellent phosphorescence life and stability in a solvent, and has important application potential.

The invention provides an aloe capsule and a preparation method thereof, the capsule comprises purified aloe gel powder, an aloe polysaccharide extract, composite prebiotics, an antioxidant plant extract, vitamin E, dietary fibers, glycerin and other components, and has the effects of relaxing bowel, enhancing immunity and the like. The preparation method comprises the steps of ultrafiltration, ultrasonic treatment, freeze drying and the like, so that the high purity of the aloe gel powder and the retention of active components are ensured. In addition, the invention further provides a preparation process of airflow mixing granulation filling, nitrogen or carbon dioxide is used as mixed gas, and uniformity and stability of capsule components are guaranteed. The aloe capsule prepared by the method has the characteristics of definite components, remarkable effect, easiness in absorption and the like, and is suitable for people who need to improve intestinal health and enhance the antioxidant capacity of organisms.

The invention discloses an immunomodulatory active peptide derived from carya illinoensis as well as a screening method and application of the immunomodulatory active peptide. According to the immunoregulation active peptide RWEF derived from the carya illinoensis, the active peptide is extracted from protein of the carya illinoensis through a specific enzymolysis process, and the obtained peptide molecule has good biological activity and stability. Experimental verification shows that the immunoregulation active peptide RWEF can effectively improve the functions of immune organs (such as spleen and thymus), enhance the activity of immune cells, promote secretion of immune factors and regulate inflammatory response. The immunomodulatory active peptide RWEF provided by the invention has a wide application prospect in health foods, pharmaceutical preparations and nutritional supplements.

This invention relates to a cyclic polypeptide molecular probe targeting neurocilia protein-1 (NRP-1), its preparation method, and its applications. The cyclic polypeptide molecular probe comprises the structure shown in Formula I or Formula II, where R1 is the structure shown in Formula III or Formula IV; and R2 is a radiolabeled nuclide or a radiolabeled nuclide including a bifunctional chelating group. The technical solution of this invention exhibits excellent targeting specificity and high sensitivity for NRP-1 protein, enabling visualization of NRP-1-highly expressing tumors (such as fibrosarcoma, lung cancer, pancreatic cancer, or breast cancer) and NRP-1-positive lesions (such as metabolic diseases, sclerotic lesions, or autoimmune diseases) on positron emission tomography (PET). It shows great promise in the early diagnosis of NRP-1-highly expressing malignant tumors and in guiding clinical NRP-1 monoclonal antibody treatment regimens.

The utility model provides a visceral artery in-situ windowing positioning mechanism. The positioning mechanism comprises an operating handle, a stress relieving pipe, a positioner conveying sheath, a positioner conveying part and an umbrella rib-shaped positioner, the positioner conveying part is arranged in the operating handle, the stress relieving tube and the positioner conveying sheath in a sliding manner, the front end of the positioner conveying part can extend outwards from the positioner conveying sheath, and an umbrella rib-shaped positioner is mounted at the front end of the positioner conveying part; the umbrella rib-shaped positioner comprises a positioner umbrella rib support composed of a plurality of shape memory metal wires, a far-end mark point and a near-end mark point are arranged at the front end and the rear end of each shape memory metal wire respectively, and each shape memory metal wire is further provided with a positioner anchoring hook at the far end of the far-end mark point. By means of the adjustable and recoverable visceral artery in-situ windowing positioning mechanism, marking of a target artery can be completed simply and conveniently, and therefore a doctor can carry out accurate laser in-situ windowing on an aorta covered stent conveniently.

The invention relates to the technical field of lipidomics and human health, in particular to screening and application of a pregnancy maternal lipid biomarker with fetal growth limitation, and the lipid biomarker is selected from one or any combination of DG 14: 0 / 18: 2, DG 16: 0 / 20: 4, TG 14: 0 / 16: 0 / 18: 1, TG 14: 0 / 16: 0 / 18: 2, TG 16: 0 / 16: 0 / 18: 0 and TG 16: 0 / 16: 0 / 18: 1. The lipid biomarker provided by the invention can accurately diagnose the pathogenesis of the fetal growth restriction, and provides a specific and noninvasive diagnosis means for the fetal growth restriction.

The present invention provides an adenine Cu-MOF-based hydrogel composite material and a preparation method and application thereof, and relates to the technical field of MOF materials. The adenine Cu-MOF-based hydrogel composite material is composed of a copper metal organic framework loaded on a hydrogel; wherein the copper metal organic framework is [Cu2(Ad)2(SA)]·3DMA; wherein the hydrogel is methacrylated gelatin; wherein the mass ratio of the copper metal organic framework to the hydrogel is (0.1-1):(5-15). The adenine Cu-MOF-based hydrogel composite material of the present invention has good biocompatibility and stability, and the MOF has an obvious effect of promoting keratinocyte proliferation at an appropriate concentration, and has the potential to promote wound healing.

This invention discloses a method, product, and application for the separation of astatine-211 in an aqueous phase based on valence state regulation. The method includes: passing a solution of astatine-211 containing a strong oxidizing acid through a sulfur-containing solid support, causing specific adsorption of positively valence astatine-211; eluting with a water-soluble reducing agent to reduce astatine-211 to astatine anions, obtaining an aqueous astatine-211 eluent. The entire process is carried out in the aqueous phase, requiring no organic solvents and avoiding radionuclide volatilization loss due to heating and evaporation. This invention also provides an eluent composition prepared by this method, sodium astatide injection, astatine-211-labeled radiotargeting drugs and their preparation methods, as well as the application of this eluent composition in the preparation of drugs for treating NIS-positive diseases. This invention achieves highly selective separation and mild, rapid elution of astatine-211, and the product exhibits excellent biocompatibility and radiation stability, and can be used directly or after simple activation to prepare targeted α-therapy drugs.

The present invention relates to a UV-absorbing polymer composition comprising a polyolefin and a UV-absorbing agent, wherein the polyolefin contains at least one benzo-cyclobutene (BCB) pendant group, the UV-absorbing agent contains at least one dienophilic group, the polyolefin is capable of forming a cross-linked polyolefin by reaction between the BCB pendant groups, and the polyolefin and the UV-absorbing agent are covalently linked by reaction between the BCB pendant groups and the dienophilic groups. The present invention also relates to a process for the preparation of a UV-absorbing polymer and to a UV-absorbing polymer prepared thereby and to the use thereof.

The invention discloses a preparation method of a simulated sputum quality control product and application of the simulated sputum quality control product in a microbiological detection kit, and belongs to the technical field of biological detection. The simulation effect on the sputum matrix is good, simulation of sputum color, bubbles and viscosity is achieved, good uniformity, dispersity and stability are achieved, and viscosity and sputum foam samples can still be maintained after the sputum matrix is stood and stored for 7 days at different storage temperatures. After being mixed with a culture, thalli are uniformly wrapped, and the bacterial strain has good biocompatibility and stability, has no influence on the morphology of the thalli, can stably simulate the dispersity of the thalli in sputum, is beneficial to the preparation of reference substances and quality control substances of in-vitro diagnosis related kits, and has a good auxiliary effect on microscopic examination of clinical microorganisms.

This invention belongs to the field of biomedical materials technology, and relates to a signal probe that simultaneously possesses CT and MRI imaging capabilities, its preparation method, and its application. The preparation method includes the following steps: dissolving bismuth citrate and iron salt in water, adjusting the pH of the solution to <7, adding polyvinylpyrrolidone, then adding gallic acid, adjusting the pH of the mixed solution to >7, and after the reaction is complete, filtering through a membrane to remove impurities, dialysis, and drying to obtain bismuth-iron nanoparticles; mixing citric acid with the bismuth-iron nanoparticle solution, stirring and reacting to obtain citric acid-treated bismuth-iron nanoparticles; further activating to obtain an activated bismuth-iron nanoparticle solution; adding RGDfk and amino-terminated polyethylene glycol to the activated bismuth-iron nanoparticle solution, stirring and reacting in the dark, dialysis, and drying to obtain a signal probe that simultaneously possesses CT and MRI imaging capabilities. The signal probe prepared by this invention has a small particle size and simultaneously possesses CT and MRI imaging functions.