35 results about "Xanthonoid" patented technology

The application discloses a three-channel fluorescence sensor array based on sulfur quantum dots and a preparation method and detection application thereof. The sensor array is composed of three kinds of sulfur quantum dots, namely C-SQDs, PSS-SQDs and beta-SQDs. When target objects exist, the three kinds of sensing units generate differentiated fluorescence responses, forming a unique "fingerprint map". By using principal component analysis to analyze the response mode, the array can successfully distinguish between structurally similar baicalein, fiscetin, myricetin, quercetin and rutin in a concentration range of 8.0-56 muM. In addition, the array can also perform semi-quantitative analysis on a single flavone compound in a range of 4.0-56 muM, and the first principal component has a good linear relationship with the logarithm of the concentration of the target object.

This invention belongs to the field of traditional Chinese medicine treatment, specifically relating to an anti-cold and detoxifying capsule pharmaceutical composition, its preparation method, and its application. The composition comprises the following components in parts by weight: 25-35 parts Angelica dahurica, 40-50 parts Scutellaria baicalensis, 2-5 parts flavonoids, 0.5-2 parts Imperatorin, 1-5 parts Artemisia capillaris, 1-5 parts phloroglucinol compounds, and 0.1-0.5 parts organic acids. The component-based composition provided by this invention has a good effect in preventing and treating wind-heat colds, and the components exhibit good synergistic effects.

A method for detecting natural flavonoid selenium, including the following steps: S1: preparing mobile phase; S2: preparing test solution; S3: testing the test solution, the present disclosure is applicable to the field of pharmaceutical technology and provides the detection method for natural flavonoid selenium to ensure direct quantification of a quality control in drug development and application. Through a standard curve, a compensation effect of a dual ternary pump can be utilized to render a response value of each substance passing through a detector correspond to an amount of substance, without being affected by the fluidity gradient and without the need to prepare standard samples again.

This invention discloses an isoflavone compound, its preparation method, and its applications. The compounds are derived by directional esterification modification of all phenolic hydroxyl groups with allyloxycarbonyl chloride, o-chlorobenzoyl chloride, or cinnamoyl chloride, using 4',7-dihydroxyisoflavone or 4',5,7-trihydroxyisoflavone as the parent nucleus. The invention also provides a mild and efficient preparation method for these compounds and confirms their significant anti-inflammatory pharmacological activity. Pharmacological studies show that compounds B and E, in particular, exhibit excellent in vitro and in vivo anti-inflammatory activity, with compound E showing superior activity compared to the positive control drug dexamethasone. These compounds can be used to prepare drugs for treating inflammatory diseases such as pneumonia and colitis.

The inventors have found that quercetin and genistein, individually, suppress the expression of some aging-related genes while promoting the expression of other aging-related genes. Therefore, the main objective was to maintain the repressive effect on some aging-related genes that quercetin, genistein, and their glycosides may have, while suppressing the effect of promoting the expression of other aging-related genes. [Solution] The above problem can be solved by combining two or three components selected from the group consisting of component (i): quercetin and / or its glycosides, component (ii): genistein and / or its glycosides, and component (iii): nobiletin and / or its glycosides.

The invention relates to a process for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, comprising the following successive steps: a) Mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component to form a solution of polylactide-co-glycolide in an organic solvent, to form a water-oil emulsion; b) Mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer, to form a water-oil-water emulsion, c) Mixing the water-oil-water emulsion with an aqueous salt solution; d) Removal of the organic solvent in the water-oil-water emulsion to form a suspension comprising the microparticles loaded with at least the flavonoid and / or flavonoid derivative; e) Separating the loaded microparticles from the liquid of the suspension. Furthermore, the invention relates to microparticles, the use of which for the manufacture of a medicinal product, a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, as well as non-medical use in cosmetics.

The inventors' primary objective was to provide a technology that suppresses inflammation, particularly in aging tissues. [Solution] The above problem can be solved by a composition containing at least one selected from the group consisting of genistein, quercetin, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof.

The invention belongs to the field of natural pharmaceutical chemistry and the field of cosmetics, and particularly relates to a skin care composition, a skin care product and application thereof.The skin care composition comprises silymarin, epigallocatechin gallate and quercetin, and the mass ratio of the silymarin to the epigallocatechin gallate to the quercetin is (3-7): (3-10): (1-5). The skin care product comprises the skin care composition, the content of the skin care composition is 0.5-10%, the skin care composition or the skin care product is applied to preparation of the skin care cosmetics, the esterified lecithin is used for encapsulating the silymarin, the epigallocatechin gallate and the quercetin, and sodium hyaluronate is matched, so that the skin care composition or the skin care product can be used for preparing the skin care cosmetics. The problems that flavonoid compounds are difficult to dissolve, permeate and absorb are effectively solved, and meanwhile, the skin care composition and sodium hyaluronate have a synergistic effect, so that the moisturizing, wrinkle removing and aging resisting effects are remarkably improved.

The application discloses a method for catalyzing sodium borohydride to produce hydrogen at low temperature, which is characterized by using natural flavonoids (including flavone, flavonol, isoflavone and the like) as a catalyst, using methanol or a mixture of methanol and water as a reaction solvent, using NaBH4 as a raw material for hydrogen production, and performing alcoholysis of NaBH4 to produce hydrogen. The catalyst used in the application is abundant in source and low in price, can catalyze sodium borohydride to produce hydrogen through alcoholysis at a wide reaction temperature range, has stable catalytic performance, high hydrogen production rate, good catalytic durability and reusability, and has important significance for the application and popularization of sodium borohydride in the field of hydrogen production.

This invention provides a method for preparing a traditional Chinese medicine health-preserving fabric. The method includes the following steps: Step 1, immersing the fabric in a metal salt solution for pretreatment, wherein the metal ions in the metal salt solution are selected from Zn. 2+ Mn 2+ Cu 2+ At least one of the following: Step 2, immerse the fabric treated in Step 1 in a flavonoid extract for coordination treatment; Step 3, wash and dry the fabric treated in Step 2 to obtain the herbal health-preserving fabric. This invention first fixes metal ions on the fabric surface through surface pretreatment, allowing the metal ions to act as a "bridge" to firmly bind flavonoid compounds to the fibers. Simultaneously, utilizing the synergistic effect of flavonoid-metal complexes, it significantly enhances the fabric's antibacterial, anti-inflammatory, and antioxidant functions, thereby improving the overall health-preserving effect.

This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.

This invention relates to an abrasive article comprising at least one binder in at least one abrasive layer. The binder contains at least one resin N, wherein the resin N is produced by a polymer formation reaction of a starting monomer composition, specifically by polycondensation, wherein the starting monomer composition comprises at least one B monomer or at least one B monomer and at least one A monomer, wherein the at least one A monomer is selected from the group consisting of phenol, catechol, catechol-like compounds, resorcinol, resorcinol-like compounds such as 1,3,5-trihydroxybenzene and phloroglucinol, 2,6-dihydroxynaphthalene, 1,8-dihydroxynaphthalene, 1,5-dihydroxynaphthalene, and flavonoids, and wherein the at least one B monomer is selected from the group consisting of aromatic aldehydes.

The application belongs to the technical field of medicine, and particularly relates to a use of a flavonoid compound in aortic valve disease or cardiovascular aging. The flavonoid compound shown in formula I is found to be capable of inhibiting the osteogenic differentiation of valve interstitial cells for the first time. In animal implementation, the flavonoid compound can significantly reduce the peak flow rate and peak pressure difference of the aortic valve of a calcified aortic valve mouse, and has a significant effect of relieving aortic valve calcification. Therefore, the flavonoid compound has a good application prospect in the preparation of a drug for relieving aortic valve disease, relieving cardiovascular aging and other related cardiovascular diseases.

The present application relates to the field of antioxidant, in particular to an antioxidant polymer and a preparation method, a flavonoid compound solution, a self-healing hydrogel and application. The antioxidant polymer synthesized by the present application not only has antioxidant property but also can realize solubilization of the flavonoid compound in aqueous solution, solves the technical problem that the flavonoid compound is usually difficult to dissolve or insoluble in water, and further obtains the aqueous solution of the flavonoid compound. The present application further prepares the aqueous solution of the flavonoid compound into a self-healing hydrogel, and obtains the antioxidant self-healing hydrogel loaded with the flavonoid compound; thereby solving the problem that the flavonoid compound cannot be directly used for wound dressing.

This invention belongs to the field of biotechnology, specifically relating to a bifunctional glycosyltransferase protein, LbUGT41, its encoding gene, and its applications. The LbUGT41 gene was cloned from Ningxia wolfberry, with a full-length nucleotide sequence of 1347 bp encoding a 448-amino acid protein. Functional verification showed that LbUGT41 possesses bifunctional catalytic activity: it can catalyze the 3-O-glucosylation of quercetin to generate isoquercitrin using UDP-glucose as a sugar donor; it can also catalyze the hydrolysis of isoquercitrin to generate quercetin in the presence of UDP. This invention provides a novel biocatalyst for the targeted modification and transformation of flavonoids, and also provides key genes and theoretical basis for research on the regulation of plant flavonoid metabolism and molecular breeding of wolfberry quality.

The application belongs to the field of medicine and relates to application of an isoflavone compound, isoformononetin (IFM), in preparation of a medicine or health care product for preventing and treating depression; in mouse hippocampal neuron cells (HT22) or mouse microglial cells (BV2), IFM can reduce neuroinflammation caused by corticosterone (CORT) or lipopolysaccharide (LPS) and increase the expression level of brain-derived neurotrophic factor (BDNF); in a chronic mild unpredictable stress mouse depression model, IFM can relieve depression-like behavior of the mouse and reduce the inflammation level of brain tissue, indicating that IFM has a good effect of relieving depression; IFM degrades PDE4D protein by directly combining with a PDE4D target protein. The isoflavone compound IFM has the advantages of outstanding effect and high safety and is expected to develop into an effective medicine for treating and preventing depression.

The application discloses a kind of chess nan linaloe leaf flavonoids compound extraction purification method and application.It belongs to flavonoids extraction technical field.The application extracts flavonoids compound in chess nan linaloe leaf by ultrasonic wave auxiliary ethanol extraction method, and is determined by single factor test and response surface method optimization optimum extraction process;Further, macroporous adsorption resin is used to purify crude extract, and obtain purified flavonoids compound.Flavonoids compound contains many active ingredients such as acacia leaf glycoside, quercetin, sakura flower element by identification.The method of the application is high in extraction efficiency, simple in operation, environmentally friendly and safe, and the obtained flavonoids compound has significant antioxidant activity and inhibitory activity of acetylcholinesterase and alpha-glucosidase, which provides technical support for the development and utilization of chess nan linaloe leaf.

This invention relates to the field of biotechnology, specifically to the construction and application of a Benzodiacetic tobacco chassis for synthesizing isoflavones. This invention reconstructs the upstream pathway for isoflavone synthesis in Benzodiacetic tobacco, further identifies and screens key rate-limiting enzymes for isoflavone synthesis in Benzodiacetic tobacco, and utilizes 2A peptides to co-express multiple key genes, further introducing flavonoid synthesis transcription factors to construct a Benzodiacetic tobacco chassis for synthesizing isoflavones. This Benzodiacetic tobacco chassis can efficiently synthesize daidzein and genistein. Furthermore, based on the constructed high-yield Benzodiacetic tobacco platform for daidzein and genistein, various isoflavones can be further synthesized, such as daidzein, genistein, puerarin, gentiopicrin, chickpea extract A, and stigmosiderin, paving the way for the industrialization of plant biosynthesis of various bioactive isoflavones and thus possessing broad application prospects.

This document relates to flavonoid compounds and methods and materials for using flavonoid compounds to treat one or more fibrotic and / or aberrant wound healing / scarring conditions (e.g., idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC)). For example, one or more flavonoid compounds having the structure of Formula (I) can be administered to a mammal (e.g., a human) having one or more fibrotic and / or aberrant wound healing / scarring conditions (e.g., IPF, NASH, and PSC) to treat the mammal.

This invention belongs to the field of biomedical technology, specifically relating to an isoflavone compound, its preparation method, and its application. This compound is derived from *Rotenoporosis capillaris* (a type of vine). Derris eriocarpa The stem of *Derris fusiforme* was analyzed using 1D and 2D nuclear magnetic resonance (NMR) spectra (1H NMR, 1C NMR, and high-resolution mass spectrometry), and its structural formula is shown below: Chemical name: 5-hydroxy-6-(2"-hydroxy-3"-methylbut-3"-enyl)-3-(4'-hydroxyphenyl)-7-methoxyisoflavone. Screening using the Sci-finder database revealed that this compound is a novel isoflavone, isolated for the first time from *Derris fusiforme*. Lipid-lowering activity experiments showed that at the same drug concentration (25 μg / mL) as the positive control, it significantly reduced intracellular total cholesterol and triglyceride levels. p <0.001). Therefore, this novel isoflavone compound can be used to prepare drugs, health products, functional foods, or special medical foods for the prevention or treatment of hypertriglyceridemia, hyperlipidemia, obesity, or metabolic syndrome.

This invention provides a wild Ganoderma lucidum strain from Luojia Mountain and its application, belonging to the field of microbial technology. The wild Ganoderma lucidum strain from Luojia Mountain is named Ganoderma lucidum strain LJ2 (…). Ganoderma The *Ganoderma lucidum* strain LJ2 (accession number: CCTCC NO: M 2026631) is rich in flavonoids, which significantly inhibit tumor cell proliferation and alleviate the lethal toxicity of *Pseudomonas donghuensis* to *C. elegans*. Therefore, *Ganoderma lucidum* strain LJ2 or its flavonoid extracts can be used as active ingredients in the preparation of antitumor drugs or formulations to alleviate bacterial toxicity. This invention provides new ideas for antitumor and antibacterial infection control, and also provides a new source for the development of natural antitumor and antitoxic products.

This invention discloses a zinc-quercetin nanocomposite, its preparation method, and its pharmaceutical applications, belonging to the field of bionanomaterials technology. This nanoparticle employs a carrier-free self-assembly strategy, directly forming a structurally stable nanocomposite by combining the natural flavonoid quercetin with zinc ions through metal-organic coordination bonds. This technology effectively overcomes the inherent defects of poor water solubility and low bioavailability of quercetin monomers, resulting in a nanocomposite with good water solubility and physiological stability. Simultaneously, zinc ions, as a key trace element for neuroregulation, can intervene in pain transmission pathways to alleviate pain; quercetin exerts a long-lasting anti-inflammatory and analgesic effect by continuously scavenging reactive oxygen species and inhibiting the release of inflammatory factors in damaged nerves or inflammatory sites. The two work synergistically in the lesion microenvironment, achieving the prevention and efficient, safe treatment of chronic pain. The preparation process is extremely simple, requiring no complex carriers, and has broad prospects for clinical translation and application.

An additive 50 for use alone as a tablet or capsule or with a base product 54 to produce an enhanced product 52 that provides health benefits 34 to a person 20 who consumes or uses the additive 50, including stimulating naturally occurring enzymes in the person's body. The additive 50 has one or more hydrogenated substances 58, such as Erythritol 58a, Xylitol 58b, hydrogenated dihydromyricetin 58c and / or Quercetin dihydrate 58d, and the flavonoid Dihydromyricetin 14a. The flavonoid 14 may be extracted from a Vine Tea plant 17 and / or a plant chosen from the genus Hovenia,16, such as the Japanese raisin tree. The additive may also have one or more of a solvent 60, such as a bicarbonate compound 60a or an alcohol solvent 60b, a pH balancing acid 62 and / or preservatives 64. The base product 54 may be a liquid 66, solid 68, powder 70, chewable 72, pharmaceutical 74, cosmetic 76 or lotion or other applied product 78. The enhanced product 52 is a base product 54 that is enhanced by the additive.

Provided is a licorice extract which can be used as a multifunctional raw material. The licorice extract includes: (A) one or more selected from the group consisting of glycyrrhizic acid, a glycyrrhizic acid derivative, glycyrrhetinic acid, and a glycyrrhetinic acid derivative; (B) licorice saponins other than the (A); and (C) licorice flavonoids, and the (B) includes at least 1.7% by mass or more of a licorice saponin H2, 0.2% by mass or more of a licorice saponin G2, and 0.2% by mass or more of macedonoside A, and the (C) includes at least 0.1% by mass or more of liquiritin apioside, 0.1% by mass or more of isoliquiritin apioside, and 0.1% by mass or more of isoliquiritin.

The present application relates to the application of isoquercitrin in the preparation of a drug for treating post-traumatic stress disorder, and belongs to the technical field of natural chemical medicine development. The present application systematically clarifies the whole-chain mechanism of isoquercitrin in treating PTSD through the "GABA A R-PINK1 / Parkin-mitophagy" pathway by means of a variety of technical means such as molecular docking, microthermal swimming, patch clamp, proteomics, cell and animal models. Compared with the clinically commonly used drugs for treating post-traumatic stress disorder, isoquercitrin, as a natural flavonoid compound, can improve the symptoms of PTSD while not damaging the learning and memory function, and has better safety. Moreover, isoquercitrin is widely sourced and has a mature preparation process. The present application provides a theoretical basis and experimental support for the application of isoquercitrin in the development of drugs for treating post-traumatic stress disorder, and has important clinical application value and industrialization prospects.

This invention provides a glycosyltransferase ThUGT1, the nucleotide sequence of which is shown in SEQ ID NO.1. This invention also provides a method for synthesizing flavonoid compounds. This invention provides the flavonoid glycosyltransferase ThUGT1 gene from *Trifolium repens*, which can serve as a regulatory gene for the biosynthesis of components such as luteolin, kaempferol, and genistein, and can be applied to the preparation of luteolinoside, kaempferol-7-O-glucoside, and genistein. This invention utilizes a heterologous expression method to biosynthesize glycosides through microbial biosynthesis, and also verifies its function and enzymatic properties. The method exhibits strong site specificity, reacting only at position 7, good solubility, and a broad substrate scope, binding to most flavonoid compounds, especially the relatively scarce 7-O-glucoside transferase. The resulting mutant can improve the yield, enabling industrial production, promoting the development of *Trifolium repens* glycosides, and providing a foundation for the widespread application of *Trifolium repens*.