152 results about "Puerarin" patented technology

The invention discloses a medicinal and edible anti-alcoholism composition and a preparation method thereof, and relates to the crossing field of biotechnology and food and medicine, the composition comprises the following components: dried orange peel powder, vitamin C, glutathione, phellinus igniarius extract, polygonatum sibiricum extract, oriental wormwood extract, isatis root extract, schisandra chinensis extract, ginseng powder, lucid ganoderma extract and licorice extract. Silymarin, puerarin, white tomato powder, watermelon powder, fucoidin, tomato powder, mung bean powder, celery powder, turmeric powder, hawthorn fruit powder, honey powder, corn peptide, soybean peptide powder, xanthan gum and stevioside are added. The composition provided by the invention has the effect of increasing the content of ethanol dehydrogenase and acetaldehyde dehydrogenase in blood after drinking, and has the capability of promoting alcohol metabolism.

The invention relates to the technical field of cosmetics, in particular to a preparation method and application of a supramolecular solvent containing puerarin. The supramolecular solvent containing puerarin comprises puerarin, a hydrogen bond donor and a hydrogen bond receptor, the molar ratio of the hydrogen bond donor to the acceptor is (1-3): (1-2). The puerarin-containing supramolecular solvent formed by using weak interaction force such as hydrogen bonds can effectively solve the problems that puerarin is easy to separate out in the product and poor in transdermal absorption and the like, and meanwhile, the puerarin-containing supramolecular solvent can synergistically promote the effect of puerarin in the oil-control acne-removal product. Cosmetics prepared by adopting the supramolecular solvent prepared by the invention have good oil control and soothing effects, and the preparation process is simple, large-scale production is easy, and the properties are stable.

The invention discloses a preparation method of a liver protection medicine composition containing dihydromyricetin, and relates to the technical field of medicine preparation.According to the method, dihydromyricetin, puerarin, pueraria flower extract, corn oligopeptide, pyrroloquinoline quinone disodium salt, curcumin and ganoderan are used as raw materials; dihydromyricetin and puerarin are stirred, homogenized and dried in a mixed solvent to prepare the liver protection medicine composition, wherein the mass ratio of dihydromyricetin to puerarin is 1: (0.5-2). A multi-target liver protection system is constructed through cooperation of multiple components, the problems that a traditional liver protection medicine is poor in component solubility, easy to degrade in activity and weak in synergistic effect are solved, the bioavailability and stability of the product are improved, the process is simple and controllable, the preparation method is suitable for industrial production and can be prepared into oral preparations such as tablets and oral liquid, and the preparation method is suitable for industrial production. The composition is suitable for protection of alcoholic and chemical liver injury.

The invention discloses puerarin hydrogel based on a natural eutectic solvent as well as a preparation method and application of the puerarin hydrogel, and belongs to the technical field of pharmaceutical preparations and transdermal drug delivery. The preparation method comprises the following steps: mixing a hydrogen bond acceptor and a hydrogen bond donor, heating and stirring to obtain a natural eutectic solvent; puerarin is mixed with the natural eutectic solvent, and a puerarin solution is obtained; mixing the puerarin solution with a polyvinyl alcohol aqueous solution to obtain a mixed solution; and pouring the mixed solution into a mold or spreading the mixed solution into a film, and then carrying out freeze-thaw cycle to obtain the puerarin hydrogel based on the natural deep-eutectic solvent. According to the invention, a natural eutectic solvent is introduced into a hydrogel system, so that a carrier system with'high solubilization, gel forming and controllable physicochemical properties' is obtained, and meanwhile, the bottleneck of low solubility and low permeability of puerarin is solved. The puerarin hydrogel based on the natural eutectic solvent can be used as a skin external preparation for local administration.

The invention discloses a bionic carrier-free nano-drug coated with a macrophage membrane as well as a preparation method and application of the bionic carrier-free nano-drug. The preparation method of the bionic carrier-free nano-drug comprises the following steps: S1, preparing PR-coated PBNPs: preparing a carrier-free self-assembled nano-drug PR-coated PBNPs from puerarin PR and probucol PB by adopting a nano-precipitation method; and S2, preparing MPR (at) PBNPs: coating the surface of the PR (at) PBNPs with a macrophage membrane, so as to obtain the bionic carrier-free nano-drug MPR (at) PBNPs. According to the nano-drug disclosed by the invention, due to the coating of a macrophage membrane, MPR-coated PBNPs can be promoted to be enriched to an AS diseased region; in the plaque region, the MPR-coated PBNPs releases PR and PB drugs, so that the oxidative stress and apoptosis of endothelium and macrophages are effectively relieved; in addition, endothelial cells can be inhibited from absorbing lipid and foam macrophages can be prevented from being formed, so that the atherosclerosis can be efficiently and safely treated.

The invention discloses a construction method and application of a specific chromatogram of a Shanhaidan pharmaceutical preparation, and belongs to the technical field of traditional Chinese medicine detection. The method comprises the following steps: preparing a test solution by using a plurality of different batches of Shanhaidan medicinal preparations in combination with high performance liquid chromatography and mass spectrometry technologies; the preparation method comprises the following steps: preparing a single reference substance solution from uridine, tanshinol, daidzin, p-hydroxybenzoic acid, puerarin, caffeic acid, 3 '-hydroxy puerarin, physcion, calycosin-7-O-beta-D-glucoside, stilbene glucoside, rosmarinic acid, alkannic acid, formononin, salvianolic acid B, daidzein and calycosin-7-one; and respectively carrying out high performance liquid chromatography analysis on the test solution and the reference solution to obtain the characteristic chromatogram of the Shanhaidan pharmaceutical preparation. The method is simple and convenient to operate, high in precision, good in reproducibility and accurate and reliable in result. And at least 16 components can be identified at one time under the same chromatographic condition, so that the detection efficiency is remarkably improved, the time and the cost are saved, and the quality of the Shanhaidan pharmaceutical preparation is comprehensively and scientifically evaluated.

The invention provides a traditional Chinese medicine composition for reducing blood sugar and blood pressure and a preparation method thereof, and belongs to the technical field of biological medicine, the composition comprises ivory white eggplant extract, parsley extract, banana zucchini rattan extract, coloured bean puffball extract, eucommia ulmoides glycoside and puerarin. The preparation method comprises the following steps: carrying out common enzymolysis on ivory white eggplant by using cellulase, pectinase and papain, and purifying by using an XAD-16 macroporous resin column and a Sephadex LH-20 gel column to obtain an ivory white eggplant extract; the method comprises the following steps: extracting parsley with an ethanol aqueous solution, and purifying with an AB-8 macroporous adsorption resin column to obtain a parsley extract; the preparation method comprises the following steps: extracting banana zucchini rattan by using an ethanol water solution, and purifying by using a D101 macroporous adsorption resin column to obtain a banana zucchini rattan extract; colored bean puffball is subjected to common enzymolysis with chitinase and ficin, extracted with a two-phase solvent and purified with an HPD-100 macroporous adsorption resin column, and the colored bean puffball extract is prepared. All the components are matched to realize synergy of reducing blood sugar and blood pressure.

The invention discloses an establishment method of an HPLC (high performance liquid chromatography) characteristic chromatogram of granules for treating common cold and clearing heat and a component content test thereof, and belongs to the technical field of pharmaceutical analys.According to the research, the HPLC characteristic chromatogram of the granules for treating common cold and clearing heat is established under the same chromatographic condition by adopting a high performance liquid chromatography, and the overall internal quality in a preparation is comprehensively reflected; the method for simultaneously determining the content of amygdalin, puerarin, cimicifugin and corydalis bungeana is established, methodology verifies that the method is simple, convenient and feasible, has good stability and repeatability, and can be used for detection in production process monitoring and quality evaluation of the cold and heat clearing granules to ensure that the quality of the cold and heat clearing granules meets the standard. The scheme not only scientifically restores the overall pharmacodynamic material basis of the compound preparation, but also provides a new generalizable normal form for quality control of traditional Chinese medicines with the advantages of low cost and high efficiency, and has milestone significance for promoting industry standardization and internationalization.

The application discloses a baicalin ternary co-amorphous drug and a preparation method and application thereof, and the amorphous substance can effectively improve the solubility and dissolution of puerarin and baicalin. The application mixes metformin hydrochloride, puerarin and baicalin according to a molar ratio of 1:1:1, and obtains the baicalin ternary co-amorphous drug through a ball milling method or a solvent-assisted milling method, the preparation method is green and efficient, the co-amorphous substance has high light stability and thermal stability, the solubility is increased by 1.7 times compared with that of a puerarin raw drug crystal, the solubility is increased by 46.8 times compared with that of a baicalin raw drug crystal, and the solubility is reduced by 14.8 times compared with that of a metformin hydrochloride raw drug crystal. The baicalin ternary co-amorphous drug has certain application prospects in liver protection, blood sugar reduction, treatment of damp-heat type colitis and cervical cancer.

The invention discloses a prebiotic black coffee beverage capable of improving the intestinal health function and a preparation method and application thereof, and belongs to the technical field of functional food. The invention discloses a prebiotic black coffee beverage with a function of improving intestinal health. The prebiotic black coffee beverage is prepared from the following raw materials: water, a black coffee concentrated solution, resistant dextrin, polydextrose, fructo-oligosaccharide, puerarin, mogroside and xanthan gum. The prebiotic black coffee drink added with prebiotics, dietary fibers and medicinal and edible components has the functions of improving intestinal health, promoting excretion and relaxing bowels, and is suitable for intestinal health management of people who have high sedentariness and irregular work and rest.

The invention relates to a male anti-ED composition containing a burdock root aqueous extract and a preparation method of the male anti-ED composition, and relates to the technical field of male anti-ED composition preparation. The composition comprises a burdock root aqueous extract, ginsenoside and puerarin, and the mass ratio of the burdock root aqueous extract to the ginsenoside to the puerarin is (5-8): (0.5-1): (0.2-0.5). The invention provides an anti-ED composition taking a burdock root aqueous extract, ginsenoside and puerarin as synergistic active components and a preparation method thereof. The curative effect is improved through a multi-target synergistic effect of ternary combination.

The invention discloses a medicinal and edible composite particle capable of relieving liver injury and a preparation method and application thereof.The particle is a puerarin-loaded phosphorylated hollow zein-chitosan oligosaccharide particle and has an efficient delivery structure with the exterior hydrophilic and the interior hydrophobic, the bioavailability is improved while the puerarin drug loading capacity is increased, and the bioavailability is improved. The circulation time in the body is prolonged, and the medicinal effect is enhanced. Meanwhile, the chitosan oligosaccharide in the components of the composite particle has a liver protection effect and can be cooperated with the anti-oxidation and anti-alcohol characteristics of puerarin, so that multi-target protection in alcoholic liver injury is realized, and the composite particle can be used for expanding and developing treatment medicines or health-care foods with anti-alcohol and liver-protecting effects and has remarkable economic and social values.

The invention discloses a method for efficiently extracting active ingredients from radix puerariae, the active ingredients comprise 3 '-hydroxypuerarin, the extraction method comprises the following steps: S1, raw material pretreatment: selecting dried radix puerariae tuberous roots, crushing and sieving with a 40-60-mesh sieve, and the invention relates to the technical field of plant active ingredient extraction. According to the method for efficiently extracting the active ingredients from the radix puerariae, through the synergistic effect of composite solvent extraction and gradient purification, synchronous and efficient enrichment is achieved on trace 3 '-hydroxypuerarin and a compound A in the radix puerariae, the extraction rate is larger than or equal to 15%, the extraction rate of the compound A is larger than or equal to 85%, and the extraction rate is increased by three times or above compared with a traditional single solvent extraction method; the total purity of the active ingredients is greater than or equal to 95%, the problems of low extraction rate of the target ingredients and difficult separation of impurities in the traditional process are solved, and the pharmacological activity of the 3 '-hydroxy puerarin and the compound A are synergistically enhanced, so that the application requirements of high-purity plant source active ingredients are met, and a high-quality raw material is provided for subsequent development.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The invention discloses a method for extracting puerarin from kudzu vine root peel by using an ultrasonic-assisted ionic liquid solution. The method comprises the following steps: by taking waste kudzu vine root peel as a raw material, carrying out drying and crushing pretreatment, carrying out oscillation extraction under an ultrasonic condition by taking an ionic liquid aqueous solution as an extraction solvent, and adsorbing and purifying an extracting solution through an adsorbent to realize separation of puerarin and the ionic liquid. According to the method, the ionic liquid is used as a green solvent, mass transfer is enhanced by combining the ultrasonic cavitation effect, the extraction rate of puerarin is remarkably increased, and efficient recovery of the ionic liquid is achieved. The process is simple and convenient to operate, can be carried out at room temperature, and has outstanding environmental protection advantages. According to the method, the extraction rate of puerarin can reach 91.4% under optimal conditions, the recovery rate of ionic liquid can reach 99.9% through adsorption and purification, and the relative content of puerarin in desorption liquid is 92.9%.

The present invention relates to the technical field of liver-protecting formula compositions, and in particular, to a liver-protecting milk thistle formula composition, and a preparation method thereof. Technical problems: the liver-protecting milk thistle formula composition, and a preparation method thereof are intended to solve the technical problems that most of existing liver-protecting compositions in the prior art are designed for the general liver protection needs of the general population and cannot specifically treat liver damage caused by excessive alcohol intake and liver diseases such as cirrhosis, acute hepatitis, hepatitis, fatty liver, cholangitis, cholelithiasis, psoriasis, and hypercholesterolemia. Technical solution: a liver-protecting milk thistle formula composition, including the following components: silymarin, puerarin, artichoke extract, glutathione, dandelion extract, and GABA. The liver-protecting formula composition has a good therapeutic effect on liver damage caused by excessive alcohol intake, and liver diseases such as cirrhosis, acute hepatitis, hepatitis, fatty liver, cholangitis, cholelithiasis, psoriasis, and hypercholesterolemia.

The application provides a method for establishing HPLC fingerprint of Changnyle capsule (I), which is characterized in that 16 active components including gastrodin, danshensu, quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiopicroside, 3'-hydroxy puerarin, puerarin, 3'-methoxy puerarin, puerarin apioside, paeoniflorin, daidzin, rosmarinic acid, shikonin, isoquercitrin, ononin, daidzein, salvianolic acid B and calycosin are used as reference substances, HPLC is adopted, methanol-acetonitrile-0.5vol% phosphoric acid aqueous solution is used as a mobile phase, different batches of samples are detected, and finally the fingerprint of Changnyle capsule (I) is obtained. The fingerprint can comprehensively represent the main components in Changnyle capsule (I), thereby being beneficial to the quality control of Changnyle capsule (I).

The invention relates to a florfenicol preparation for reversing drug resistance, and every 100 kg of the florfenicol preparation is prepared from the following raw materials by weight: 30 to 50 kg of florfenicol, 5 to 10 kg of puerarin, 0.5 to 1 kg of magnesium stearate, and the balance of silicon dioxide. The florfenicol preparation is subjected to low-temperature crushing treatment, the crystal form of the medicine can be prevented from being converted, the dissolution rate of the medicine is prevented from being reduced, the florfenicol and the puerarin are reasonably proportioned according to the formula, the optimal reverse drug resistance effect is achieved, and meanwhile, the product process is particularly suitable for industrial production.

The invention discloses a hydrogel dressing with antibacterial property, antioxidant property and pH responsiveness as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of biomedical materials. An aldehyde group generated after ring opening of genipin as a chemical cross-linking agent and an amino group in a high-molecular polymer are subjected to a Schiff base reaction to realize chemical cross-linking, puerarin molecules are self-assembled through non-covalent bonds including hydrogen bonds and hydrophobic interaction, and a gel network is formed; and Ag-coated CR composite nanoparticles synthesized by a microalgae extract and silver nitrate are loaded. The multifunctional hydrogel material provided by the invention has antibacterial, antioxidant and pH-responsive properties, shows excellent antibacterial ability for common pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, and can effectively inhibit wound infection.

The present invention relates to the technical field of veterinary medicine, and specifically discloses a composition for treating cow mastitis and a preparation method thereof. The composition includes: 0.5 part-2 parts of a composite sodium chlorite effervescent tablet, 1.2 parts-1.5 parts of puerarin, 1.8 parts-2.0 parts of a chitosan-derived quaternary ammonium salt, 1 part-5 parts of modified nano zinc oxide, 2 parts-6 parts of magnesium-aluminum hydrotalcite, 1.6 parts-3 parts of an antibacterial agent, 5 parts-10 parts of a film former, 2 parts-4 parts of a plasticizer, 3 parts-7 parts of a surfactant, 1 part-2 parts of a thickener, and 550 parts-650 parts of distilled water. The composition provided by the present invention can fundamentally treat and prevent cow mastitis under the synergistic effect of each component, with a cure rate of more than 90%, and will not cause drug residues, thereby avoiding the generation of drug residues and bacterial resistance problems in cow's milk. The composition is suitable for promotion in animal husbandry and has broad application prospects.

The invention provides application of lactobacillus brevicornu and a fermentation composition thereof in hangover alleviating and liver protection, and relates to the technical field of biological fermentation, the lactobacillus brevicornu is lactobacillus brevicornu, the strain number of the lactobacillus brevicornu is KMHD10-222, and the registration number of the lactobacillus brevicornu in the China General Microbiological Culture Collection Center is CGMCC No. 32358. Traditional Chinese medicine substrates can be fermented, and the hangover-alleviating and liver-protecting effects of fermentation products are enhanced. The content of rare ginsenoside, total polysaccharide, total flavone, total phenol, puerarin, daidzein and dihydromyricetin of the lactobacillus brevis KMHD10-222 fermentation substrate extracting solution is increased, the effects of promoting ethanol metabolism and improving the alcoholic liver disease can be improved, and the effects of dispelling the effects of alcohol and protecting the liver are achieved.

The present invention relates generally to methods and compositions useful for treating skin on a subject. In some embodiments, methods and compositions disclosed herein comprise topical or oral administration of nutraceutical and / or topical composition, wherein the composition comprises at least two of puerarin, collagen, and hyaluronic acid.

The invention discloses a preparation method of glucosyl puerarin, which belongs to the technical field of pharmaceutical chemicals, and comprises the following steps: S1, adding sugar for reaction, mixing puerarin with pure water, adjusting the pH value to 4.5-5.5, adding beta-cyclodextrin, heating to 45-55 DEG C, adding cyclodextrin glucosyltransferase for reaction for 16-22 hours, then adjusting the pH value to 0.1-0.8, adding activated carbon, filtering filtrate and staying overnight at low temperature; s2, desugaring reaction: adjusting the pH value of the filtrate to 3.8-4.5, heating to 55-65 DEG C, adding saccharifying enzyme and glucose oxidase to react for 25-40 minutes, adjusting the pH value to 0.5-1.2, and filtering; s3, column purification: enabling a reaction solution to pass through a mixed column containing sulfonated modified XAD-16 and amino modified HPD-720 resin, and performing graded elution to collect an ethanol eluent; s4, concentrating and drying to obtain a product. The problems that the water solubility of puerarin is poor, the purity of glucosyl puerarin is low, and impurities are difficult to remove can be solved.

The application provides a pueraria ferment as well as a preparation method and application thereof. The preparation method of the plant ferment comprises the following steps: step 1, crushing dry pueraria root powder, mixing with water to obtain a pueraria root powder mixture; step 2, mixing the pueraria root powder mixture with a compound enzyme preparation to perform enzymolysis, to obtain an enzymolysis liquid; step 3, adding a carbon source into the enzymolysis liquid, mixing, and then performing a two-stage fermentation process; the first-stage fermentation is aerobic fermentation by using a bacterial agent containing yeast and acetic acid bacteria, and the second-stage fermentation is anaerobic fermentation by using a bacterial agent containing lactobacillus; and step 4, filtering the fermented mixture to obtain a clear solution, and the pueraria ferment is obtained. The obtained pueraria ferment has high contents of active ingredients such as puerarin and glucuronic acid, has good antioxidant capacity, has a health care effect, and has a liver protection effect.

The utility model relates to the technical field of puerarin extraction, in particular to a built-in detachable fresh air exchange module of an air purification door. Comprising a door body, a door lock arranged in the door body, a hinge arranged on one side of the door body, an air outlet formed in the front wall of the door body, an air inlet formed in the back wall of the door body, a fan arranged in the door body and a purification assembly arranged in the door body and located at the top end of the fan. And the sound insulation layer is arranged in the door main body and sleeves the fan. According to the air purification device, the purification assembly is arranged, the fan conveys air to pass through the purification assembly, the contact surface of filtered air and washing and disinfecting liquid is increased through the porous structure of the purification layer, and formaldehyde benzene series in the air are effectively adsorbed, dissolved, filtered and disinfected; the porous sponge material of the sound insulation layer can be used for buffering the ventilation module in the door main body when the door main body is opened and closed, and noise generated when the ventilation module is used can be reduced.

The invention discloses injectable hydrogel as well as a preparation method and application thereof. The injectable hydrogel is formed by self-assembling a natural plant active component, a framework material and an inorganic nano material, the natural plant active component comprises any one of puerarin, resveratrol, curcumin and quercetin; the framework material comprises any one of chitosan, gelatin, sodium alginate, hyaluronic acid and a polylactic acid-glycolic acid copolymer; the inorganic nano material comprises any one of mesoporous silica, calcium phosphate nano particles, zinc oxide nano particles and hydroxyapatite. The injectable hydrogel composed of puerarin, chitosan and mesoporous silica realizes the synergy of local immune regulation and tissue regeneration functions, and can be used for skeletal muscle defect repair.

The invention relates to the technical field of separation and purification devices, in particular to a separation and purification method and system.The separation and purification system for radix puerariae effective substances comprises a machine box, a plurality of supporting frames and a separation and purification device, and the separation and purification device comprises a lifting assembly, a decocting box, an electric heating plate, a sealing door, a filter screen and a liquid discharging pipe; the crushed radix puerariae and water are put into a decocting box, and then a lifting assembly is controlled to drive the decocting box to move downwards into a machine box; the electric heating plate is electrified, the electric heating plate heats and decocts the radix puerariae and the water, and the effective substance puerarin of the radix puerariae is dissolved in the water; after the puerarin is decocted for a certain time, the lifting assembly is controlled to drive the decocting box to move upwards, water dissolved with the puerarin falls onto a filter screen to be filtered, the filter screen is used for separating and filtering impurities generated during decoction, and a purified puerarin extracting solution is obtained; after radix puerariae blocks are decocted, impurities generated during decoction can be filtered, and the quality of finished products is improved.

The invention belongs to the field of medicines, and particularly relates to a quality detection method of a clearing and deacidification mixture. According to the invention, a characteristic spectrum method for simultaneously detecting 10 main active components (paeoniflorin, puerarin, gentiopicroside, loganic acid, astilbin, benzoylpaeoniflorin, resveratrol, rhein, rhizoma dioscoreae septemlobae A and rhizoma dioscoreae septemlobae B) in the mixture is established for the first time, the limitation of single component quality control is overcome, and the overall quality of a medicine can be evaluated more comprehensively and objectively; by optimizing a sample pretreatment process and chromatographic gradient elution conditions, interference of a complex matrix is effectively eliminated, and good separation of each component is ensured. The method is high in specificity, negative, free of interference and capable of accurately recognizing target components.

The application discloses a content determination method of Xintong oral liquid, which adopts UPLC method to determine the contents of puerarin, daidzin, 2,3,5,4 ’ tetrahydroxystilbene-2-O-beta-D-glucoside, naringin and icariin in the preparation. The quality detection method is stable and reliable, has strong specificity and good reproducibility, can comprehensively and effectively control the quality of the Xintong oral liquid, is favorable for stabilizing the product quality, ensures the safety and effectiveness of clinical medication, and thus better meets the needs of medical treatment and market.

The invention relates to the technical field of fruit wine brewing, and discloses a lotus root medicated diet fruit wine with lipid-lowering and liver-protecting efficacy, which comprises the following components: (1) a neonisin flavone-hawthorn ester compound with the content of 300 mg / L or more; (2) puerarin-selenium nanoparticles, wherein the content of the puerarin-selenium nanoparticles is 100 [mu] g / L or above; and (3) lotus root source prebiotics (lotus root polysaccharide-prebiotics network) with the content of 4.5 g / L or more. The flavonoid raw materials and the hawthorn ester are co-fermented to prepare the compound, so that not only is the biological activity of natural flavonoids enriched, but also the fat solubility and bioavailability of the components are improved through esterification modification, and the blood fat level can be more efficiently adjusted in vivo. Through the synergistic effect of flavone and hawthorn ester, the dual effects of cooperatively lowering lipid and resisting oxidation can be achieved, and the blood lipid lowering potential of the product is remarkably improved.