171 results about "Responsive polymer" patented technology

The invention discloses a preparation method and application of a pH-responsive controllable oil-water separation material, polyurethane sponge is used as a substrate, polypyrrole is attached to the sponge substrate through an in-situ polymerization method, a pH-responsive polymer is introduced into the sponge substrate through a soaking method, and finally the pH-responsive controllable oil-water separation material is obtained. The controllability of the material in the oil-water separation process is reflected as follows: due to the introduction of the pH responsive polymer, the surface of the material has pH responsiveness, the surface of the material has different wettability by adjusting the pH value, different types of oil-water mixtures can be controllably separated in a targeted manner, and the adsorption and desorption of oil products can be realized. Due to the introduction of polypyrrole, the material has good photo-thermal conversion capacity, the viscosity of crude oil can be effectively reduced, and the absorption rate of the crude oil can be improved. The material with pH responsiveness has wide application prospects in the fields of oil-water separation, oil product adsorption and desorption and crude oil absorption.

The invention belongs to the technical field of sewage treatment, and particularly relates to an intelligent response filter material, a preparation method thereof and a denitrification deep-bed filter tank. The intelligent response filter material is of a three-layer composite structure and sequentially comprises a carbon source inner core, a transition layer and a wrapping layer from the inner layer to the outer layer; the carbon source core comprises aquatic plant powder, aggregate and reinforced fibers, the transition layer adopts a hydrophilic modified porous carrier, and the wrapping layer adopts a pH responsive polymer. According to the invention, the intelligent response type filter material prepared from aquatic plant straws is adopted, and the pH response type envelope can automatically adjust the release rate of a carbon source according to the pH change caused by the denitrification process, so that intelligent on-demand supply of the carbon source is realized, and the denitrification efficiency and the utilization rate of the carbon source are greatly improved.

The invention belongs to the technical field of biological medicine, and relates to a composite polypeptide composition as well as a preparation method and application thereof. According to the technical scheme, pH responsive polymer loaded oligopeptide-1, acetyl heptapeptide-4 and palmitoyl tripeptide-1 are adopted as a core, hyaluronic acid is adopted for wrapping, a hyaluronic acid layer adsorbs palmitoyl tripeptide-8, heptapeptide-6 and decapeptide-4, and the composite polypeptide with a core-shell structure is prepared and used for treating inflammatory skin diseases. In the acute stage of inflammation, the active ingredients on the outer layer quickly inhibit the activation of proinflammatory factors and immune cells and relieve red, swollen and heat pain, and the gel outer layer formed by hyaluronic acid realizes continuous release, prolongs the action time and supplements moisture to the skin; the pH-responsive polymer of the inner layer releases active ingredients at the inflammation part, so that relapse is prevented, and the skin barrier function is repaired. The composition plays a role from multiple dimensions of inflammation regulation, barrier repair, oxidation resistance and the like through a multi-layer structure design and a multi-component synergistic effect.

The present disclosure generally relates to carbon sequestration materials, and related systems, articles, and methods. In some embodiments, the carbon sequestration material comprises a gel. In some embodiments, the gel comprises a hydrophilic material, a thermo-responsive polymer, and a carbon dioxide capture medium. In accordance with some embodiments, the gel, when in the presence of water, is capable of sequestering and / or releasing gaseous carbon dioxide. In some embodiments, the gel has a relatively large sequestration capacity such that a relatively large amount of carbon dioxide per gram of gel can be sequestered by the gel. In some embodiments, the gel sequesters a surprisingly large amount of carbon dioxide when exposed to relatively humid conditions. In some embodiments, the gel releases an advantageous amount of gaseous carbon dioxide that was previously sequestered by the gel.

Provided is a new method for controlling ion conductivity using a polymer solution that dissolves in an organic solvent at a low temperature to form a transparent solution, and undergoes phase separation when the temperature increases, more specifically, using a temperature-responsive polymer that undergoes lower critical solution temperature (LCST)-type phase separation.　This method for controlling ion conductivity changes, according to the temperature, the ion conductance of a temperature-responsive ionic solution which contains a temperature-responsive polymer, a salt, and an organic solvent, and in which the salt is dissociated into ionic components. Preferably, the temperature-responsive polymer is a polymer that exhibits lower critical solution temperature-type phase separation.

Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.

The invention discloses a formula and application of a long-acting high-molecular polymer dust suppressant, and relates to the field of dust treatment. The long-acting high-molecular polymer dust suppressant comprises the following components: 5%-15% of a composite high-molecular polymer emulsion, 0.5%-3% of an environment-responsive polymer, 0.1%-1.5% of a nano reinforcing material, 0.2%-2% of a bio-based water-retaining agent, 0.05%-0.3% of a crosslinking catalyst and the balance of water. Through the synergistic effect of the composite high-molecular polymer emulsion, the environment-responsive polymer, the nano reinforcing material, the bio-based water-retaining agent and the cross-linking catalyst, a three-layer composite structure is formed, and the environment-friendly dust suppression agent has the advantages of long-acting stable dust suppression, high environmental adaptability, ecological friendliness, restoration function, integration of multiple functions, adaptation to multiple scenes and the like; the defects in the prior art can be effectively overcome.

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The application discloses an oral nano-vaccine and a preparation method and application thereof, and relates to the technical field of immunology, and specifically discloses an oral nano-vaccine which comprises a nano-particle wrapped by a biomimetic bacterial membrane vesicle and an outer layer; the nano-particle comprises an antigen and a biodegradable polymer material; the biomimetic bacterial membrane vesicle comprises an ionizable flagellar lipoprotein, an immune adjuvant, a phospholipid, a sterol lipid and a polyethylene glycol lipid; and the outer layer is a pH-responsive polymer. The oral nano-vaccine provided by the application combines the immune activation advantages of natural bacterial membrane vesicles and the precise regulation characteristics of synthetic materials, significantly improves the transmembrane penetration capacity of the antigen in the intestinal epithelium and the overall activation effect of the mucosal immune system. The oral nano-vaccine provided by the application can protect the antigen and the immune adjuvant from degradation and realize precise release in the intestinal microenvironment; and the oral nano-vaccine significantly improves the bioavailability and safety of an oral tumor vaccine, and lays a key technical foundation for clinical transformation and large-scale production of the oral tumor vaccine.

The application discloses a catalyst for preparing methylaniline and a preparation method and application thereof, and belongs to the technical field of catalysts. The catalyst is prepared by modifying an activated carbon carrier with zirconium, cerium or nickel, treating the carrier with high-temperature nitrogen, loading active components Pd and pH-responsive polymers, solving the problems of low dispersion of the active components, easy poisoning and activity attenuation, and having good pH responsiveness and environmental adaptability. The preparation method optimizes a carrier modification process, adopts an impregnation method combined with timed stirring, controls reaction parameters, improves catalyst performance, realizes high selectivity and high yield of methylaniline, and has the advantages of high selectivity of the catalyst for methylaniline, inhibition of side reactions, adoption of a fixed bed reactor, simplification of operation, reduction of safety hazards, efficient reaction at a lower reaction temperature and pressure, and reduction of energy consumption and production cost.

To provide a method for producing temperature-responsive beads through a process that is easy to perform on an industrial scale.SOLUTION: A method for producing temperature-responsive beads comprises a coating agent containing at least a temperature-responsive polymer having a lower critical solution temperature (LCST) in the range of 0°C or more to 50°C or less, and a carrier, the method comprising at least the steps of: dispersing the carrier in a reaction solution having the coating agent dissolved therein; and applying a poor solvent of the coating agent to a liquid containing the coating agent and the carrier to precipitate the coating agent on the surface of the carrier.SELECTED DRAWING: None

The invention relates to the technical field of drug loading systems, and discloses a nanoparticle applied to photodynamic therapy and a preparation method thereof.The nanoparticle is of a core-shell-crown composite structure and sequentially comprises an inner core layer, an outer core layer, an inner shell layer and an outer shell layer from inside to outside, the inner core layer is composed of NaYF4 up-conversion nanoparticles, and the outer core layer is composed of NaYF4 up-conversion nanoparticles; the middle layer is a mesoporous Zr-MOF layer; the shell layer is a pH responsive polymer layer which is formed by connecting a polyethylene glycol-polycaprolactone block copolymer with folic acid through a hydrazone bond; the targeting canopy layer comprises double targeting ligands, and the double targeting ligands are respectively a bicyclo [6.1. 0] nonyne functionalized iRGD peptide and an azide functionalized anti-EGFR (epidermal growth factor receptor) nano antibody 7D12. The nanoparticles have the advantages of high stability, strong targeting property, high photosensitizer loading and the like, and can efficiently generate active oxygen.

The invention relates to antibacterial whitening shower gel and a preparation method thereof in the technical field of personal care products, and solves the technical problems of mutual antagonism of effects and lack of intelligent response capability caused by chemical incompatibility of antibacterial and whitening components in existing products. According to the technical scheme, the shower gel comprises a shower gel substrate and a pH-temperature-sensitive dual-carrier synergistic release system, the system is composed of pH response polymer microcapsules and temperature-sensitive phospholipid lipidosome, the pH response polymer microcapsules entrap antibacterial components, the temperature-sensitive phospholipid lipidosome entraps whitening components, and the carrier concentration ratio is 1.8: 1-2.2: 1. The pH response threshold value of the pH response polymer microcapsule is 5.3 to 5.7, and the phase change temperature of the temperature-sensitive phospholipid liposome is 36.5 to 37.5 DEG C. The preparation method comprises the following steps: preparing a pH response polymer microcapsule by adopting an interfacial polymerization method, preparing a temperature-sensitive phospholipid liposome by adopting a film hydration method, compounding according to a carrier concentration ratio, and mixing with a shower gel matrix. The time-sharing precise delivery that the antibacterial component is preferentially released for 2-3 minutes and the whitening component is delayed to be released for 4-5 minutes is realized.

Provided is a novel technique with which a temperature-responsive polymer, a hydrophilic polymer, and a hydrophobic polymer can be produced separately in a simple manner. The polymerizable composition contains the following monomers (A-1) and (B-1). (A-1) is a monomer represented by formula (1-1), and (B-1) is a monomer represented by formula (2-1) (in formula (1-1), R1 represents an alkanediyl group having 1-5 carbon atoms, and n represents an integer of 1-10). ) (In formula (2-1), R2 represents a linear alkanediyl group having 1-5 carbon atoms. ).

The invention discloses a method for preventing and treating myocardial hypertrophy through calcium steady-state regulation and control of cassia twig and liquorice decoction, and belongs to the technical field of traditional Chinese medicine pharmacy and nano medicine. The nano-system has a core-shell structure, and a core of the nano-system wraps monarch and minister effect components composed of cassia twig and licorice fat-soluble components and is composed of an ATP responsive polymer; a shell of the pH-responsive adjuvant drug delivery system wraps an adjuvant effect component group composed of liquorice water-soluble components, the pH-responsive adjuvant drug delivery system is composed of a pH-responsive polymer, the surface of the pH-responsive polymer is modified with AT1R targeting peptide, and a preparation method of the pH-responsive adjuvant drug delivery system comprises the following steps: respectively preparing MMG and AEG; two-step self-assembly is carried out through a microfluidic technology, and AEG is used as a molecular template in the second step to guide the shell polymer to coat the core. The nano system disclosed by the invention can actively target hypertrophic myocardial cells, preferentially release AEG in a focus subacid environment, and then release MMG in a high ATP environment in the cells, so that materialization of a monarch, minister, assistant and guide compatibility theory is realized, and the targeting property, bioavailability and synergistic treatment effect of drugs are remarkably improved.

The present application relates to the technical field of soft coal seam drilling, and discloses an intelligent control drill rod and blowout hole device for soft coal seam drilling, which comprises a front-end sensing unit, a relay sensing unit, a hydraulic servo motor, a frequency converter, a shape memory alloy framework, a thermal-responsive polymer expansion gel layer and a control unit. The device can expand to 3 times the original diameter within 2 seconds through thermal triggering, forming a multi-stage labyrinth seal. The control unit is installed with an embedded AI chip to run an LSTM pressure time sequence prediction model, and combines temperature and vibration multi-source data fusion to judge the blowout risk level, solving the problems of lack of real-time gas pressure dynamic monitoring capability of traditional drill rods, reliance on artificial experience to judge blowout risk, and response lag. The single position pressure sensor is easily disturbed by local rock layer mutation, has a high false alarm rate, and cannot distinguish between normal pressure fluctuations and blowout precursors, so the device realizes early blowout warning and actively suppresses blowout accidents.

The invention relates to a preparation method of peppermint essence, which solves the problems of quick volatilization and poor durability of the traditional peppermint essence by optimizing the combination of essence components and a slow-release carrier by adopting a multi-layer microcapsule slow-release technology and a nanocapsule technology. According to the method, essence components such as menthol, menthone and leaf isovalerate are mixed with at least two layers of microcapsules, the outer layer microcapsules slowly release fragrance, the inner layer microcapsules quickly release fragrance, and it is ensured that the fragrance is kept for a long time in the using process. Meanwhile, the essence is uniformly dispersed in different carrier systems through ultrasonic-assisted emulsification by adopting a nanocapsule technology, so that the stability and dispersity of the essence are improved. In addition, the temperature-responsive and pH-responsive polymer materials are introduced, so that the release rate of the essence can be adjusted according to the external environment, and the adaptability of the essence is further enhanced.

The invention relates to a shape memory composite material and a preparation method and application thereof, and belongs to the technical field of intelligent materials. The shape memory composite material comprises a core material and a sheath material wrapping the core material, the core material comprises a metal material, and the melting point of the metal material is 25-80 DEG C; the sheath material comprises a magnetic response polymer material, and the magnetic response polymer material comprises a neodymium iron boron material and a high polymer material. The shape memory composite material disclosed by the invention has two programming modes of force programming and magnetic programming, so that the programming modes of the material can be flexibly selected in different environments, and accurate shape control is realized. And in addition, multiple initial forms and temporary shape adjustment under force programming and magnetic programming are supported, magnetic heat recovery modes are diversified, and wider application possibility is provided.

A pressure sensing system (100) can include an ultrasound responsive polymer element which resonates at a resonance frequency when exposed to ultrasound waves (112) at an input frequency, at least one sensor (114) configured to directly or indirectly detect the resonance frequency, and at least one memory device (116) that has instruction that, when executed by at least one processor, cause the memory device (116) to correlate the resonance frequency detected to a pressure. Additionally, a method of detecting pressure can include identifying an area where pressure monitoring is desired, orienting an ultrasound responsive element (110) adjacent to that area, directing ultrasound waves (112) toward the ultrasound responsive element (110), detecting the resonance frequency produces by the ultrasound responsive element, and correlating that to a pressure.

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

The invention discloses a bio-responsive high polymer material and application thereof, and belongs to the technical field of biomedical materials. The bio-responsive high-molecular material provided by the invention contains polymers shown as formulas i to viii. Wherein the polymers of the formulas i to viii have excellent fluorescence performance, aggregation-induced fluorescence enhancement performance, multicolor luminescence performance and biological response capability based on a redox reversible switch, and can be applied to sensing, counterfeiting prevention, metal ion detection, multicolor imaging of in-vivo and in-vitro cells and / or tissues and quantitative detection of in-vivo and in-vitro oxidized and / or reducing substances; active oxygen in in-vivo and in-vitro tissues and cells can be removed to achieve long-acting anti-inflammatory and anti-oxidation effects, and the compound can be used for treatment of oxidative stress related diseases and visual monitoring of the treatment process; the biological activity of enhancing tissue retention, stimulating collagen generation, repairing tissue and resisting oxidation and aging of the tissue is achieved, and the effect of filling and repairing in-vivo cells and tissue can be effectively improved; the compound also has the capability of being chelated with metal ions to form a high-molecular metal complex, and can be used for resisting tumors, resisting bacteria, filling and repairing tissues, promoting collagen generation and the like.

Described herein are therapeutic pH-responsive micelle compositions comprising block copolymers and biological therapeutic agents useful in the treatment of cancer, methods for making such micelles, and intermediate compositions useful for making such micelles.

The present invention discloses a CO2-responsive adsorbent material, a preparation method thereof, and its application in treating wastewater containing surfactants. The CO2-responsive adsorbent material of the present invention comprises a base sponge and a CO2-responsive polymer. The base sponge is a dopamine-coated sponge grafted with 2-bromoisobutyryl bromide. The CO2-responsive polymer is a homopolymer of any one monomer selected from a primary amine system, an amidine / guanidine system, a tertiary amine system, or a nitrogen-containing azole heterocyclic system, or a copolymer of two or more monomers. When used to treat wastewater containing anionic surfactants, the CO2-responsive adsorbent material of the present invention has a high adsorption capacity, is simple to operate, and is relatively low in cost.

This invention relates to the field of biomedicine and discloses a composition for treating non-small cell lung cancer metastasis that targets replication stress vulnerability and its application. The composition includes a dual-responsive polymer prodrug, which consists of a block copolymer backbone, a matrix metalloproteinase cleavage peptide sequence coupled to the hydrophilic end, and an active molecular group coupled to the hydrophobic end based on an asymmetric grafting structure. The active molecular group comprises a replication stress inducer and an ATR kinase inhibitor. This invention maintains the amorphous phase of the micelle core through the asymmetric grafting structure, eliminating the permeation barrier caused by spontaneous crystallization of components. This amorphous core provides a proton permeation channel, ensuring the synchronous in-situ release of multiple target drugs, thereby blocking the DNA replication fork repair pathway and inducing mitotic catastrophe, maintaining the spatiotemporal overlap of multiple drug interventions in the pathological target area, and avoiding the risk of drug resistance.

The invention belongs to the technical field of concrete repairing, and particularly relates to an interface bonding material for concrete repairing and a preparation method and application thereof. The interface bonding material for concrete repair comprises the following components in parts by mass: a component A: 5-15 parts of functionalized graphene, 8-12 parts of a humidity response polymer, 4-8 parts of a temperature response polymer, 3-5 parts of a pH response polymer, 30-35 parts of an epoxy resin matrix, 10-15 parts of modified acrylic resin, 2-3 parts of a coupling agent and 3-5 parts of a nano reinforcing agent; the component B is a modified amine curing agent; the functionalized graphene is graphene of which the surface contains at least one of carboxyl, amino and hydroxyl. The interface binding material for concrete repair is good in environment adaptability and good in binding and anti-permeability performance.

The invention discloses a nano-channel based on Pd-Co cyanogen gel nano-enzyme, a preparation method and application of the nano-channel in glucose detection, and belongs to the technical field of biosensors. The nano-channel based on Pd-Co cyanogen glue nano-enzyme is a TiO2 nano-channel (TiNM) with two open ends, the two open ends are a large opening end and a small opening end respectively, metal organic frameworks (MOFs) are grown in situ in the TiNM through a biomimetic mineralization method to immobilize Pd-Co cyanogen glue nano-enzyme molecules, and a metal organic framework composite nano-enzyme structure is formed. Meanwhile, the end face of the small opening end is coated with a pH response polymer to form a gating structure. Glucose generates gluconic acid and hydrogen peroxide under catalysis of Pd-Co cyanogen gel nano-enzyme, the pH change in the channel is triggered, and the pH response polymer is dissolved, so that the gating structure is activated to be opened. The sensor is used for glucose detection, has relatively high selectivity and relatively strong anti-interference capability on glucose, and has good repeatability and operation stability.

The application discloses a kind of super-hydrophobic material and its preparation method and application, belong to functional material field.The application first uses bis (3-amino propyl) end-capped poly (dimethylsiloxane), diisocyanate compound, dissolves in organic solvent, carries out prepolymerization, then slowly adds the polyamino compound of tertiary amino group, carries out addition polymerization reaction, obtains pH response type polymer solution;Afterwards, hydrophobic nanoparticles are added in pH response type polymer solution, and mixed solution is obtained;Finally, the mixed solution is used to treat cellulose fiber material, and a pH-responsive and self-repairing super-hydrophobic material is obtained.The application utilizes the protonation and deprotonation of pH-responsive polymer in different pH environments to provide super-hydrophobicity and underwater super-oleophobicity for the surface of super-hydrophobic material, and at the same time, the pH-responsive super-hydrophobic material has the properties of organic solvent resistance, abrasion resistance, ultraviolet resistance, heat resistance, etc.

The invention discloses a cellulose-based light-emitting polymer and a preparation method and application thereof, the cellulose-based light-emitting polymer has a structure as shown in a formula (I), and the cellulose-based light-emitting polymer is prepared by carrying out click polymerization reaction on an organic light-emitting group with AIE characteristics and ethyl cellulose in an organic solvent under the catalysis of an organic base. The obtained polymer has both high transparency and high ultraviolet impedance effect, also has fluorescence characteristic, and realizes ultraviolet shielding and indication functions for ultraviolet sensitive materials. Along with the increase of the grafting rate, the fluorescence color can be regulated from blue-green to orange red, the grafting-rate-dependent multi-color luminescence characteristic is presented, and the method can be applied to the field of multi-color fluorescence two-dimensional codes. The acid-responsive polymer is developed through secondary grafting, can realize fluorescence discoloration under acidic stimulation, and can be used for constructing a dynamic multicolor encoding device with high data storage density and enhanced encryption capability. The invention provides an innovative method for developing reversible and multifunctional fluorescent cellulose materials.

The invention provides a preparation method of a controllable slow-release urea fertilizer based on coal-based quantum carbon dot coating, and relates to the technical field of fertilizer preparation, the preparation method comprises the following steps: taking urea, a coal-based quantum carbon dot dispersion liquid, a natural high-molecular polymer binder, trace elements and a response type polymer as raw materials, and carrying out raw material pretreatment, urea particle coating treatment and post-treatment; the response type polymer introduced into the coating material and the coal-based quantum carbon dots can form a synergistic controlled release system, hydroxyl and carboxyl on the surfaces of the coal-based quantum carbon dots and amino and ether bonds (-O-) on molecular chains of the response type polymer can form hydrogen bonds and coordinate bonds, and a stable composite coating layer network structure is constructed; when the soil environment changes, the acting force between the functional groups reversibly changes, the change amplitude of the porosity of the coating layer is further regulated and controlled, the regulation and control precision of the nutrient release rate is improved by 15%-20%, and meanwhile, the problem of nutrient burst release caused by local damage of the coating layer can be avoided.

A biosensor for monitoring surface binding events is disclosed. The biosensor comprises an array of nanoparticles and an analyte responsive polymer. The array of nanoparticles includes a plurality of nanoparticles distributed across the nanoparticle array. The analyte responsive polymer includes a recognition element at a first end of the polymer and a terminus at a second end of the polymer distal from the recognition element, the terminus end being conjugated to the nanoparticles in the array. When the recognition element reacts with an analyte, the analyte responsive polymer creates an electrochemical signal at the surface of the nanoparticle array which can be measured to monitor surface events of the analyte responsive polymer.