206 results about "Responsive polymer" patented technology

The invention discloses a preparation method and application of a pH-responsive controllable oil-water separation material, polyurethane sponge is used as a substrate, polypyrrole is attached to the sponge substrate through an in-situ polymerization method, a pH-responsive polymer is introduced into the sponge substrate through a soaking method, and finally the pH-responsive controllable oil-water separation material is obtained. The controllability of the material in the oil-water separation process is reflected as follows: due to the introduction of the pH responsive polymer, the surface of the material has pH responsiveness, the surface of the material has different wettability by adjusting the pH value, different types of oil-water mixtures can be controllably separated in a targeted manner, and the adsorption and desorption of oil products can be realized. Due to the introduction of polypyrrole, the material has good photo-thermal conversion capacity, the viscosity of crude oil can be effectively reduced, and the absorption rate of the crude oil can be improved. The material with pH responsiveness has wide application prospects in the fields of oil-water separation, oil product adsorption and desorption and crude oil absorption.

The invention provides a microorganism curing biochar material and a heavy metal sewage treatment method thereof. The microorganism curing biochar material comprises modified biochar, functional microorganisms, an intelligent responsive polymer coating and quantum dots. The high-performance material is prepared through acid treatment, loading of metal oxide modified biochar, compounding with specific functional microorganisms, coating of an intelligent responsive polymer coating and bonding of quantum dots, when heavy metal sewage is treated, all the components have a synergistic effect, the adsorption and conversion capacity is improved, the environmental adaptability is enhanced, real-time monitoring is achieved, and the application prospect is wide. The sewage treatment efficiency and quality are effectively improved; pretreatment is set in the sewage treatment process, and the addition proportion, the reaction temperature, the stirring rotating speed, the reaction time and the like of a microorganism solidified biochar material are reasonably controlled, so that the high removal rate of various heavy metal ions is realized; meanwhile, the microorganism solidified biochar material can be repeatedly used, so that the use of a large number of chemical agents is avoided, the secondary pollution is reduced, and remarkable economic and environmental benefits are brought.

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention relates to the technical field of resin materials, in particular to an epoxy anhydride composition capable of being chemically thickened and a preparation method thereof, and the epoxy anhydride composition consists of the following components in parts by weight: 35-45 parts of epoxy resin; 40-55 parts of a modified anhydride curing agent; 3-8 parts of a chemical thickening agent; 0.5 to 2 parts of a latent accelerator; 5 to 20 parts of a toughening agent; 0.5 to 5 parts of nano clay modified by a surfactant; 0.01 to 0.5 part of graphene quantum dots modified by a surface active agent; 0.1 to 1 part of a two-dimensional transition metal carbide / nitride modified by a surfactant; 0.1 to 2 parts of a thermally responsive polymer; 0.05 to 1 part of a photoresponsive molecule; 0.5 to 3 parts of nano particles; and 0-10 parts of high-performance fiber. The heat and humidity resistance, the size stability and the deformation resistance of the material are remarkably improved, the rapid heating and cooling circulation adaptability is enhanced, the good size stability is maintained, and the conductivity and the electromagnetic shielding performance can be enhanced.

The invention belongs to the technical field of sewage treatment, and particularly relates to an intelligent response filter material, a preparation method thereof and a denitrification deep-bed filter tank. The intelligent response filter material is of a three-layer composite structure and sequentially comprises a carbon source inner core, a transition layer and a wrapping layer from the inner layer to the outer layer; the carbon source core comprises aquatic plant powder, aggregate and reinforced fibers, the transition layer adopts a hydrophilic modified porous carrier, and the wrapping layer adopts a pH responsive polymer. According to the invention, the intelligent response type filter material prepared from aquatic plant straws is adopted, and the pH response type envelope can automatically adjust the release rate of a carbon source according to the pH change caused by the denitrification process, so that intelligent on-demand supply of the carbon source is realized, and the denitrification efficiency and the utilization rate of the carbon source are greatly improved.

The invention belongs to the technical field of biological medicine, and relates to a composite polypeptide composition as well as a preparation method and application thereof. According to the technical scheme, pH responsive polymer loaded oligopeptide-1, acetyl heptapeptide-4 and palmitoyl tripeptide-1 are adopted as a core, hyaluronic acid is adopted for wrapping, a hyaluronic acid layer adsorbs palmitoyl tripeptide-8, heptapeptide-6 and decapeptide-4, and the composite polypeptide with a core-shell structure is prepared and used for treating inflammatory skin diseases. In the acute stage of inflammation, the active ingredients on the outer layer quickly inhibit the activation of proinflammatory factors and immune cells and relieve red, swollen and heat pain, and the gel outer layer formed by hyaluronic acid realizes continuous release, prolongs the action time and supplements moisture to the skin; the pH-responsive polymer of the inner layer releases active ingredients at the inflammation part, so that relapse is prevented, and the skin barrier function is repaired. The composition plays a role from multiple dimensions of inflammation regulation, barrier repair, oxidation resistance and the like through a multi-layer structure design and a multi-component synergistic effect.

The invention discloses a flexible anti-fouling and anti-drag composite coating with temperature responsiveness and a preparation method and application of the flexible anti-fouling and anti-drag composite coating. The flexible antifouling anti-drag composite coating comprises a substrate layer, a flexible buffer layer, an antifouling response layer and a hydrophobic surface layer which are sequentially formed on the surface of a base material, wherein the substrate layer comprises adhesive resin, a positively charged polymer and a particle filler; the flexible buffer layer comprises flexible polymer resin, a negatively charged polymer, a polymer drag reducer and an anti-ultraviolet additive; the hydrophobic surface layer comprises flexible polymer resin, a temperature-responsive polymer microcapsule encapsulated with an antifouling agent, a pore-foaming agent, an anti-ultraviolet additive and super-hydrophobic micro-nano particles. The flexible anti-fouling and anti-drag composite coating with temperature responsiveness provided by the invention has strong binding force with a base material, and also has anti-fouling property, corrosion protection property and anti-drag property; meanwhile, the preparation method provided by the invention has the advantages of wide application range, large-area coating and the like.

Provided is a hybrid hydrogel composition and methods for its preparation and use in 3D printing biomaterials for tissue engineering applications. The hybrid hydrogel composition comprises discrete hydrogel particles of a first crosslinked polymeric network, interpenetrated- through and threaded by a second crosslinked polymeric network, dispersed in a medium. The first polymer is a thermo-responsive polymer, while the second is a protein-based thermo¬ denaturing polymer. The process for preparing this composition involves mixing swelled hydrogel nanoparticles of the first polymer with a non-crosslinked hydrogel of the second polymer in the presence of a crosslinking agent for the first polymer. The 3D printing method utilizes this composition below the LCST of the thermo-responsive polymer, followed by temperature increase wherein the second polymer cures and fixes the printed ink. This approach enables the creation of high-resolution structures, including artificial tissues with capillary blood vessels, featuring dimensions less than 50 μm.

The present disclosure generally relates to carbon sequestration materials, and related systems, articles, and methods. In some embodiments, the carbon sequestration material comprises a gel. In some embodiments, the gel comprises a hydrophilic material, a thermo-responsive polymer, and a carbon dioxide capture medium. In accordance with some embodiments, the gel, when in the presence of water, is capable of sequestering and / or releasing gaseous carbon dioxide. In some embodiments, the gel has a relatively large sequestration capacity such that a relatively large amount of carbon dioxide per gram of gel can be sequestered by the gel. In some embodiments, the gel sequesters a surprisingly large amount of carbon dioxide when exposed to relatively humid conditions. In some embodiments, the gel releases an advantageous amount of gaseous carbon dioxide that was previously sequestered by the gel.

The invention discloses an anti-corrosion, anti-fouling and anti-drag composite coating as well as a preparation method and application thereof. The anti-corrosion, anti-fouling and anti-drag composite coating comprises a substrate layer, a corrosion blocking layer, a connecting layer and a flexible anti-fouling layer which are sequentially formed on the surface of a base material. Wherein the substrate layer comprises adhesive resin, a positively charged polymer, a filler and a diluent; the corrosion barrier layer comprises flexible polymer resin, a negatively charged polymer and a two-dimensional nanosheet; the connecting layer comprises adhesive resin, a positively charged polymer, a filler and a connecting agent; the flexible anti-fouling layer comprises flexible polymer resin and a temperature-responsive polymer microcapsule encapsulated with an anti-fouling agent. The anti-corrosion, anti-fouling and anti-drag composite coating disclosed by the invention is high in binding force with a base material and also has anti-corrosion, anti-fouling and anti-drag properties; meanwhile, the preparation method provided by the invention has the advantages of wide application range, large-area coating and the like.

Provided is a new method for controlling ion conductivity using a polymer solution that dissolves in an organic solvent at a low temperature to form a transparent solution, and undergoes phase separation when the temperature increases, more specifically, using a temperature-responsive polymer that undergoes lower critical solution temperature (LCST)-type phase separation.　This method for controlling ion conductivity changes, according to the temperature, the ion conductance of a temperature-responsive ionic solution which contains a temperature-responsive polymer, a salt, and an organic solvent, and in which the salt is dissociated into ionic components. Preferably, the temperature-responsive polymer is a polymer that exhibits lower critical solution temperature-type phase separation.

The invention discloses a preparation method of a light and temperature dual-response fluorescent photonic crystal composite material. The preparation method comprises the following steps: preparation of gold nanorods, preparation of quantum dots, preparation of a light response polymer, preparation of temperature response hydrogel, preparation of a photonic crystal template and preparation of the composite material. The light and temperature dual-response fluorescent photonic crystal composite material has light and temperature response and fluorescence performance, has important research value and application prospect, and is expected to realize innovative application in multiple fields of biomedicine, photoelectric devices, environment monitoring and the like.

Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.

The invention discloses a formula and application of a long-acting high-molecular polymer dust suppressant, and relates to the field of dust treatment. The long-acting high-molecular polymer dust suppressant comprises the following components: 5%-15% of a composite high-molecular polymer emulsion, 0.5%-3% of an environment-responsive polymer, 0.1%-1.5% of a nano reinforcing material, 0.2%-2% of a bio-based water-retaining agent, 0.05%-0.3% of a crosslinking catalyst and the balance of water. Through the synergistic effect of the composite high-molecular polymer emulsion, the environment-responsive polymer, the nano reinforcing material, the bio-based water-retaining agent and the cross-linking catalyst, a three-layer composite structure is formed, and the environment-friendly dust suppression agent has the advantages of long-acting stable dust suppression, high environmental adaptability, ecological friendliness, restoration function, integration of multiple functions, adaptation to multiple scenes and the like; the defects in the prior art can be effectively overcome.

The invention relates to the technical field of antibacterial materials, and provides a light-enzyme-heat synergistic antibacterial nano composite material and a preparation method thereof.The preparation method comprises the steps that 1, a copper-based chalcogenide with a plasma resonance effect serves as a structural template, a transition metal oxide intermediate layer and a bismuth oxyhalide epitaxial layer are sequentially constructed on the surface of the copper-based chalcogenide with the plasma resonance effect through a step-by-step continuous solvothermal method, and the copper-based chalcogenide with the plasma resonance effect serves as the structural template; forming a core-shell heterojunction with Z-type energy band matching; (2) pre-assembling a natural enzyme and a monatomic nano-enzyme in a buffer system to form a composite catalytic unit with an electron transfer channel; and (3) by taking the core-shell heterojunction as a polymerization core, under the precise temperature control condition of 0-10 DEG C, initiating active free radical polymerization through an interface, constructing a thermal response polymer shell layer on the surface of the heterojunction, and encapsulating the composite catalytic unit in a functional microdomain of a polymer network in situ. The anti-bacterial fabric can achieve a better synergistic anti-bacterial effect.

The application discloses an oral nano-vaccine and a preparation method and application thereof, and relates to the technical field of immunology, and specifically discloses an oral nano-vaccine which comprises a nano-particle wrapped by a biomimetic bacterial membrane vesicle and an outer layer; the nano-particle comprises an antigen and a biodegradable polymer material; the biomimetic bacterial membrane vesicle comprises an ionizable flagellar lipoprotein, an immune adjuvant, a phospholipid, a sterol lipid and a polyethylene glycol lipid; and the outer layer is a pH-responsive polymer. The oral nano-vaccine provided by the application combines the immune activation advantages of natural bacterial membrane vesicles and the precise regulation characteristics of synthetic materials, significantly improves the transmembrane penetration capacity of the antigen in the intestinal epithelium and the overall activation effect of the mucosal immune system. The oral nano-vaccine provided by the application can protect the antigen and the immune adjuvant from degradation and realize precise release in the intestinal microenvironment; and the oral nano-vaccine significantly improves the bioavailability and safety of an oral tumor vaccine, and lays a key technical foundation for clinical transformation and large-scale production of the oral tumor vaccine.

The application discloses a catalyst for preparing methylaniline and a preparation method and application thereof, and belongs to the technical field of catalysts. The catalyst is prepared by modifying an activated carbon carrier with zirconium, cerium or nickel, treating the carrier with high-temperature nitrogen, loading active components Pd and pH-responsive polymers, solving the problems of low dispersion of the active components, easy poisoning and activity attenuation, and having good pH responsiveness and environmental adaptability. The preparation method optimizes a carrier modification process, adopts an impregnation method combined with timed stirring, controls reaction parameters, improves catalyst performance, realizes high selectivity and high yield of methylaniline, and has the advantages of high selectivity of the catalyst for methylaniline, inhibition of side reactions, adoption of a fixed bed reactor, simplification of operation, reduction of safety hazards, efficient reaction at a lower reaction temperature and pressure, and reduction of energy consumption and production cost.

To provide a method for producing temperature-responsive beads through a process that is easy to perform on an industrial scale.SOLUTION: A method for producing temperature-responsive beads comprises a coating agent containing at least a temperature-responsive polymer having a lower critical solution temperature (LCST) in the range of 0°C or more to 50°C or less, and a carrier, the method comprising at least the steps of: dispersing the carrier in a reaction solution having the coating agent dissolved therein; and applying a poor solvent of the coating agent to a liquid containing the coating agent and the carrier to precipitate the coating agent on the surface of the carrier.SELECTED DRAWING: None

The invention relates to the technical field of drug loading systems, and discloses a nanoparticle applied to photodynamic therapy and a preparation method thereof.The nanoparticle is of a core-shell-crown composite structure and sequentially comprises an inner core layer, an outer core layer, an inner shell layer and an outer shell layer from inside to outside, the inner core layer is composed of NaYF4 up-conversion nanoparticles, and the outer core layer is composed of NaYF4 up-conversion nanoparticles; the middle layer is a mesoporous Zr-MOF layer; the shell layer is a pH responsive polymer layer which is formed by connecting a polyethylene glycol-polycaprolactone block copolymer with folic acid through a hydrazone bond; the targeting canopy layer comprises double targeting ligands, and the double targeting ligands are respectively a bicyclo [6.1. 0] nonyne functionalized iRGD peptide and an azide functionalized anti-EGFR (epidermal growth factor receptor) nano antibody 7D12. The nanoparticles have the advantages of high stability, strong targeting property, high photosensitizer loading and the like, and can efficiently generate active oxygen.

The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a β-(1,4)-glucoside bond or / and a lactose with a β-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that β-(1,4)-glucoside bond provided by cellobiose or / and β-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (β-glucosidase or / and β-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.

The invention relates to antibacterial whitening shower gel and a preparation method thereof in the technical field of personal care products, and solves the technical problems of mutual antagonism of effects and lack of intelligent response capability caused by chemical incompatibility of antibacterial and whitening components in existing products. According to the technical scheme, the shower gel comprises a shower gel substrate and a pH-temperature-sensitive dual-carrier synergistic release system, the system is composed of pH response polymer microcapsules and temperature-sensitive phospholipid lipidosome, the pH response polymer microcapsules entrap antibacterial components, the temperature-sensitive phospholipid lipidosome entraps whitening components, and the carrier concentration ratio is 1.8: 1-2.2: 1. The pH response threshold value of the pH response polymer microcapsule is 5.3 to 5.7, and the phase change temperature of the temperature-sensitive phospholipid liposome is 36.5 to 37.5 DEG C. The preparation method comprises the following steps: preparing a pH response polymer microcapsule by adopting an interfacial polymerization method, preparing a temperature-sensitive phospholipid liposome by adopting a film hydration method, compounding according to a carrier concentration ratio, and mixing with a shower gel matrix. The time-sharing precise delivery that the antibacterial component is preferentially released for 2-3 minutes and the whitening component is delayed to be released for 4-5 minutes is realized.

Provided is a novel technique with which a temperature-responsive polymer, a hydrophilic polymer, and a hydrophobic polymer can be produced separately in a simple manner. The polymerizable composition contains the following monomers (A-1) and (B-1). (A-1) is a monomer represented by formula (1-1), and (B-1) is a monomer represented by formula (2-1) (in formula (1-1), R1 represents an alkanediyl group having 1-5 carbon atoms, and n represents an integer of 1-10). ) (In formula (2-1), R2 represents a linear alkanediyl group having 1-5 carbon atoms. ).

The invention discloses a method for preventing and treating myocardial hypertrophy through calcium steady-state regulation and control of cassia twig and liquorice decoction, and belongs to the technical field of traditional Chinese medicine pharmacy and nano medicine. The nano-system has a core-shell structure, and a core of the nano-system wraps monarch and minister effect components composed of cassia twig and licorice fat-soluble components and is composed of an ATP responsive polymer; a shell of the pH-responsive adjuvant drug delivery system wraps an adjuvant effect component group composed of liquorice water-soluble components, the pH-responsive adjuvant drug delivery system is composed of a pH-responsive polymer, the surface of the pH-responsive polymer is modified with AT1R targeting peptide, and a preparation method of the pH-responsive adjuvant drug delivery system comprises the following steps: respectively preparing MMG and AEG; two-step self-assembly is carried out through a microfluidic technology, and AEG is used as a molecular template in the second step to guide the shell polymer to coat the core. The nano system disclosed by the invention can actively target hypertrophic myocardial cells, preferentially release AEG in a focus subacid environment, and then release MMG in a high ATP environment in the cells, so that materialization of a monarch, minister, assistant and guide compatibility theory is realized, and the targeting property, bioavailability and synergistic treatment effect of drugs are remarkably improved.

The present invention discloses a super-slippery anti-fouling and drag-reducing composite coating with photothermal responsiveness, its preparation method and applications. The super-slippery anti-fouling and drag-reducing composite coating includes: a base layer, a homogeneous heat-absorbing layer, a porous heat-absorbing layer and a thermoresponsive super-slippery layer formed in sequence on the surface of a substrate; wherein, the base layer includes a positively charged polymer, an adhesive and a filler; the homogeneous heat-absorbing layer includes a hydrophobic resin, a negatively charged polymer and light-absorbing particles; the porous heat-absorbing layer includes a hydrophobic resin and light-absorbing particles, and the porous heat-absorbing layer has a porous structure; the thermoresponsive super-slippery layer includes paraffin and temperature-responsive polymer microcapsules encapsulating an anti-fouling agent. The super-slippery anti-fouling and drag-reducing composite coating with photothermal responsiveness provided by the present invention has a strong bonding force with the substrate, and also has the functions of storing a thermoresponsive phase change material, anti-fouling property and super-slippery property; at the same time, the preparation method provided by the present invention has the advantages of wide application range and large-area coating.

The present application relates to the technical field of soft coal seam drilling, and discloses an intelligent control drill rod and blowout hole device for soft coal seam drilling, which comprises a front-end sensing unit, a relay sensing unit, a hydraulic servo motor, a frequency converter, a shape memory alloy framework, a thermal-responsive polymer expansion gel layer and a control unit. The device can expand to 3 times the original diameter within 2 seconds through thermal triggering, forming a multi-stage labyrinth seal. The control unit is installed with an embedded AI chip to run an LSTM pressure time sequence prediction model, and combines temperature and vibration multi-source data fusion to judge the blowout risk level, solving the problems of lack of real-time gas pressure dynamic monitoring capability of traditional drill rods, reliance on artificial experience to judge blowout risk, and response lag. The single position pressure sensor is easily disturbed by local rock layer mutation, has a high false alarm rate, and cannot distinguish between normal pressure fluctuations and blowout precursors, so the device realizes early blowout warning and actively suppresses blowout accidents.

The invention relates to a preparation method of peppermint essence, which solves the problems of quick volatilization and poor durability of the traditional peppermint essence by optimizing the combination of essence components and a slow-release carrier by adopting a multi-layer microcapsule slow-release technology and a nanocapsule technology. According to the method, essence components such as menthol, menthone and leaf isovalerate are mixed with at least two layers of microcapsules, the outer layer microcapsules slowly release fragrance, the inner layer microcapsules quickly release fragrance, and it is ensured that the fragrance is kept for a long time in the using process. Meanwhile, the essence is uniformly dispersed in different carrier systems through ultrasonic-assisted emulsification by adopting a nanocapsule technology, so that the stability and dispersity of the essence are improved. In addition, the temperature-responsive and pH-responsive polymer materials are introduced, so that the release rate of the essence can be adjusted according to the external environment, and the adaptability of the essence is further enhanced.

The invention relates to a shape memory composite material and a preparation method and application thereof, and belongs to the technical field of intelligent materials. The shape memory composite material comprises a core material and a sheath material wrapping the core material, the core material comprises a metal material, and the melting point of the metal material is 25-80 DEG C; the sheath material comprises a magnetic response polymer material, and the magnetic response polymer material comprises a neodymium iron boron material and a high polymer material. The shape memory composite material disclosed by the invention has two programming modes of force programming and magnetic programming, so that the programming modes of the material can be flexibly selected in different environments, and accurate shape control is realized. And in addition, multiple initial forms and temporary shape adjustment under force programming and magnetic programming are supported, magnetic heat recovery modes are diversified, and wider application possibility is provided.

A pressure sensing system (100) can include an ultrasound responsive polymer element which resonates at a resonance frequency when exposed to ultrasound waves (112) at an input frequency, at least one sensor (114) configured to directly or indirectly detect the resonance frequency, and at least one memory device (116) that has instruction that, when executed by at least one processor, cause the memory device (116) to correlate the resonance frequency detected to a pressure. Additionally, a method of detecting pressure can include identifying an area where pressure monitoring is desired, orienting an ultrasound responsive element (110) adjacent to that area, directing ultrasound waves (112) toward the ultrasound responsive element (110), detecting the resonance frequency produces by the ultrasound responsive element, and correlating that to a pressure.

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

The invention discloses a bio-responsive high polymer material and application thereof, and belongs to the technical field of biomedical materials. The bio-responsive high-molecular material provided by the invention contains polymers shown as formulas i to viii. Wherein the polymers of the formulas i to viii have excellent fluorescence performance, aggregation-induced fluorescence enhancement performance, multicolor luminescence performance and biological response capability based on a redox reversible switch, and can be applied to sensing, counterfeiting prevention, metal ion detection, multicolor imaging of in-vivo and in-vitro cells and / or tissues and quantitative detection of in-vivo and in-vitro oxidized and / or reducing substances; active oxygen in in-vivo and in-vitro tissues and cells can be removed to achieve long-acting anti-inflammatory and anti-oxidation effects, and the compound can be used for treatment of oxidative stress related diseases and visual monitoring of the treatment process; the biological activity of enhancing tissue retention, stimulating collagen generation, repairing tissue and resisting oxidation and aging of the tissue is achieved, and the effect of filling and repairing in-vivo cells and tissue can be effectively improved; the compound also has the capability of being chelated with metal ions to form a high-molecular metal complex, and can be used for resisting tumors, resisting bacteria, filling and repairing tissues, promoting collagen generation and the like.