25 results about "Responsive polymer" patented technology

The application discloses an oral nano-vaccine and a preparation method and application thereof, and relates to the technical field of immunology, and specifically discloses an oral nano-vaccine which comprises a nano-particle wrapped by a biomimetic bacterial membrane vesicle and an outer layer; the nano-particle comprises an antigen and a biodegradable polymer material; the biomimetic bacterial membrane vesicle comprises an ionizable flagellar lipoprotein, an immune adjuvant, a phospholipid, a sterol lipid and a polyethylene glycol lipid; and the outer layer is a pH-responsive polymer. The oral nano-vaccine provided by the application combines the immune activation advantages of natural bacterial membrane vesicles and the precise regulation characteristics of synthetic materials, significantly improves the transmembrane penetration capacity of the antigen in the intestinal epithelium and the overall activation effect of the mucosal immune system. The oral nano-vaccine provided by the application can protect the antigen and the immune adjuvant from degradation and realize precise release in the intestinal microenvironment; and the oral nano-vaccine significantly improves the bioavailability and safety of an oral tumor vaccine, and lays a key technical foundation for clinical transformation and large-scale production of the oral tumor vaccine.

The application discloses a catalyst for preparing methylaniline and a preparation method and application thereof, and belongs to the technical field of catalysts. The catalyst is prepared by modifying an activated carbon carrier with zirconium, cerium or nickel, treating the carrier with high-temperature nitrogen, loading active components Pd and pH-responsive polymers, solving the problems of low dispersion of the active components, easy poisoning and activity attenuation, and having good pH responsiveness and environmental adaptability. The preparation method optimizes a carrier modification process, adopts an impregnation method combined with timed stirring, controls reaction parameters, improves catalyst performance, realizes high selectivity and high yield of methylaniline, and has the advantages of high selectivity of the catalyst for methylaniline, inhibition of side reactions, adoption of a fixed bed reactor, simplification of operation, reduction of safety hazards, efficient reaction at a lower reaction temperature and pressure, and reduction of energy consumption and production cost.

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

This invention relates to the field of biomedicine and discloses a composition for treating non-small cell lung cancer metastasis that targets replication stress vulnerability and its application. The composition includes a dual-responsive polymer prodrug, which consists of a block copolymer backbone, a matrix metalloproteinase cleavage peptide sequence coupled to the hydrophilic end, and an active molecular group coupled to the hydrophobic end based on an asymmetric grafting structure. The active molecular group comprises a replication stress inducer and an ATR kinase inhibitor. This invention maintains the amorphous phase of the micelle core through the asymmetric grafting structure, eliminating the permeation barrier caused by spontaneous crystallization of components. This amorphous core provides a proton permeation channel, ensuring the synchronous in-situ release of multiple target drugs, thereby blocking the DNA replication fork repair pathway and inducing mitotic catastrophe, maintaining the spatiotemporal overlap of multiple drug interventions in the pathological target area, and avoiding the risk of drug resistance.

A biosensor for monitoring surface binding events is disclosed. The biosensor comprises an array of nanoparticles and an analyte responsive polymer. The array of nanoparticles includes a plurality of nanoparticles distributed across the nanoparticle array. The analyte responsive polymer includes a recognition element at a first end of the polymer and a terminus at a second end of the polymer distal from the recognition element, the terminus end being conjugated to the nanoparticles in the array. When the recognition element reacts with an analyte, the analyte responsive polymer creates an electrochemical signal at the surface of the nanoparticle array which can be measured to monitor surface events of the analyte responsive polymer.

The application discloses a kind of ion response type high polymer film wrapped active ingredient spinning solution and its preparation method and application, the spinning solution includes the following components: polymer matrix, antioxidant and solvent;The polymer matrix includes sodium alginate and polyvinyl alcohol;The mass ratio of sodium alginate and polyvinyl alcohol is 1: (2.5-5). Sodium alginate in spinning solution has good ion response and biocompatibility, under the action of Ca 2+ , Al 3+ And other metal ions can be quickly crosslinked to form gel film, realize the wrapping of active ingredient;Polyvinyl alcohol has excellent spinning performance and mechanical properties, and can improve the stability of spinning solution and the mechanical strength of fiber by compounding with sodium alginate, avoid the problems such as broken wire and needle blockage in spinning process, suitable for electrospinning process application.

The present disclosure relates to an environment-responsive polymer for high-temperature low-calcium oil reservoirs and a preparation method thereof, the environment-responsive polymer for high-temperature low-calcium oil reservoirs, by mole percentage, its components include: temperature-resistant monomer: 1.5mol%-3.5mol%, acrylamide: 80mol%-91mol%, divalent metal ion synergistic monomer: 7mol%-18mol%, and the balance is water; the present disclosure makes full use of a small amount of divalent metal ions in the oil reservoir environment, realizes thickening effect through the synergistic effect of divalent metal ions and the polymer, and significantly improves the thermal stability, viscosity increasing effect, environmental responsiveness and temperature resistance of the polymer, converts the adverse conditions into favorable conditions, improves the application performance of the polymer in the high-temperature low-calcium oil reservoir, and provides a new and efficient polymer for oil displacement for the development of high-temperature low-calcium oil reservoirs.

A wafer cleaning device according to an embodiment includes a chamber configured to accommodate a cleaning solution including a thermo-responsive polymer, the chamber having a structure with open top, a head assembly configured to suction one surface of a wafer and move the wafer so that the other surface of the wafer comes into contact with the cleaning solution, and a temperature adjustment unit arranged in the chamber and configured to adjust a temperature of the cleaning solution.

The present invention provides a chip for detecting bacteria, a manufacturing method therefor, and a method for detecting bacteria, the chip comprising: a substrate; a plurality of pillar structures on the substrate; and a reaction layer formed of a thermo-responsive polymer on the plurality of pillar structures, wherein the thermo-responsive polymer exhibits hydrophilicity or hydrophobicity depending on temperature.

The application provides a temperature-responsive polymer, which comprises a repeating unit shown in the following formula I; the formula I is a polymerization product of two monomers of 2-(2-methoxyethoxy)methyl acrylate (MEO2MA) and 2-(2-hydroxyethoxy)ethyl methacrylate (HEO2MA); in the formula I, x is 1-100; y is 20-500. The smart window prepared from the temperature-responsive polymer has the characteristics of wide temperature response range, high light transmittance, excellent heat insulation performance and long-term stability, and can be widely applied to light-collecting and temperature-controlling parts in various scenes such as residential buildings, commercial buildings and public facilities, and has significant energy-saving value and market prospect.

The application discloses a carbon dioxide responsive hollow fiber emulsion separation membrane and a preparation method thereof. The separation membrane comprises a hollow fiber membrane substrate and a carbon dioxide responsive polymer layer covalently grafted on the surface of the substrate, the polymer layer comprises a tertiary amine group and forms a covalent connection comprising a Si-O bond with the surface hydroxyl group of the substrate through hydrolysis condensation of a hydrolysable silane group. The preparation method comprises the following steps: synthesizing a silane-terminated carbon dioxide responsive polymer; performing surface hydroxylation activation on the hollow fiber membrane substrate; and after pre-hydrolysis of the polymer in an ethanol / water system, reacting the polymer with the activated membrane to realize covalent grafting through silane bridging. The separation membrane can be reversibly switched between a hydrophobic oleophilic state and a hydrophilic underwater oleophobic state through carbon dioxide and nitrogen bubbling or heating treatment in a water environment, and is used for separating a water-in-oil emulsion (W / O) and an oil-in-water emulsion (O / W).

This invention provides a novel method for controlling ionic conductivity using a polymer solution that dissolves in an organic solvent at low temperatures to form a transparent solution and undergoes phase separation upon heating; specifically, a temperature-responsive polymer that induces lower critical solution temperature (LCST) type phase separation. The method allows the ionic conductivity of a temperature-responsive ionic solution containing a temperature-responsive polymer, a salt, and an organic solvent, wherein the salt dissociates into ionic components, to change with temperature. Preferably, the temperature-responsive polymer is one that exhibits LCST type phase separation.

A pressure sensing system (100) can include an ultrasound responsive polymer element which resonates at a resonance frequency when exposed to ultrasound waves (112) at an input frequency, at least one sensor (114) configured to directly or indirectly detect the resonance frequency, and at least one memory device (116) that has instruction that, when executed by at least one processor, cause the memory device (116) to correlate the resonance frequency detected to a pressure. Additionally, a method of detecting pressure can include identifying an area where pressure monitoring is desired, orienting an ultrasound responsive element (110) adjacent to that area, directing ultrasound waves (112) toward the ultrasound responsive element (110), detecting the resonance frequency produces by the ultrasound responsive element, and correlating that to a pressure.

The present disclosure introduces a sprayable formulation for the enhanced treatment of inflammatory bowel disease (IBD). A lyophilized formulation (102) comprises probiotic- derived extracellular vesicles (EVs) (104) sourced from the VSL#3 probiotic blend, encapsulated within a thermo-responsive polymer matrix (106) made from poly(N-isopropyl acrylamide) (PNIPAM) and hyaluronic acid. Available as an off-the-shelf lyophilized powder, the formulation (102) is easy to store and rehydrate for use. Upon application, the lyophilized formulation (102) undergoes a phase transition at physiological temperature, forming a gel-like coating over the inflamed areas of the gut. This matrix (106) ensures localized delivery of the encapsulated EVs (104) directly to the disease site. The combination of hyaluronic acid and probiotic-derived EVs (104) reduces inflammation and promotes mucosal healing, addressing critical aspects of gut health in IBD management.

The present disclosure relates to contraceptive devices providing enhanced sensation to the user. The contraceptive devices contain adhesives containing a stimuli-responsive polymer that readily delaminates without pain following application of a stimulus. The present disclosure also relates to fractional condoms that cover the glans of the penis. Methods of applying and removing the contraceptive devices, as well as methods of making the contraceptive devices, are also provided.

This application provides a tumor phototherapy formulation, its preparation method, and its application, belonging to the field of biomedical technology. The tumor phototherapy formulation includes a carrier, a pH-responsive polymer chain grafted onto the surface of the carrier, and catalase and indocyanine green loaded onto the pH-responsive polymer chain and the surface of the carrier. The carrier comprises polydopamine nanoparticles with a mesoporous cup-like structure. This formulation not only possesses targeted motility, achieving efficient accumulation at the tumor site by utilizing the hydrogen peroxide concentration gradient and pH-responsive motility behavior between the tumor microenvironment and the normal physiological environment, but also, through effective combination and synergistic effects with the suitable photosensitizer indocyanine green, combines and significantly enhances the photothermal and photodynamic therapeutic effects, achieving highly efficient tumor killing.

The application discloses smart paper based on fluorine-containing maleimide-based stimulus-responsive polymer and application thereof. Maleimide, perfluoroalkyl alcohol, triphenylphosphine and diisopropyl azodicarboxylate are reacted to obtain fluorine-containing maleimide monomer; the fluorine-containing maleimide monomer and a dienyl amine monomer are dissolved in an organic solvent, and an initiator is added to carry out polymerization to obtain fluorine-containing maleimide-based stimulus-responsive polymer; the fluorine-containing maleimide-based stimulus-responsive polymer is dissolved in THF, heated and stirred to carry out reaction to obtain a uniform deep red transparent solution, paper is soaked in the deep red transparent solution and ultrasonic treatment is carried out, and then drying is carried out to obtain smart paper. The smart paper prepared by the application has excellent acid stimulus response and pollution resistance, and has a good application prospect in information storage, double anti-counterfeiting and other aspects of functional paper.

The application discloses a preparation method of photo-crosslinking stabilized temperature-responsive ionic polymer micelles, and specifically comprises the following steps: preparing a PNIPAM-based polymer and a urea group-containing intermediate; preparing a positive ion polymer by using the urea group-containing product, N-triethyl-(4-vinyl benzyl) ammonium chloride, p-styrene-7-hydroxy-4-methyl coumarin and AIBN; preparing a negative ion polymer by using the urea group-containing product, sodium p-styrene sulfonate, p-styrene-7-hydroxy-4-methyl coumarin and AIBN; and irradiating aqueous solutions of the positive ion polymer and the negative ion polymer with ultraviolet light, and then mixing to obtain composite ionic polymer micelles. Based on a modular polymerization route of thiol-ene click chemistry, a temperature-sensitive PNIPAM unit, an ultraviolet light-crosslinkable photosensitive group and an ionizable quaternary ammonium salt / sulfonate group are integrated, so that a temperature-ultraviolet light dual-responsive polymer with positive / negative ion characteristics is constructed.

This invention proposes a thermoresponsive polymer solid electrolyte based on initiator-inhibitor synergistic regulation, its preparation method, and a lithium metal battery. The thermoresponsive polymer solid electrolyte comprises a Lewis lithium salt initiator, a cationic polymerization inhibitor, and a solvent. The Lewis lithium salt initiator includes a lithium salt capable of reacting with trace amounts of water to form a protic acid, the cationic polymerization inhibitor includes a lithium salt capable of coordinating with the Lewis lithium salt initiator, and the solvent includes a cationic polymerization solvent. The lithium metal battery containing this electrolyte system maintains a high ionic conductivity liquid state during room temperature cycling, significantly suppresses severe side reactions between lithium metal and the electrolyte under thermal abuse conditions, reduces the interfacial heat generation rate and the risk of electrolyte volatilization, and improves the thermal stability of the electrolyte.

Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception. 20 26 20 54 09 08 J ul 2 02 6 2 0 2 6 2 0 5 4 0 9 0 8 J u l 2 0 2 6

This invention discloses a highly stable thermosensitive color-changing microsphere ink composition and its preparation method. The composition comprises 10-30 parts of thermosensitive color-changing microspheres, 20-40 parts of binder resin, 0.5-3 parts of intramolecular synergistic stabilizer, 0.5-2 parts of additives, and the balance being a dispersion medium. The thermosensitive color-changing microspheres have a core-shell structure, with the shell containing silane-modified photothermal conversion nanomaterials and the outer surface covalently grafted with temperature-responsive polymers. This invention constructs a complete chain system of active thermal stress management, dynamic interface buffering, and molecular-level synergistic protection, fundamentally solving the problem of ink functional degradation caused by dynamic thermo-mechanical coupling stress, significantly improving the ink's cycle stability, weather resistance, and storage stability, and is suitable for fields such as intelligent anti-counterfeiting and temperature-sensing labeling.

This invention discloses a stimulus-responsive polymer magnetic bead, its preparation method, and a method for targeted extraction of ribonucleic acid (RNA), belonging to the fields of biomedical nanomaterials and molecular diagnostics. The polymer magnetic bead comprises a magnetic carrier and a stimulus-responsive polymer grafted onto its surface. This polymer contains thermosensitive N-isopropylacrylamide segments and functional monomer segments with phosphate group affinity. The preparation method includes surface bromination of the magnetic carrier, followed by grafting the copolymer via atom transfer radical polymerization. In RNA extraction applications, these magnetic beads utilize the stimulus-responsive properties of the polymer chains to achieve dynamic adsorption and static elution, enabling direct and efficient capture of RNA from tissue lysate. This invention significantly improves the concentration, purity, and integrity of extracted RNA, while simplifying the operation steps, shortening the extraction time, and greatly reducing the use of toxic reagents, offering outstanding advantages such as low cost, high efficiency, and environmental friendliness.

This invention discloses a cashew nut shell-based fluorescent compound, its preparation method and uses, and fluorescent polyurethane materials prepared from it and their uses. The cashew nut shell-based fluorescent compound has the following structural formula: [Structure formula would be inserted here]. This invention introduces boron-containing structural units into the cashew nut shell molecule to form a B←N coordination structure, thereby giving it fluorescent emission properties and exhibiting fluorescent response behavior to various metal ions. Furthermore, the compound molecule contains reactive hydroxyl and / or amino groups, which can participate in polyurethane reactions as functional units to construct a fluorescent responsive polymer material system. Based on the above characteristics, the material can produce fluorescence changes under the action of metal ions, realizing information writing, and can achieve information regulation or recovery under external stimuli, thereby being used for information anti-counterfeiting.

The application belongs to the technical field of medicine, and particularly relates to a tumor microenvironment responsive polymer-drug conjugate as well as a preparation method and application thereof. The polymer-drug conjugate has a structure as shown in formula (1), wherein R1 is a hydrophilic group with anti-protein adsorption capacity; R2 is a microenvironment responsive group; R3 is a linker which is connected with R1 and R2 through a carbon-carbon bond, a phosphorus ester bond, an ester bond, an amide bond, an urethane bond and an ether bond respectively, and is connected with R4 through various chemical bonds formed through bio-orthogonal chemical reaction; R4 is an anti-tumor drug group with a-linker-Drug structure, and linker is a group with at least one of reduction, active oxygen, pH and enzyme responsiveness. The polymer-drug conjugate obtained in this way can be enriched and penetrated in a large amount at a tumor tissue site, and through the breaking of the responsive linker bond, the drug is released at the tumor tissue site, thereby producing a good tumor treatment effect.

Disclosed herein is a light control glass that can be produced through a simple process and can offer stable performance. The light control glass includes transparent substrates facing each other and a light control material disposed between the transparent substrates, the light control material being a mixture of a temperature-responsive polymer (PNIPAM) having a lower critical solution temperature and a material (thermoreversible gelation polymer: TGP) that turns into a gel at a temperature equal to or lower than the lower critical solution temperature. In addition, FTO or ITO may be disposed on the surfaces of the transparent substrates being in contact with TGP.