PH/reduction dual-sensitive multifunctional nano-micelle for tumor chemotherapy and photothermal combined therapy and application of pH/reduction dual-sensitive multifunctional nano-micelle

A nanomicelle, combined therapy technology, applied in antitumor drugs, drug combinations, medical preparations with non-active ingredients, etc., can solve the problems of tumor cell apoptosis, ablation, necrosis, etc., and achieve enhanced uptake and accelerated drug release. , the effect of high drug loading
CN108354901AInactive Publication Date: 2018-08-03INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
0 Cites 30 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2018-08-03
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a pH / reduction dual-sensitive multifunctional nano-micelle for tumor chemotherapy and photothermal combined therapy and application of the pH / reduction dual-sensitive multifunctional nano-micelle. The pH / reduction dual-sensitive multifunctional nano-micelle is characterized in that a PCL-acetal-PEG polymer with pH sensitive characteristic, a PCL-ss-PEG-ss-PCL polymer withreduction sensitive characteristic and a phospholipid DSPE-PEG-NH2 with an active group are used as raw materials and are blended to prepare a pH / reduction intelligent responsive polymer nano-micelleas a carrier; a chemotherapeutic drug and a photosensitizer coat a hydrophobic core of the micelle; a casing is made of hydrophilic PEG and has the characteristic of long circulation and space stability; a folic acid targeting group is modified on the surface of the micelle by a covalent bond; the drug loading capacity is 4 to 10 percent, and the mass ratio of the chemotherapeutic drug to the photosensitizer is 0.5 to 2; the particle size is smaller than 200 nm. The pH / reduction dual-sensitive multifunctional nano-micelle disclosed by the invention has the advantages of good dispersity, smallparticle size, better photothermal conversion effect and high drug loading capacity and encapsulation efficiency; the effect of improving tumor suppression by tumor targeted administration, fluorescence imaging of a tumor site, pH / reduction triggered drug release and chemotherapy and photothermal combined therapy can be realized; the pH / reduction dual-sensitive multifunctional nano-micelle has a broad clinical application prospect in combined targeting therapy of tumors.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to a pH / reduction dual-sensitive multifunctional nanomicelle for tumor chemotherapy and photothermal combined therapy and its application, specifically, it has tumor targeting and has dual responsiveness of pH and reduction sensitivity to the tumor microenvironment, and It can efficiently entrap chemotherapy drugs and photosensitizers to achieve synergistic therapeutic effects on tumors. It is a multifunctional hybrid micellar drug delivery system that targets tumor chemotherapy and photothermal combined effects. Background technique

[0002] Tumors, especially malignant tumors, seriously threaten human health. Due to their characteristics of invasion, recurrence, metastasis, and infinite proliferation, the treatment of tumors has become a major clinical problem. Chemotherapy is currently the most important means of clinical treatment of tumors, but chemotherapy drugs have disadvantages such as non-specific binding, instab...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More