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A kind of preparation method of graft modified xanthan gum nano microgel

A technology of graft modification and xanthan gum, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the uncontrollable drug release rate, poor use effect, lack of Specific binding of tumor cells and other issues, to achieve excellent anti-protein adsorption effect, convenient post-processing, prolonging the effect of circulation time

Active Publication Date: 2019-10-18
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the release of drugs by traditional nano-scale drug carriers is generally only controlled by diffusion, and the drug release rate is uncontrollable, and lacks specific binding to tumor cells. In vivo, it can only rely on the EPR effect of tumor tissues to concentrate in lesions. Poor use of the

Method used

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  • A kind of preparation method of graft modified xanthan gum nano microgel
  • A kind of preparation method of graft modified xanthan gum nano microgel
  • A kind of preparation method of graft modified xanthan gum nano microgel

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1-1) Synthesis of N,N-bis(acryloyl)cystamine:

[0032] Dissolve 4.5g of cystamine hydrochloride in 25mL of deionized water, and stir in an ice-water bath for 30min; dissolve 3.6g of acryloyl chloride in 5mL of dichloromethane, and dissolve 3.2g of NaOH in 10mL of deionized water; Add acryloyl chloride solution and NaOH solution dropwise, keep stirring in an ice-water bath for 5 hours after the dropwise addition, and wash the white solid with 50mL ultrapure water three times, then recrystallize it with ethyl acetate and dry it in a vacuum oven at 30°C until constant Heavy, the white product was sealed and stored;

[0033] 1-2) Synthesis of grafted modified xanthan polymer and preparation of nano-microgel:

[0034] Add 100mL of deionized water into a 250mL three-necked flask, add 1g of xanthan gum into the three-necked flask under mechanical stirring, after it is completely dissolved, pass nitrogen gas for 30min, then raise the temperature to 60°C, and drop 0.106g of an ...

Embodiment 2

[0038] Configure xanthan gum aqueous solution as in Example 1-2), add dropwise 0.183g cerium ammonium nitrate aqueous solution to xanthan gum solution, stir and oxidize for 30min, add 5g AMPS aqueous solution and 0.100g N,N-bis(acryloyl) The dichloromethane solution of cystamine, after reaction is finished, obtain graft modified xanthan gum polymer sample and graft modified xanthan gum nano-microgel aqueous solution as embodiment 1-2) aftertreatment method, then according to The preparation method in Example 1-3) obtained the drug-loaded graft modified xanthan gum nano-microgel, and obtained S2.

Embodiment 3

[0040] Configure xanthan gum aqueous solution as in Example 1-2), add dropwise 0.259g cerium ammonium nitrate aqueous solution to xanthan gum solution, stir and oxidize for 30min, add 7.500g AMPS aqueous solution and 0.150g N,N-bis(acryloyl ) the dichloromethane solution of cystamine, after the reaction is completed, the post-treatment method obtains the graft modified xanthan gum polymer sample and the graft modified xanthan gum nano microgel aqueous solution as in embodiment 1-2), and then According to the preparation method in Example 1-3), the drug-loaded graft-modified xanthan gum nano-microgel was obtained, and S3 was obtained.

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Abstract

The present invention relates to the technical field of biomedical materials, especially to a preparation method for a graft-modified xanthan gum nano-sized microgel: firstly preparing N,N-bis(acryloyl)cystamine, and then carrying out graft polymerization and crosslinking reactions on xanthan gum with 2-acrylamido-2-methylpropane sulfonic acid and N,N-bis(acryloyl)cystamine, preparing and obtaining a graft-modified xanthan gum polymer, and forming a polymer nano-sized microgel in an aqueous solution. The graft polymerization of 2-acrylamido-2-methylpropane sulfonic acid onto xanthan gum can increase the drug-loading capability of the xanthan gum nano-sized microgel. The reductive sensitivity of the nano-sized microgel is imparted by the introduction of a disulfide bond. The nano-sized microgel of the present invention has a good biocompatibility and is degradable in vivo, and is anticipated to be used as an anti-cancer drug carrier and to be used in a controlled-release manner.

Description

technical field [0001] The invention relates to a preparation method of graft-modified xanthan gum nano-microgel, which belongs to the technical field of modification of natural polymer materials. Background technique [0002] Malignant tumors are one of the major diseases that threaten human life and health. At present, surgical treatment, traditional Chinese medicine conditioning, radiotherapy and chemotherapy are usually used to treat such diseases. Although there are more than 90 anti-tumor drugs in clinical practice, most of them are Most of them have the disadvantages of short metabolic time, poor targeting and strong drug resistance of tumors. Compared with traditional small-molecule anti-tumor drugs, the combination of nano-scale carriers and drug molecules can enhance drug stability, prolong the circulation time of drugs in the body, and reduce their damage to normal tissues. However, the release of drugs by traditional nano-scale drug carriers is generally only co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F222/38C08F220/58A61K9/107A61K47/36A61K31/704A61P35/00
CPCA61K9/0019A61K9/1075A61K31/704A61K47/36C08F251/00C08F220/585
Inventor 徐杰倪才华张丽萍石刚桑欣欣
Owner JIANGNAN UNIV
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