88 results about "Cystamine" patented technology

The invention relates to the technical field of films, in particular to a flexible film special for a handwriting board and a preparation method of the flexible film. The flexible film is obtained by coating a release film with coating slurry and carrying out thermocuring, wherein the coating slurry contains modified polyurethane, a flatting agent, a defoaming agent and ethyl acetate. According to the modified polyurethane, polycarbonate diol, isophorone diisocyanate and other raw materials are subjected to a reaction, and a nano particle chain extender containing disulfide bonds is added. The nano particle chain extender containing disulfide bonds is prepared by modifying nano silicon dioxide and grafting cystamine dihydrochloride and diamino polyethylene glycol. Through nanoparticle surface modification and dynamic disulfide bond network construction, molecular-level coupling of a rigid reinforced phase and a flexible substrate, inhibition of nanoparticle aggregation and balance of strength and toughness are realized, the dynamic disulfide bond network can self-repair microcracks, and a high-quality special flexible film solution is provided for a high-performance handwriting board.

The invention discloses a bulletproof composite material and a preparation method thereof, and relates to the technical field of bulletproof composite materials. The bulletproof composite material is formed by compounding aramid fibers and a resin matrix, wherein the resin matrix comprises the following raw materials in parts by weight: 60-70 parts of epoxy resin, 5-8 parts of a modified toughening agent, 4-5 parts of a curing agent, 1-2 parts of a heat stabilizer, 1-2 parts of an inorganic filler, 0.5-1 part of a coupling agent and 2-5 parts of a wetting agent; the preparation method comprises the following steps: reacting cyanuric chloride with 4-hydroxyphenylboronic acid to generate an intermediate 1; reacting the intermediate 1 with 3-amino-1, 2-epoxypropane to generate an intermediate 2; reacting the intermediate 2 with cystamine to generate an intermediate 3, and reacting the intermediate 3 with dopamine to generate the modified toughening agent. The bulletproof composite material prepared by the invention has good ballistic protection performance, multiple impact resistance and self-repairing performance.

The invention relates to a super-absorbent paper diaper and a preparation method and application thereof.The super-absorbent paper diaper comprises a bottom film, a core layer, a surface layer and elastic side seals and is characterized in that the core layer is prepared from, by weight, 50-60 parts of acrylic water-absorbent resin, 20-30 parts of polyacrylamide microspheres, 20-30 parts of quaternized chitosan, 10-15 parts of modifier and 1-5 parts of catalyst; wherein the modifier is a composition of tartaric acid, 2-acrylamide-2-methylpropanesulfonic acid and N, N '-bis (acryloyl) cystamine in a mass ratio of 1: (2-3): (1-1.5). Wherein the acrylic water-absorbent resin provides basic water-absorbent capacity, the polyacrylamide microspheres enhance adsorption and prevent gel blockage, the quaternized chitosan improves antibacterial property and electrolyte adsorption capacity, the catalyst ensures that the reaction is fully carried out, and all the components of the modifier cooperate with one another to enhance hydrophilicity; the water absorption performance, the structural stability and the salt tolerance of the core layer are jointly improved.

The invention discloses a waterproof polyurethane material, a preparation method and application of the waterproof polyurethane material in a flexible cable, and relates to the technical field of polymer cable materials. The polyurethane material comprises the following raw material components: polyurethane, a thermoplastic polyester elastomer, a compatilizer, an inorganic filler, a dynamic cross-linking agent and an organic tin catalyst, the dynamic cross-linking agent comprises lipoic acid and / or cystamine; the inorganic filler is composed of mica powder and zirconium oxide according to the mass ratio of (2-6): 1. According to the polyurethane material disclosed by the invention, a specific amount of the specific dynamic crosslinking agent is added, so that local failure caused by stress concentration can be avoided, the fatigue resistance and the water vapor permeation resistance are enhanced, and the environmental adaptability and durability of a seabed are improved.

The invention relates to the technical field of lithium adsorbents, in particular to a preparation and application method of a porous microsphere adsorbent for extracting lithium, and the preparation method comprises the following steps: preparing a water phase solution containing methacrylic acid, water and an emulsifier; the preparation method comprises the following steps: preparing an oil phase solution containing a fluorinated methacrylate monomer containing beta-diketone, cyclohexyl methacrylate, methoxyethyl methacrylate, N, N-bis (acryloyl) cystamine, ethylene glycol dimethacrylate, azodiisobutyronitrile and a solvent; dropwise adding the oil-phase solution into the water-phase solution for gradient emulsification, adding sodium persulfate to initiate polymerization, and performing centrifugal drying to obtain porous microspheres; and immersing the porous microspheres into a NaOH solution for hydrolysis activation, and drying to obtain the porous microsphere adsorbent for selective adsorption of lithium ions. Wherein the beta-diketone can enhance the targeted adsorption effect of the adsorbent on lithium ions and has relatively high selectivity and adsorption capacity, and the strong electron-withdrawing property of CF3 further polarizes carbonyl and enhances the coordination ability of the lithium ions.

The invention provides a preparation method and application of cystamine modified hyaluronic acid hydrogel. The preparation method comprises the step of synthesizing hydrogel with a three-dimensional network structure by taking hyaluronic acid as a carrier and cystamine as a cross-linking agent. The insoluble drug is entrapped by the hydrogel, so that the solubility of the insoluble drug is effectively improved. The preparation method disclosed by the invention is simple in process, the prepared hydrogel has excellent performance and has the characteristics of uniform pores, good hydrophilicity, high drug loading capacity and high encapsulation efficiency, and the prepared drug-loaded hydrogel can slowly and continuously release drugs and has good antioxidant and antibacterial properties.

The invention belongs to the field of medicines, and particularly discloses a cystamine derivative impurity of tiagliptin hydrobromide and a control method thereof, and the control method comprises the following steps: dissolving a starting material tetrahydrothiazole in an organic solvent, washing with water, stirring, standing, separating liquid, retaining an organic phase, and spin-drying to obtain purified tetrahydrothiazole. Compared with the prior art, the method has the advantages that cysteamine and cystamine impurities in the thiazolidine are reduced by washing and extracting the starting material thiazolidine, so that the content of cystamine derivative impurities in the tiagliptin API is less than 0.1%, the product purity is effectively improved, and the quality consistency of tiagliptin raw material medicines in multi-batch production is better; repeated recrystallization of API is avoided, the yield is increased to 80% from 36%, and the production cost is reduced; the operation is simple and easy to realize.

The invention provides shape memory water-based hydraulic damping fluid containing electromagnetic rheological polymer composite particles and a preparation method of the shape memory water-based hydraulic damping fluid, and belongs to the field of water-based hydraulic damping fluid. Ferroferric oxide is synthesized through an oxidation-precipitation method, the dispersity and stability of particles are improved through sodium citrate on the basis of the excellent magnetic performance of the ferroferric oxide, and meanwhile, a silicon dioxide shell layer is coated through a sol-gel method so as to enhance the chemical stability and oxidation resistance of the ferroferric oxide. And further modifying and introducing isocyanate propyl triethoxy silane and cystamine dihydrochloride to construct self-repairing and shape memory functions on the surfaces of the particles. And in combination with the shape memory characteristic of a polyurethane matrix, magnetic response, dynamic regulation and control and multifunctional application are realized. And the finally prepared electromagnetic rheological polymer composite particle material has excellent performance and wide application prospect.

The invention discloses a PTFE binder based on disulfide bond-hydrogen bond synergistic modification and a preparation method and application thereof, and belongs to the technical field of all-solid-state batteries. The method for preparing the PTFE binder based on disulfide bond-hydrogen bond synergistic modification comprises the following steps: firstly, activating the surface of PTFE through plasma treatment, and then sequentially grafting cystamine molecules containing disulfide bonds and 1, 3-dipropyl-6-aminouracil to construct a dynamic covalent cross-linked network and a multi-hydrogen bond cross-linked network. The invention further discloses the PTFE binder obtained through modification by the method and application of the PTFE binder in an all-solid-state battery. The solid electrolyte membrane prepared by compounding the modified PTFE binder and sulfide electrolyte shows excellent interface stability and ionic conductivity. The problems of poor interfacial compatibility, insufficient mechanical adaptability and the like of a traditional PTFE binder are solved, and a high-performance binder solution is provided for all-solid-state lithium batteries. The preparation process is simple, the cost is controllable, and the method has remarkable industrial application value.

The invention belongs to the technical field of analytical chemistry, and particularly relates to application of a sulfydryl modified magnetic material in thallium enrichment and separation, namely a sample pretreatment method for detecting thallium in a water body. The sulfydryl modified magnetic material is prepared by grafting cystamine to the surface of a magnetic material through amidation reaction and then opening a disulfide bond by using a reducing agent to expose sulfydryl. It is found that the sulfydryl modified magnetic material can rapidly and efficiently conduct selective enrichment on trace thallium ions in a large-volume water sample, the sulfydryl modified magnetic material is used for pretreatment of thallium detection such as ICP-MS, AAS and ICP-OES and pretreatment matched with a portable on-site thallium detector, a more accurate thallium content detection result can be obtained, the detection sensitivity is greatly improved, and the method is suitable for large-scale popularization and application. Meanwhile, operation is easy, treatment time is short, waste liquid and waste gas are not generated, and cost is low.

The invention relates to the technical field of microbial probiotic preparations, in particular to a sodium alginate multifunctional composite microsphere as well as a preparation method and application thereof. The sodium alginate multifunctional composite microspheres are obtained by dissolving the carbohydrate vesicles, the traditional Chinese medicine nanoparticles and the probiotics in a sodium alginate solution and then dropwise adding the solution into a calcium chloride solution through an ionic cross-linking effect. According to the invention, the amphiphilic xylooligosaccharide-cystamine derivative with H2S response is synthesized through a click reaction on the basis of prebiotic xylooligosaccharide. And the amphipathic saccharide vesicles are obtained through self-assembly by virtue of hydrophilic and hydrophobic effects. Sanguinarine iodide prepared by purification, separation and reflux and baicalin are self-assembled in an aqueous solution through a non-covalent bond, and the traditional Chinese medicine nanoparticles are prepared through ultrasonic treatment. An in-vitro simulated release experiment proves that the sodium alginate multifunctional composite microsphere is relatively low in release rate under an acidic condition, so that substances are favorably delivered to intestinal tracts; and the release of encapsulated substances can be better realized in neutral and alkaline environments.

The invention relates to the technical field of battery diaphragms, in particular to a wood fiber composite diaphragm and a preparation method thereof. According to the diaphragm, renewable softwood pulp is used as a basic raw material, after aldehyde groups are introduced through sodium periodate oxidation, tannic acid, zinc acetate and cystamine are utilized to synergistically construct a zinc coordination network functional layer; then, molecular crosslinking with methoxypolyethylene glycol, polyethylene glycol, hexamethylene diisocyanate, gamma-aminopropyltriethoxysilane and nano silicon dioxide is realized under the action of a catalyst; and finally, the paper-making and hot-pressing processes are performed to prepare and mold. The diaphragm is particularly suitable for being applied to high-safety and high-performance aqueous metal zinc batteries, and an innovative technical path is provided for industrialization and green upgrading of zinc ion battery diaphragm materials.

The application discloses a bulletproof composite material and a preparation method thereof, and relates to the technical field of bulletproof composite materials.The bulletproof composite material is composed of aramid fiber and a resin matrix, wherein the resin matrix comprises the following raw materials in parts by weight: 60-70 parts of epoxy resin, 5-8 parts of a modified toughening agent, 4-5 parts of a curing agent, 1-2 parts of a heat stabilizer, 1-2 parts of an inorganic filler, 0.5-1 parts of a coupling agent and 2-5 parts of a wetting agent;the intermediate 1 is generated by the reaction of cyanuric chloride and 4-hydroxyphenylboronic acid;the intermediate 2 is generated by the reaction of the intermediate 1 and 3-amino-1,2-epoxypropane;the intermediate 3 is generated by the reaction of the intermediate 2 and cystamine;and the modified toughening agent is generated by the reaction of the intermediate 3 and dopamine.The bulletproof composite material prepared by the application has good ballistic protection performance, anti-multiple impact performance and self-repairing performance.

The invention provides a star polymer for promoting lung function repair and a preparation method thereof. The preparation method comprises the following steps: carrying out epoxy group modification on hydroxyl chalcone to obtain epoxidized chalcone, grafting the epoxidized chalcone to an amino group on a side arm of a star-shaped copolymer mother nucleus by using an introduced epoxy group, and grafting a polyethylene glycol chain segment on the side arm of the star-shaped copolymer mother nucleus to increase the water solubility; the defects that the chalcone compound is high in melting point and difficult to dissolve in water are improved in a targeted manner. Besides, the core of the star-shaped copolymer comprises a cystamine structure, and is easy to generate reduction reaction in a living body, so that the degradation and absorption of the star-shaped polymer in the living body are promoted, and finally the effects of improving the anti-inflammatory activity of the star-shaped polymer and promoting lung function repair are achieved.

The invention belongs to the technical field of medicines, and discloses application of cystamine in preparation of a medicine for treating sepsis encephalopathy. Wherein the sepsis encephalopathy is sepsis encephalopathy simulated by an endotoxemia model or an in-vitro reactive astrocyte model. It is found for the first time that cystamine can inhibit the pathological process of sepsis encephalopathy through multiple ways, and the death rate and cognitive impairment of sepsis model mice are remarkably improved. The invention provides a new thought for preparing a sepsis encephalopathy treatment product, and has a wide application prospect.

The invention discloses a degradable environment-friendly flame retardant and a preparation method thereof, and relates to the technical field of flame retardant materials, the degradable environment-friendly flame retardant comprises a three-dimensional dynamic covalent network structure formed by cross-linking cystamine-syringaldehyde Schiff base and phytic acid-syringaldehyde ester; the three-dimensional dynamic covalent network structure is loaded with manganese ions coordinated with phosphate groups in a post-introduction mode, through a phytic acid-cystamine-manganese ion ternary synergistic flame-retardant system, the flame-retardant property is remarkably improved, and meanwhile, based on a triple degradable response mechanism of imine bonds, ester bonds and disulfide bonds, the flame-retardant property is remarkably improved. And the material is endowed with excellent degradability.

The invention discloses a PVA-cystamine cross-linked material as well as a preparation method and application thereof, and relates to the technical field of PVA materials. Cystamine is introduced into a PVA main chain in an amido bond form through an active ester method mediated by a carbodiimide catalyst and an N-hydroxyamide compound, so that a disulfide bond (-S-S-) is successfully introduced into a PVA skeleton, and the obtained hydrogel has an oxidation-reduction dual-state response characteristic. In a normal physiological environment (low glutathione concentration), the disulfide bond stably exists, and the structural integrity of the film is maintained; by taking glutathione (GSH), the disulfide bond can be triggered to break, so that the network structure is disintegrated, and the targeted controllable degradation of the material is realized. The reaction conditions in the preparation process of the material are mild, the use of high-toxicity reagents is avoided, the biocompatibility of the material is improved, and the material is suitable for the fields with extremely high safety requirements, such as medical devices and implantable drug carriers.

The invention provides an anti-tumor targeting nano material and a preparation method thereof, and belongs to the field of novel targeting nano drugs. The method comprises the following steps: stirring and mixing up-conversion nanoparticles, calcium peroxide nanoparticles, manganese chloride and a chemotherapeutic drug in a water phase to obtain a drug-loading core; cystamine and 3-aminophenylboronic acid are dissolved in water, EDC and NHS are added, a first amidation reaction is carried out, and a cross-linking agent is obtained; dispersing the drug-loading core in a polyacrylic acid solution, adding a cross-linking agent, and then carrying out a cross-linking reaction to obtain an intermediate product; activating carboxyl on the surface of the intermediate product, and then carrying out second amidation reaction with cRGD-PEG-NH2, so as to obtain the anti-tumor targeting nano material. According to the application, a multifunctional nano platform integrating targeted enrichment, double-response precise drug release, chemotherapy-chemical kinetics-immune collaborative treatment and up-conversion imaging tracing is constructed, and specific efficient killing of tumors and inhibition of metastasis and relapse of the tumors are realized.

The application relates to the technical field of solid electrolytes, in particular to a gel polymer electrolyte and a preparation method and application thereof, the preparation method of the gel polymer electrolyte comprises the following steps: S1, mixing polyethylene glycol diacrylate, N,N'-bis(acryloyl)cystamine and tris(2-hydroxyethyl)isocyanuric acid triacrylate in a protective atmosphere to obtain a polymer monomer mixture, then placing the polymer monomer mixture and an initiator in a lithium-based electrolyte, stirring, and obtaining a precursor solution; S2, solidifying the precursor solution to obtain the gel polymer electrolyte. The preparation method provided by the application is simple in process, raw materials are easy to obtain, and the method is easy to put into large-scale production. Meanwhile, the gel polymer electrolyte prepared has good mechanical properties and high room-temperature ionic conductivity.

The application discloses a preparation method and application of a flexible disulfide bond modified hyperbranched polymer-based carbonized polymer dot, and belongs to the technical field of nano fluorescent materials, and aims to solve the problems of complicated operation, expensive equipment and low fluorescent quantum yield and insufficient sensitivity of existing carbonized polymer dots caused by difficulty in main chain flexibility regulation in traditional iron ion detection methods. The method controls the molar ratio of 1,6-hexanediamine and bisacryloyl cystamine to regulate the number of disulfide bonds of the hyperbranched polyamide-amine precursor, and then performs nitrogen hetero-Michael addition reaction with tris(2-aminoethyl)amine to form a flexible main chain structure, and then performs acid treatment, citric acid hydrothermal carbonization and ion exchange purification steps to obtain the carbonized polymer dot with high fluorescent quantum yield and main chain flexibility. The obtained material can be used for high-sensitivity quantitative detection of ferric ions in meat by-products (liver, blood and the like) and the field of microbial antibacterial.

The present application relates to a kind of superabsorbent paper diaper and its preparation method and application, including bottom film, core layer, face layer and elastic side seal, it is characterized in that, the core layer includes the following weight parts of preparation raw material: 50-60 parts acrylic water-absorbing resin, 20-30 parts polyacrylamide microspheres, 20-30 parts quaternary ammonium chitosan, 10-15 parts modifier and 1-5 parts catalyst;Wherein, the modifier is the combination of tartaric acid, 2-acrylamide-2-methylpropane sulfonic acid and N,N'-bis (acryloyl) cystamine with mass ratio 1: (2-3) : (1-1.5).Wherein, acrylic water-absorbing resin provides basic water-absorbing capacity, polyacrylamide microspheres enhance adsorption and prevent gel blockage, quaternary ammonium chitosan improves antibacterial properties and electrolyte adsorption capacity, catalyst ensures that reaction proceeds fully, modifier each component mutually synergistic enhances hydrophilicity, jointly improves the water-absorbing performance, structural stability and salt tolerance of core layer.

The present invention provides a functional double-network chitosan hydrogel, a preparation method and an application. The present invention utilizes acrylic acid and N,N-bis(acryloyl)cystamine as a cross-linking agent to simply polymerize and cross-link acryloyl chitosan to prepare a single-network hydrogel and optimize the mechanical properties of the product. Then, copper ions are introduced to carry out complexation of the carboxyl groups in the network to complete the double network construction of the hydrogel, further enhancing its mechanical properties. The use of copper ions has a role value in both structural optimization of the hydrogel and antibacterial application effect. Compared with the prior art, the preparation process of the double-network hydrogel of the present invention is simple and green, and the double-network structure of different forms provides its adjustable and excellent mechanical properties. The positive charge of the rich amino groups carried by chitosan gives the hydrogel an antibacterial function, and the metal ions involved in constructing the second network further enhance the antibacterial ability of the material, that is, the hydrogel has a dual antibacterial effect.

The invention belongs to the field of biological medicine, and particularly relates to a high-selectivity sensitizer for solid tumor radiotherapy and a preparation method thereof.The sensitizer comprises two newly-designed modified compounds: a derivative based on a diamino-anthraquinone structure and capable of enhancing radiation energy deposition and relieving tumor hypoxia; and the other one is a cystamine derivative containing a diselenide bond, and can effectively consume overexpressed glutathione in tumor cells and enhance the generation of active oxygen. The preparation method comprises the following steps: dissolving the two modified compounds and the biodegradable polymer in an organic solvent to form an organic phase, dissolving phospholipid polyethylene glycol amino in warm water, blending with a stabilizer in a buffer solution to form a water phase, dropwise adding the organic phase into the water phase through a nano-precipitation method, self-assembling to form nano-particles, and filtering and purifying to obtain a final product. The sensitizer can specifically target tumor tissues, the radiotherapy effect is remarkably improved through a multiple synergistic mechanism, meanwhile, the damage to normal tissues is reduced, the preparation process is simple and convenient, and the reproducibility is good.

This invention relates to the field of crop disease control technology, specifically to a composition containing antimicrobial peptides that enhances crop disease resistance. The composition comprises a synergistic and stable antimicrobial peptide carrier, a toad antimicrobial peptide (Buforin), cephalosporin B, and an antimicrobial peptide activator loaded onto the synergistic and stable antimicrobial peptide carrier. This invention prepares the synergistic and stable antimicrobial peptide carrier by reacting a mixture of cystamine, kasugamycin, and sorbitol glycidyl ether. This carrier enables precise controlled release of antimicrobial peptides at target sites, significantly prolongs the half-life of antimicrobial peptides in plants, solves the problems of easy degradation and short duration of action of conventional antimicrobial peptides, and synergistically enhances the stability of antimicrobial peptides, preventing aggregation or inactivation during loading and storage, thereby improving the bioavailability and persistence of antimicrobial peptides in field application.

The invention relates to a cystamine derivative or a salt thereof and an application of the cystamine derivative or the salt in preparation of a medicine with an anti-oxidation effect. According to the application of the cystamine derivative or the salt of the cystamine derivative in preparation of the medicine with the anti-oxidation effect, the cystamine derivative has the structural characteristics shown in a formula (1), a formula (2) or a formula (3). The research finds that the cystamine derivative or the salt thereof with the structural general formula can exert a better antioxidant effect, can be used for preventing and treating or improving diseases related to oxidative stress, has a protection effect on neuroglial cells and nerve cells, and has the characteristics of high efficiency and safety. # imgabs0 #

The invention relates to the technical field of novel biomedical materials, in particular to polyhydroxy poly-beta-amide as well as a preparation method and application thereof. The invention provides a preparation method of polyhydroxy poly-beta amide, which comprises the following steps: A) mixing dopamine, N, N '-bis (acryloyl) cystamine, an alcohol substance, an amine compound and alkali liquor, and then carrying out Michael addition reaction in a protective gas atmosphere; the Michael addition reaction is carried out under a dark condition; b) diluting the reaction solution in the step A) with an alcohol substance until the reaction is stopped; and C) adjusting the pH value of the reaction liquid obtained in the step B) to 3-5 to obtain the polyhydroxy poly-beta-amide. The polyhydroxy poly-beta-amide can replace ionizable lipid in a traditional LNP system, has good mRNA packaging capability and transfection efficiency, is expected to promote further development of an mRNA delivery system, and improves the clinical application prospect of the polyhydroxy poly-beta-amide in the fields of vaccines, gene therapy and the like.

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

The invention provides composite recombinant collagen peptide hydrogel as well as preparation and application thereof, and relates to the field of biomedical materials. The hydrogel comprises the following components: recombinant III-type collagen peptide, recombinant I-type collagen peptide, oxidized chondroitin sulfate, cystamine modified polyethylene glycol and antibacterial peptide loaded PLGA (poly (lactic-co-glycolic acid)) microspheres, wherein the oxidized chondroitin sulfate and amino groups of the collagen peptide are cross-linked through Schiff base bonds to form a first network; sulfydryl of the cystamine modified polyethylene glycol and carboxyl of the collagen peptide are cross-linked through disulfide bonds to form a second network. A double-network structure is constructed through a Schiff base bond and a disulfide bond, the mechanical strength and fatigue resistance of the hydrogel are remarkably improved, the hydrogel has excellent biocompatibility, a mild light-operated crosslinking process is adopted, active ingredients are prevented from being damaged by a high temperature / chemical initiator, and the hydrogel is particularly suitable for diabetic foot ulcer wound repair.

The application discloses a kind of anticorrosive coating and the method of forming anticorrosive coating, the anticorrosive coating includes the following weight parts of raw materials: N,N'-bis (acryloyl) cystamine 3~8 parts, ring sulfur resin 5~15 parts, amino propyl terminated polydimethylsiloxane 5~10 parts, dicyclopentadiene phenol epoxy resin 15~30 parts, vinyl resin 100~150 parts, silane coupling agent 2~5 parts, multifunctional curing agent 5~10 parts, epoxy curing agent 3~8 parts, initiator 0.5~2 parts, filler 30~60 parts.The anticorrosive coating of the application can dynamically repair the microdefects of anticorrosive coating, to reduce the penetration path of corrosive medium, and improve the bonding force between concrete substrate, finally realize the anticorrosion effect of improving anticorrosion coating.

The invention discloses a ferroptosis inhibitor for improving liver toxicity of a GPR40 agonist TAK-875. The ferroptosis inhibitor comprises an iron complexing agent, an antioxidant, a lipoxygenase (LOX) inhibitor, an ACSL4 inhibitor, nitrogen oxide and selenium supplement, the iron complexing agent comprises deferoxamine, deferiprone, Deferasirox, curcumin and hepcidin, so that unstable iron in cells can be reduced, and a Fenton reaction can be inhibited; the antioxidant is prepared from Ferrostain-1, Liproxstain-1, Trolox and XJB-5-131, and the antioxidant is prepared from the following raw materials: sodium alginate, sodium alginate and sodium alginate; the lipoxygenase (LOX) inhibitor comprises Zileuton, AA861, PD146176 and baicalin, the ACSL4 inhibitor comprises Troglitazole, Rosiglitazole and Pioglitazole, the nitrogen oxides comprise TEMPO and PHOXNO, the Fenton reaction can be blocked, and the generation of hydroxyl free radicals can be inhibited; the selenium supplement comprises selenium, methyl selenocysteine and selenocystamine, the abundance of GPX4 is supplemented, and the lipid peroxide removing capacity is enhanced. Compared with the prior art, the invention has the advantage that the iron inhibitor is effectively proved to treat hepatotoxicity.