32 results about "Cystamine" patented technology

The invention relates to the technical field of battery diaphragms, in particular to a wood fiber composite diaphragm and a preparation method thereof. According to the diaphragm, renewable softwood pulp is used as a basic raw material, after aldehyde groups are introduced through sodium periodate oxidation, tannic acid, zinc acetate and cystamine are utilized to synergistically construct a zinc coordination network functional layer; then, molecular crosslinking with methoxypolyethylene glycol, polyethylene glycol, hexamethylene diisocyanate, gamma-aminopropyltriethoxysilane and nano silicon dioxide is realized under the action of a catalyst; and finally, the paper-making and hot-pressing processes are performed to prepare and mold. The diaphragm is particularly suitable for being applied to high-safety and high-performance aqueous metal zinc batteries, and an innovative technical path is provided for industrialization and green upgrading of zinc ion battery diaphragm materials.

The invention discloses a degradable environment-friendly flame retardant and a preparation method thereof, and relates to the technical field of flame retardant materials, the degradable environment-friendly flame retardant comprises a three-dimensional dynamic covalent network structure formed by cross-linking cystamine-syringaldehyde Schiff base and phytic acid-syringaldehyde ester; the three-dimensional dynamic covalent network structure is loaded with manganese ions coordinated with phosphate groups in a post-introduction mode, through a phytic acid-cystamine-manganese ion ternary synergistic flame-retardant system, the flame-retardant property is remarkably improved, and meanwhile, based on a triple degradable response mechanism of imine bonds, ester bonds and disulfide bonds, the flame-retardant property is remarkably improved. And the material is endowed with excellent degradability.

The invention discloses a PVA-cystamine cross-linked material as well as a preparation method and application thereof, and relates to the technical field of PVA materials. Cystamine is introduced into a PVA main chain in an amido bond form through an active ester method mediated by a carbodiimide catalyst and an N-hydroxyamide compound, so that a disulfide bond (-S-S-) is successfully introduced into a PVA skeleton, and the obtained hydrogel has an oxidation-reduction dual-state response characteristic. In a normal physiological environment (low glutathione concentration), the disulfide bond stably exists, and the structural integrity of the film is maintained; by taking glutathione (GSH), the disulfide bond can be triggered to break, so that the network structure is disintegrated, and the targeted controllable degradation of the material is realized. The reaction conditions in the preparation process of the material are mild, the use of high-toxicity reagents is avoided, the biocompatibility of the material is improved, and the material is suitable for the fields with extremely high safety requirements, such as medical devices and implantable drug carriers.

The invention provides an anti-tumor targeting nano material and a preparation method thereof, and belongs to the field of novel targeting nano drugs. The method comprises the following steps: stirring and mixing up-conversion nanoparticles, calcium peroxide nanoparticles, manganese chloride and a chemotherapeutic drug in a water phase to obtain a drug-loading core; cystamine and 3-aminophenylboronic acid are dissolved in water, EDC and NHS are added, a first amidation reaction is carried out, and a cross-linking agent is obtained; dispersing the drug-loading core in a polyacrylic acid solution, adding a cross-linking agent, and then carrying out a cross-linking reaction to obtain an intermediate product; activating carboxyl on the surface of the intermediate product, and then carrying out second amidation reaction with cRGD-PEG-NH2, so as to obtain the anti-tumor targeting nano material. According to the application, a multifunctional nano platform integrating targeted enrichment, double-response precise drug release, chemotherapy-chemical kinetics-immune collaborative treatment and up-conversion imaging tracing is constructed, and specific efficient killing of tumors and inhibition of metastasis and relapse of the tumors are realized.

The application relates to the technical field of solid electrolytes, in particular to a gel polymer electrolyte and a preparation method and application thereof, the preparation method of the gel polymer electrolyte comprises the following steps: S1, mixing polyethylene glycol diacrylate, N,N'-bis(acryloyl)cystamine and tris(2-hydroxyethyl)isocyanuric acid triacrylate in a protective atmosphere to obtain a polymer monomer mixture, then placing the polymer monomer mixture and an initiator in a lithium-based electrolyte, stirring, and obtaining a precursor solution; S2, solidifying the precursor solution to obtain the gel polymer electrolyte. The preparation method provided by the application is simple in process, raw materials are easy to obtain, and the method is easy to put into large-scale production. Meanwhile, the gel polymer electrolyte prepared has good mechanical properties and high room-temperature ionic conductivity.

The application discloses a preparation method and application of a flexible disulfide bond modified hyperbranched polymer-based carbonized polymer dot, and belongs to the technical field of nano fluorescent materials, and aims to solve the problems of complicated operation, expensive equipment and low fluorescent quantum yield and insufficient sensitivity of existing carbonized polymer dots caused by difficulty in main chain flexibility regulation in traditional iron ion detection methods. The method controls the molar ratio of 1,6-hexanediamine and bisacryloyl cystamine to regulate the number of disulfide bonds of the hyperbranched polyamide-amine precursor, and then performs nitrogen hetero-Michael addition reaction with tris(2-aminoethyl)amine to form a flexible main chain structure, and then performs acid treatment, citric acid hydrothermal carbonization and ion exchange purification steps to obtain the carbonized polymer dot with high fluorescent quantum yield and main chain flexibility. The obtained material can be used for high-sensitivity quantitative detection of ferric ions in meat by-products (liver, blood and the like) and the field of microbial antibacterial.

The invention belongs to the field of biological medicine, and particularly relates to a high-selectivity sensitizer for solid tumor radiotherapy and a preparation method thereof.The sensitizer comprises two newly-designed modified compounds: a derivative based on a diamino-anthraquinone structure and capable of enhancing radiation energy deposition and relieving tumor hypoxia; and the other one is a cystamine derivative containing a diselenide bond, and can effectively consume overexpressed glutathione in tumor cells and enhance the generation of active oxygen. The preparation method comprises the following steps: dissolving the two modified compounds and the biodegradable polymer in an organic solvent to form an organic phase, dissolving phospholipid polyethylene glycol amino in warm water, blending with a stabilizer in a buffer solution to form a water phase, dropwise adding the organic phase into the water phase through a nano-precipitation method, self-assembling to form nano-particles, and filtering and purifying to obtain a final product. The sensitizer can specifically target tumor tissues, the radiotherapy effect is remarkably improved through a multiple synergistic mechanism, meanwhile, the damage to normal tissues is reduced, the preparation process is simple and convenient, and the reproducibility is good.

This invention relates to the field of crop disease control technology, specifically to a composition containing antimicrobial peptides that enhances crop disease resistance. The composition comprises a synergistic and stable antimicrobial peptide carrier, a toad antimicrobial peptide (Buforin), cephalosporin B, and an antimicrobial peptide activator loaded onto the synergistic and stable antimicrobial peptide carrier. This invention prepares the synergistic and stable antimicrobial peptide carrier by reacting a mixture of cystamine, kasugamycin, and sorbitol glycidyl ether. This carrier enables precise controlled release of antimicrobial peptides at target sites, significantly prolongs the half-life of antimicrobial peptides in plants, solves the problems of easy degradation and short duration of action of conventional antimicrobial peptides, and synergistically enhances the stability of antimicrobial peptides, preventing aggregation or inactivation during loading and storage, thereby improving the bioavailability and persistence of antimicrobial peptides in field application.

The invention relates to the technical field of novel biomedical materials, in particular to polyhydroxy poly-beta-amide as well as a preparation method and application thereof. The invention provides a preparation method of polyhydroxy poly-beta amide, which comprises the following steps: A) mixing dopamine, N, N '-bis (acryloyl) cystamine, an alcohol substance, an amine compound and alkali liquor, and then carrying out Michael addition reaction in a protective gas atmosphere; the Michael addition reaction is carried out under a dark condition; b) diluting the reaction solution in the step A) with an alcohol substance until the reaction is stopped; and C) adjusting the pH value of the reaction liquid obtained in the step B) to 3-5 to obtain the polyhydroxy poly-beta-amide. The polyhydroxy poly-beta-amide can replace ionizable lipid in a traditional LNP system, has good mRNA packaging capability and transfection efficiency, is expected to promote further development of an mRNA delivery system, and improves the clinical application prospect of the polyhydroxy poly-beta-amide in the fields of vaccines, gene therapy and the like.

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

The application discloses a kind of anticorrosive coating and the method of forming anticorrosive coating, the anticorrosive coating includes the following weight parts of raw materials: N,N'-bis (acryloyl) cystamine 3~8 parts, ring sulfur resin 5~15 parts, amino propyl terminated polydimethylsiloxane 5~10 parts, dicyclopentadiene phenol epoxy resin 15~30 parts, vinyl resin 100~150 parts, silane coupling agent 2~5 parts, multifunctional curing agent 5~10 parts, epoxy curing agent 3~8 parts, initiator 0.5~2 parts, filler 30~60 parts.The anticorrosive coating of the application can dynamically repair the microdefects of anticorrosive coating, to reduce the penetration path of corrosive medium, and improve the bonding force between concrete substrate, finally realize the anticorrosion effect of improving anticorrosion coating.

The invention discloses a bifidobacterium animalis subsp. Lactis composition for regulating intestines and stomach and a preparation method of the bifidobacterium animalis subsp. Lactis composition, and relates to the technical field of biology. A rigid hydrophobic group is introduced into sodium alginate for grafting modification, the rigid hydrophobic group of 4-aminoethyl biphenyl is grafted to a sodium alginate molecular chain through 1, 4-butanediol diglycidyl ether, and meanwhile, the sodium alginate molecular chain and cystamine-chitosan into which a disulfide bond is introduced are subjected to electrostatic compounding modification design; the bifidobacterium animalis subsp. Lactis is embedded, so that the survival rate of the bifidobacterium animalis subsp. Lactis in intestines and stomach is effectively improved, and the effective gastrointestinal regulation function of the bifidobacterium animalis subsp. Lactis is realized.

The invention provides a polyamide flexibilizer containing dynamic disulfide bonds, a preparation method and a self-repairing powder coating composition. According to the polyamide toughening agent containing the dynamic disulfide bonds, the toughening agent is of an organic-inorganic composite structure; the organic structure comprises a polyamide main body, and the polyamide main body is formed by condensation polymerization of at least one binary aliphatic diacid, at least one binary aliphatic diamine and cystamine; the polyamide toughening agent containing the dynamic disulfide bond can form a stably dispersed tough phase in a powder coating system and effectively absorb and disperse external stress, so that the coating does not crack under a 180-degree bending condition, and the impact resistance and the flexibility of the coating are remarkably improved; after scratches or microcracks are generated on the surface of the coating, molecular rearrangement and reconstruction of disulfide bonds can occur under the mild heat treatment condition of about 60 DEG C, so that a damaged area is spontaneously healed, the scratches obviously disappear within 30 minutes, and the repairing efficiency can reach 85% or above.

The invention discloses an ultraviolet curing composite proton exchange membrane and a preparation method and application thereof.The preparation method comprises the steps that a composite solution is cast on a carrier, ultraviolet irradiation, drying and aftertreatment are conducted, the ultraviolet curing composite proton exchange membrane is obtained, and the composite solution comprises perfluorinated sulfonic acid resin, lithium titanium aluminum phosphate, a cross-linking agent and a photoinitiator; the cross-linking agent is cystamine, and the post-treatment comprises the following steps: soaking in hydrogen peroxide, water, sulfuric acid and water in sequence. The perfluorinated sulfonic acid resin is used as a basis, cystamine is used as a cross-linking agent, a dynamic cross-linked network is formed through disulfide bonds of cystamine, the diaphragm has a self-repairing function, lithium titanium aluminum phosphate powder is doped, and after lithium titanium aluminum phosphate is embedded into the perfluorinated sulfonic acid resin, an additional ion transmission path can be formed, so that the proton conductivity of the diaphragm is improved, and the proton conductivity of the diaphragm is improved. And the rigid structure of the lithium titanium aluminum phosphate enhances the mechanical strength of the perfluorosulfonic acid resin and improves the dimensional stability of the proton exchange membrane.

There is provided microparticles crosslinked with disulfide bonds and methods of producing the same. The microparticles are particularly useful for the cryopreservation of cells. The disulfide bonds are provided from a functionalization of methacrylic anhydride based microparticles with cystamine or from using methacrylic anhydride based monomers containing a cystamine link core with the disulfide bond, and beneficially by combining both modes of disulfide crosslinking. Other uses for these microspheres include as printing support materials (jammed gels) for 3D printing hydrogels, optionally containing therapeutic cells.

The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

The invention relates to a cross-linked aramid polymer and a preparation method thereof, and the cross-linked aramid polymer is characterized in that the cross-linked aramid polymer comprises a modified aramid main chain containing a furan ring; a triple dynamic cross-linked network is formed by a Diels-Alder bond cross-linking agent, a disulfide bond cross-linking agent and an imine bond cross-linking agent; and the functional filler is an aramid nanocrystal, a silver nanowire or polycaprolactone. Bismaleimide, cystamine and glutaraldehyde / glyoxal are introduced into a polymer main chain, and a functional filler of aramid nanocrystals, silver nanowires or polycaprolactone is introduced, so that the modulus, the electromagnetic shielding effectiveness and the shape memory performance of aromatic polyamide can be remarkably improved, meanwhile, efficient self-repairing is achieved, and the shape memory performance of the aromatic polyamide is improved. And the wide application in the fields of aerospace, flexible electronics, intelligent materials and the like can be promoted.

The application belongs to the technical field of biological medicine material preparation, and particularly relates to albumin nanoparticles loaded with ferroptosis related drugs and a preparation method thereof. The ferroptosis related drug composition comprises porphyrin drugs, unsaturated fatty acid drugs-cystamine and sulfosuccinimidyl oleate (SSO). The porphyrin drugs, the unsaturated fatty acid drugs-cystamine and the SSO are slowly added dropwise into an albumin solution under stirring, the drugs enter the hydrophobic cavities of the albumin, and uniform nanoparticles are spontaneously formed. The obtained nanoparticles are small in size and uniform, can efficiently deliver drugs through passive targeting mediated by the EPR effect and active targeting mediated by the Gp60-Caveola-SPARC pathway, improve stability, reduce accumulation at non-target sites and systemic toxicity, amplify the effect of ferroptosis after combination compared with the ferroptosis related drugs used alone, and thus produce a synergistic anti-tumor effect.

The invention belongs to the technical field of materials, and particularly relates to a polyimide film based on aliphatic disulfide bonds and a preparation method of the polyimide film. The diamine-cystamine CY containing aliphatic disulfide bonds is introduced into a polyimide system, a traditional preparation process is changed, and the polyimide film based on the aliphatic disulfide bonds is prepared. The aliphatic disulfide bond-based polyimide film prepared by the invention has the characteristics of excellent mechanical property, self-repairing property, optical property, high and low temperature resistance and the like, and the average light transmittance reaches 88.1%; the mechanical property is excellent, and the tensile strength and the elongation at break respectively reach 101.22 MPa and 5.04%; the self-repairing performance is excellent, multiple times of self-repairing can be achieved under the condition that hot pressing and a catalyst are not needed, and the self-repairing efficiency reaches 98%. The method is expected to be applied to the frontier fields of aerospace, electronic equipment, industry, military and the like.

The invention belongs to the technical field of solar cells, and particularly relates to a polymerizable N, N-dimethyl formamide. The invention discloses a polymerizable N, N '-bis (acryloyl) cystamine-metal cluster colloidal solution as well as a preparation method and application thereof, the polymerizable N, N'-bis (acryloyl) cystamine-metal cluster colloidal solution which is uniform in particle size and is uniformly dispersed in a solvent is obtained by adopting a liquid-phase laser irradiation technology, and stable metal nanoclusters of the colloidal solution have good conductivity; based on the metal nanocluster and N, N-dimethyl formamide, according to the perovskite solar cell and the preparation method of the perovskite solar cell, the application of a single organic molecule and a nanocluster in the perovskite solar cell is compensated by the advantage of synergistic assembly of N, N '-bis (acryloyl) cystamine molecule polyfunctional groups, and the N, N'-bis (acryloyl) cystamine-metal cluster is implanted into a perovskite layer as a seed crystal regulation additive, so that the light efficiency and the operation stability of the perovskite solar cell are improved.

The adhesive is prepared from polyethylene glycol diglycidyl ether, bisphenol A diglycidyl ether and the double-ammonia curing agent, and cystamine can be added at the same time. The adhesive has relatively high bonding strength, can be circularly bonded and can be completely degraded at the same time.

The invention discloses an amino acid derivative-fluoride nano preparation and a preparation method and application thereof, and belongs to the technical field of biological medicines.The preparation method comprises the steps that firstly, L-lysine and S-allylcysteine are modified to prepare an L-lysine targeting ligand and an S-allylcysteine active ligand; then taking the L-lysine targeting ligand, the S-allylcysteine active ligand and fluoride as reaction monomers, adding an initiator ammonium persulfate, an accelerator tetramethylethylenediamine and a cross-linking agent N, N '-bis (acryloyl) cystamine, and carrying out a reaction in a buffer solution system in an inert gas protection atmosphere; the amino acid derivative-fluoride nano preparation is obtained. The amino acid derivative-fluoride nano preparation can integrate an L-lysine targeting biological membrane, SAC inhibition of a QS signal and fluoride penetration of an EPS barrier, and lung bacterial infection is treated based on a multi-dimensional strategy of membrane rupture, bacteriostasis and synergy.

The invention belongs to the technical field of medical materials, and relates to an antibacterial suture line for surgical suture and a preparation method thereof. The preparation method comprises the following steps: dissolving 2-amino-5-acetylpyridine in a hydrobromic acid glacial acetic acid solution, adding a bromine-containing acetic acid solution, and reacting to obtain an intermediate 1; adding the intermediate 1 into tetrahydrofuran, adding triethylamine and acetic anhydride, and reacting to obtain an intermediate 2; adding the intermediate 2 and thiourea into absolute ethyl alcohol to react to obtain an intermediate 3; adding the intermediate 3 and p-nitrobenzaldehyde into absolute methanol, and adding glacial acetic acid to react to obtain an intermediate 4; adding phosphorus oxychloride into N, N-dimethylformamide, and adding the intermediate 4 to react to obtain an intermediate 5; dissolving the intermediate 5 in a mixed solvent, and adding cystamine to react to obtain an antibacterial agent; the medical silk suture line is soaked in dimethyl sulfoxide dissolved with the antibacterial agent, and the medical silk suture line is obtained through ultrasonic treatment, soaking, rinsing and drying. The antibacterial suture line disclosed by the invention has multi-mechanism synergistic enhanced antibacterial performance, an environment response type active release mechanism and excellent interface affinity.

The invention discloses amino acid zwitterionic nanogel and application thereof. The nanogel is prepared by using methylacryloyl lysine as a monomer and disulfide bond-containing N, N '-bis (acryloyl) cystamine as a cross-linking agent through a dispersion polymerization method. The surface of the nanogel is rich in amino groups and carboxyl groups, and the nanogel has typical zwitter-ion characteristics and is easy to modify targeting groups. The nanogel has excellent biocompatibility, colloidal stability and remarkable protein adsorption resistance, and meanwhile, due to an internal disulfide bond structure, the nanogel can be subjected to reduction responsive degradation in a tumor microenvironment of high-concentration glutathione, so that intelligent controlled release of drugs is realized. Experiments show that the doxorubicin-loaded nanogel has an efficient killing effect on tumor cells, is very low in toxicity to normal cells, and shows huge application potential in a drug delivery system, especially in the aspects of targeted delivery and controlled release of anti-tumor drugs.

The application belongs to the technical field of medical materials and relates to a bacteriostatic suture for surgical suturing and a preparation method thereof. The preparation method comprises the following steps: 2-amino-5-acetylpyridine is dissolved in a hydrobromic acid glacial acetic acid solution, an acetic acid solution containing bromine is added, and an intermediate 1 is obtained through reaction; the intermediate 1 is added to tetrahydrofuran, triethylamine and acetic anhydride are added, and an intermediate 2 is obtained through reaction; the intermediate 2 and thiourea are added to anhydrous ethanol, and an intermediate 3 is obtained through reaction; the intermediate 3 and p-nitrobenzaldehyde are added to anhydrous methanol, and an intermediate 4 is obtained through reaction; phosphorus oxychloride is added to N,N-dimethylformamide, and the intermediate 4 is added to obtain an intermediate 5 through reaction; the intermediate 5 is dissolved in a mixed solvent, and cystamine is added to obtain an antibacterial agent; and the medical silk suture is immersed in dimethyl sulfoxide containing the antibacterial agent, and is subjected to ultrasonic treatment, soaking, rinsing and drying to obtain the bacteriostatic suture. The bacteriostatic suture has the advantages of multi-mechanism synergistic enhanced bacteriostatic performance, an environment-responsive active release mechanism and excellent interface affinity.

The invention discloses a PVA (Polyvinyl Alcohol) material based on redox-pH (Potential of Hydrogen) dual response as well as a preparation method and application thereof, and relates to the technical field of PVA materials. Through selective oxidation of periodate on PVA, an aldehyde group functional group is introduced to a PVA main chain, and subsequently modifiable active sites are constructed. A pharmaceutically acceptable salt of cystamine is used as a difunctional cross-linking agent, and is efficiently subjected to a Schiff base reaction with an aldehyde group in PVA to form a dynamic imine bond network, so that the PVA material is endowed with a pH response characteristic; meanwhile, a central disulfide bond in a cystamine molecule is introduced into a three-dimensional cross-linked network in situ, so that the material is endowed with excellent redox responsiveness on the premise of keeping the completeness of the cystamine molecule. The process is mild in condition, low in potential toxicity and high in reaction speed, the whole crosslinking process can be completed within several hours, the preparation period is greatly shortened, and the production efficiency is improved.

The application discloses a kind of multilayer nano activation material and its preparation method and in sterilization and deodorization application, belong to air purification material technical field, including structural reinforcement layer, catalytic oxidation layer, isolation layer, acid source layer;The structural reinforcement layer includes cystamine modified chondroitin sulfate and nanocellulose;The catalytic oxidation layer includes mesoporous silica loaded with sodium chlorite and metal-phenolic nano particles@metal-doped hollow mesoporous manganese dioxide;The isolation layer includes pullulan and hydrophobic nanosilica;The acid source layer includes citric acid microcapsule and sodium alginate.The material set catalytic degradation, intelligent sterilization, malodor decomposition multi-functional synergy integration, realize stable storage, intelligent trigger and efficient synergistic purification organic unity, can be widely applied to air purifier, washing and protection product, textile fiber, building paint, wall material and so on many kinds of scene.

The invention discloses a preparation method and application of a novel water-soluble propofol nano-composite, and relates to the technical field of nano-composite drug research and development, and the key points of the technical scheme are as follows: firstly, preparing Pdots from a conjugated polymer F8BT and an amphiphilic polymer PSMA through a nano coprecipitation method; then promoting a phenolic hydroxyl group of propofol and an acylation reagent chloroacetyl chloride to be subjected to a substitution reaction by DMAP to generate ester, and reacting amino on cystamine and an acyl chloride bond on the ester under the catalysis of potassium carbonate and potassium iodide to generate PPF-SS-NH2; carrying out condensation reaction on amino of the PPF-SS-Pdots and carboxyl of Pdots to obtain a PPF-SS-Pdots nano compound; and finally, synthesizing the PRP from the nano-composite and RVG-29 through an electrostatic adsorption effect. The anesthesia onset time and maintenance time of PRP are equivalent to those of common propofol, the awakening time is remarkably shortened, meanwhile, injection pain and other side effects are reduced, and rapid detection is achieved.

The invention discloses a mitochondrial targeted anti-cancer drug based on cyanine and lonidamine and a preparation method and application thereof, and belongs to the technical field of drugs for treating tumors. Cyanine molecules and 3-mercaptobenzoic acid are subjected to a nucleophilic substitution reaction to prepare a cyanine derivative; the preparation method comprises the following steps: carrying out a coupling reaction on a cyanine derivative and a selenocystamine compound to prepare a cyanine-connexon conjugate with an amino terminal; the cyanine-connexon conjugate and lonidamine are subjected to a coupling reaction, and the targeted anti-cancer drug is obtained. According to the mitochondrial targeting anti-cancer drug based on cyanine and lonidamine and the preparation method and application thereof, after the drug targets tumor cell mitochondria, cyanine molecules generate a photodynamic effect and a photothermal effect at the same time under the irradiation of near-infrared light, ROS and high temperature are generated in situ, the mitochondrial structure and function are directly damaged, and the drug can be used for preparing the mitochondrial targeting anti-cancer drug based on cyanine and lonidamine. The ROS also synchronously triggers diselenide bond breakage, lonidamine is accurately released, and mitochondrial dysfunction and metabolic crisis are further aggravated.

The invention discloses a recyclable epoxy resin insulating sleeve and a preparation method thereof, and relates to the technical field of epoxy resin insulating material preparation. According to the insulating sleeve, protocatechuic aldehyde and cystamine are adopted as raw materials, a bio-based epoxy Vitrimer system containing an imine bond and a disulfide bond is constructed through imidization and epoxidation reactions, a hyperbranched structure is introduced, the hyperbranched structure and bio-based epoxy are blended, and methylhexahydrophthalic anhydride and dithiodipropionic anhydride are co-cured to form a reversible cross-linked network, so that the insulating sleeve is prepared. The obtained sleeve has high glass transition temperature, excellent electrical insulation performance, good mechanical strength, good self-repairing capability and recoverability, can be reprocessed for multiple times through hot pressing, and is high in performance retention rate. The raw material is suitable for a 35kV power system insulating sleeve, solves the problems that a traditional epoxy resin insulating material is difficult to recycle and large in environmental burden, and has a good application prospect.