41results about "Monocomponent polypeptides artificial filament" patented technology

An artificial polypeptide fiber of the present invention is an artificial fiber containing a polypeptide as a main component, and has a stress of 350 MPa or more and a toughness of 138 MJ / m3 or more. A method for producing an artificial polypeptide fiber of the present invention is a method for producing the artificial polypeptide fiber obtained by spinning a spinning solution (6) containing a polypeptide derived from natural spider silk proteins and performing drawing of at least two stages. The drawing of at least two stages includes a first-stage drawing (3) in wet heat and a second-stage drawing (4) in dry heat. Thereby, the present invention provides high-toughness artificial polypeptide fibers having favorable stress and rupture elongation, and a method for producing the same.

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.

A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.

Process of making polypeptide fibers including the steps of contacting a polypeptide with a solution of formic acid a divalent metal ion salt, or contacting a decrystallized polypeptide with formic acid having a water content less than 3 wt % and concentrating the resulting solution to a polypeptide concentration greater than 10 wt %.

The invention relates to a preparation method of water stability gamma-polyglutamic acid nanometer fibers. The preparation method comprises the steps of: (1) preparing trifluoroacetic acid water solution of which the mass percentage concentration is 5%-10%, dissolving gamma-polyglutamic acid in the trifluoroacetic acid solution and stirring the solution for 6-8 hours to obtain gamma-polyglutamic acid solution; (2) spinning the gamma-polyglutamic acid solution via static spinning to obtain gamma-polyglutamic acid nanometer fibers; and (3) dissolving the gamma-polyglutamic acid nanometer fibersand EDC (ethylene dichloride) in methanol to have a reaction at room temperature for 3-5 hours, adding cystamine dihydrochlorid to have a reaction for 48-72 hours after the reaction is ended, rinsing, freezing and drying the products after the reaction of cystamine dihydrochlorid is ended, thus obtaining gamma-polyglutamic acid nanometer fibers with good water stability. The preparation method ofthe water stability gamma-polyglutamic acid nanometer fibers is simple and convenient in operation and has moderate technique conditions; the raw materials are easy to obtain, and the prepared gamma-polyglutamic acid nanometer fibers have good biocompatibility so the gamma-polyglutamic acid nanometer fibers have latent application merits in the field of the histological engineering bracket.

The present invention relates to a method of spinning a polypeptide polymer containing fibre. It further relates to a polymer fibre obtainable by said method and to uses thereof. The invention also relates to products comprising said polymer fibre.

A micromachined spinneret is disclosed which has one or more orifices through which a fiber-forming material can be extruded to form a fiber. Each orifice is surrounded by a concentric annular orifice which allows the fiber to be temporarily or permanently coated with a co-extrudable material. The micromachined spinneret can be formed by a combination of surface and bulk micromachining.

A water-insoluble polyglutamic acid (PGA) fiber and a preparation method thereof are provided. In the preparation method, the PGA is cross-linked by a cross-linking agent and then passes through a spinning nozzle to form PGA fibers. Therefore, the highly water-absorbing PGA, which cannot be spun by conventional methods, can be spun to form PGA fibers and maintain the high water-absorption ability.

Provided is a modified fibroin, including a domain sequence represented by Formula 1: [(A)n motif-REP]m, in which the domain sequence has an amino acid sequence having a reduced content of (A)n motif equivalent to an amino acid sequence in which, at least, one or a plurality of the (A)n motifs is deleted, as compared to naturally occurring fibroin.[In Formula 1, (A)n motif represents an amino acid sequence consisting of 4 to 20 amino acid residues and the number of alanine residues relative to the total number of amino acid residues in the (A)n motif is 83% or more, REP represents an amino acid sequence consisting of 10 to 200 amino acid residues, m represents an integer of 8 to 300, and a plurality of (A)n motifs or the like may be the same amino acid sequence or different amino acid sequences.]

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50 / 50 to about 95 / 5 weight / weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.

A method for preparing a polyglutamic acid (γ-PGA) fiber having antibacterial and water absorption properties is provided. The method includes providing a γ-PGA fiber and immersing it in a sodium hypochlorite solution. A relation exists between an immersing time T of the γ-PGA fiber and a concentration X of the sodium hypochlorite solution as shown in the formula below:10.2≦(T−64.55X2+50X)≦15.2,wherein X is 0.006-0.4 wt %.

A method of producing polyamide material with peptides is disclosed. The method includes: mixing a peptide material and water to form a peptide solution; mixing caprolactam and the peptide solution to form a first solution; adding a catalyst into the first solution to form a second solution; adding an antioxidant into the second solution to form a third solution; causing a ring-opening reaction in the third solution; heating the third solution to a dehydration temperature to dewater the third solution; forming a polyamide material with peptides.

Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.

Disclosed is a method for purifying a recombinant protein of interest from a recombinant cell expressing intracellularly the recombinant protein as an insoluble matter, comprising treating the recombinant cell under conditions where a protein derived from a host cell dissolves in a first aprotic polar solvent to which an inorganic salt is added or not but the recombinant protein does not dissolve, removing a first soluble fraction, and then treating the resulting first insoluble fraction under conditions where the recombinant protein dissolves in a second aprotic polar solvent to which an inorganic salt is added.

The subject invention pertains to peptide-based materials comprising cross-linked peptides with random amino acid sequences that are soluble in water or ethanol before crosslinking but insoluble in water after crosslinking.

The present invention relates to compositions comprising: a polypeptide, wherein at least a portion of the polypeptide has a coiled coil structure; and a chelate comprising a chelating agent and a metal ion; and wherein the chelate is bound to at least one amino acid of the polypeptide. In a preferred embodiment the polypeptide is a silk fibroin, wherein at least a portion of said silk fibroin has a coiled coil structure.

Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a β-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.

Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.

The present invention provides a modified fibroin fiber having a shrinkage history of being irreversibly shrunk after spinning, the modified fibroin fiber containing modified fibroin, wherein a fiber diameter of a raw material fiber before being irreversibly shrunk exceeds 25 μm.

Provided is a fiber for rubber reinforcement, which can be produced using a biologically derived raw material and is not susceptible to breakage even when compounded with a rubber material. The first rubber-reinforcing fiber according to the present invention is characterized by using a protein fiber containing a hydrophobic protein. The second rubber-reinforcing fiber according to the present invention is characterized by using a protein fiber having an initial tensile modulus of elasticity of 2.0 GPa or more when wet. The rubber-reinforcing fibers are preferably provided with a coating layer on the surface, and the coating layer is formed from an aqueous adhesive composition.