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Method for production of polymer containing fibres

a technology of polymer fibres and fibres, which is applied in the field of polymer fibre formation methods, can solve the problems of difficult to find a commercially viable process for mass-producing spider silk, the requirements of methods are usually too harsh for the involvement of biological materials such as proteins or cells, and the combination of all these properties has proved difficult, so as to increase the elongational viscosity of the solution. , the effect of increasing the viscosity

Inactive Publication Date: 2013-07-04
AMSILK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about a way to create fibers that can hold cells and enzymes, which can be used for bioengineering and tissue culture. These fibers can also be used to screen cells and make wound healing materials. They can be produced using a spinning solution made of polymer, compound to increase viscosity, and solvent. The technical effects of this invention include allowing for the incorporation of cells and enzymes into fibers, which can be used for tissue engineering and high-throughput screening. Additionally, the invention allows for the creation of strong, elastic fibers with low weight that can be used in various commercial products.

Problems solved by technology

The methods usually have requirements too harsh for the involvement of biological material such as proteins or cells, regarding conditions in terms of temperature, pressure or the use of chemicals and solvents.
However, combining all these properties has proved difficult.
However, it has been difficult to find a commercially viable process to mass-produce spider silk.
Artificial production has encountered problems in achieving both sufficient protein yield and quality thread assembly.
Still, fibre drawing from aqueous solutions of these proteins is not possible, since such a solution, by itself, does not exhibit sufficient elongational viscosity.
For example, it is not possible to pull out a stable fluid filament of water due to the high surface tension of water.
Artificial spinning dopes with low protein concentrations (10-20 mg / ml eADF3 and eADF4) do not show Tr>>1. The surface tension is still much larger than the viscosity effects, so also Oh<<1, therefore, fibre formation from these low protein concentration solutions has not been possible.
However, increasing the protein concentration increases the shear viscosity of the solution, and the processibility of a fluid with very high (>1 Pa s) shear viscosity is rather poor.
Furthermore, the method has a low technical hurdle with fibres being drawn directly from the silk polypeptide solution at ambient or near ambient conditions.

Method used

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  • Method for production of polymer containing fibres
  • Method for production of polymer containing fibres
  • Method for production of polymer containing fibres

Examples

Experimental program
Comparison scheme
Effect test

example 1

Principle of the Drawing Process

[0198]FIG. 1A shows an aliquot of spinning solution consisting of C16 as the constituent polymer, PAA as the elongational viscosity enhancing polymer, and water as the solvent on a glass microscopy slide, in contact with a plain glass needle as the drawing tool. Pulling the needle, which is in contact with the spinning solution, away from the solution produces a thin fluid filament. This filament, if drawn quickly enough, exists long enough to allow evaporation of the solvent water and the formation of a thin and light fibre (FIG. 1B). The fibres contain protein, which can be shown by IR spectroscopy and by fluorescence microscopy when labelled protein is used.

example 2

Fibres from a Low Concentration Spider Silk Protein

[0199]100 μl spinning solution (10 mg / ml FITC-C16, 1.0 wt % / vol PAA) were placed on a glass microscopy slide. A plain glass needle (5 cm long and 1 mm in diameter) was brought into contact with the spinning solution and then pulled away from the microscopy slide by hand at variable speeds. This process resulted in a fibre being pulled from the spinning solution, the quality of the fibre depended on the speed used. At or above a pulling speed of 10 cm / s, the fibres appeared smooth and homogenous (FIG. 1 C). When pulling at speeds below the threshold, droplets of liquid were still coating the fluid filament and remained after fibre deposition on a clean glass microscopy slide (FIG. 1D). Good fibre formation occurred at a pulling speed of 10 cm / s and above.

example 3

Fibres Pulled by a Falling Steel Bead

[0200]100 μl spinning solution (10 mg / ml C16, 1.0 wt % / vol PAA) were placed next to the rim of glass microscopy slide. A steel bead of 1 mm diameter was placed between rim and a spinning solution, touching the spinning solution. While the microscopy slide was being held by hand, it was tilted slightly to cause the bead falling off the rim. Surprisingly, the falling bead pulled a fibre from the spinning solution not unlike the needle from Example 1. The process of the bead falling and producing a fibre can be compared to a falling spider producing a fibre, although obviously the reservoir of spinning dope is at different ends of the fibre.

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Abstract

The present invention relates to a method of spinning a polypeptide polymer containing fibre. It further relates to a polymer fibre obtainable by said method and to uses thereof. The invention also relates to products comprising said polymer fibre.

Description

[0001]The present invention relates to a method of spinning a polymer fibre. It further relates to a polymer fibre obtainable by said method and to uses thereof. The invention also relates to products comprising said polymer fibre.BACKGROUND OF THE INVENTION[0002]Conventional methods of polymer fibre formation have considerable shortcomings, regarding both methods and products. The methods usually have requirements too harsh for the involvement of biological material such as proteins or cells, regarding conditions in terms of temperature, pressure or the use of chemicals and solvents. The products are normally designed to feature superiority in one property, such as strength, elasticity or weight. However, combining all these properties has proved difficult.[0003]Natural spider silk can assume different forms, depending on the gland it is produced in (Gosline et al., J. Exp. Biol. (202):3295, 1999). Its properties are remarkable: Its tensile strength can be superior to that of steel...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): D01F1/02D01F6/68
CPCC07K7/06C07K14/43563D01F6/68D01F1/02D01F4/00D01D5/00Y10T442/30Y10T442/60
Inventor BAUSCH, ANDREASRAMMENSEE, SEBASTIAN
Owner AMSILK
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