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16749results about How to "High viscosity" patented technology

Crosslinked hyaluronic acid compositions for tissue augmentation

A hyaluronic acid (HA) composition includes crosslinked, water-insoluble, hydrated HA gel particles. The HA includes crosslinks represented by the following structural formula:
HA—U—R2—U—HA
The variables are defined herein. A method of augmenting tissue in a subject includes inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with the HA composition, and applying force to the syringe, to deliver the HA composition into the subject. A method of preparing the HA composition, includes forming water-insoluble, dehydrated crosslinked HA particles, separating the water-insoluble, dehydrated particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method of preparing the crosslinked HA composition includes crosslinking a precursor of the crosslinked HA with a biscarbodiimide in the presence of a pH buffer and dehydrating the crosslinked HA. Also included is a method of augmenting tissue in a subject that is in need of tissue augmentation. A method of stabilizing crosslinked HA includes hydrating water-insoluble, dehydrated crosslinked HA with a physiologically compatible aqueous solution that includes a local anesthetic, wherein the value of storage modulus G′ for the stabilized composition is at least about 110% of the value of G′ for a non-stabilized composition,. Also included is the stabilized HA composition.
Owner:ANIKA THERAPEUTICS INC

Cast form water borne coating and technique for preparing the same

The invention relates to an auxiliary material for casting a mould, in particular to a casting mould water-based coating formulation for a sand mould or an expendable pattern casting (EPC), and a process for preparing the same. The casting mould water-based coating formulation consists of refractory powder, a suspending agent, a bonding agent, a surfactant, a defoaming agent, a corrosion remover and water. The process comprises the following steps: adding the suspending agent to the water directly, and mixing and dispersing the mixture in a high speed dispersion machine; adding auxiliary agents including the defoaming agent, the surfactant, the corrosion remover, and the like to the water, and mixing the auxiliary agents; adding the refractory powder to the mixture to be mixed; and adding the bonding agent to the mixture to be mixed, and then adding water to adjust the coating until the coating has the thickness in a using state to obtain the finished product. The coating prepared by the process has the effects that the coating ensures that a high-density low-viscosity coating has excellent suspension property and storage stability, a coating layer is not easy to crack after drying, the coating is advantageous to improve the capacity of the coating to resist high temperature metal corrosion, and the like.
Owner:深圳市景鼎现代科技有限公司
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