234results about How to "High level" patented technology

Chimeric proteins, and methods for their production and use are disclosed. The chimeric proteins comprise a flexible linker between two zinc finger DNA-binding domains, wherein the linker comprises eight or more amino acids between the second conserved histidine residue of the carboxy-terminal zinc finger of the first domain and the first conserved cysteine residue of the amino-terminal zinc finger of the second domain.

A device for imaging a relief object without illuminating a platen is disclosed. The device includes a single electrode electroluminescent device, which may be inorganic or organic, and a current source. The current source is coupled to the single electrode of the electroluminescent device and to the relief object to be imaged. The valleys and ridges of the relief object couple current to the electroluminescent device at different magnitudes which causes the electroluminescent device to generate light at different intensities that correspond to the ridges and valleys of the relief object. The generated light forms an image of the relief object which may be focused by optical elements onto a sensor array for capture and image processing. In another embodiment of the invention, a one-to-one sensor array is located proximate the electroluminescent device to capture the image. In an embodiment of the invention which insulates the relief object from current, the electroluminescent device is covered with a variable resistance layer and the variable resistance layer is covered with a flexible electrode. One lead from the current source is coupled to the flexible electrode and another lead is coupled to the single electrode. When a relief object is brought in contact with the flexible electrode, a localized pressures generated by the ridges of the relief object form conductive paths through the variable resistance layer which are lower in electrical resistance than those formed by pressure in the areas adjacent the valleys of the relief object. The different magnitudes of current delivered through the conductive paths to the electroluminescent device cause the electroluminescent device to generate an image of the relief object without exposing the relief object to electrical current.

An object of the present invention is to provide an excellent process for production of a surface-treated particulate water-absorbent resin wherein the process adopts a surface-treatment process that can enhance the properties (which the water-absorbent resin is desired to have) to extremely high levels, and also can solve the prior problems in such as safety, and further can sufficiently carry out the treatment even at a reaction temperature near room temperature. As a means of achieving this object, the process according to the present invention for production of a surface-treated particulate water-absorbent resin is characterized by comprising the steps of: adding a treating liquid to a particulate water-absorbent resin as a base polymer, wherein the treating liquid contains a radically polymerizable compound; and then irradiating the particulate water-absorbent resin with active energy rays while fluidizing the particulate water-absorbent resin, thereby surface-treating it.

A method and apparatus are disclosed for a waking system that wakes an individual gradually over a period of time in order to promote the wellness of that individual. The user sets the system controller with a desired final wakeup time, which is the time that the user must be awake. When the actual time reaches a stimulus introduction time (i.e. some time prior to the desired final wakeup time), the system controller causes the introduction of stimulus. The system further comprises a detection system that measures a parameter correlated to the individual's sleep level (preferably motion). This measured parameter is then used in a feedback loop to control the level of stimulus experienced by the individual. In this manner, the user is woken gradually over a period of time between the stimulus introduction time and the desired final wakeup time, without introducing any sudden shocks to the user's physiological systems.

The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR2 gene encoding β1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors and host cells relating to α-mannosidase resistance on glycans.

Systems and methods are provided for managing a robotic assistant. Environment data corresponding to a current environment is collected to determine a type of the current environment based on the collected environment data. One or more objects in the current environment are detected. The one or more objects are associated with the type of the current environment. For each of the one or more objects, one or more interactions are identified based on a type of the respective object and the type of the current environment. Object libraries corresponding to the one or more objects are downloaded. The object libraries include interaction data corresponding to the respective identified one or more interactions. At least a portion of the one or more interactions are executed upon the respective one or more objects.

CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (78) and (88) and/or (91). The CDR-grafted light chains comprise donor residues at at least one of positions (1) and/or (3) and (46) and/or (47) or at at least one of positions (46, 48, 58) and (71). The CDR-grafted antibodies are preferably humanized antibodies, having non human, e.g. rodent, donor and human acceptor frameworks, and may be used for in vivo therapy and diagnosis. A generally applicable protocol is disclosed for obtaining CDR-grafted antibodies.

The present invention relates to methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. The method can include adding substrate continuously or clarifying continuously. The present invention also relates to methods for producing high protein distiller's dried grain from fermentation of plant material, and to the high protein distiller's dried grain produced. The present invention further relates to reduced stack emissions from drying distillation products from the production of ethanol.

Sulfonated aliphatic-aromatic polyester compositions having improved thermal properties, and articles such as films, coatings and laminates, produced from the sulfonated aliphatic-aromatic polyester compositions, are provided. Some of the films are biocompostable. Films made from the sulfonated aliphatic-aromatic copolyesters can be used to make shaped articles, such as sheets, thermoformed containers, and coatings for, for example, films and other substrates. The sulfonated aliphatic-aromatic copolyesters are produced from a mixture of aromatic dicarboxylic acids, aliphatic dicarboxylic acids, certain glycols, and components containing alkali metal or alkaline earth metal sulfonate groups, such as a metal 5-sulfoisophthalic acid derivative.

A semiconductor device, such as a memory device or radiation detector, is disclosed, in which data storage cells are formed on a substrate. Each of the data storage cells includes a field effect transistor having a source, drain, and gate, and a body arranged between the source and drain for storing electrical charge generated in the body. The magnitude of the net electrical charge in the body can be adjusted by input signals applied to the transistor, and the adjustment of the net electrical charge by the input signals can be at least partially cancelled by applying electrical voltage signals between the gate and the drain and between the source and the drain.

A system, method and computer program product for executing a query on linked data sources. Embodiments of the invention generate an instance graph expressing relationships between objects in the linked data sources and receive a query including at least first and second search terms. The first search term is then executed on the instance graph and a summary graph is generated using the results of the executing step. A second search term is then executed on the summary graph.

Personal care products are provided. An exemplary personal care product includes a composition that is applied to the body or clothing, or an article applied against the body; a plurality of particles associated with the composition or a component of the article, the plurality of particles, at least some of the plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 90%, so that the perceptibility of the first fragrance is minimized prior to its release; and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition or article does not contain an antiperspirant active.

A communication and security device for a portable computer is disclosed including a housing, a connector provided on the housing for physical connection to the portable computer, a computer interface coupled to the connector for communicating data with the portable computer, a wireless modem coupled to the computer interface for communicating data between the portable computer and a remote device via a wireless network, a regulator operable to regulate power in the communication and storage device, and a processor coupled to control the regulator, the processor coupled to the wireless modem and arranged to process at least one security command received by the wireless modem to control the regulator in response to the received command.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A control device of a variable damping force damper for controlling a damping force of a damper used in a vehicle suspension system comprises: relative displacement detection means for detecting a value corresponding to a relative displacement between a vehicle body and a wheel in a vertical direction; relative speed detection means for detecting a value corresponding to a relative speed between the vehicle body and the wheel in the vertical direction; multiplying means for multiplying the value corresponding to the relative displacement and the value corresponding to the relative speed; and means for setting a damping force control target value of the damper based on the output from the multiplying means.

The present invention relates to methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. The method can include fractionating the plant material. The present invention also relates to methods for producing high protein distiller's dried grain from fermentation of plant material, and to the high protein distiller's dried grain produced. The method can include drying a co-product by ring drying, flash drying, or fluid bed drying. The present invention further relates to reduced stack emissions from drying distillation products from the production of ethanol.

There is provided a thermosetting light-reflecting resin composition that has a high level of various characteristics required of optical semiconductor element mounting boards, such as optical properties and thermal discoloration resistance, provides high releasability during molding such as transfer molding, and allows molding processes to be performed continuously. There are also provided a highly-reliable optical semiconductor element mounting board and an optical semiconductor device each produced with the resin composition, and methods for efficient production thereof. A thermosetting light-reflecting resin composition is prepared and used, which includes (A) an epoxy resin, (B) a curing agent, (C) a curing catalyst, (D) an inorganic filler, (E) a white pigment, (F) an additive, and (G) a release agent as major components, wherein the resin composition, after curing, has a diffuse reflectance of 80% or more at a light wavelength of 400 nm; and the resin composition is possible to perform transfer molding 100 times or more continuously.

A permanent hair coloring composition is described, the hair coloring composition being produced by combining individually packaged dye, developer and salt components just prior to application to the hair, wherein the dye, developer and salt components are formulated to provide the hair coloring composition with relatively high levels of ammonium carbonate salt, additional soluble carbonate salt other than ammonium carbonate salt, and chelating agent, the ammonium carbonate salt to additional carbonate salt being present in a ratio, by weight of from about 1:0.6 to about 1:1.6, wherein, based on the combined weight of the dye, developer and salt components, the composition has a total soluble carbonate salt content of greater than about 10% by weight, and at least about 1 % by weight of chelating agent. Kits for preparing and methods for using such hair coloring compositions are also disclosed.

The present disclosure relates to plastic or polymeric container with reclosable zippers which make the package child-resistant. In one typical embodiment, this is achieved by a zipper with a high internal opening force and a low external opening force, wherein three flanges are sealed to the bag walls, and one external flange is left unsealed. In order to encounter the low external opening force, the user must grab the unsealed external flange while applying an external opening force to the zipper.

A dilatation balloon for use in combination with a catheter device, the balloon having a waist, cone and body portion and having a first layer formed from a first polymeric composition, the balloon having a second layer disposed on at least a portion of the first layer, the second layer formed from a second polymeric composition which is crosslinked on at least a portion of the dilatation balloon, and methods of making and using the same.

The present invention relates to a upper body exercise apparatus that combines upper body movements to achieve assisted push-up and dip exercise. More particularly, the present invention is associated with an exercise apparatus having separately supported platform for a portion of a user combining coordinated upper body exercise with the motion of the platform. When the torso of a user is positioned on the platform, energy storage devices absorb energy during the down stroke of push-up exercise. As the user begins the up stroke, the absorbed energy assists the user during the up stroke. A pair of handles are provided for dip exercise where the lower body contacts the platform. Further, the exercise apparatus provides adjustable energy storage.

A method (100) of researching and analyzing information contained in documents that belong to a first database (200) and are organized according to a first set of fields (210) for an electronic search and retrieval by a computer (850). The method includes the steps of: a) conducting an electronic search (202) of the first database to retrieve at least one document; b) developing user-defined fields (300); c) reading (310) the at least one document to retrieve information pertaining to the user-defined fields; d) entering into a second database (510) the at least one document, values of the first set of fields for the at least one document, the user-defined fields and the retrieved information pertaining to the user-defined fields; and e) analyzing (506) the information contained in the second database.

Certain appropriately substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with excessive TGFβ activity and certain viral disorders.

EEG-based acceleration of second language learning is accomplished by measuring via single-trial EEG a learner's cognitive response to the presentation (visual or auditory) of language learning materials and updating a user model of latent traits related to language-learning skills in accordance with the cognitive response. The user model is suitably updated with each trial, each trial being triggered by learner fixation on a portion of visual materials and/or a next phoneme in auditory materials. Additional discrimination may be achieved through the use of saccades or fixation duration features.

A method and a device for adjusting a seat are provided. The method includes the acts of detecting a pressure exerted by a user on the seat via a pneumatic sensor and/or a hydraulic sensor, and adjusting the seat based on the pressure exerted by the user. The device includes a pneumatic or hydraulic lifting element, a pneumatic or hydraulic pressure sensor connected to the lifting element, and a control unit connected to the pressure sensor. The pressure sensor detects a pressure exerted by a user on the seat, and the control unit controls the first lifting element to adjust the seat based on the pressure exerted by the user.

A neutron detector technology based on ¹⁰B thin film conversion of neutrons and detection of neutron capture reaction products in a counter gas within a thin straw tube detector body is described. This neutron detector is based on gas-filled thin wall straw tubes, modified for the conversion of neutrons in a very thin coating, or layer, of ¹⁰B, applied for example as a sputter-coated film of ¹⁰B₄C, that lines the interior, or inside of the straw tube surface; and the subsequent detection of the neutron reaction products in the counter gas. One embodiment of this invention employs a closely-packed array of ¹⁰B₄C-lined straw tubes employing a very thin and therefore high efficiency ¹⁰B₄C layer, hence removing the barrier to efficient neutron capture reaction product escape while still providing for efficient neutron capture by providing a plurality of very thin ¹⁰B converters, each individual converter element providing efficient reaction product escape. Using such densely packed straw tube detectors of small diameter, a reasonable stack depth allows a high neutron detection efficiency to be achieved on the 1-10 Å wavelength range of thermal neutrons. The position of each interacting neutron can be accurately obtained with for example, resistive charge division readout combined with straw decoding electronics to determine the identity of the struck straw.

Using spread-spectrum encoding the spread the spectrum of information signals transmitted in an optical communications system enables significantly higher levels of inter-channel interference to be tolerated than in conventional optical communication systems. This allows the bandwidth of the optical channels of the optical communication system to be increased, and the bit rate of the channels to be increased. Applying spread-spectrum encoding to the information signals increases the bit rate of each information signal by a factor of L, but significantly more than L spread-spectrum information signals can be transmitted in the same optical channel and can be successfully recovered at the receiver. Accordingly, using spread spectrum encoding provides a significant increase in the capacity of the optical communication system.

The present invention presents apparatuses and systems for operating multiple computers from a single console using a secured KVM device, while preventing information leakage between the computers. The system comprises several hosts connected through a secured KVM device to keyboard and mouse and one or more user displays. Secured KVM enables standard bi-directional communication between Secured KVM and user keyboard and mouse and between hosts peripheral ports and Secured KVM. Secured KVM physically enforces unidirectional data flow from attached keyboard and mouse to attached hosts peripheral ports to avoid potential leakages between hosts.

The present invention provides a method for identification of differentially methylated genomic CpG dinucleotide sequences within genomic target sequences that are associated with cancer in an individual by obtaining a biological sample comprising genomic DNA from the individual measuring the level or pattern of methylated genomic CpG dinucleotide sequences for two or more of the genomic targets in the sample, and comparing the level of methylated genomic CpG dinucleotide sequences in the sample to a reference level of methylated genomic CpG dinucleotide sequences, wherein a difference in the level or pattern of methylation of the genomic CpG dinucleotide sequences in the sample compared to the reference level identifies differentially methylated genomic CpG dinucleotide sequences associated with cancer. As disclosed herein, the methods of the invention have numerous diagnostic and prognostic applications. The methods of the invention can be combined with a miniaturized array platform that allows for a high level of assay multiplexing and scalable automation for sample handling and data processing. Also provided by the invention are genomic targets and corresponding nucleic acid probes that are useful in the methods of the invention as they enable detection of differentially methylated genomic CpG dinucleotide sequences associated with cancer, for example, adenocarcenomas and sqamous cell carcinomas of the lung.

A security system is provided in multiple geographic regions having a master server with a master database storing information for access control in each of the regions, and each region has an access control system having a regional server with a regional database storing information for access control in the region, one or more cameras for capturing video data, and one more digital video recorders for storing video data from the cameras. In each region, the regional server receives events from one of the access control system, or other systems which may be present in the region, such as intrusion detection systems, fire systems, or information systems. When received event data is linked in the regional database to a camera in the region, the regional server generates a record to store event video information in the regional database having data representative of the event, the camera linked to the event, the digital video recorder storing video data from the linked camera, and date and time information related to a period of time over which the event occurred. At the regional level, one or more regional video archive servers are provided in each region for archiving video data from the region's digital video recorders. At the master level, a master video archive server is coupled to the master server for archiving video data from the regional video archive servers. If a regional video archive server is not present in a region, video data may be archived from the region's digital video recorders to the master video archive server via the master server. If the video data archived at the regional or master level is associated with event video information stored in a regional database, such event video information is updated to include data representative of the video archive server containing the video data related to the events and the file names under which such video data related to the events are stored on that video archive server.