119 results about "Action potential" patented technology

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

Sensing an evoked response to electrical stimulation of target tissue of a patient in conjunction with an intra-luminal electrode. The intra-luminal electrode may be implanted in a blood vessel or similar lumen proximal to the target tissue and the sensed signals and / or delivered stimulation may pass through the blood vessel. or other lumen, walls. In some examples the evoked response may be an evoked compound action potential (ECAP), which may also be evoked resonant neural activity (ERNA). The electrical stimulation may elicit a measurable response indicative of a thought pattern or neural state that would otherwise be undetectable using a non-evoked biopotential.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

The invention provides a method for removing noise signals in a brain-computer interface through a force-electric decoupling method, and the method comprises the steps: collecting signals generated in the brain-computer interface, including electric signals transmitted by nerve fibers, interference electric signals and electric signals caused by force signals of various loads in the brain; electric signals caused by action potential are removed through the force-electricity constitutive relation of the liquid-containing porous material, electric signals caused by force signals of various loads in the brain are decoupled, and electric signals conducted by nerve fibers are reserved. According to the method, noise signals generated due to the electrokinetic effect in the brain-computer interface can be effectively removed, and electric signals conducted by nerve fibers can be accurately obtained.

A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.

A spinal cord machine interface (SCMI) device is described. The SCMI includes an intraspinal probe, composed of at least one implantable shank. The implantable shank include a sensing electrode array and a stimulating electrode array. The SCMI also includes an application specific integrated circuit (ASIC). The ASIC is configured to detect action potentials from a patient's spine using the sensing electrode array and to stimulate a target action of the patent using the stimulating electrode array according to a location of the action potentials in a spinal cord and a learned mapping of the location of the action potentials to the target action.

Methods, systems, and computer-implementable algorithms for determining time-varying pulses for a patient with an implantable stimulator device (ISD) are disclosed. At least one time-invariant tonic stimulation pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements can be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements can include one or more features determined from an epidural spinal cord electrogram (ESG) signal detected by the ISD, which can include an evoked compound action potential. The one or more measurements are used to determine a score for the TVP, which is useful in selecting the best TVP for use with the patient, or for adjusting the modulation function applied to the tonic stimulation parameters.

Compounds having a 3,4,6-substituted benzocyclobuten-1-yl-methylamine structure, pharmaceutical compositions and methods employing use thereof for treating acute or chronic bipolar disorders, neuropsychiatric disorders, neurodegenerative conditions and other health conditions associated with neuronal excitability or dysregulated synaptic neurotransmission. The disclosed compounds selectively and rapidly reduce the frequency of action potentials in cortical pyramidal neurons by modulating presynaptic glutamate release while preserving GABAergic neurotransmission and single action potential properties. Selective modulation of excitatory neurotransmission achieves rapid therapeutic effects within minutes to hours after ingestion without disrupting inhibitory transmission, presenting a therapeutic approach for neurological conditions characterized by neuronal hyperexcitability and other pathological excitatory-inhibitory neurotransmission imbalance.

In some embodiments, a method of providing a neurostimulation therapy to a patient, comprises: generating electrical pulses, by an implantable pulse generator (IPG), comprising respective bursts of a plurality of anodic pulses with each anodic pulse being separated by a time gap, wherein (1) the plurality of anodic pulses comprise successively increasing charge; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each burst of anodic pulses is followed by a discharge phase of intermittent time periods to discharge charge build up from the anodic pulses; and (4) each successive intermittent time period increases in time through the discharge phase to avoid action potential (AP) generation; and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient.

Devices, systems, and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce arrhythmia, such as tremor of the heart, and thus eliminates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically used to avoid delivery of energy during portions of the cardiac cycle that are susceptible to effect to induce fibrillation. Thus, parameters are manipulated herein to reduce the probability of inducing an arrhythmia. Typically, high voltage energy may trigger premature action potentials within the myocardium because the delivered energy increases myocardial cell membrane permeability, allowing ion transport, which may induce arrhythmias, especially ventricular fibrillation. However, shorter pulse durations (i.e., higher frequencies, e.g., 100 kHz to 600 kHz) and biphasic waveform shapes both theoretically and practically reduce the probability of inducing an arrhythmia.

The invention provides an efficient enrichment and purification method of adipose-derived stem cell exosomes. According to the invention, the sex determining gene is used for distinguishing and identifying the adipose-derived mesenchymal stem cells from different sources for the first time, and then the culture medium containing specific sex hormone and regulatory factors is used for realizing in-vitro amplification of the adipose-derived mesenchymal stem cells, so that convenience is provided for preparation of the adipose-derived mesenchymal stem cell exosome. According to different sources of adipose-derived stem cell exosomes, different effects of the adipose-derived stem cell exosomes are respectively verified, and the male adipose-derived stem cell exosomes can realize skin injury repair by effectively promoting fibroblast proliferation; the female adipose-derived stem cell exosome can realize nerve injury protection by regulating the nerve conduction velocity and action potential incubation period of an injured part.

Therapy can be determined using evoked compound action potentials (ECAPs). For example, a medical device includes stimulation generation circuitry and processing circuitry. The processing circuitry is configured to determine whether a characteristic of a first ECAP is greater than a threshold ECAP characteristic value. Based on the characteristic of the first ECAP being greater than the threshold ECAP characteristic value, the processing circuitry is configured to decrease a parameter of a first set of pulses delivered by the stimulation generation circuitry after the first ECAP. Additionally, the processing circuitry is configured to determine whether a characteristic of a second ECAP is less than the threshold ECAP characteristic value, and based on the characteristic of the second ECAP being less than the threshold ECAP characteristic value, increase a parameter of a second set of pulses delivered by the stimulation generation circuitry after the second ECAP.

An adaptive dual-threshold generator based on a nonlinear energy operator for action potential detection, wherein a NEO circuit generates suitable positive and negative thresholds by processing a signal to be detected. The positive and negative thresholds are transmitted to a peak voltage comparator and a valley voltage comparator via a peak hold circuit and a valley hold circuit. The signal to be detected is compared with the positive and negative thresholds by the peak voltage comparator and the negative voltage comparator, respectively. After the negative threshold is detected, a window delay circuit is used. Only when a positive peak is captured within a window period and exceeds the positive threshold, authentication detection of the action point is achieved. An adder is then used to superimpose the positive and negative peaks, and a synthesized detection result is output. Finally, a counter is used to count the number of action potentials contained in the signal to be detected, thereby achieving action potential detection based on an adaptive dual-threshold generator of a nonlinear energy operator.

This document discusses, among other things, systems and methods for providing pain relief to a patient. Recording circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to external stimulation of a location where the patient is experiencing pain. The received electrical signals may be stored in a memory. Internal stimulation may then be applied to the patient and control circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to the internal stimulation. The control circuitry may then adjust electrical parameters of the internal stimulation, such as to reduce a difference between the electrical signals corresponding to evoked compound action potentials produced in response to the internal stimulation and electrical signals corresponding to evoked compound action potentials produced in response to the external stimulation.

The invention relates to the technical field of biomedical engineering, and provides a tongue body motion form reconstruction and neuromuscular lesion recognition method, which comprises the following steps: S1, acquiring a multi-modal original signal by using a flexible electrode array attached to a lingual surface, and recording a system timestamp; s2, performing targeted filtering, artifact removal and feature extraction processing on the multi-mode original signal; s3, reconstructing a local dynamic curved surface of the lingual surface by adopting a preset model, and inferring an overall position and posture sequence of the tongue body in combination with an IMU signal; s4, a joint optimization objective function is constructed, and a tongue body three-dimensional dynamic form sequence is obtained through iterative solution; s5, performing motion unit action potential MUAP decomposition and feature extraction on the surface electromyogram signal sEMG; and S6, constructing lesion feature vectors based on the multi-dimensional abnormal features, and analyzing and generating a tongue lesion risk map TDM through a machine learning model. The defects that real motion reconstruction, form inference and neuromuscular lesion positioning of the tongue cannot be achieved through an existing tongue detection technology are overcome.

Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

Systems and methods for programming a neuromodulation system are provided. One or more electrodes may be determined to enable at least one of a target stimulation therapy or a target alternative stimulation therapy. The device may be programmed with one or more parameters based on the target stimulation therapy or the target alternative stimulation therapy. A signal corresponding to the stimulation when a user performs an aggressor movement may be received and one or more parameters may be adjusted when the signal corresponding to the stimulation when the user performs the aggressor movement does not include an electrically evoked compound action potential (ECAP). Alternatively or additionally, one or more thresholds may be set when the signal corresponding to the stimulation when the user performs the aggressor movement includes the ECAP.

Evaluation and adjustment of time-varying pulse patterns in spinal cord stimulator systems are disclosed. Methods, systems, and computer-implemented algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant stimuli pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements may include one or more features determined from electrospinal cord (ESG) signals detected by the ISD, which may include evoked composite action potentials. One or more measurements are used to determine a score of TVP, which is useful in selecting an optimal TVP for use with a patient, or in adjusting a modulation function applied to an ankylosing stimulation parameter.

The invention discloses a progressive risk prevention and control system and method for an electrical stimulation physiotherapy instrument, and belongs to the technical field of medical equipment. The system integrates a central control unit, and an electrode contact quality detection module, a nerve excitation threshold detection module, an electromagnetic environment interference detection module, a risk grade evaluation module and a strategy generation module which are electrically connected with the central control unit. The system evaluates the risks of electrode poor contact, nerve over-excitation and electromagnetic interference respectively by detecting a micro-current contact impedance dynamic spectrum, a myoelectricity composite action potential incubation period change rate and a stimulation waveform distortion entropy. The system adopts a progressive detection method, divides risks into three levels according to key indexes such as a contact quality index, a latency drift index and waveform distortion entropy, and automatically generates corresponding prevention and control strategies for different risk levels, such as automatic deoxidation pulse, adaptive reduction of stimulation parameters or emergency termination of treatment. Accurate risk identification and dynamic prevention and control in the electrical stimulation physiotherapy process are realized, and the safety is improved.

Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

This application discloses a personalized rehabilitation system for cochlear implant surgery based on multimodal data fusion, belonging to the field of rehabilitation equipment technology. The system includes: a data acquisition and processing module for acquiring the original electrically evoked compound action potential (EEP) signals of the test subject and generating a neural response feature vector based on the original EEP signals; a personalized parameter mapping module for generating the test subject's subjective comfort threshold for the maximum electrical stimulation level based on the neural response feature vector and the test subject's clinical data; adjusting the subjective comfort threshold based on real-time biofeedback signals; and a rehabilitation training module for constructing a VR training scenario, electrically stimulating the test subject's cochlea according to the subjective comfort threshold, and acquiring the test subject's real-time biofeedback signals in the VR training scenario. This application effectively applies objective original EEP signals to personalized parameter mapping of the cochlear implant, reducing reliance on the test subject's subjective feedback and improving the accuracy and efficiency of mapping.

To solve the problem of the present invention, a biological electrode for measuring an action potential of an intestine and predicting a defecation timing based on the potential waveform, an intestinal potential measuring device using the biological electrode, and a defecation prediction method are provided. The biological electrode (2) includes a sheet body (3) having a back surface (31) as an attachment surface (31). The sheet body (3) includes a plurality of electrode patch portions (300, 301) that can be arranged at intervals along an intestinal canal (91) of a large intestine and have electrodes (4) for acquiring an intestinal potential exposed on the back surface (31), a central device mounting portion (310, 301) that is arranged within a range in which the plurality of electrode patch portions (300, 301) are annularly connected and has a plurality of connected terminals (311) that are electrically connected to connection terminals (50) of an electrogastrograph (5) and a mounting portion (312) for temporarily fixing a temporary fixing portion (51) of the electrogastrograph (5) exposed on a surface (30), and a lead wire extension portion (320, 321) in which lead wires (322) that connect the plurality of electrode patch portions (300, 301) and the plurality of connected terminals (311) are fixed, respectively.

A pulse generator system that facilitates asynchronous ignition of recruited neurons includes an implantable pulse generator (IPG) that is capable of sensing a degree of synchronous ignition of recruited neurons in tissue of a patient and modifying a stimulation procedure to facilitate asynchronism and reduce sensory abnormalities. An evoked composite action potential (ECAP) of the recruited neurons is sensed by the at least one non-active electrode as a measure of synchronism. An ECAP algorithm operable in the IPG evaluates the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are a synchronous fire or a non-synchronous fire. If the shape parameter indicates significant synchronism, the ECAP algorithm may adjust the stimulation procedure to facilitate non-synchronous firing.