208 results about "Action potential" patented technology

Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP -based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve the use of electrode leads implanted within the spine of a patient to record nerve responses induced by a stimulus. The disclosed neural responses differ in various aspects from the electrical responses previously measured in the SCS context, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur at a later time after inducing the stimulation pulse. Another significant feature is that when the frequency of evoked stimulation is ultra-low, such as about 10 Hz or less, the disclosed neural response is most significantly observed at a consistent, relatively constant amplitude as a whole. The disclosed methods and systems may use these neural responses as indications of pain, treatment, and / or another clinically relevant dimension to guide / confirm stimulation placement, as well as feedback control for stimulation parameters.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP-based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

The invention relates to the use of cannabidiol (CBD), at a dose of greater than 300 mg / day, in combination with a standard anti-epileptic drug (SAED) which acts via sodium or calcium channels, for use in the treatment of epilepsy. The SAED is preferably one which •modities low-threshold or transient neuronal calcium currents, or •reduces high-frequency neuronal firing and sodium-dependent action potentials and enhances GABA effects. Preferred SAEDs are ethosuximide and valproate.

The invention relates to the technical field of medical health data information decoding analysis and processing, and particularly discloses a dynamic pain nerve decoding and intervention system based on a prefrontal lobe time sequence characteristic window, which comprises a signal acquisition module, a dynamic window control module, a phase prediction module, an intervention execution module and an event driving controller. The dynamic window control module intelligently adjusts the duration of a signal analysis window through real-time calculation of the energy ratio of a # imgabs 0 # frequency band to a # imgabs 1 # frequency band, and accurately locks a transient characteristic window in a pain outbreak period; the phase prediction module realizes millisecond-level synchronization of stimulation pulse and a rising edge of action potential of a neural cluster based on a two-factor mapping mechanism of an individualized conduction velocity level and an oscillation frequency; the event-driven controller reduces the power consumption to a wearable device level while maintaining 10 ms-level real-time response through a dynamic resource allocation strategy.

The invention provides a closed-loop rTMS regulation and control system driven by a biomarker. Relates to the technical field of closed-loop rTMS diagnosis and treatment. In the previous closed-loop rTMS intervention process, mostly evoked potentials, such as action potentials and local field potentials, which have limited representation degrees on autonomous motion functions are monitored; therefore, a closed-loop rTMS intervention system capable of dynamically monitoring spontaneous rhythmic oscillation PMBS with high representativeness on the upper limb movement function is established, the existing closed-loop rTMS intervention paradigm mostly depends on operation tasks, scales or EMG measurement and other means to evaluate the intervention curative effect, interaction between hemispheres represented by EEG is considered in the assessment of the upper limb movement rehabilitation capacity, and the intervention effect is improved. Therefore, the movement coordination of the upper limbs on the two sides is evaluated.

According to the three-dimensional electric field coupling modeling method for analgesia provided by the invention, the propagation process of an electric field in each physiological tissue is accurately simulated by constructing a multi-layer bionic tissue model, so that the accuracy and effect of analgesia treatment are improved; calculating the conductivity and dielectric constant of each layer of tissue, performing numerical simulation on electric field distribution by using a finite element analysis technology, optimizing electrode configuration and electrical stimulation parameters, and ensuring the uniformity and stability of the electric field of a target area; a neurophysiology model is integrated, the conduction law of nerve fiber action potential is dynamically simulated, the stimulation effect of electric field intensity on nerve fibers is quantitatively analyzed, analgesia parameters are further optimized, and accurate control over pain signal transmission is achieved. The problems that in an existing electrical stimulation technology, electric field distribution is not uniform, electrode contact is not stable, and the stimulation effect is difficult to last are effectively solved, wide clinical application prospects are achieved, and an efficient, stable and accurate solution is provided especially in non-invasive treatment of chronic pain.

The application provides a heart electrophysiology simulation system, comprising: an image acquisition module for acquiring a plurality of thoracic cavity images; the three-dimensional grid reconstruction module is used for obtaining a ventricle three-dimensional grid through a finite element method according to the plurality of thoracic cavity images; the ventricular conduction network construction module is used for generating a ventricular conduction network according to the ventricular three-dimensional grid, the ventricular conduction network comprises a plurality of first grid points, and the geometric position of each first grid point shares the point cloud of the ventricular three-dimensional grid; the electrophysiological parameter simulation module is used for simulating the conduction process of the heart action potential in the ventricle according to the geometric position of the first grid point and electrophysiological parameters, and the electrophysiological parameters comprise cell level parameters and tissue level parameters; and the dynamic simulation module is used for simulating the cardiac electric signal according to the conduction process of the cardiac action potential in the ventricle to obtain a dynamic simulation result.

Methods and systems for performing spinal cord stimulation in the cervical spine while sensing for an evoked response, such as an evoked synaptic action potential (ESAP) at a different location from the location of stimulation. A first lead may be positioned in the cervical spine for issuing therapy pulses, and sensing is performed at a thoracic or lumbar location, or a caudal cervical location relative to the location of stimulation. First and second leads may be used in a single system, or two separate systems, one for stimulation and another for sensing, may be used.

The invention discloses application of a Cpeb3 gene inhibitor and a copper death inhibitor in preparation of a medicine for treating myocardial ischemia-reperfusion injury, and relates to the technical field of myocardial ischemia-reperfusion injury. By specifically reducing or knocking out Cpeb3 expression, myocardial repair can be remarkably promoted, action potential stability is improved, and the death rate is reduced. Therefore, Cpeb3 is a specific intervention target spot of copper death in Gpc6 + CMs. The small molecule inhibitor of Cpeb3 can remarkably reverse changes of copper death, aerobic respiration and / or glycolysis caused by Cpeb3 activation. In addition, the copper death inhibitor can improve the survival rate of myocardial cells, reverse the change of aerobic respiration and / or glycolysis induced by Cu, and reverse the change of glycolysis, pentose phosphate pathway and tricarboxylic acid cycle metabolites caused by Cu stimulation. Therefore, the invention provides a new solution for prevention and treatment of myocardial ischemia reperfusion injury, and has a good application prospect.

A method of evaluating spinal cord stimulation (SCS), comprising obtaining neural response data generated by a spinal cord stimulator, where the neural response data describes one or more neural signals evoked in the spinal cord of a patient by applying diagnostic stimuli. One or more evoked compound action potentials (ECAPs) associated with the respective one or more neural signals are detected. The one or more detected ECAPs are processed to generate one or more evaluation metrics, and the one or more evaluation metrics are used to generate a confidence score indicating a degree of effectiveness of SCS on the patient.

Disclosed are various examples and embodiments of systems, devices, components and methods configured to estimate the action potential wave propagation in a patient's heart, and subsequently to detect at least one location or type of at least one source of, or rotational phenomenon associated with, at least one cardiac rhythm disorder using intracardiac electrodes and a modified multi-frame Horn-Schunck algorithm to generate a map corresponding to a spatial map, the map being configured to reveal on a monitor or display to a user the at least one location of the at least one source of the at least one cardiac rhythm disorder.

The disclosure relates to a computer-implemented method for monitoring diaphragmatic response to phrenic nerve stimulation. The method comprises receiving in real-time a diaphragmatic CMAP signal. The method comprises computing a baseline value of a characteristic of the CMAP signal. The characteristic represents a diaphragmatic response intensity to a phrenic nerve stimulation. The method comprises determining a threshold value of the characteristic, representing a boundary of values of the characteristic indicative of upcoming diaphragmatic palsy. The determining of the threshold value includes shifting the baseline value. The method comprises receiving in real-time a ECG signal. The method comprises repeating in real-time: detecting a QRS complex in the ECG signal, monitoring the CMAP signal, computing a real-time value of the characteristic, comparing the real-time value to the threshold value, and outputting an alert when the threshold is passed. The real-time value of the characteristic is asynchronous to the QRS complex.

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

The invention discloses a target physiotherapy instrument based on unipolar electricity and a target adjusting method thereof, and the target physiotherapy instrument comprises a physical sign detection bracelet which is used for detecting the heartbeat and body temperature of a human body and transmitting the heartbeat and body temperature to a host, and the host adjusts the parameters of a required electric field according to the heartbeat and body temperature changes; the power adjusting circuit controls the space electric field generator to output an electric field with corresponding electric field intensity according to the parameters of the required electric field; the frequency adjusting circuit is used for controlling the duration and the frequency of action potential periods in different periods according to the cell types of different targeted parts; and the space electric field generator comprises an electric field emission unit and a booster circuit connected with the frequency regulation circuit, and the electric field emission unit outputs to a targeted part according to regulation and control of the power regulation circuit and the frequency regulation circuit to form a monopolar space electric field. By monitoring the temperature and heartbeat changes of the human body in real time, parameters are automatically adjusted and adjusted, and the method has the advantages of being high in adjusting speed and high in precision.

Device / system that provides pain relief by delivering stimulation that neither generates action potentials nor completely blocks neural transmission (in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve) to alter the frequency of physiologically generated neural transmission.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

The present invention relates to the technical field of microbial pharmaceutical chemistry, specifically to a method for preparing a Penicillium fungus ( Penicillium daleae The present invention relates to the medical use of a polyketide compound with a unique cage-like structure isolated from the fermentation product of a strain of the bacterium Mycobacterium spp. Using patch-clamp techniques to measure the action potential discharge frequency and spontaneous excitatory post-synaptic currents (sEPSCs) of hippocampal basket cells, the present invention confirmed that the compound has significant inhibitory activity on neuronal excitability and is non-toxic to N2a neurons at active concentrations. The compound can be used to prepare new drugs for treating diseases associated with neuronal hyperexcitability.

Sensing an evoked response to electrical stimulation of target tissue of a patient in conjunction with an intra-luminal electrode. The intra-luminal electrode may be implanted in a blood vessel or similar lumen proximal to the target tissue and the sensed signals and / or delivered stimulation may pass through the blood vessel. or other lumen, walls. In some examples the evoked response may be an evoked compound action potential (ECAP), which may also be evoked resonant neural activity (ERNA). The electrical stimulation may elicit a measurable response indicative of a thought pattern or neural state that would otherwise be undetectable using a non-evoked biopotential.

The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.

An example apparatus for electro-medical stimulation includes a current generator to generate a sine wave output treatment signal, and a processor coupled to the current generator to modulate a frequency and a power of the sine wave output treatment signal over a cycle of stimulation treatment to produce periods of action potential for a stimulatory treatment phase and periods of non-action potential for a rest treatment phase. The cycle of stimulation treatment includes a first time period followed by a second time period, and during the first time period, the cycle of stimulation treatment is in a period of action potential for the stimulatory treatment phase, and during the second time period, the cycle of stimulation treatment is in a period of non-action potential for the rest treatment phase.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

The invention discloses a myocardial cell intracellular action potential recording system based on double-phase pulse electroporation, and belongs to the technical field of electrophysiological recording, and the system comprises a double-phase pulse electroporation module which is connected with a microcontroller and a myocardial cell sensor, and is used for receiving a pulse signal sent by the microcontroller, converting the pulse signal into a double-phase pulse signal, and transmitting the double-phase pulse signal to the myocardial cell sensor; issuing to myocardial cells; the myocardial cell sensor is used for acquiring intracellular electric signals, transmitting the intracellular electric signals to the data acquisition card module through the first-stage amplification circuit and the second-stage amplification circuit which are connected in sequence, and outputting the intracellular electric signals to the microcontroller through the analog-to-digital converter, so that the intracellular action potential recording of myocardial cells is completed. According to the application, the biphase pulse signal is used as the electroporation stimulation signal, so that the damage to the cell membrane can be effectively reduced, the integrity and physiological activity of the cell can be maintained, and the electrical signal change of the cell before and after stimulation can be better recorded, thereby better recording the intracellular action potential and reflecting the electrophysiological characteristics of the cell.