66 results about "Action potential" patented technology

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

Sensing an evoked response to electrical stimulation of target tissue of a patient in conjunction with an intra-luminal electrode. The intra-luminal electrode may be implanted in a blood vessel or similar lumen proximal to the target tissue and the sensed signals and / or delivered stimulation may pass through the blood vessel. or other lumen, walls. In some examples the evoked response may be an evoked compound action potential (ECAP), which may also be evoked resonant neural activity (ERNA). The electrical stimulation may elicit a measurable response indicative of a thought pattern or neural state that would otherwise be undetectable using a non-evoked biopotential.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.

Therapy can be determined using evoked compound action potentials (ECAPs). For example, a medical device includes stimulation generation circuitry and processing circuitry. The processing circuitry is configured to determine whether a characteristic of a first ECAP is greater than a threshold ECAP characteristic value. Based on the characteristic of the first ECAP being greater than the threshold ECAP characteristic value, the processing circuitry is configured to decrease a parameter of a first set of pulses delivered by the stimulation generation circuitry after the first ECAP. Additionally, the processing circuitry is configured to determine whether a characteristic of a second ECAP is less than the threshold ECAP characteristic value, and based on the characteristic of the second ECAP being less than the threshold ECAP characteristic value, increase a parameter of a second set of pulses delivered by the stimulation generation circuitry after the second ECAP.

The invention relates to the technical field of biomedical engineering, and provides a tongue body motion form reconstruction and neuromuscular lesion recognition method, which comprises the following steps: S1, acquiring a multi-modal original signal by using a flexible electrode array attached to a lingual surface, and recording a system timestamp; s2, performing targeted filtering, artifact removal and feature extraction processing on the multi-mode original signal; s3, reconstructing a local dynamic curved surface of the lingual surface by adopting a preset model, and inferring an overall position and posture sequence of the tongue body in combination with an IMU signal; s4, a joint optimization objective function is constructed, and a tongue body three-dimensional dynamic form sequence is obtained through iterative solution; s5, performing motion unit action potential MUAP decomposition and feature extraction on the surface electromyogram signal sEMG; and S6, constructing lesion feature vectors based on the multi-dimensional abnormal features, and analyzing and generating a tongue lesion risk map TDM through a machine learning model. The defects that real motion reconstruction, form inference and neuromuscular lesion positioning of the tongue cannot be achieved through an existing tongue detection technology are overcome.

Evaluation and adjustment of time-varying pulse patterns in spinal cord stimulator systems are disclosed. Methods, systems, and computer-implemented algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant stimuli pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements may include one or more features determined from electrospinal cord (ESG) signals detected by the ISD, which may include evoked composite action potentials. One or more measurements are used to determine a score of TVP, which is useful in selecting an optimal TVP for use with a patient, or in adjusting a modulation function applied to an ankylosing stimulation parameter.

The invention discloses a progressive risk prevention and control system and method for an electrical stimulation physiotherapy instrument, and belongs to the technical field of medical equipment. The system integrates a central control unit, and an electrode contact quality detection module, a nerve excitation threshold detection module, an electromagnetic environment interference detection module, a risk grade evaluation module and a strategy generation module which are electrically connected with the central control unit. The system evaluates the risks of electrode poor contact, nerve over-excitation and electromagnetic interference respectively by detecting a micro-current contact impedance dynamic spectrum, a myoelectricity composite action potential incubation period change rate and a stimulation waveform distortion entropy. The system adopts a progressive detection method, divides risks into three levels according to key indexes such as a contact quality index, a latency drift index and waveform distortion entropy, and automatically generates corresponding prevention and control strategies for different risk levels, such as automatic deoxidation pulse, adaptive reduction of stimulation parameters or emergency termination of treatment. Accurate risk identification and dynamic prevention and control in the electrical stimulation physiotherapy process are realized, and the safety is improved.

Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

This application discloses a personalized rehabilitation system for cochlear implant surgery based on multimodal data fusion, belonging to the field of rehabilitation equipment technology. The system includes: a data acquisition and processing module for acquiring the original electrically evoked compound action potential (EEP) signals of the test subject and generating a neural response feature vector based on the original EEP signals; a personalized parameter mapping module for generating the test subject's subjective comfort threshold for the maximum electrical stimulation level based on the neural response feature vector and the test subject's clinical data; adjusting the subjective comfort threshold based on real-time biofeedback signals; and a rehabilitation training module for constructing a VR training scenario, electrically stimulating the test subject's cochlea according to the subjective comfort threshold, and acquiring the test subject's real-time biofeedback signals in the VR training scenario. This application effectively applies objective original EEP signals to personalized parameter mapping of the cochlear implant, reducing reliance on the test subject's subjective feedback and improving the accuracy and efficiency of mapping.

To solve the problem of the present invention, a biological electrode for measuring an action potential of an intestine and predicting a defecation timing based on the potential waveform, an intestinal potential measuring device using the biological electrode, and a defecation prediction method are provided. The biological electrode (2) includes a sheet body (3) having a back surface (31) as an attachment surface (31). The sheet body (3) includes a plurality of electrode patch portions (300, 301) that can be arranged at intervals along an intestinal canal (91) of a large intestine and have electrodes (4) for acquiring an intestinal potential exposed on the back surface (31), a central device mounting portion (310, 301) that is arranged within a range in which the plurality of electrode patch portions (300, 301) are annularly connected and has a plurality of connected terminals (311) that are electrically connected to connection terminals (50) of an electrogastrograph (5) and a mounting portion (312) for temporarily fixing a temporary fixing portion (51) of the electrogastrograph (5) exposed on a surface (30), and a lead wire extension portion (320, 321) in which lead wires (322) that connect the plurality of electrode patch portions (300, 301) and the plurality of connected terminals (311) are fixed, respectively.

Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP)signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.

The invention discloses an external field generator, a probe based on external field driving and a neural electrode system. Wherein the neural electrode system comprises an external field generator and a probe which are in signal connection; the probe is used for being fixed in a designated brain area and collecting action potentials of neurons in the brain, and the probe is provided with a composite coating containing an external field response material and a conductive material. The external field generator is used for driving the external field response material in the composite coating to drive the conductive material to perform gradient migration along the short axis of the scar so as to form a continuous conductive micro-channel. The external field response conductive material is used between the glial cells to construct the conductive micro-channel, so that the insulated glial scar is converted into the artificial neural pathway, the total impedance of an electrode-tissue interface is reduced by a plurality of orders of magnitude, the fidelity of electroencephalogram signals is remarkably improved, and the service life of the electrode is prolonged.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

The invention discloses a 3D printing flexible nano-silver electrode array device and an intracellular electrophysiological detection method thereof, a novel flexible nano-silver electrode array FlexNEA device is developed by using a multi-material electric field driven micro-jet 3D printing technology, and a simple, efficient and low-cost strategy is provided for manufacturing of micro-nano sensing devices. In combination with an independently researched and developed integrated biosensing-regulation electrophysiological system, sensitive intracellular action potential recording of myocardial cells is realized through minimally invasive electroporation, so that repeatable intracellular access and accurate efficacy evaluation are realized.

The present disclosure relates to systems and methods for analyzing extracellular electrophysiological recordings are disclosed. Extracellular electrophysiological recordings captured by at least one recording device are received, and for each of a plurality of neurons, a waveform feature representing a shape of an extracellular action potential and an interspike-interval feature representing a temporal distribution of intervals between successive action potentials are extracted. One or more conditional variational autoencoders, conditioned on a recording source descriptor associated with the recording device, generate a waveform latent code and a timing latent code from the respective features. The waveform latent code and the timing latent code are fused to produce a multimodal latent embedding for each neuron. One or more analysis operations are performed on the multimodal latent embeddings to generate an analysis result characterizing the plurality of neurons, including batch harmonization to reduce source-dependent variation and classification of neurons into neuronal categories.

A neural stimulation device is disclosed, including: a pulse generator, an evoked compound action potential (ECAP) sensor, and a neural stimulation controller. The neural stimulation controller instructs the ECAP sensor to sense an ECAP after a pulse is generated by the pulse generator within a first pulse generation cycle, adjust an amplitude of a pulse generated within a second pulse generation cycle in response to a peak-to-peak value of the ECAP being not in a comfort range, and adjust, according to an expected peak-to-peak value, an amplitude of a pulse generated within a third pulse generation cycle in response to a peak-to-peak value of the ECAP after the pulse is generated within the second pulse generation cycle being still not in the comfort range. The expected peak-to-peak value is in the comfort range including an amplitude dimension of the pulse and a peak-to-peak value dimension of the ECAP.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for performing spinal cord stimulation in the cervical vertebra while sensing evoked responses, such as evoked burst actuation potentials (ESAPs) at locations different from the stimulation location. The first lead may be positioned in the cervical vertebra for emitting a therapy pulse and performing sensing at a thoracic or lumbar location, or at a cervical caudal location relative to a stimulation location. The first and second leads may be used in a single system, or two separate systems may be used, one for stimulation and the other for sensing.

Controlling a neural stimulus comprises applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured, and from the measured evoked response a feedback variable is derived. Loop backoff behaviour is adjusted by applying a non-identity function to the feedback variable to produce a revised feedback variable, and completing a feedback loop by using the revised feedback variable to control the at least one stimulus parameter so as to maintain the feedback variable at a setpoint. Additionally, or alternatively, loop gain can be adjusted in response to a change in the loop setpoint, and / or a logarithm of the stimulus parameter can be controlled.

The application discloses a design method of an alternating current stimulation Hodgkin-Huxley cardiac Purkinje fiber model, and the dynamic characteristics of the model under different alternating current parameters and different initial conditions are observed through a phase plane orbit, a waveform, a bifurcation diagram and a Lyapunov exponent spectrum, and multiple coexisting membrane action potential modes are revealed, corresponding to the same or different periodic coexisting attractors in a phase diagram. The model experiences period, quasi-period and forward or reverse period-doubling bifurcation with the change of an amplitude A or a frequency f, and it is proved that the cardiac Purkinje fiber model with alternating current injection has complex nonlinear characteristics. By changing a current I m , a sodium ion equilibrium potential E Na and a potassium ion equilibrium potential E K , heartbeat frequency rules are observed, and state conversion of the cardiac Purkinje fiber between normal, abnormal and sudden cardiac arrest is found. The application provides a reference for exploring the evolution rules of nonlinear dynamics in the HH CPF model, protecting life and heart health.

Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and / or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient, such as to quantify or measure lead migration and adjust a neurostimulation therapy for the patient to account for an impact of any detected lead migration, or other purposes (e.g., to guide an implant procedure).

The invention discloses photosynthesis-imitating radio stimulation hydrogel as well as a preparation method and application thereof. The hydrogel is prepared by taking polyvinylpyrrolidone, pyrrole, protein and sodium copper chlorophyllin as raw materials. By imitating the primary photochemical reaction in photosynthesis, a high-conductivity and high-compliance hydrogel biological interface in which the chlorophyll-protein compound efficiently captures light energy and the modified polypyrrole nano particles quickly diffuse carriers is constructed, and the generated photocurrent can effectively induce action potential, so that the bioactivity of the hydrogel is improved. Accurate regulation and control of nerve excitation and composite muscle action potential are realized, and a key basis is provided for regulation of electrophysiological signals in a nerve repair process; the biological interface exhibits multiple therapeutic effects, including immediate reconstitution of neural function, promotion of neural repair while inhibiting muscle atrophy, and acceleration of epidermal wound healing.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.