7 results about "Interneuron" patented technology

The present application relates to a kind of neural network global one-time structured pruning method, system, equipment and medium, wherein, method includes: by single forward propagation, in the neural network to be pruned using calibration dataset and parallelly capturing the input activation tensor of all target layers;According to input activation tensor, the intermediate neuron weight of each target layer is synchronously calculated differential entropy index and amplitude response intensity, and after normalization and fusion, static global importance atlas is formed;According to the importance threshold value determined according to preset pruning rate, based on global importance atlas, one-time generates the index set of all global pruning to be pruned whose mixed importance score is below importance threshold value;Based on index set, the weight matrix of each target layer is executed one-time physical structured pruning.By doing so, the present application generates static global importance atlas by single forward propagation and parallelly capturing activation tensor, and completes no-mask one-time pruning by physical structured pruning.

Methods for generating mature somatostatin+ interneurons from human forebrain neural progenitor cells are provided using chemically-defined culture media in a two-stage culture protocol. The mature somatostatin+ interneurons are generated from medial ganglionic eminence neural progenitor cells (MGE-NPCs), which themselves are differentiated from pluripotent stem cells. Culture media, isolated cell populations and kits are also provided.

Provided herein are methods of generating hindbrain cells, including respiratory hindbrain cells, from pluripotent stem cells. Also provided are methods of generating a three-dimensional organoid comprising a population of hindbrain cells including a heterogeneous population of interneurons.

This article describes a method for generating mature somatostatin-interneurons from human forebrain neural progenitor cells in a two-stage culture protocol using a chemically defined culture medium. Mature somatostatin-interneurons are generated from medial ganglion ridge neural progenitor cells (MGE-NPC), which themselves are derived from pluripotent stem cells. The article also provides the culture medium, isolated cell populations, and kits.

A computer-implemented method of training a neural network to recognize sensory patterns includes obtaining input data, preprocessing the input data in one or more preprocessors of the neural network, and applying the preprocessed input data to a core portion of the neural network. The core portion of the neural network includes a plurality of principal neurons and a plurality of interneurons, and is configured to implement a feedback loop from the interneurons to the principal neurons that supports persistent unsupervised differentiation of multiple learned sensory patterns over time. The method further includes obtaining an output from the core portion, and performing at least one automated action based at least in part on the output obtained from the core portion. The neural network may be adaptively expanded to facilitate the persistent unsupervised differentiation of multiple learned sensory patterns over time by incorporating additional interneurons into at least the core portion.

The application belongs to the technical field of animal experiment models, and discloses a method for constructing a mouse model of autism spectrum disorder and application. Pregnant mice are orally exposed to different doses of 1-NP every day during the whole gestation period, the pregnant mice naturally give birth, and the offspring mice are evaluated for autism-like behaviors at PND28 after birth by using a three-chamber social experiment. The offspring mice are evaluated for autism-like behaviors at PND70 after birth by using a three-chamber social experiment. Maternal 1-NP exposure during pregnancy delays the migration of intermediate neurons in the forebrain of fetal mice, and the autism-like behaviors. 1-NP exposure during pregnancy down-regulates the expression of intermediate neuron migration-related genes by reducing DNA hydroxymethylation of the intermediate neuron migration-related genes. 1-NP exposure during pregnancy damages the synthesis of mitochondrial tricarboxylic acid cycle alpha-ketoglutarate (alpha-KG). Maternal alpha-KG supplementation during pregnancy improves the migration of intermediate neurons in 1-NP exposed fetal mice and the autism-like behaviors of offspring mice.

Methods for deriving dorsal interneurons (dIs) of all types, dI1-dI6, and for producing dIs in large quantities without changing their identity, are described. A method for producing dIs in vitro comprises contacting neuromesodermal progenitor cells (NMPs) with specific factors following two variations on a protocol. The methods described herein provide a disease model for sensory processing disorders, such as fibromyalgia, and autism. Cells can be obtained from an individual subject using a skin biopsy to develop the stem cells that can then be used for study and testing that is tailored to the individual subject.