2 results about "Bronchoconstriction" patented technology

A novel strain, Lactobacillus paracasei ATG-E1 (Accession No. KCTC 14245BP), and a composition containing the same for preventing or treating respiratory diseases which are caused by fine particulate matter. The Lactobacillus paracasei ATG-E1 strain reduces the number of immune cells bronchoalveolar and lung tissues and inhibits the expression of inflammatory cytokines such as interleukin-17A (IL-17A), tumor necrosis factor-α (TNF-α), macrophage inflammatory protein 2 (MIP2), C-X-C motif chemokine ligand 1 (CXCL-1), macrophage inflammatory protein-α (MIP-1α) or interleukin-6 (IL-6). Therefore, the Lactobacillus paracasei ATG-E1 strain can be used for a treatment or health functional food for various respiratory diseases such as acute and chronic bronchitis, catarrhal bronchitis, bronchitis obliterans, inflammatory bronchitis, bronchial asthma, atopic asthma, non-atopic asthma, atopic IgE-mediated asthma, allergic asthma, non-allergic asthma, chronic bronchoconstriction, acute bronchoconstriction, chronic obstructive pulmonary disease, bronchial adenoma, pulmonary tuberculosis, emphysema, lung abscess, pulmonary fibrosis, lung cancer, airway cancer, bronchoalveolar cancer, and bronchial cancer.

This invention discloses a medicinal and edible homologous composition and its application in the preparation of drugs or foods for improving chronic lung diseases, belonging to the field of pharmaceutical technology. The medicinal and edible homologous composition of this invention uses donkey-hide gelatin and astragalus as the principal ingredient, apricot kernel and burdock seed as the assistant ingredient, loquat leaf as the adjuvant ingredient, and platycodon and licorice as the auxiliary and guiding ingredients. Through the use of volatile oil extraction and re-addition techniques, as well as the separate "melting" of donkey-hide gelatin, the heat-sensitive volatile oil components in the raw medicinal materials are preserved, and a networked regulatory mode of "synthesis promotion-degradation inhibition-signal enhancement" is constructed, achieving deep activation of the cAMP pathway. The medicinal and edible homologous composition has pharmacological activities that improve lung function and inhibit airway inflammation. The activity is significantly superior to that of donkey-hide gelatin, roflumilast, and hormones used alone; the medicinal and edible homologous composition exhibits excellent synergistic effects in the treatment of COPD and asthma, and has improving and therapeutic effects on chronic lung diseases induced by inflammation, bronchoconstriction, and mucus secretion, and can delay the progression of COPD and asthma, providing a new approach and direction for the preparation of drugs or foods that improve chronic lung diseases; this invention can provide core technical support for the secondary development of traditional Chinese medicine compound prescriptions and the creation of new drugs, thereby effectively promoting the modernization of traditional Chinese medicine.