583 results about "Pulmonary tuberculosis" patented technology

Methods and systems are disclosed for the detecting of whether a subject has a lung disorder such as asthma, tuberculosis or lung cancer. Monitoring the subject's health and prognosis is also disclosed.

The invention discloses an automatic pulmonary tuberculosis detection system on an X-ray chest radiograph based on a characteristic pyramid network (FPN). An X-ray chest radiograph of pulmonary tuberculosis is marked; a Faster R-CNN network learning module with an FPN as the rear end is adopted for training and learning, pulmonary tuberculosis lesion symptoms are mastered, and the automatic diagnosis and detection capacity of the pulmonary tuberculosis lesion symptoms is obtained, so that the automatic detection, positioning and probability prediction of the pulmonary tuberculosis lesion are achieved, and a final pulmonary tuberculosis detection result is obtained. The FPN serves as the rear end of the detection network, the semantic features in a multi-scale network layer can be better combined, each layer is independently predicted, and fusion is finally carried out, so that focuses of different scales can be better detected. Based on a recognition technology of the deep learning network to the digital image, the automatic detection, positioning and probability prediction of the tuberculosis focus are realized, the accuracy of the focus detection is improved, and the risk of thedelayed treatment of a tuberculosis patient is reduced.

The present invention relates to methods useful for the treatment or prevention of disease-related wasting. The methods of the invention comprise the administration of an effective amount of a JNK Inhibitor. In one embodiment, the disease is HIV, AIDS, cancer, end-stage renal disease, kidney failure, chronic heart disease, obstructive pulmonary disease or tuberculosis. The methods can further comprise the administration of a therapeutic or prophylactic agent useful for the treatment or prevention of HIV, AIDS, cancer, end-stage renal disease, kidney failure, chronic heart disease, obstructive pulmonary disease, chronic infectious diseases (e.g., osteoarthritis and bacterial endocarditis), chronic inflammatory diseases (e.g., scleroderma and mixed connective tissue disease) or tuberculosis.

Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation. The active agent may be administered with or incorporated into the formulation, or may be administered after the conductive formulation is administered. When applied to mucosal lining fluids, the formulation alters the physical properties such as the surface tension, surface elasticity, and bulk viscosity of the mucosal lining. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. The formulations may be administered for several different purposes: reducing the spreading of infectious diseases, both viral and bacterial, such as SARS, influenza, tuberculosis, and RSV in humans and hoof and mouth disease in cloven-tooted animals; minimizing ambient contamination due to particle formation during breathing, coughing, sneezing, or talking which is particularly important in the clean room applications; decreasing or preventing the occurrence of obstructive sleep apnea and some cases of irritable bowel syndrome; and controlling the uptake kinetics of drug molecules and pathogens.

A Chinese medicine for treating pulmonary tuberculosis is prepared from 16 Chinese- medicinl materials including tuckahoe, coix seed, Chinese angelica root, coolfberry fruit, etc.

The invention discloses a plasma exosome circRNA marker for non-small cell lung cancer, as well as a detection primer and kit thereof. The circRNA marker is one or more of circ_0047921, circ_0007761,or circ_0056285. In a plasma exosome of an NSCLC patient, the expression level of the above-mentioned circRNAs is significantly different from that of plasma exosomes of other lung disease patients and healthy people. The invention also provides a specific primer group and a kit thereof for detecting circ_0047921, circ_0007761 and circ_ 0056285 respectively. The marker provided by the invention can be used alone in the diagnosis of NSCLC, and has certain accuracy, and a combination of the marker can significantly improve the accuracy of diagnosis (the AUC is 0.894, and the sensitivity and specificity are 87.25% and 80.00% respectively), and can differentiate NSCLC patients from other patients with lung diseases including pulmonary tuberculosis, chronic obstructive pulmonary disease and other disease patients, which is helpful to realize early detection of NSCLC.

The present disclosure relates to systems, methods, and formulations for the pulmonary administration of one or more therapeutic agents, in dry powder form, in a single, large dose quantity. These formulations, methods, and systems are useful in the treatment of patients suffering from toxic or harmful gas exposure, such as nerve gas exposure, as well as in the treatment of patients suffering from diseases of the pulmonary system, including tuberculosis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).

The invention provides a method for predicting the susceptibility of an individual to pulmonary tuberculosis, the method comprising amplifying genomic DNA of pulmonary tuberculosis patients and normal control individuals using oligonuecleotide primers, sequencing the amplified PCR product and identifying the sequence variation computationally by comparing it with the already existing sequence of human SP-A2 gene.

Embodiments of the disclosure can include biomarkers for systems, methods, and devices for detecting and identifying certain substances, such as chemicals, volatile organic compounds (VOCs), volatile gases (VGs), ketones, cannabis, controlled substances, pharmaceuticals, or anesthetics, in the exhaled breath of a subject or person in real-time; and further diagnosing, treating, and addressing one or more associated health conditions or diseases, including a virus, such as COVID-19, tuberculosis (TB), lung cancer, or chronic obstructive lung disease (COPD).

The invention discloses an ambroxol hydrochloride oral solution and a preparation method thereof, and relates to a preparation method of western medicine, in particular to a medical production formula used for curing bronchitis and a preparation method thereof; the preparation method comprises the following steps: sucrose, preservatives and purified water are dissolved in a mixing mode so as to prepare simple syrup; the ambroxol hydrochloride, corrigents and preservatives are dissolved by the purified water so as to prepare ambroxol hydrochloride solution; the ambroxol hydrochloride solution and the simple syrup are stirred and mixed evenly, the corrigents and the preservatives are added successively and discontinuously and then the purified water is added to adjust the concentration. The invention has simple and reasonable process, and is easy to operate practically and the produced products have good stability; the products can used as common phlegm-eliminating drugs, has functions of increasing the liquid level of the respiratory tract, reducing mucus secretion, enhancing the secretion of pulmonary surfactant and the movement of cilium and preventing cough to a certain extent, and is applicable to acute respiratory disease and chronic respiratory disease, such as ropy sputum and difficult cough caused by acute bronchitis and chronic bronchitis, bronchial asthma and pulmonary tuberculosis, etc.

The invention belongs to the field of medicinal preparations and a novel medical technology and relates to an in situ gel preparation loaded with Kangfuxin and its preparation method and use. The in situ gel preparation loaded with Kangfuxin has temperature sensibility. The in situ gel preparation loaded with Kangfuxin is characterized in that Kangfuxin as a raw material and polymers are dissolved in a buffer solution or purified water according to a ratio. Because of polymer reverse-phase gel properties, the in situ gel preparation loaded with Kangfuxin is in a liquid state and can freely flow at a room temperature (of 20 DEG C) under storage conditions, and when the in situ gel preparation loaded with Kangfuxin is spread on a wound, under the action of a body temperature, the in situ gel preparation loaded with Kangfuxin forms fast semi-solid gel. The in situ gel preparation loaded with Kangfuxin is convenient for patient use, improves patient compliance, can effectively store drugs and can slowly release drugs so that drug action time is prolonged and drug efficacy is improved. Through oral administration, the in situ gel preparation loaded with Kangfuxin can be used for treating blood stasis, stomachache, gastrorrhagia, gastric ulcer and duodenal ulcer and assistantly treating Yin deficiency and pulmonary tuberculosis, and phthisis. Through external administration, the in situ gel preparation loaded with Kangfuxin can be used for treatment and anti-adhesion of metal-inflicted wounds, trauma wounds, ulcer wounds, fistula wounds, burn wounds, scald wounds, bedsore wounds and surgical wounds.

The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis. Preferably, these methods are universally applicable to a variety of sample types, are applicable as one-tube-processes, are 15 suitable for performance in a high-throughput setting, and are automatable.

The invention provides an image processing method for detecting a pulmonary tuberculosis focus in a chest X-ray DR film. The image processing method comprises the following steps of extracting a lung area image through an active shape model; extracting SURF key feature points of a lung area image; extracting texture descriptors of the key feature points; assigning the kind of the key feature points; performing clustering and combination on the texture descriptors according to a k-means clustering algorithm, and performing classified making on a combination result; setting a group of dimension values, and combining the texture marks of the lung area image according to a sequence from a least dimension value to a minimum dimension value; and deleting the class of which the number of samples is smaller than 5% of the total number in the combining result, thereby only reserving main classes in the combination result, eliminating abnormities and obtaining an image processing result. The image processing method can be used for automatically processing the DR films. The image processing method is applied for screening the pulmonary tuberculosis. The lung DR films which may represent the pulmonary tuberculosis can be screened. The image processing method can be used for large-number pulmonary tuberculosis screening. The image processing method has advantages of high screening efficiency and objective and stable conclusion.

A sample collection apparatus which measures biological samples and can be used to provide the early detection of respiratory diseases, for example tuberculosis induced by the pathogen mycobacterium tuberculosis. The sample collection apparatus has a sample collection unit and a corresponding complementary reader unit. The collection unit collects a sample exhaled from the user through a collection vessel with an optical interrogation region. The sample is spread on the inside of the vessel over the interrogation region and subsequently analyzed. The test results are displayed via the reader unit.

The present invention belongs to the field of gene engineering and diagnosis reagent technology, and aims at providing specific Rv3425 antigen for detecting tuberculosis and superior to available tuberculosis detecting reagent. The present invention provides specific Rv3425 antigen with high sensitivity in detecting pulmonary tuberculosis and other kinds of tuberculosis. The specific Rv3425 antigen as one immune dominant B-cell target antigen is used in preparing tuberculosis detecting reagent kit with high sensitivity, high safety and high reliability.

The invention discloses a reagent for detecting tubercle bacillus infection in vitro and a method thereof. The reagent comprises M233 polypeptide represented by SEQ ID No.1; and cytokine released from T cells is detected by contacting the M233 polypeptide or an analog thereof with the T cells of a tubercle bacillus host to determine whether the T cells identify the M233 polypeptide or the analog thereof. The reagent has the advantages of high sensitivity, good specificity, being free from interference of BCG vaccine and non-tuberculosis mycobacteria vaccine, being capable of detecting active pulmonary tuberculosis patients, the patients with dormant infection and healthy persons who contact with mycobacterium nontuberculosis. The reagent and the method are especially applicable to detecting tuberculosis and / or dormant infection thereof for Chinese people.

The invention provides mycobacterium tuberculosis protein Rv2693c and / or Rv1984c in development and / or designing of products capable of discrimination, diagnosis, auxiliary diagnosis, screening and / or auxiliary screening of latent tuberculosis infection. The invention further provides protein chips prepared from the two mycobacterium tuberculosis proteins. The protein chips prepared in the invention are used for detecting the levels of IgM antibodies respectively corresponding to the twp proteins in serum of a patient with latent tuberculosis infection and of a normal person, and detection results of the antibodies respectively corresponding to the three protein are analyzed together so as to determine whether an examined person suffers from latent tuberculosis infection; detection results show that optimal operating points of the protein chips provided by the invention in auxiliary diagnosis of latent tuberculosis infection have specificity of 80.3% and sensitivity of 75.6%, both higher than indexes of diagnosis of latent tuberculosis infection in the prior art.

The invention discloses a method for quickly detecting mycobacterium tuberculosis, which comprises the following steps: 1, infecting phage with the mycobacterium tuberculosis; 2, killing the phage notinfecting outside the mycobacterium tuberculosis; 3, amplifying the infecting phage; and 4, after labeling gold with antiphage antibody, adopting quick immunochromatography to detect whether the phage exists or not so as to judge whether the mycobacterium tuberculosis exists in a sample. In addition, the invention also discloses a corresponding kit, which comprises sample treating fluid, proliferous liquid, a killing agent, mycobacterium smegmatis, mycobacteriophages and a phage colloidal gold method immunity-chromatography test pen. The method and the kit can quickly and accurately detect the mycobacterium tuberculosis so as to meet the requirement of quickly diagnosing pulmonary tuberculosis and timely medicate the patient.

The invention relates to a traditional Chinese medicine composition for treating pulmonary tuberculosis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of oyster, 15-25 parts of light wheat, 10-20 parts of selfheal, 10-20 parts of adenophora tetraphylla, 10-20 parts of Astragalus membranaceus, 10-20 parts of Thunberg Fritillary Bulb, 10-20 parts of rhizoma bletillae, 10-20 parts of asparagus fern, 10-20 parts of radix rehmanniae recen, 5-15 parts of Radix Ophiopogonis, 5-15 parts of lily, 5-15 parts of radix scrophulariae, 5-15 parts of rhizoma picrorhizae, 5-15 parts of Chinese yam, 5-15 parts of Angelica sinensis, 5-15 parts of Poria cocos, 5-15 parts of radix paeoniae alba, 5-15 parts of garden burnet, 5-15 parts of ephedra root, 5-15 parts of Platycodon grandiflorum, 5-15 parts of radix stemonae, 5-15 parts of radices stellariae dichotomae, 5-15 parts of hairyvein agrimony and 3-9 parts of liquorice. The traditional Chinese medicine composition provided by the invention has the advantages of exact curative effect, short treatment period, no toxic and side effects, low cost and the like.

The invention relates to a medicine for treatment of a pulmonary tuberculosis disease, which comprises the following Chinese herbal medicines: radix stemonae, radix rehmanniae, dwarf lilyturf root, lily, pericarpium trichosanthis, dead nettle, fritillaria thunbergii, scutellaria, herba houttuyniae, American ginseng, radix paeoniae alba, licorice, campanulaceae, Indian iphigenia bulb, hemsley rockvine root, coastal glehnia root and the like, which are prepared into powder, liquid, tablets, pellets, soup, granules and oral liquid. The medicine has the advantages of convenience in administration, no toxic or side effects, strong sterilization rate, and obvious curative effects for the treatment of the pulmonary tuberculosis disease.

The invention provides fragrant solomonseal rhizome instant rice flour prepared from a Chinese medicinal herb fragrant solomonseal rhizome taken as an auxiliary additive and capable of improving related nutrients required by a human body and disease-resistant function. Meanwhile, the fragrant solomonseal rhizome instant rice flour has health care effects such as nourishing lung and relieving cough, producing body fluid and nourishing stomach, clearing away heat and moistening skin and the like, has certain disease-resistant function on pulmonary tuberculosis cough, diabetes mellitus, hypertension and heart disease under the pharmacological action of the fragrant solomonseal rhizome, and has the characteristics of being nutrient, good to eat, clear and translucent, having smooth surface, no cloudy soup after long-time soaking and no breakage of noodles, being instant and convenient and the like. The invention adopts a method for processing fragrant solomonseal that: rootstocks dug in autumn are subjected to hair root removal, cleaning, drying of surface water, and are freshly crushed into pulp; the pulp is dried at a constant temperature (65DEG C) for 6 hours in the stirring condition; and the pulp is subjected to secondary crushing until the granularity is 400 meshes (standby). The fragrant solomonseal rhizome instant rice flour comprises the following raw materials in proportion: 85 percent of nonglutinous rice flour and 15 percent of the fragrant solomonseal rhizome, and is prepared by process flows such as rice selection and matching, rice cleaning and moistening, rice-water separation, crushing, mixing, flour extraction and silk extrusion, repeated cooking and ageing, carding and forming, moulding in a box and drying, finished product cutting, packaging and the like.

The invention discloses a medicine for treating phthisis, which is prepared by the following traditional Chinese medicine raw materials in weight portion: herba ephedrae, almond, tambac, notoginseng, dragon's blood, balloon flower, bulbus fritillariae cirrhosae, bletilla striata, saffron, aweto, scurfpea fruit, rhizoma drynariae, root of straight ladybell, radix scutellariae, costus root, tuber pinellia, tuckahoe, oldenlandia diffusa, ordate houttuynia, honeysuckle, fresh hawthorn, endodermis of chicken gizzard and liquorice. The medicine for treating phthisis has the advantages of quick effect, drug ingredients conservation, good treating effect, high curative rate, uneasy relapse after cure and convenient preparation. The medicine has 94.5 percent of effective rate and 91 percent of curative rate.

The present invention discloses an anoectochilus roxburghii-hosui pear health care beverage and a preparation method thereof. Each 500 ml of the health care beverage is prepared from the following raw materials: 90 g of fresh anoectochilus roxburghii, 100-360 g of hosui pear, 15-25 g of sucrose, 0.009 g of citric acid, 0.0375-0.0765 g of sodium erythorbate, and the balance of distilled water. According to the present invention, anoectochilus roxburghii and hosui pear are prepared into a mixed beverage, such that advantage complementation is achieved, the pear juice is sweet and refreshing, and unique flavor of the anoectochilus roxburghii is regulated; and the anoectochilus roxburghii-hosui pear health care beverage can be suitable for consumption populations with different ages and different genders, especially for hepatitis patients, pulmonary tuberculosis patients, constipation patients, acute and chronic tracheitis patients, upper respiratory tract infection patients, high blood pressure patients, heart disease patients and esophageal cancer patients.

Disclosed is a Chinese medicament for treating pulmonary tuberculosis which compirses Chinese angelica root 12g, dried rehmannia root 20g, coptis root 4g, baikal skullcap root 12g, phellodendron bark 15g, astragalus root 50g, root of balloonflower 15g, Sichuan fritillary bulb 6g, beach silvertop root 15g, roor of sessile stemona 27g, pericarpium trichosanthis 15g, mulberry bark 15g, batryticated silkworm 12g, smoked plum 15g, light wheat 15g, oyster 20g, poria cocos wolf 15g, Chinese yam 20g, cardamom seed 6g, root of pilose asiabell 20g, ophiopogon root 15g, schisandra fruit 6g. The Chinese medicament has simplified recipe and low price.

Vaccination with the combination of Ag85B-TB10.4 and IC31® adjuvant generated a high amount of polyfunctional CD4+T cells expressing high levels of IFN-γ, TNF-α, and IL-2. This in turn led to significant protection against infection with M. tuberculosis in the mouse aerosol challenge model of tuberculosis. Both the immunogenicity of the vaccine and its ability to protect against TB infection was highly dependent on the antigen dose. Thus, whereas the standard antigen dose of 5 μg, as well as 15 μg, did not induce significant protection against M. tuberculosis, reducing the dose to 0.5 μg increased both the immunogenicity of the vaccine as well as its protective efficacy to a level comparable to that observed in BCG vaccinated mice. Thus, the IC31® adjuvant, with the specified antigen dose, can induce a strong protective Th1 response against M. tuberculosis.

The invention discloses a method used for air purification and the disinfection of an air conditioning ventilation system. Photo-catalysed nano active water can kill bacteria, viruses and microorganism in the air, can decompose organic contaminant in the air, moistens the air with the photo-catalysed nano active water by a moistener, sends the moistened air into the ventilation system of the air conditioner, and disinfects the ventilation system of the air conditioner. Meanwhile, the photo-catalysed nano active water purifies the air and decomposes an organic nutriment depending on which the oxidation bacteria and viruses survive, thus killing the bacteria and viruses. The method used for air purification and the disinfection of an air conditioning ventilation system has important significance and obvious effect for preventing various epidemic situations such as poultry flu, SARS, hepatitis B, pulmonary tuberculosis, etc. and purifying the harmful gases indoors such as formaldehyde, benzene, etc. Furthermore, disinfection and treatment can also be carried out by spraying and sprinkling the active water by the moistener, an air purifier and a sprayer. The method used for air purification and the disinfection of an air conditioning ventilation system is suitable for public places, families, animal living places, crop greenhouses, flowers, gardens, etc. The technique of the invention has low cost and is easy to be generalized and applied.

The invention relates to the technical field of biomarkers, in particular to a biomarker of active pulmonary tuberculosis. The biomarker of active pulmonary tuberculosis is selected from at least one of the following six circRNAs: hsa_circ_0005836, hsa_circ_0009128, hsa_circ_0003519, hsa_circ_0023956, hsa_circ_0078768, hsa_circ_0088452. Specifically, hsa_circ_0005836 has the most obvious down-regulated expression. The biomarker of active pulmonary tuberculosis can be used as a therapeutic target, and is beneficial to development of new drugs.

The invention relates to a traditional Chinese medicine for treating pneumoconiosis and drug-tolerant pulmonary tuberculosis and a preparation method thereof, which improve and eliminate the pathological residues through the synergy of all medicine according to the dialectic theory of the traditional Chinese medicine, thus leading the body fluid and other organic substances to be transferred to the lung and achieving the effect of rapidly relieving and getting rid of disease and health recovery. The traditional Chinese medicine prepared in the invention comprises the raw materials with weight ratios as follows: 8-12 parts of cordyceps sinensis, 3-7 parts of tokay, 250-350 parts of Pinellia tuberifera, 25-300 parts of Chinese wolfberry, 250-350 parts of Bletilla hyacinthina reichb, 15-50 parts of balloon flower, 3-20 parts of mulberry bark, 3-20 parts of shizandra berry, 250-350 parts of liquorice root, 45-55 parts of bulb of fritillary, 15-25 parts of almond, 15-25 parts of Tatarian Aster Root, 25-35 parts of coltsfoot, 15-25 parts of Blackberrykiky Rhizome, 8-12 parts of root of straight ladybell, 8-12 parts of dried orange peel, 8-12 parts of sugared sesame powder, 10-20 parts of polygala tenuifolia, 8-12 parts of red tangerine peel, 15-25 parts of ginkgo seed, 15-25 parts of trichosanthes kirilowii shell, 15-25 parts of white muscardine silkworm, 8-12 parts of placenta hominis, 4-8 parts of Scutellaria baicalensis, 8-12 parts of radix peucedani, 8-12 parts of perilla seed.

The invention discloses an oral administration Chinese medicinal decoction for treating phthisis which is prepared from beach silvertop root 12g, ophiopogon root 12g, dried rehmannia root 18g, roor of sessile stemona 15g, bletilla striata 20g, Chinese yam 30g, poria cocos wolf 15g, Sichuan fritillary bulb 12g, donkey-hide gelatin 15g, notoginseng 3g, hairy vein agrimony 30g, mahonia stem 30g, pseudostellaria root 15g and white atractylodes rhizome 15g.

The invention discloses a Miao medicament for treating pulmonary tuberculosis. The Miao medicament is prepared by four medicinal materials in parts by weight of 20-25 parts of Japanese orixa root, 10-15 parts of common bletilla tuber, 10-15 parts of Chinese ladiestresses root and 15-20 parts of selfheal spike. A preparation method of the Miao medicament comprises the steps of: cleaning the four medicinal materials, drying by using hot air, disinfecting by using ultraviolet rays, then grinding into 60-mesh powder, and finally uniformly mixing according to the weight proportion of the medicinal materials, and loading into a capsule to obtain the Miao medicament, wherein the weight of each capsule is 1 g. A taking method is realized as follows, the Miao medicament is orally taken twice one day, and 5-6 capsules are taken once by using boiling water. The Miao medicament for treating the pulmonary tuberculosis has the advantages of fewer medicinal materials, convenience in processing and remarkable treatment effect, and is suitable for treating patients suffering from the pulmonary tuberculosis.