The invention relates to a preparation medicament for clearing away heat and toxic material and its preparation method. The preparation medicament is a classic Chinese medicinal preparation, and mainly has effects in clearing away heat and toxic material; and can be used for treating wine-heat type common cold, fever, swollen sore throat, better taste and dry throat, chogh, yellow phlegm, brown urine, obstipation, supurative tonsillitis, acute pharyngitis, acute bronchitis, and simple pneumonia. Conventional preparation with effects in clearing away heat and toxic material has incomplete drug absorption, low bioavailability, and slow therapeutic effect. The invention conjugate Taraxacum mongolicum, Polygonum cuspidatum, dahurian patrinia and Barbat Skullcap; has good effects in clearing away heat and toxic material; and is an effective medicine in treating wine-heat type common cold, fever, swollen sore throat, better taste and dry throat, chogh, yellow phlegm, brown urine, obstipation, supurative tonsillitis, acute pharyngitis, acute bronchitis, and simple pneumonia. The preparation is effective in treating simple pneumonia; and has a total effective rate of 91.00% for treating acute tonsillitis, and 94% for acute pharyngitis.