10 results about "Acute bronchitis" patented technology

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

The invention relates to a preparation method and application of a traditional Chinese medicine atomization inhalant for diffusing the lung and reducing phlegm, the preparation is prepared from eight medicinal materials including honey ephedra, bitter apricot kernel reformed, aster tataricus and the like through a staged extraction-multi-stage refining-composite stabilization integration process, volatile oil components are subjected to exclusive distillation concentration, non-volatile components are subjected to ethanol-water two-phase extraction, and then the volatile oil components are subjected to ethanol-water two-phase extraction to obtain the traditional Chinese medicine atomization inhalant for diffusing the lung and reducing phlegm. Chitosan flocculation is coupled with precise ultrafiltration to realize deep purification; molecular-level stabilization fusion of volatile oil and a refined water phase is innovatively realized through a composite surfactant system, and finally, a high-stability sterile solution meeting the requirement of an inhalant is prepared. The process overcomes the common problems that a compound traditional Chinese medicine atomized preparation is poor in clarity, effective components are easy to degrade and the atomization performance is poor, and it is ensured that the active components can be efficiently converted into lung targeted deposition superfine aerosol. The product is suitable for respiratory system diseases such as acute bronchitis, asthma turbid phlegm obstructing lung syndrome and the like, and has the advantages of quick response, high local drug concentration and good safety.

Provided are a Hedera helix extract, a preparation method therefor, and use thereof. The preparation method comprises extracting Hedera helix leaves with 75%-85% ethanol, concentrating, adjusting the pH value to 9.5-11, standing, filtering to obtain a crude extract, passing the crude extract through a chromatographic column, and eluting with 60%-80% ethanol to prepare the Hedera helix extract. The chromatographic column is an HPD100 macroporous resin column, a polyamide column or a C18 column. The Hedera helix extract can be used for preparing drugs with anti-inflammatory, expectorant, and antitussive effects, as well as for treating acute bronchitis.

The invention relates to a firewood-huang heat-clearing granule as well as a preparation method and application thereof. The radix bupleuri and rhizoma anemarrhenae heat-clearing granules are prepared from 8-25 parts of radix bupleuri, 6-20 parts of rhizoma anemarrhenae, 8-25 parts of radix scutellariae, 8-25 parts of folium isatidis, 8-25 parts of mint and 20-50 parts of rhizoma phragmitis, and the preparation method comprises the steps of raw material pretreatment, alcohol extraction, concentration and drying, granulation and the like. The traditional Chinese medicine composition is suitable for diseases such as pneumonia, acute bronchitis, epidemic cerebrospinal meningitis, epidemic encephalitis B, gastrointestinal type cold and the like. Animal experiments prove that the granule has a remarkable antipyretic effect, is exact in curative effect, good in safety and good in stability, and has important clinical application value.

The invention provides a traditional Chinese medicine composition and a preparation method and application thereof.The traditional Chinese medicine monomer composition in the traditional Chinese medicine composition comprises amygdalin-usnic acid-beta-sitosterol which is derived from traditional Chinese medicine bitter apricot kernel, pericarpium citri reticulatae and rhizoma pinelliae preparata in a compatible combination mode, all the components have a synergistic effect, and through apparent indexes, the traditional Chinese medicine composition can be used for preparing the traditional Chinese medicine composition. The traditional Chinese medicine monomer composition and the traditional Chinese medicine compatibility combination thereof are used for evaluating and investigating the effect of the traditional Chinese medicine monomer composition and the traditional Chinese medicine compatibility combination thereof on inhibiting acute bronchitis of mice according to indexes such as acute bronchitis, tissue pathological observation, inflammatory factors and sputum dilution, the acute bronchitis treatment effect is remarkable, the medical application of the traditional Chinese medicine monomer composition is expanded, the traditional Chinese medicine compatibility combination is optimized, and the traditional Chinese medicine composition has a good application prospect in treatment of bronchitis. Especially, a new treatment idea is provided for treatment of acute bronchitis.

The invention discloses a children Maxingshigan mixture, which relates to the technical field of traditional Chinese medicine pharmacy, and has the technical key points that the children Maxingshigan mixture is prepared into an oral liquid dosage form by mixing ephedra, bitter apricot kernel, gypsum, liquorice, folium isatidis, houttuynia cordata, trichosanthes peel and scutellaria baicalensis according to a specific weight ratio and adding auxiliary materials. The preparation method comprises the following steps: pretreating the raw materials, decocting and extracting twice, merging filtrate, refrigerating and finely filtering, concentrating in vacuum, preparing liquid to a constant volume, filtering and filling at a terminal, sterilizing and the like. The mixture disclosed by the invention has the effects of diffusing lung, depressing qi, clearing heat and eliminating phlegm, is mainly used for treating heat cough and asthma syndromes caused by exogenous evil entering the interior and transforming heat in children, and is particularly suitable for patients with acute bronchitis with the syndromes. The dosage form is convenient for children to take, stable in quality and exact in curative effect.

The invention provides an application of exosomes secreted by autologous stem cell culture in bronchitis COPD treatment, based on an autologous adipose-derived stem cell (ADSCs) organ-like cell directional culture technology, stem cells are induced to be differentiated into bronchial organ-like cells, the exosomes secreted by the bronchial organ-like cells are collected, and the COPD treatment of bronchitis is realized. Through atomization administration, chronic bronchitis, acute bronchitis and chronic bronchitis can be treated. The exosome of the tissue cells of the autologous bronchial mucosa directly reaches the bronchial mucosa through aerosol inhalation, and plays a role through the following ways: anti-inflammation: inhibiting an NF-kappa B pathway, and reducing the release of IL-6 and TNF-alpha; epithelium repair: activating a Wnt / beta-catenin signal to promote basal cell proliferation and enhance a mucus cilia removal function; immunoregulation: regulating and controlling polarization of macrophages to M2 anti-inflammatory phenotype. Therefore, local concentration is high, whole-body side effects are avoided, the whole path of trachea-bronchus-alveolus alveolus is covered, and precise targeted repair is achieved.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

A hederasaponin composition and a hedera leaf extract. The hederasaponin composition comprises hederasaponin C, α-hederasaponin, hederasaponin B, and hederasaponin D in a mass ratio of 12-25:5-10:1:1-2. The hederasaponin composition and the hedera leaf extract can be used for preparing drugs for treating or preventing acute bronchitis, expectorants, and antitussives.

The invention belongs to the technical field of traditional Chinese medicines and provides a traditional Chinese medicine composition for treating acute and chronic cough and a preparation method thereof. The composition comprises thunberg fritillary bulb, trichosanthes kirilowii maxim, white mulberry root-bark, honeysuckle, fructus forsythiae, scutellaria baicalensis, radix isatidis, rhizoma pinelliae preparata, semen armeniacae amarae, fructus arctii, poria cocos, pericarpium citri reticulatae, lumbricus, peach kernel, platycodon grandiflorum, magnolia flower, lily and liquorice, is mainly used for treating the phlegm-heat obstructing lung syndrome, and has the common symptoms of cough, yellow and thick phlegm cough, fever, asthma, red, swollen and painful throat or nasal obstruction, dry mouth and the like. The traditional Chinese medicine composition disclosed by the invention has a very good curative effect on acute bronchitis, acute attack of chronic bronchitis, cough allergic asthma and cough after cold, particularly can quickly relieve the symptoms such as catarrhal symptom, nasal obstruction, saliva, excessive sputum and cough, and has a wide market application prospect.