39 results about "Liquid Dosage Form" patented technology

A pharmaceutical liquid dosage form of Trientine and / or pharmaceutically acceptable salts thereof is provided, which are suitable for oral administration. A process of preparing the liquid dosage form and use for treatment of Wilson's disease and related diseases are also provided.

Described herein are dosage forms comprising the compound:wherein the dosage form can be a solid dosage form, a liquid dosage form, or a solid amorphous dispersion.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

The invention discloses a system and a method for rapidly selecting a human body nutrient solution dosage form, and belongs to the technical field of biomedical detection. The system comprises a sample preprocessing unit, an integrated sensor unit and a microprocessor unit, a core theoretical model is established by taking conductivity k and refractive index n as a core quantitative basis, then core quantitative calculation and proportion estimation are performed by taking pH and turbidity as qualitative recognition and correction factors, and finally, nutrient solution supplement suggestions are intelligently decided and output. According to the method, the leap that quantitative estimation can be achieved only by rough judgment depending on experience of doctors when the nutrient solution is supplemented to a patient with the nutrient solution lost is achieved, the result is more scientific and reliable, the technical problem that component analysis of approximate chromatography is achieved through a low-cost and rapid method is solved, and the method has good clinical application value and market prospects.

The invention belongs to the technical field of agricultural pest control, and particularly relates to a novel drosophila melanogaster attractant and a preparation method and application thereof. The invention discloses a novel drosophila melanogaster attractant which comprises the following components in percentage by mass: 10%-20% of brown sugar, 1%-5% of acetic acid, 1%-5% of ethanol, 1%-5% of phenethyl alcohol, 0.5%-2.0% of oleic acid, 0.1%-1% of palmitoleic acid, 0.1%-0.5% of sodium benzoate, 0.2%-0.5% of ascorbic acid, 0.2%-0.3% of sodium carboxymethyl cellulose, 0.5%-1.0% of sodium dodecyl benzene sulfonate and the balance of water. Field test results show that the novel drosophila melanogaster attractant is high in trapping rate of drosophila melanogaster on fruit crops, the used raw materials are low in price, the preparation process is simple, the dosage form is a liquid dosage form, field application is facilitated, the novel drosophila melanogaster attractant can be widely applied to prevention and control of field drosophila melanogaster, and the market prospect is good.

The invention provides a recombinant respiratory syncytial virus vaccine as well as a preparation method and application thereof, and belongs to the technical field of viral vaccine preparations. Wherein the recombinant respiratory syncytial virus vaccine is a vaccine preparation in a liquid dosage form comprising pre-F protein antigen; wherein the amino acid sequence of the pre-F protein antigen is any one of the amino acid sequences as shown in SEQ ID NO. 1 to SEQ ID NO. 3. The recombinant respiratory syncytial virus vaccine provided by the invention is a liquid vaccine preparation comprising a recombinant respiratory syncytial virus (RSV) protein stock solution, the vaccine preparation has better stability, and the self-made recombinant respiratory syncytial virus vaccine is proved to have good immunogenicity through immune experiment research on a BALB / c mouse by intramuscular injection.

The invention belongs to the technical field of insecticides, and particularly provides a compound low-toxicity insecticidal solution which comprises the following components in percentage by mass: 2-5% of allicin, 1-10% of essential oil, 2-5ppm of methoprene and the balance of water. The compound low-toxicity insecticidal liquid provided by the invention is in a liquid dosage form and has effective insect expelling and killing effects, the used active components are non-toxic to livestock, the compound low-toxicity insecticidal liquid can be sprayed in a breeding environment and feed for disinfection in a spraying manner, the compound low-toxicity insecticidal liquid is convenient and rapid to use, and the compound low-toxicity insecticidal liquid has the effects of improving the breeding environment, reducing the ammoniacal odor of a breeding house and facilitating the growth of livestock and poultry.

Disclosed herein are novel IEX-NSAID complexes comprising a nonsteroidal anti-inflammatory drug (NSAID) or a salt thereof bound to an ion-exchange (IEX) resin, as well as liquid dosage forms thereof, and their use for treating, ameliorating, preventing, or reducing the severity of numerous conditions, or their symptoms, for with NSAID are the prescribed treatment. Also disclosed herein are methods for making the aforementioned IEX-NSAID complexes, and liquid dosage forms thereof.

The invention discloses a low-disubstituted impurity ciprofloxacin hydrochloride liquid pharmaceutical preparation and a preparation method thereof, and belongs to the field of pharmacy. Aiming at the problem that the light stability and the damp-heat stability of the existing ciprofloxacin hydrochloride solution preparation are difficult to improve synchronously, the preparation disclosed by the invention is composed of ciprofloxacin hydrochloride, tryptophan, weakly acidic buffer pair salt, a solvent and pharmaceutically acceptable auxiliary materials, and the pH value of the preparation is 5.5-7.0. According to the invention, tryptophan is added and the pH is cooperatively regulated, so that the light stability and the damp-heat stability of the preparation are remarkably improved, and the preparation process is simple, convenient and controllable, can be adapted to various liquid dosage forms such as injections, eye drops and oral solutions, and has a good industrial conversion prospect.

A controlled-release multilayer microparticle containing a pharmaceutically active compound, which is intended for oral administration or direct administration in the stomach, which may be done using a liquid pharmaceutical composition containing the microparticle. The microparticle may include: a core that includes the pharmaceutically active compound, which may be pramipexole; a controlled-release intermediate coating layer; and an outmost external protection coating layer surrounding the controlled-release intermediate coating layer. The external protection coating layer may include a mixture of: a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5; and a hydrophobic and / or insoluble component. Also disclosed are a liquid pharmaceutical composition containing the microparticles, a kit for the preparation of the liquid pharmaceutical composition, a pharmaceutical solid composition reconstitutable as the liquid composition, a process of preparing the liquid composition, and a method for treating disease with the liquid composition.

The utility model relates to the technical field of quality detection in the pharmaceutical industry, discloses a manual lamp inspection auxiliary tool for pre-filled syringe liquid dosage form products, and aims to improve the lamp inspection efficiency and reduce the labor cost. The tool comprises a clamping body composed of two oppositely arranged clamping plates, and clamping force is applied between the clamping plates through a torsional spring. The clamping plate is provided with a clamping part, and the clamping part is provided with a flexible material or a clamping head, so that a plurality of pre-filled syringes can be clamped at one time. And a detachable combined structure is adopted between the clamping part and the clamping plate. And the front end of the clamping part is provided with the LED lighting device with adjustable brightness, so that the detection precision is improved. The inner sides of the clamping plates are coated with anti-static coatings, and static interference is prevented. And the clamping block is provided with a buffer pad and a stepped groove to adapt to different bottleneck sizes and protect bottle bodies. And due to the arrangement of the opening part and the grasping part, the product can be conveniently clamped and turned over. The device is simple in structure and convenient to operate, the efficiency of manual lamp inspection is remarkably improved, and the device is suitable for large-scale production and quality inspection of pre-filled syringes.

The present disclosure relates to compositions comprising coenzyme Q10 and a water soluble excipient, and methods for treating coenzyme Q10 deficiency in a subject, including oral administration of the composition. The composition can be in a solid or liquid dosage form, such as a ball, a granule, a tablet, a capsule, an oral solution and a soft capsule, and is used for oral administration. The composition may comprise coenzyme Q10 and a binder mixture coated on a tablet core, wherein the tablet core comprises a sugar, microcrystalline cellulose, or a mixture thereof. The composition is an immediate release formulation having high solubility in an aqueous medium.

The application discloses a method for evaluating the stability of a liquid dosage form medicine packaged in a vial and application thereof. Compared with a traditional filling process, the application controls the mass-volume ratio of oxygen in the injection liquid, reduces the difference in the residual oxygen amount in the headspace between batches of products, is highly repeatable and controllable. The application provides a reliable basis for parameter setting in the production and processing process of oxygen-sensitive injection liquid, helps to promote the product quality improvement of the injection liquid medicine, reduces quality problems caused by oxygen, maintains the long-term stability of the injection liquid medicine in the storage and transportation process, and saves production cost.

The invention aims to provide a composition capable of reducing lactic acid accumulation caused by exercise and relieving fatigue and spasm phenomena, and particularly provides a liquid dosage form composition in a concentrated form, the composition at least comprises the following components in percentage by mass: 45-55% of carbohydrate, 5-10% of sodium salt, 5-10% of potassium salt, 5-10% of acidulant and the balance of water. The mass content of the sodium salt is 2%-4% by sodium ions, and the mass content of the potassium salt is 1%-3% by potassium ions.

An oral pharmaceutical composition is provided that can comprise a rho kinase inhibitor, for example, fasudil, a pharmaceutically acceptable salt thereof, a hydrate thereof, a prodrug thereof, a substituted derivative thereof, or a metabolite thereof, or any combination thereof, the rho kinase inhibitor having a bitter taste; and an ion exchange resin. The ion exchange resin can partially or fully mask the bitter taste of the rho kinase inhibitor, making the composition more palatable. The composition can comprise a solid dosage form, and / or a liquid dosage form. The solid dosage form can comprise a powder, granules, a tablet, or a capsule, or any combination thereof. The composition can be present, for example, in a unit dose, in an amount sufficient to treat a neurodegenerative disease. A method of treating the neurodegenerative disease with the oral pharmaceutical composition is provided. The method can ameliorate a symptom of a neurodegenerative disease.

The invention belongs to the field of vaccines, and provides an adjuvant composition containing MF59 and CpG. The invention discloses a full-liquid preparation RSV vaccine containing the adjuvant composition. The vaccine contains RSV pre-F protein. The preparation method of the all-liquid preparation RSV vaccine comprises the operation of carrying out compatibility on the RSV pre-F protein and the adjuvant composition. According to the adjuvant composition and the full-liquid preparation RSV vaccine based on the adjuvant composition, the conformation of pre-F protein before fusion can be kept stable in a liquid dosage form, the preparation cost of the vaccine can be greatly reduced, and meanwhile the cellular immune effect and the humoral immune effect of the vaccine are improved.

The invention relates to lactobacillus acidophilus CBBM004 and application thereof in intestinal health care, kidney health care and hypoglycemic products, and belongs to the technical field of microorganism application. The lactobacillus acidophilus CBBM004 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on March 20, 2025, the preservation number is CGMCC No.33903, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the lactobacillus acidophilus is separated from human intestinal tracts. The strain has a remarkable application effect in intestinal health care, kidney health care and hypoglycemic products. The application forms of the strain comprise powder, granules, capsules, tablets, pills, drops or liquid dosage forms, and a new choice is provided for development of related food, health care products or medicine products.

Disclosed herein are novel IEX-NSAID complexes comprising a nonsteroidal anti-inflammatory drug (NSAID) or a salt thereof bound to an ion-exchange (IEX) resin, as well as liquid dosage forms thereof, and their use for treating, ameliorating, preventing, or reducing the severity of numerous conditions, or their symptoms, for with NSAID are the prescribed treatment. Also disclosed herein are methods for making the aforementioned IEX-NSAID complexes, and liquid dosage forms thereof.

The invention discloses a borneol inclusion compound, a bone pain relieving tincture gel emplastrum and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparation preparation. The preparation process of the borneol clathrate compound comprises the following steps: adding borneol into ethanol, and dissolving, so as to obtain a borneol ethanol solution; the preparation method comprises the following steps: adding water into hydroxypropyl beta-cyclodextrin to prepare hydroxypropyl beta-cyclodextrin paste; adding the borneol ethanol solution into the hydroxypropyl-beta-cyclodextrin paste, mixing, adding water in a room temperature environment, and grinding until the hydroxypropyl-beta-cyclodextrin is a saturated aqueous solution; carrying out ultrasonic treatment on the saturated aqueous solution to obtain an inclusion solution, carrying out spray drying on the inclusion solution, and washing to obtain the borneol inclusion compound; the mass ratio of the hydroxypropyl beta-cyclodextrin to the borneol is 4: (0.3-0.7). According to the invention, the medicinal effect of the original dosage form is ensured, the extraction efficiency of the decoction pieces is greatly improved, and the liquid dosage form is changed into the solid dosage form, so that the medication comfort and compliance are improved.

This invention provides a PND cyclodextrin inclusion complex, its preparation method, and its applications, relating to the field of pharmaceutical formulation technology. The method for preparing the PND cyclodextrin inclusion complex of this invention does not use organic solvents, is simple and easy to control, and has low cost. The technical solution of this invention greatly improves the solubility of PND in water, enhances the therapeutic effect of PND, and improves the stability of PND. This inclusion complex is suitable for preparing clinically required solid and liquid dosage forms, including infusions, injections, powder injections, oral solutions, novel nasal drops, nasal sprays, syrups, tablets, capsules, granules, and dispersible tablets. This inclusion complex can be used to prepare drugs for the prevention and treatment of influenza A virus infection.

The present invention relates to a controlled-release multilayer microparticle containing a pharmaceutically active compound, said microparticle being intended for oral administration or direct administration to the stomach in the form of a liquid pharmaceutical composition. It also relates to the liquid pharmaceutical composition containing it, a kit for preparing said liquid pharmaceutical composition, a pharmaceutical solid composition intended for reconstitution in the form of said liquid composition and a process for preparing said liquid composition.

The invention provides a preparation method of plant liquid superoxide dismutase, which comprises the following steps: 1) planting rosa roxburghii: applying an organic compound fertilizer, picking rosa roxburghii when the rosa roxburghii is ripe to 100%, and 2) removing burrs of fresh rosa roxburghii by using an old washing machine or special burr removing equipment. Washing the hairs and thorns with water, drying in the sun or in the shade to remove moisture on the surfaces of the fresh fruits, and cutting to remove seeds; and (3) using a stainless steel drill-shaped barrel or porcelain jar. 10-12kg of fresh rosa roxburghii tratt fruits without seeds are contained in each barrel or cylinder, and the weight of the added cane sugar is 1.6 times that of the fresh fruits. And 4) after the reaction is completed, filtering by using a stainless steel filter screen with coarse pores to obtain fruit juice, and then squeezing pomace on the filter screen by using a hydraulic machine until no fruit juice drips from the pomace. The preparation method of the plant liquid superoxide dismutase can breed more SOD (superoxide dismutase).

According to a first aspect of the invention, there is provided health supplement composition comprising: a therapeutically effective amount of at least one active ingredient selected from Calcium Carbonate, Maize Starch, Magnesium Stearate, Microcrystalline Cellulose, Vitamin D3, and Vitamin K2; and at least one pharmaceutically acceptable excipient selected from the group consisting of binders, disintegrants, stabilizers, lubricants, diluents, and preservatives, wherein the composition is formulated for oral administration in a powder, tablet, capsule, or liquid dosage form.In an embodiment, the composition is provided in a powder / granular form, typically packaged in tablets, as well as in a liquid form or as an additive to a liquid such as water, juice, or vegetable glycerine. Other delivery forms for the novel supplement may be utilized to meet particular operating circumstances or environments. Consequently, the invention is not limited to a specific delivery system but covers any and all suitable delivery systems.

A payload delivery module (120) for an ingestionable device comprises a piston (121), a hollow needle (122), a membrane (129), a fluid dosage form (130), and a valve (125). The piston (121) has an interior (121c). The needle (122) is coupled to the piston (121). The membrane (129) is coupled to the piston (121) to define a reservoir in the interior (121c). The fluid dosage form (130) is disposed within the reservoir and contains at least one therapeutic agent. The valve (125) is coupled to the piston (121) to control the flow of the fluid dosage form from the reservoir to the needle (122).

The present invention relates to a liquid dosage form pharmaceutical composition containing plasmid DNA. The liquid dosage form containing plasmid DNA according to the present invention exhibits excellent efficacy in terms of storage stability of the plasmid DNA, which is a pharma- ceutical active ingredient, and can be usefully used as a pharmaceutical composition with excellent product stability and safety.

The present invention relates to a liquid dosage form pharmaceutical composition containing plasmid DNA. The liquid dosage form containing plasmid DNA according to the present invention exhibits excellent efficacy in terms of storage stability of the plasmid DNA, which is a pharma- ceutical active ingredient, and can be usefully used as a pharmaceutical composition with excellent product stability and safety.

The invention provides a method for breeding liquid superoxide-rich disproportionated active enzyme by sugar soaking after forcefully freezing and unfreezing roxburgh rose fruits, which comprises the following steps: 1) planting roxburgh rose: artificially planting roxburgh rose, and picking after the roxburgh rose fruits are ripe to 100%, and 2) removing burrs of fresh roxburgh rose fruits by using an old washing machine or special burr removing equipment. The method comprises the following steps: washing hair with water, stabbing cleanly, drying in the sun or in the shade to remove moisture on the surface of the fresh fruits; (3) performing strong freezing and unfreezing on the cut and seeded roxburgh rose fresh fruits, and performing sugar soaking with cane sugar of which the weight is 1.8 times of that of the roxburgh rose fresh fruits; and 4) after the reaction is completed, filtering to obtain fruit juice. According to the method for breeding the liquid dosage form rich in superoxide disproportionation active enzyme after strong freezing and unfreezing, a larger amount of SOD can be bred.

The invention relates to a preparation method of a human immune globulin freeze-dried dosage form for subcutaneous injection, and belongs to the technical field of blood products. The preparation method comprises the following steps: (1) performing precipitation separation on components I, II and III in plasma; (2) octanoic acid precipitation separation; (3) primary ultrafiltration; (4) inactivating; (5) anion exchange chromatography; (6) carrying out secondary ultrafiltration; (7) carrying out affinity chromatography; (8) filtering with a nano-membrane; (9) performing ultrafiltration for the third time; and (10) sub-packaging and freeze-drying. Compared with an existing hypodermic injection human immune globulin liquid dosage form, the hypodermic injection human immune globulin freeze-dried dosage form provided by the invention does not need an additional one-way flow ultrafiltration step, and the protein is freeze-dried, can be stored at room temperature and is longer in validity period.

According to the preparation method, the oral liquid is prepared into an oral liquid dosage form by taking a cosolvent, an acidifying agent, a pH regulator, a flavoring agent, a buffer solution and a solvent as auxiliary materials, the clinical compliance of a patient is improved, and meanwhile, the oral dosage form of the fumarate directly acts on gastric parietal cells, so that the oral dosage form of the fumarate directly acts on the gastric parietal cells; compared with tablets, active substances in the stomach can be released and act on gastric wall cells only after being disintegrated and dissolved, the solution reaches the stomach after being orally taken, the active substances can directly act on the gastric wall cells, the medicine effect can be quickly exerted, and a better treatment effect is provided for patients with acute gastrointestinal discomfort.

The invention relates to the technical field of probiotic preparations, and particularly discloses a composition of Ackermann muciniphila and prebiotics and application of the composition in prevention and treatment of poultry bacterial pneumonia. The composition of Ackermann muciniphile and prebiotics is prepared by the following method: performing high-density fermentation culture on Ackermann muciniphile, and performing centrifugation, washing and freeze drying to prepare high-activity bacterial powder; the prebiotics are mixed with the high-activity bacterial powder in proportion after being purified and sterilized, and the activity of the bacterial strain in the storage and use process is protected by adopting a microcapsule embedding technology. The product can be prepared into powder, granules or liquid dosage forms, is convenient to add into poultry feed or drinking water, is added into the feed or drinking water according to the proportion of 0.1-0.5% in the susceptible period of poultry, and can remarkably reduce the incidence rate of poultry bacterial pneumonia after being continuously used for 7-14 days.