35results about How to "Less irritating to blood vessels" patented technology

The invention discloses a taxol submicroemulsion. The submicroemulsion comprises taxol-cholesterol complex, injection oil, injection water, emulsifier, assistant emulsifier and isosmotic agent, wherein the weight ratio of taxol to cholesterol in the taxol-cholesterol complex is (1: 0.09) to (1: 0.90). The invention also discloses a preparation method and application of the taxol submicroemulsion. The oil-in-water taxol submicroemulsion, the pH value of which is 4 to 6 and the average particle size of which is less than 600nm, is prepared by taking the cholesterol complex as an intermediate carrier through the step of dissolving the cholesterol complex into an oil phase by using the improvement of the drug oil solubility by the cholesterol complex. The taxol submicroemulsion is used for treating malignant tumors and has higher safety and efficiency.

The invention provides PGE1 (prostaglandin E1) freeze-dried microemulsion composition. The composition is prepared from PGE1, a non-ionic emulsifier, chondroitin sulfate, anionic phospholipid and a freeze-drying protective agent, and raw materials and components comprise, in percentage by mass, 0.001%-0.04% of PGE1, 1%-55% of the non-ionic emulsifier, 0.1%-20% of anionic phospholipid, 0.6%-28% of an oil phase and 5%-98% of the freeze-drying protective agent. The encapsulation efficiency and the stability of the composition are significantly improved, reduction of free drug concentration is facilitated, vascular irritation of a preparation is reduced, and the composition is safer and more stable.

The invention relates to a method for preparing clarithromycin ion-pair lipid microsphere injection by using cholesterol succinate monoester (CHEMS). Based on 100ml injection, it contains: clarithromycin 0.05g-0.5g; cholesterol succinate monoester 0.3g-0.6g; medium-chain fatty acid triglyceride 10g-20g; soybean oil for injection 0-10g; egg yolk lecithin 0.2g~4g; soybean lecithin 0g~4g; Pluronic F‑68 0.2g~1g; glycerin 2g~5g; water for injection 70g~90g. The physical and chemical properties of the clarithromycin ion-pair lipid microsphere injection of the present invention meet the requirements for intravenous administration, and can withstand high-pressure steam sterilization at 121° C. for 10 minutes. At the same time, this study is the first in the world to apply ion-pairing technology to the preparation of nano-preparations, which improves the transmembrane ability of clarithromycin, reduces bacterial drug resistance, and improves drug efficacy. The samples prepared in this study have good physical and chemical stability in long-term storage, and have little vascular irritation, which can improve patient compliance and curative effect.

The invention discloses an antihypertensive drug fat milk injection and a preparation method thereof. The antihypertensive drug fat milk injection is a clevidipine butyrate fat milk injection and contains clevidipine butyrate and a pharmacologically acceptable medical excipient; the medical excipient comprises an oil-phase medium, an emulsifier, an osmotic pressure regulator, a stabilizer, a metalcheating agent, a pH value regulator and injection water. The antihypertensive drug fat milk injection has stable quality and high safety and is not irritant to blood vessels.