Liquiritigenin injection and preparation method and application thereof

A liquiritigenin and injection technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of serious first-pass effect and low bioavailability of oral preparations of liquiritigenin , to achieve the effect of safe and reliable clinical use, high bioavailability and good clinical effect

Active Publication Date: 2014-04-23
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Purpose of the invention: the purpose of the present invention is to solve the deficiency of oral preparations of liquiritigenin in the prior art, provide a kind of liquiritigenin injection and its preparation method, to solve the problem of serious first-pass effect and low bioavailability of oral preparations of liquiritigenin

Method used

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  • Liquiritigenin injection and preparation method and application thereof
  • Liquiritigenin injection and preparation method and application thereof
  • Liquiritigenin injection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. A liquiritigenin injection, which contains 50 mg of liquiritigenin, 40 mL of propylene glycol, and water for injection in every 100 mL of the liquiritigenin injection, with a pH value of 4.0 to 6.0.

[0052] 2, the preparation method of glycyrrhizin injection, it comprises the following steps:

[0053] First, take 50 mg of liquiritigenin, stir until it is completely dissolved in 40 mL of propylene glycol, add 60 mL of water for injection, then perform ultrafiltration with a 5000 Dalton hollow fiber ultrafiltration membrane, and after filtration, adjust the pH value to 4.0-6.0 with hydrochloric acid or sodium hydroxide , filled with nitrogen, sealed in ampoules, and then sterilized at 121°C and 0.11MPa for 15 minutes.

Embodiment 2

[0055] 1. A liquiritigenin injection, which contains 10 mg of liquiritigenin, 20 mL of propylene glycol, and water for injection in every 100 mL of the liquiritigenin injection, with a pH value of 4.0 to 6.0.

[0056] 2, the preparation method of glycyrrhizin injection, it comprises the following steps:

[0057] First, take 10mg of liquiritinin, stir until it is completely dissolved in 20mL of propylene glycol, add 80mL of water for injection, then perform ultrafiltration with a 5000 Dalton hollow fiber ultrafiltration membrane, and after filtration, adjust the pH value to 4.0-6.0 with hydrochloric acid or sodium hydroxide , filled with nitrogen, sealed in ampoules, and then sterilized at 121°C and 0.11MPa for 15 minutes.

Embodiment 3

[0059] 1. A liquiritigenin injection, which contains 500 mg of liquiritigenin, 50 mL of propylene glycol, and water for injection in every 100 mL of the liquiritigenin injection, with a pH value of 4.0 to 6.0.

[0060] 2, the preparation method of glycyrrhizin injection, it comprises the following steps:

[0061] First, take 500mg of liquiritinin, stir until it is completely dissolved in 50mL of propylene glycol, add 50mL of water for injection, and then use a 5000 Dalton hollow fiber ultrafiltration membrane for ultrafiltration, after filtration, adjust the pH value to 4.0-6.0 with hydrochloric acid or sodium hydroxide , filled with nitrogen, sealed in ampoules, and then sterilized at 121°C and 0.11MPa for 15 minutes.

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Abstract

The invention discloses a liquiritigenin injection and a preparation method and application thereof. Each 100mL of liquiritigenin injection provided by the invention contains 10mg-1000mg of liquiritigenin, 20-50mL of propylene glycol and the balance of injection water; the liquiritigenin injection has a pH value of 4.0-6.0. According to the liquiritigenin injection, through a plenty of experiments, the dissolving solvent and the consumption thereof of the liquiritigenin injection, the concentration of liquiritigenin, and the pH value of the injection are screened, and thus an optimal injection formula is obtained; meanwhile, according to the solubility, the stability, the vascular stimulation, the hemolysis and the like, a preparation process of the liquiritigenin injection is screened. Experiments indicate that the liquiritigenin injection prepared by adopting the preparation method is small in irritation, free from hemolytic activity, high in safety, especially better in stability, strong in anti-tumor activity, capable of overcoming the defects of serious first-pass effect, low bioavailability and the like of an existing preparation, and better in clinical effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a liquiritigenin injection with excellent stability and multiple antitumor effects and a preparation method thereof. Background technique [0002] Malignant tumor is one of the diseases that seriously threaten human health and life. It has the characteristics of long treatment course, difficult to cure, and heavy economic and mental burden, which brings a heavy burden to patients and society. Since the 1970s, the incidence of cancer in my country has been on the rise. The annual number of cancer cases is about 2 million, and the number of cancer deaths exceeds 1.4 million. Among them, the high incidence of liver cancer is very serious, and the mortality rate ranks third in cancer mortality. Every year, 110,000 people die from liver cancer, accounting for about 45% of the total number of deaths from liver cancer in the world. In this rega...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/352A61K47/10A61P35/00A61P35/02
Inventor 蔡云清蔡宝昌顾杰姚仲青秦昆明张金龙刘晓
Owner NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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