1449 results about "Glycyrrhizin" patented technology

The invention relates generally to compositions comprising antioxidants useful for reducing oxidative stress and lipid peroxidation, and treating chronic liver disease, chronic hepatitis C virus infection and non-alcoholic steatohepatitis. In particular, the invention relates to the preparation and oral administration of compositions comprising glycyrrhizin, schisandra, ascorbic acid, L-glutathione, silymarin, lipoic acid, and d-alpha-tocopherol. The invention also relates to the preparation and parenteral administration of compositions comprising glycyrrhizin, ascorbic acid, L-glutathione, and vitamin B-complex, preferably by infusion or intravenous injection. The invention further relates to methods of using the antioxidants, oral compositions and parenteral compositions.

The invention discloses a slowly-released compound acidifier for poultry and livestock feed, a preparation method thereof and feed containing the same. The compound acidifier comprises the following compositions in part by weight: 30 to 80 parts of complex organic acid, 15 to 50 parts of supplementary materials and 5 to 20 parts of coating agents. The complex organic acid is citric acid, fumaric acid, malic acid, lactic acid, linoleic acid, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid and oleanolic acid, and the supplementary materials are silicon dioxide, hydroxypropyl methylcellulose and ethyl cellulose. The acidifier is scientifically proportioned, has strong efficiency and is long-acting and slow-releasing, nutrients in the feed are free from being damaged, the acidifier has good fluidity and is easy to be uniformly mixed with the feed, the digestive absorption of nutrients can be promoted, the conversion rate of the feed can be improved, the productivity of poultry and livestock can be improved, the time for domestic animals for sale can be effectively shortened, the health of gastrointestinal mucosa of the animals can be protected, the immunologic function of the animals can be strengthened, and diseases can be prevented.

The invention relates to methods and compositions for masking the taste of minerals in ingestible products. In particular, tannic acid glycyrrhizin and acesulfame potassium are added to compostions comprising minerals such as potassium, calcium, magnesium, iron, copper, chromium, zinc and mixtures in order to reduce or eliminate the unpleasant taste or aftertase associated with these minerals.

The present invention is directed to the use of one or more rebaudioside C polymorphs, or stereoisomers thereof, to enhance the sweet taste of a flavoring, such as glucosylated steviol glycoside, rebaudioside A, ammoniated glycyrrhizin, neohespherdin dihydrochalcone or thaumatin.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

The present invention discloses preparation process of licoflavone from licorice and licorice slag, and features licoflavone is extracted from crushed licorice or licorice slag after extracting glycyrrhetic acid through adding organic solvent for soaking, filtering, and concentrating the filtrate; and that the prepared licoflavone contains licochalcone, isoliquiritigenin, glabidin, liquiritin, liquiritigenin and other components. The preparation process is simple, high in yield and suitable for industrial production.

The invention discloses a medicine for treating pruritus caused by dermatitis, eczema and insect bite, and applications thereof. The medicine is a preparation prepared by the following components according to weight percentage: 0.1 percent to 90 percent of glycyrrhizic acid or physically acceptable salt of glycyrrhizic acid or glycyrrhetic acid or physically acceptable salt of glycyrrhetic acid, 0 percent to 90 percent of total matrines or physically acceptable salt of total matrines or oxymatrine or physically acceptable salt of oxymatrine or matrine or physically acceptable salt of matrine, 0 percent to 90 percent of hibiscus syriacus acid or physically acceptable salt of hibiscus syriacus acid or pseudolaric acid B or physically acceptable salt of pseudolaric acid B or osthole or total coumarins of fructus cnidii, and 1 percent to 5 percent of menthol or borneol. The medicine has the effect of anti-inflammatory, bacteriostasis and relieving itching, has unique therapeutic effect on pruritus caused by dermatitis, eczema and insect bite. The raw materials used by the medicine are nontoxic and cheap with low cost.

The invention belongs to the technical field of cosmetics and particularly relates to a spray agent containing wormwood hydrolat and a preparation method thereof. The spray agent containing wormwood hydrolat is mainly prepared from the wormwood hydrolat, rose hydrolat, chamomile extract, trehalose, allantoin, dipotassium glycyrrhizinate, hyaluronic acid, glycerinum, preservative and water. The spray agent containing the wormwood hydrolat has the functions of sterilization property, antianaphylaxis and antiphlogosis and itching relieving of broad spectrum and meanwhile has the effects of slowing down skin aging, promoting blood circulation of skin, supplementing water, moisturizing, refreshing and restoring consciousness. The spray agent containing wormwood hydrolat is free of stimulation to skin, the phenomenon of skin poisoning can be avoided after the spray agent is used for a long time, and the spray agent is suitable for being used for various people, especially suitable for being used by people with sensitive skin.

The invention discloses a feed additive for improving disease resistance of livestock and poultry and a production method thereof. The feed additive contains 5 to 10 percent of lentinan, 10 to 15 percent of astragalus polysaccharides, 5 to 10 percent of compound glycyrrhizin, 2 to 5 percent of epimedium herb, 3 to 5 percent of szechwon tangshen root, 3 to 5 percent of beta-glucan, 3 to 5 percent of yeast selenium, 6 to 10 percent of zinc methionine, 2 to 5 percent of potassium chloride, 12.9 to 34.9 percent of vitamin, and 0.1 percent of folic acid. The production method comprises the following steps: a, weighing raw materials in percentage; b, mixing the lentinan, the astragalus polysaccharides, the compound glycyrrhizin, the epimedium herb and the szechwon tangshen root for the first time to obtain a primary mixture; c, adding the beta-glucan, the yeast selenium, the zinc methionine and the potassium chloride into the primary mixture for mixing for the second time to obtain a secondary mixture; and d, adding the folic acid and the vitamin into the secondary mixture for mixing for the third time to obtain a finished product. The additive can effectively strengthen the disease resistance of animals, improves palatability and has good growth promoting effect.

The invention relates to high-effective mosquito repelling liquid medicine which is characterized by comprising the following components by weight percent: 2%-7% of N, N-Diethyl-m-toluamide, 0.2%-2% of glycyrrhiza extract (0.1%-90% of glycyrrhizinic acid or glycyrrhetinic acid or physiologically acceptable salt thereof), 0.2%-2% of flavescens extract (0%-90% of matrine or oxymatrine or physiologically acceptable salt thereof), 0%-50% of menthol or borneol and 0.01%-2% of plant essential oil. The high-effective mosquito repelling liquid medicine is the hormone-free preparation made of pure Chinese herbal medicine for external application and is prepared by uniquely combining the high-effective repellent with the components having the anti-inflammatory, the antibacterial and the antipruritic effect, thereby being innovative. The high-effective mosquito repelling liquid medicine of the invention has the function of repelling the mosquito, relieving the itching, refreshing the consciousness and protecting the skin from the insect bite and can repel the mosquito for 5-7 hours. The high-effective mosquito repelling liquid medicine of the invention is non-toxic to the skin and mucous membrane, can not cause the allergic reaction and has higher stability.

The invention provides a method for oriented biosynthesis of GAMG, and belongs to the technical fields of biosynthesis and biotransformation. The method comprises the following steps: producing corresponding beta-D-glucuronidase by penicillium purpurogenum stoll in a fermentation medium; adding the obtained beta-D-glucuronidase into conversion solution containing glycyrrhizic acid substrate, orientedly hydrolyzing the glycyrrhizic acid under the action of enzyme, and obtaining a coarse product of GAMG; and performing organic solvent extraction, resin adsorption and purification to obtain a GAMG product. The method takes microbialenzyme as a catalyst, and has high reaction efficiency, no pollution, simple steps, and low cost; and the product is single and has high purity.

A composite medicine or its medicinal kit for preventing and treating hepatitis B, hepatitis B, hepatitis C, AIDS and tumor features that its contains kurarinol (or kurarinol oxide) and glycyrrhizic acid, or their pharmacological acceptable salts.

The invention discloses a moisturizing, whitening, acne removing, grease controlling and relieving skin beautifying composition. The composition is mainly prepared from the following raw materials: raspberry ketone glucoside, arbutin, matrine, fructo-oligosaccharide, tea tree oil, dipotassium glycyrrhizinate, an extracting solution of leaf of Tasmanian bluegum, tea polyphenol, a peony root extract, tremella polysaccharide, hyaluronic acid with low molecular weight, hyaluronic acid with high molecular weight, transparent xanthan gum, zinc gluconate, Carbomer 940, hydroxyethyl cellulose, 1,3-butanediol, nicotinamide, D-panthenol, tranexamic acid, vitamin C ethyl ether, triethanolamine, an emulsifier, water, and the like. The moisturizing, whitening, acne removing, grease controlling and relieving skin beautifying composition has the beneficial effects that the composition is rich in plant essence, is reasonable in proportioning and can achieve the effects of effectively comforting and smoothening pores, cleaning hair follicles, balancing grease excretion, promoting wound healing and ensuring no pockmarks after healing and low recurrence probability; besides, the composition is also rich in moisturizing ingredients, so that the skins can be hydrated and bright, fine lines can be reduced and smooth and fair skins can be restored after the composition is used for a long term.

A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a drug dissolved or dispersed in an aqueous medium. The aqueous medium consists essentially of water, about 3% to about 10% w/v polyvinylpyrrolidone, about 60% to about 75% w/v of C₃-C₆ polyol that includes more than 55% w/v of a non-reducing disaccharide, trisaccharide or tetrasaccharide such as sucrose, optionally about 0.01% to about 0.5% w/v of a glycyrrhetic acid, glycyrrhizinate derivative or salt thereof, and one or more flavorants, and preferably includes one or more preservatives. The liquid composition is room temperature stable, and may have a pleasant taste.

A chewing spirulina tablet is prepared from spirulina and two or more of dextrin, microcrystalline cellulose, mannitol, xylitol, aspartame, glycyrrhizin, essence powder, superfine silica gel powder, and magnesium stearate through mixing, granulating by use of alcohol solution containing polyvitone K30, drying and die pressing.

The invention provides a glycyrrhetic acid and phospholipid composites of glycyrrhetate and process for preparing same by forming phospholipid compound in suitable dissolvent from glycyrrhizinic acid and its salts with a definite quantity of lecithin, thus converting the physical and chemical property, and improving the bioavailability of the glycyrrhizic acid and its salts.

The invention relates to a new type of liver targeted drug carrier- glycyrrhetate modified chitosan/ carboxylated chitosan compound drug carrier nanometer particle as well as its preparing method. The preparing procedure includes the following steps: dissolving the glycyrrhetate into carboxylated chitosan of a certain density; adding certain amount of chitosan solution which contains drug into the carboxylated chitosan while stirring; nanometer particles form automatically because of the electrostatic interaction among different molecules. The invention has simple preparing procedures, mile operating conditions and it has no poisoning or side effects of the organic solvents. Since the glycyrrhizin has characteristic of targeting at the liver, the product in the invention has the function of active targeting which leads to high effect liver targeting capabilities. The invention is applicable to the entrapment of medicine that contains electrical group (such as doxorubicin hydrochloride), protein drugs and medicine that has certain water-solubility in neutral pH conditions.

The invention provides whitening essence and a preparation method thereof. The whitening essence consists of the following components of glycerine, 1,3-butanediol, sodium hyaluronate, EDTA-2Na, polyglycerol-10, sodium polyacrylate, xanthan gum, hydroxyacetophenone, dipotassium glycyrrhizinate, hydrolyzed sclerotium gum, gluconic acid sodium salt, glycereth-26, caprylhydroxamic acid, glycerol caprylate, 3-o-ethyl ascorbic acid, tranexamic acid, ceramide, phenethyl resorcinol, diglucosyl gallic acid and water. The whitening essence disclosed by the invention can refrain conversion of tyrosine tomelanin before the tyrosine is in preparation of conversion to the melanin, so that the activity of the tyrosinase is also high, generation of more melanin cannot be caused, and transfer of skin melanin can also be restrained. Besides, the whitening essence has powerful antioxidant ability, has light protection effects on skin, can control dermatitis, and is a whitening product most comprehensivein action mechanism at present, so that whitening effects can be achieved.