Quality detection method of traditional Chinese medicine preparation

A quality testing method and technology for traditional Chinese medicine preparations, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to distinguish the quality, unevenness, and inability to reflect the overall curative effect, etc., and achieve the control quality, the method is simple, and the accuracy high effect

Active Publication Date: 2020-04-21
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Abstract
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Problems solved by technology

[0003] At present, there are detection methods for single medicinal materials in traditional Chinese medicine prescriptions. However, Wenjing Decoction has complex ingredients, and the active ingredient is often not a single ingredient, but several ingredients work together to play a therapeutic role. Any single ingredient cannot reflect its whole. Curative effect, the determination of the content of any single component can not reflect the overall curative effect
Therefore, the current quality testing methods for Wenjingtang are not enough to explain the quality of Wenjingtang, nor can they distinguish many products of varying quality on the market

Method used

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  • Quality detection method of traditional Chinese medicine preparation

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preparation example Construction

[0061] (1) Preparation of the reference substance solution: respectively use gallic acid, paeonifloride glycoside, paeoniflorin, ferulic acid, liquiritin, β-ecdysterone, ligusticolide I, liquiritigenin, cinnamic acid, cinnamic aldehyde, Paeonol, ammonium glycyrrhizinate and ligustilide were used as reference substances, dissolved in a solvent to obtain gallic acid reference substance solution, paeonifloride glycoside reference substance solution, paeoniflorin reference substance solution, ferulic acid reference substance solution, liquiritin Reference substance solution, β-ecdysterone reference substance solution, chuanxiong lactone I reference substance solution, glycyrrhizin reference substance solution, cinnamic acid reference substance solution, cinnamon aldehyde reference substance solution, paeonol reference substance solution, ammonium glycyrrhizinate Reference substance solution and ligustilide reference substance solution;

[0062] (2) Preparation of the test solution...

Embodiment 1

[0116] The preparation method of embodiment 1 Wenjingtang granules

[0117] Weigh 150g Angelica, 150g Chuanxiong, 150g Radix Paeoniae Alba, 150g Cinnamon, 150g Cortex Moutan, 150g Curcuma, 300g Ginseng, 300g Licorice, and 300g Achyranthes bidentata, crush the above medicinal materials into the coarsest powder, add 27000mL of water, soak for 30min, boil on high heat, Turn to low heat, keep boiling slightly for 30 minutes, pass through a 300-mesh sieve while it is hot, concentrate until the Baume degree is 20, and make a clear paste, add 4%-8% of the clear paste amount of starch, mix well, and set the temperature at 50-100 °C in a vacuum oven to obtain a dry paste.

[0118] Grinding the dry cream into powder, adding 1%-4% magnesium stearate in the amount of the clear cream, mixing evenly, performing granulation and sizing to obtain granules.

Embodiment 2

[0119] The preparation method of embodiment 2 Wenjingtang capsules

[0120] Weigh 150g Angelica, 150g Chuanxiong, 150g Radix Paeoniae Alba, 150g Cinnamon, 150g Cortex Moutan, 150g Curcuma, 300g Ginseng, 300g Licorice, and 300g Achyranthes bidentata, crush the above medicinal materials into the coarsest powder, add 27000mL of water, soak for 30min, boil on high heat, Turn to low heat, keep boiling slightly for 30 minutes, pass through a 300-mesh sieve while it is hot, concentrate until the Baume degree is 20, and make a clear paste, add 4%-8% of the clear paste amount of starch, mix well, and set the temperature at 50-100 °C in a vacuum oven to obtain a dry paste.

[0121] The dry paste is crushed into powder, packed into hard gelatin capsules to obtain capsules.

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Abstract

The invention relates to a quality detection method of a traditional Chinese medicine preparation. The method comprises the following steps: respectively taking gallic acid, albiflorin, paeoniflorin,ferulic acid, liquiritin, beta-ecdysterone, senkyunolide I, glycyrrhizin, cinnamic acid, cinnamyl aldehyde, paeonol, ammonium glycyrrhizinate and ligustilide as reference substances, and establishinga fingerprint spectrum of the traditional Chinese medicine preparation by adopting high performance liquid chromatography; identifying Chinese angelica, the rhizome of chuanxiong, radix paeoniae alba,moutan bark, ginseng, cassia bark, licorice root and the root of bidentate achyranthes of the traditional Chinese medicine preparation by adopting thin-layer chromatography. The traditional Chinese medicine preparation is prepared by using the following raw materials: Chinese angelica, the rhizome of chuanxiong, radix paeoniae alba, cassia bark, moutan bark, zedoray rhizome, ginseng, licorice root and the root of bidentate achyranthes. With the two detection ways, comprehensive quality evaluation can be conducted on the meridian-warming decoction traditional Chinese medicine preparation. Themethod is simple, convenient, high in accuracy and high in reproducibility; a scientific basis can be provided for quality detection and evaluation of the meridian-warming decoction traditional Chinese medicine preparation, and the product quality is effectively controlled.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to a quality detection method for traditional Chinese medicine preparations. Background technique [0002] Wenjing decoction is the ancestral prescription for regulating menstruation. The prescription comes from "Women's Encyclopedia of Good Prescriptions". The function of removing blood stasis and relieving pain. In the prescription, cinnamon warms the meridian and dispels cold, clears the meridians and regulates the meridian; Paeoniae officinalis and Radix Glycyrrhiza act together to relieve spasm and relieve pain. Clinically, it can be used for menstrual bleeding and irregular menstruation caused by various palace colds. It is widely used and the effect is good. [0003] At present, there are detection methods for single medicinal materials in traditional Chinese medicine prescriptions. However, Wenjing Decoction has complex ingredients, and the active ingredient is ofte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/90
CPCG01N30/02G01N30/06G01N30/34G01N30/90
Inventor 柴玉爽何源峰朱启亮罗丽陈纹平尹震宁娜苏碧茹张春波
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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