310results about How to "Accurate mass" patented technology

A high fidelity distributed plant simulation technique includes a plurality of separate simulation modules that may be stored and executed separately in different drops or computing devices. The simulation modules communicate directly with one another to perform accurate simulation of a plant, without requiring a centralized coordinator to coordinate the operation of the simulation system. In particular, numerous simulation modules are created, with each simulation module including a model of an associated plant element and these simulation modules are stored in different drops of a computer network to perform distributed simulation of a plant or a portion of a plant. At least some of the simulation modules, when executing, perform mass flow balances taking into account process variables associated with adjacent simulation modules to thereby assure pressure, temperature and flow balancing (i.e., conservation of mass flow) through the entire simulation system. In a dynamic situation, a transient mass storage relay technique is used to account for transient changes in mass flow through any non-storage devices being simulated by the simulation modules. Moreover, adjacent simulation modules located in different drops communicate directly with one another using a background processing task, which simplifies communications between adjacent simulation modules without the need for a central coordinator.

The invention relates to a coupling of two sides of a synergetically cooperating fixation system in medical equipment and apparatus, illustrated by way of example of an external fixator with rod-like guide elements, wherein a point-precise and internally tension-free clamping connection is formed by in each case two planar parallel disposed faces. The complementary, uncoated coupling surface is shape-matchingly impressed "de novo" and "uniquely" during each coupling closure by a static press-on force based on a diamond, plastic grain layer of a chaotic profile solidly attached to one of the faces, such that a clamping connection with the multilatent force-form match closure is furnished.

A system and method of driving weight management product sales in a multi-level marketing environment using a body impedance data acquisition device, a weight management software program, nutritional supplements and a standardized sales pathway software program, resulting in direct sales, lead generation and new distributor sign up. A prospect's personal information and lean body mass data are input to the weight management computer software program for determining an individualized weight management plan, where the lean body mass data are obtained using the body impedance data acquisition device. The prospect is presented weight management product packages for purchase, individualized according to the derived weight management plan and becomes a client upon purchasing a product package. The new customer is presented a business opportunity in becoming a new distributor of the weight management products and, if enlisted, is provided product discounts and sales software tools for facilitating weight management product sales.

The invention presents a method for examining genetic material (deoxyribonucleic acid, DNA) to detect the presence of pre-known mutations, especially single nucleotide polymorphisms (SNP), using mass spectrometry with ionization by matrix-assisted laser desorption (MALDI). The invention uses nucleoside triphosphates with modified sites for the method of primer extension in a duplicating, enzymatic reaction and at least partially removal of primers from the extension product, in combination with product neutralization by chemical treatment of the modified sites, so that the resulting DNA products can be, by using special matrix materials, preferredly ionized in an adduct-free form over other constituents in the reaction solution without any further cleaning. The method is particularly suitable for simultaneous identification of several mutations by multiplexing.

Accurate mass measurement is carried out for product ions of a sample. A method for accurate mass determination of ions with Trap-TOF / μs includes steps of generating ions of an analyte sample and a standard material; introducing the ions of the analyte sample and the standard material together into an ion trap to trap them; selecting a precursor ion from the ions of the analyte sample to leave the precursor ion and a standard material ion in the ion trap and eliminate other ions; exciting and dissociating the precursor ion to generate product ions; ejecting the precursor ion, its product ions, and the standard material ion trapped in the ion trap to introduce these ions into the TOF mass spectrometer; and measuring a mass spectrum with the TOF mass spectrometer, where correction for accurate masses of the product ions is carried out based on the standard material ion measured.

A time of flight type mass spectrometer (TOF-MS) of the present invention includes: a flight space containing a loop orbit on which ions fly once or more than once; a flight controller for making ions of a same mass to charge ratio fly the loop orbit at several values of number of turns; a flight time measurer for measuring a length of flight time of the ions; and a processor for determining the mass to charge ratio of the ions based on a relationship between the value of number of turns and the length of flight time of the ions. The speed of ions flying a loop orbit depends on their mass to charge ratios. For ions of the same mass to charge ratio, the difference between the lengths of flight time of the ions flying the loop orbit N turns and of the ions flying the loop orbit N+1 turns depends on the speed of the ions, so that the difference depends on the mass to charge ratio of the ions. The difference in the length of flight time is unrelated to the variation in the starting time (jitter), variation in the detection timing (jitter), etc, so that the value of the mass to charge ratio can be precisely determined free from errors caused by such disturbing factors.

A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open / close device for opening and closing a flow of the gas the ion source inhales.

A method for determining the mass of a motor vehicle while taking different driving situations into consideration, involving an evaluation of a vehicle acceleration, wherein apart from a driving force of a vehicle drive unit, resistance forces resulting from rotational forces, air resistance, rolling resistance, the slope descending force and a braking force are taken into consideration. Additionally, a multitude of different driving situations may be evaluated, wherein the individual results are stored and combined suitably into a collective mass value. Further, different driving situations can be weighted differently in determining the mass value.

A pressure and flow calculation technique can be used in a distributed process network simulation system that uses the sequential solving method to perform better or faster simulations of a process flow, especially with respect to process junction nodes at which flow either converges or diverges. The pressure and flow variable determination technique uses a grouped node identification technique that identifies a local set of nodes for each junction node of the process network to use when solving for the pressure at the junction node, a grouped node iteration technique that uses the grouped set of nodes at each junction node to perform iterative pressure calculations at the junction node, and a flow-based pressure calibration technique at each junction node to enable the system to perform highly accurate pressure and flow variable determination at each junction node in real-time.

A method of manufacturing an inlayed panel uses the steps of providing an art master rendering as constitute a decorative design for the inlaid panel; scanning electronically the art master to form an art master data file; transferring the art master data file to a CAD software system to form an art master CAD file; coordinating a laser beam to cut-through a first background panel and create negative image voids; driving a CNC laser cutting machine in response to the machine code coordinates; coordinating a laser beam to cut through a second panel for forming positive images that become inlay elements; bonding the first background panel and the second panel; placing the inlay element in appropriate voided spaces; and finishing the composite panel and the inlay elements. A decorative panel is also formed of panel portions cut by laser using data inputted directly into a computer graphics system.

A radiation imaging apparatus in which early recognition of breast cancer can be made possible by acquiring both a radiation tomographic image that accurately displays a tumor mass and a radiation planar image that accurately displays calcification. The apparatus includes an image processing unit for generating a tomographic image signal in a first imaging mode and generating a planar image signal in a second imaging mode, a computing unit for computing an imaging direction for obtaining a radiation planar image based on a location designated in a radiation tomographic image, and a control unit for controlling a rotational driving device and a radiation generating unit to obtain the radiation tomographic image in the first imaging mode, and controlling the rotational driving device according to the computed imaging direction and controlling the radiation generating unit to obtain the radiation planar image in the second imaging mode.

A measure of abundance is determined for an element or element combination within a sample, the element or element combination having at least one isotopic variant. An isotopic mass spectral pattern is identified for the element or element combination that indicates an expected abundance and expected mass-to-charge ratio difference for each isotopic variant. These are identified relative to the respective abundance and mass-to-charge ratio of a principal isotope. The isotopic mass spectral pattern is compared with mass spectral data from a molecular mass analysis of the sample to identify peak groups, each matching the isotopic mass spectral pattern. A measure of abundance is determined for the element or element combination as a function of the intensity measurement of one or more peaks from each of the identified peak groups.

The invention relates to a quality detection method of a traditional Chinese medicine preparation. The method comprises the following steps: respectively taking gallic acid, albiflorin, paeoniflorin,ferulic acid, liquiritin, beta-ecdysterone, senkyunolide I, glycyrrhizin, cinnamic acid, cinnamyl aldehyde, paeonol, ammonium glycyrrhizinate and ligustilide as reference substances, and establishinga fingerprint spectrum of the traditional Chinese medicine preparation by adopting high performance liquid chromatography; identifying Chinese angelica, the rhizome of chuanxiong, radix paeoniae alba,moutan bark, ginseng, cassia bark, licorice root and the root of bidentate achyranthes of the traditional Chinese medicine preparation by adopting thin-layer chromatography. The traditional Chinese medicine preparation is prepared by using the following raw materials: Chinese angelica, the rhizome of chuanxiong, radix paeoniae alba, cassia bark, moutan bark, zedoray rhizome, ginseng, licorice root and the root of bidentate achyranthes. With the two detection ways, comprehensive quality evaluation can be conducted on the meridian-warming decoction traditional Chinese medicine preparation. Themethod is simple, convenient, high in accuracy and high in reproducibility; a scientific basis can be provided for quality detection and evaluation of the meridian-warming decoction traditional Chinese medicine preparation, and the product quality is effectively controlled.

The invention provides a novel series-parallel connection mass spectrum device system. The system comprises mass spectrum necessary basic subsystems, such as a set of quadrupole mass filter system, a special quadrupole rod / linear ion trap mass analyzer system, an ion guidance system, a quadrupole deflector, a hyperbolic quadrupole rod mass analyzer and ion counter system, a low air pressure linear ion trap mass spectrometer and electron multiplier system, a flight time mass spectrum system, a multi-path gas flow control system, a vacuum gauge, a multi-section differential motion vacuum system and the like. Furthermore, the invention provides a method for operating above systems to perform quantitative analysis in a triplet quadrupole rod mode, qualitative analysis in a quadrupole filtering medium combined high / low air pressure ion trap mode, and quick / high-mass precision analysis in a quadrupole filtering combined flight time mass spectrum mode on ultra-trace materials in a complex matrix, a method for utilizing an effective combination of three different mass analyzers to achieve optimal ion optical parameter adjustment and a method for performing high-precision qualitative and quantitative analysis on the ultra-trace materials.

A fixing element and inspection system for examining the status of the fixing element are provided in the present invention. The fixing has a sensing material disposed therein for transforming the force acting on the fixing element into an electrical signal. A signal processing unit, powered by a radio frequency circuit, is coupled to the sensing material for transforming the electrical signal into a readable signal and then transmitting the readable signal to the inspection system through radio frequency so as to monitor the status of the fixing element. By means of the present invention, it is capable of inspecting and monitoring the status of a great amount of fixing elements rapidly and precisely, especially in occasion that extreme safety should be highly concerned, for example, fixing elements secured to the airplane.

The invention provides a detection method for illegal additives in weight-losing type Chinese patent medicines and health foods. A Q-Orbitrap high-resolution mass spectrometer is adopted and a Full MS Scan / dd-MS2 (Top N) scanning mode is carried out so that positive and negative ions are detected at the same time; the separation, high-precision first-grade mass spectrometric scanning and high-precision second-grade mass spectrometric scanning of analytes in a sample can be finished in an analyzing period to obtain accurate mass quantity and accurate fragment ion information; chromatography retention time, a first-grade mass spectrum and a second-grade mass spectrum of the sample are compared with those of a weight-losing type chemical component comparison product to determine that whether weight-losing type chemical medicines are doped into the sample or not; and rapid screening, confirmation and quantification can be carried out on a potential positive sample. The detection method has the advantages of high sensitivity, good selectivity, strong confirmation, simplicity and rapidness of operation and the like, can be used for accurately screening, has the sensitivity beyond comparison of traditional HPLC and low-resolution LC-MS, and can be used for identifying, confirming and quantitatively analyzing compounds in a single analysis period (12 minutes).

Laser desorption / ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.

An ionization apparatus according to the present invention has a mechanism for causing metal ions emitted from an ion emitter to attach to an introduced target gas so as to generate ions of the sample gas and emits the ions of the sample gas to a mass spectrometer. The mass spectrometer has a zone in which one or both of an electric field and magnetic field are formed. As the electrode for causing the generation of cleaning plasma in the ionization zone generating the ions of the sample gas, the ion emitter is used. The ion emitter causes the generation of plasma in connection with a hollow vessel and removes deposits on components facing the ionization zone by the plasma. The plasma cleaning process is performed consecutively at a suitable timing after the ionization process. Due to the above configuration, deteriorated performance in ionization can be restored in a short time, a memory effect can be prevented, and accurate mass spectrometry becomes possible. The ionization apparatus of the present invention is suitable for a mass spectrometry apparatus.

The invention discloses preparation and quality detection method of compound prescription cortex phellodendri chinensis fluid. The quality detection method comprises the identification of forsythia fruit, cortex phellodendri, honeysuckle and dandehon herb, the checking of lonicerae flos, and the content determination of forsythin and berberine hydrochloride. According to the determination method, spots with the same colors are formed in a qualified test article thin-layer chromatogram and in corresponding positions of a reference substance thin-layer chromatogram, and negative control is interference-free, and the method is good in selectivity, simple and accurate. The checking method of lonicerae flos adopts a high performance liquid chromatography, is good in specificity, and can distinguish the situation that lonicerae flos is adopted in the compound prescription cortex phellodendri chinensis fluid to pretend honeysuckle flower to charge material. The content determination of forsythin and berberine hydrochloride is good in linear relation and high in recovery test accurancy, has good repeatability and stability, can accurately and strictly detect the quality of the compound prescription cortex phellodendri chinensis fluid, and guarantees a high quality standard level of the compound prescription cortex phellodendri chinensis fluid.

A combination of “bottom up” and “top down” MS analysis of posttranslational modifications in complex proteins is described. The method comprises digestion of the protein with an enzyme that forms larger peptide fragments than trypsin (>3000 D), performing HPLC with the fragments and applying a new data acquisition strategy using on-line coupling with e.g. LTQ-FTMS, a hybrid mass spectrometer that couples a linear ion trap with a Fourier transform ion cyclotron resonance (FTICR) cell. The method is applied to analysis of posttranslational modifications of protein isoforms.

The invention discloses a heavy vehicle mass and mass center detection device. The existing devices mainly use side weighing methods, the number of sensors is small, and the devices have certain limitations. The detection device comprises a foundation pit, a four-degree-of-freedom (4DOF) platform, pressure sensors, a vehicle to be detected and a horizontal table board; the 4DOF platform is arranged in a foundation, and a plurality of pressure sensors are arranged on the upper surface of an upper cylindrical portion of an upper platform of the 4DOF platform from center to periphery along an Archimedes spiral; and the horizontal table board is covered on the pressure sensors, and the vehicle to be detected is arranged on the horizontal table board. The 4DOF platform can rotate along an X axis, a Y axis and a Z axis, and the pressure sensors in the device work out the mass and the position of the mass center of the vehicle rapidly according to different positions and pressure gained in the detection during rotating movement. According to the detection device, the measurement accuracy of the sensors is guaranteed by arrangement optimization of the sensors, and the measured mass and the position of the mass center are more accurate and reliable.

The invention belongs to the field of cutting equipment for building blocks and particularly relates to a cutting production line for the building blocks. The production line comprises a rack and main conveying device arranged on the rack; a No.1 cutting machine, a No.2 cutting machine and a No.3 cutting machine are sequentially arranged on the rack; a transverse distributing and turning mechanism for turning the building blocks by 90 degrees is arranged between the No.1 cutting machine and the No.2 cutting machine; and a reversing mechanism for reversing the building blocks is arranged between the No.2 cutting machine and the No.3 cutting machine. The production line is applicable to cutting of concrete building blocks and building block foam bricks, can perform six-surface cutting on the building blocks automatically, has the high production efficiency and guarantees the appearance quality and the size accuracy of finished products.

The invention provides a dual-phase capsule for preventing and treating chronic pelvic inflammation and a preparation method and a detection method thereof. The dual-phase capsule for preventing and treating chronic pelvic inflammation is prepared by extracting 20g of Chinese pulsatilla root, 20g of nutgrass galingale rhizome, 12g of twotooth achyranthes, 12g of Chinese atractylodes, 8g of amur corktree bark and 8g of selinum japenious seed serving as bulk pharmaceuticals, adding a proper amount of superfine silica powder and low-substituted hydroxypropyl cellulose, and adding 80 percent ethanol as a wetting agent. Aiming at the defects in the prior art, a preparation process of the dual-phase capsule for preventing and treating chronic pelvic inflammation is optimized, so that the curative effect of the dual-phase capsule on chronic pelvic inflammation is more remarkable. A systematic, complete and effective component identification and content determination method is established, so that the quality of the dual-phase capsule can be controlled effectively, and the clinical curative effect is ensured.

The present invention relate to an autoantigen screening method by combining immunoaffinity chromatography, disease-related cell lines, and mass spectrometry technology, which offers greater screening efficiency and speed than known technologies. The method for screening autoantigen by using autoantibodies in patient's body by utilizing the chromatographic column packed with autoantibodies, through the affinity between autoantibody and autoantigen, and the extract of disease-related cell lines or pathological tissues, whereby an autoantigen screening platform is established.

A method for identifying unadulterated traditional Chinese medicine based on stable isotope fingerprint specifically comprises the following steps: 1, firstly testing stable nitrogen isotope composition and proportion of unadulterated traditional Chinese medicine; 2, secondly testing stable hydrogen isotope composition and proportion of unadulterated traditional Chinese medicine; 3, thirdly constructing stable isotope fingerprint; 4, finally identifying unadulterated traditional Chinese medicine. The invention can fast, accurately and effectively identify the quality, origin place and adulteration of unadulterated traditional Chinese medicine with good popularization value.

An ion trap / time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS / MS and MSn has an ion source for ionizing a sample, an ion trap capable of temporarily trapping ions, and a time-of-flight mass spectrometer. The ion source produces ions of the sample as a measurement target and ions of a reference sample each having a known mass value. A precursor ion is selected from among the ions of the measurement target sample, and the selected precursor ion is excited and fragmented in the ion trap to produce a product ion. The reference sample ions are introduced to and trapped in the ion trap. The trapped product ion and reference sample ions are expelled out of the ion trap and introduced to the time-of-flight mass spectrometer, thereby obtaining a mass spectrum.

A reloadable training munition having a reusable shell base having a propulsion system reload inserted into a hollow cavity of the shell base and a reusable single piece projectile inserted into the shell base, the projectile having a hollow body portion, a driving band adjacent the body portion, and a nose portion adjacent the driving band having void spaces for controlling both density and mass properties of the nose portion.