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Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation

An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P-diastolic P), and / or dP / dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (.tau.); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (E.sub.ES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and / or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.
Owner:MEDTRONIC INC

Vestibular stimulation system and method

InactiveUS6314324B1Augmenting or controlling a patient's natural respiratory functionImprovement effortsInternal electrodesExternal electrodesPhysical medicine and rehabilitationPhysical therapy
An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and / or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and / or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power / control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and / or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.
Owner:RIC INVESTMENTS LLC

Vestibular stimulation system and method

InactiveUS6748275B2Augmenting or controlling a patient's natural respiratory functionImprovement effortsInternal electrodesExternal electrodesSleep inductionControl unit
An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and / or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and / or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power / control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and / or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.
Owner:RIC INVESTMENTS LLC

Strained silicon on insulator from film transfer and relaxation by hydrogen implantation

Transistors fabricated on SSOI (Strained Silicon On Insulator) substrate, which comprises a strained silicon layer disposed directly on an insulator layer, have enhanced device performance due to the strain-induced band modification of the strained silicon device channel and the limited silicon volume because of the insulator layer. The present invention discloses a SSOI substrate fabrication process comprising various novel approaches. One is the use of a thin relaxed SiGe layer as the strain-induced seed layer to facilitate integration and reduce processing cost. Another is the formation of split implant microcracks deep in the silicon substrate to reduce the number of threading dislocations reaching the strained silicon layer. And lastly is the two step annealing / thinning process for the strained silicon / SiGe multilayer film transfer without blister or flaking formation.
Owner:SHARP KK

Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring

ActiveUS8577458B1Restore autonomic balanceImprove long-term patient outcomeInternal electrodesHeart stimulatorsNervous systemHeart rate monitoring
An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and to record the sensed heart rate as data into a memory.
Owner:LIVANOVA USA INC

Vestibular stimulation system and method

InactiveUS20020072781A1Augmenting or controlling a patient's natural respiratory functionImprovement effortsInternal electrodesExternal electrodesSleep inductionControl unit
An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and / or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and / or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power / control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and / or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.
Owner:RIC INVESTMENTS LLC

Silicon device on Si:C-OI and SGOI and method of manufacture

A semiconductor structure and method of manufacturing is provided. The method of manufacturing includes forming shallow trench isolation (STI) in a substrate and providing a first material and a second material on the substrate. The first material and the second material are mixed into the substrate by a thermal anneal process to form a first island and second island at an nFET region and a pFET region, respectively. A layer of different material is formed on the first island and the second island. The STI relaxes and facilitates the relaxation of the first island and the second island. The first material may be deposited or grown Ge material and the second material may deposited or grown Si:C or C. A strained Si layer is formed on at least one of the first island and the second island.
Owner:IBM CORP

Systems and Methods for Directing Brain Activity

Methods and devices are provided for monitoring and manipulating a person's brainwaves to achieve a desired mental state. A method of improving a student's test-taking ability includes analyzing EEG data to determine a student's focus level during an exam and providing a suggestion to the student for improving the student's focus level. A method of manipulating brain activity includes measuring a listener's brainwave frequency and providing binaural beats to the listener to guide the listener to a desired mental state. The binaural beats may be incorporated into music in such a way that they may not be distinguished over the music. A portable apparatus includes EEG electrodes connected to earphones with malleable wire that facilitates preferential placement and stability on a user's scalp.
Owner:AXIO

Apparatus and method for increasing spin relaxation times for alkali atoms in alkali vapor cells

An atomic vapor cell apparatus and method for obtaining spin polarized vapor of alkali atoms with relaxation times in excess of one minute is provided. The interior wall of the vapor cell is coated with an alkene-based material. The preferred coatings are alkenes ranging from C18 to C30 and C20-C24 are particularly preferred. These alkene coating materials, can support approximately 1,000,000 alkali-wall collisions before depolarizing an alkali atom, an improvement by roughly a factor of 100 over traditional alkane-based coatings. Further, the method involves a combination of one or more of the following: the use of a locking device to isolate the atoms in the volume of the vapor cell from the sidearm used as a reservoir for the alkali metal vapor source, careful management of magnetic-field gradients, and the use of the spin-exchange-relaxation-free (SERF) technique for suppressing spin-exchange relaxation.
Owner:RGT UNIV OF CALIFORNIA

Method of treating cellulite

A treatment for subcutaneous fat and / or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.
Owner:CANDELA CORP

Silicon device on Si:C-OI and SGOI and method of manufacture

A semiconductor structure and method of manufacturing is provided. The method of manufacturing includes forming shallow trench isolation (STI) in a substrate and providing a first material and a second material on the substrate. The first material and the second material are mixed into the substrate by a thermal anneal process to form a first island and second island at an nFET region and a pFET region, respectively. A layer of different material is formed on the first island and the second island. The STI relaxes and facilitates the relaxation of the first island and the second island. The first material may be deposited or grown Ge material and the second material may deposited or grown Si:C or C. A strained Si layer is formed on at least one of the first island and the second island.
Owner:IBM CORP

Pressure sensitive adhesive composition for optical members, pressure sensitive adhesive layer for optical members, pressure sensitive adhesive optical member and image display

The present invention provides a pressure sensitive adhesive composition for optical members, which is excellent in durability, re-releasability and stress relaxation, as well as a pressure sensitive adhesive composition for optical members, which hardly increases adhesion after storage for a long time and does not leave a residual adhesive on glass upon disposal or repair. The pressure sensitive adhesive composition for optical members according to the present invention comprises 100 parts by weight of an acrylic polymer (A) having a weight-average molecular weight of 500,000 or more, containing at least 50 wt % alkyl (meth)acrylate having an alkyl group with 5 or more carbon atoms and 0.2 to 2 wt % unsaturated carboxylic acid as the monomer unit, 0.1 to 4 parts by weight of an acrylic polymer (B) having a weight-average molecular weight of 2,000 to 50,000, containing at least 70 wt % alkyl(meth)acrylate and 1 to 7 wt % unsaturated carboxylic acid as the monomer unit and having a higher carboxylic acid equivalent than that of the acrylic polymer (A), 0.01 to 1 part by weight of a silane coupling agent, and a crosslinking agent.
Owner:NITTO DENKO CORP

Porphyrin compounds as telomerase inhibitors

InactiveUS6087493ARegulating telomerase functionModulating tumor proliferation and mortalitySugar derivativesMicrobiological testing/measurementTelomeraseDna interaction
The present invention has identified compounds with extended aromatic chromophores that bind the G-quadruplex formed by the folding of single-stranded human telomeric DNA. These compounds have been shown to be effective telomerase inhibitors and are contemplated to be useful in developing cancer treatments. A model of cationic porphyrin interaction with quadruplex DNA by intercalation has been established and in combination with structure activity relations has provided novel porphyrin compounds that exhibit discrimination between binding duplex and quadruplex DNA and show improved activity against telomerase.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Semiconductor device

A device includes a substrate; a buffer layer; and a device formation layer, wherein the buffer layer is formed by sequentially stacking, a plurality of times, a first nitride-based semiconductor layer made of a material having a lattice constant lower than a lattice constant of a material of the substrate; a first composition graded layer made of a material having a lattice constant gradually higher than the lattice constant of the first nitride-based semiconductor layer in a thickness direction; a second nitride-based semiconductor layer made of a material having a lattice constant higher than the lattice constant of the first nitride-based semiconductor layer; and a second composition graded layer made of a material having a lattice constant gradually lower than the lattice constant of the second nitride-based semiconductor layer in the thickness direction, and the second composition graded layer is thicker than the first composition graded layer.
Owner:SANKEN ELECTRIC CO LTD

Dispersible alcohol/cleaning wipes via topical or wet-end application of acrylamide or vinylamide/amine polymers

ActiveUS20060003649A1Desired level of strength of the fibrous substrateEnhance a fibrous substrateCosmetic preparationsToilet preparationsFiberPolymer
The present invention is directed to a wet wipe product. The wet wipe product comprises a fibrous substrate and a triggerable binder formulation. The triggerable binder formulation is capable of binding the fibers in the fibrous substrate. The triggerable binder formulation may include acrylamide polymers, vinylamide / amine polymers, and mixtures. The triggerable binder formulation is insoluble in a wetting composition comprising an insolubilizing agent but is dispersible in disposal water.
Owner:MGL TECHNICAL ASSOC LLC

Elastic Tourniquet Capable of Infinitely Adjustable Compression

A tourniquet band is made of an elastic material and has a plush surace on one side and a series of hook fastener material patches on the reverse side. The woven structure includes a series of parallel elastic threads covered by a dense yet loosely coiled bundle of non-elastic threads. The non-elastic threads are oriented to form the plush surface while allowing the elastic core thread to elongate for applying pressure to a body part by elastic compression when the tourniquet is wrapped around the body part and secured by joining the hook material with the plush surface.
Owner:THORPE PATRICIA E

Silicone-containing ocular lens material with high safety and preparing method thereof

The present invention provides a safe ocular lens material having high oxygen permeability, excellent surface wettability, the excellent lubricity / easy lubricating property of surface, little in surface adhesive and superior flexibility and stress relaxation, in addition, suppressing elution of a monomer from the final product. That is, the present invention relates to an ocular lens material comprising at least one kind of a compound (A) having an ethylenically unsaturated group and polydimethylsiloxane structure through a urethane bond and at least one kind of a pyrrolidone derivative (B) in which a polymerizable group is a methylene group.
Owner:MENICON CO LTD

Semiconductor device

In order to realize a higher reliability TFT and a high reliability semiconductor device, an NTFT of the present invention has a channel forming region, n-type first, second, and third impurity regions in a semiconductor layer. The second impurity region is a low concentration impurity region that overlaps a tapered potion of a gate electrode with a gate insulating film interposed therebetween, and the impurity concentration of the second impurity region increases gradually from the channel forming region to the first impurity region. And, the third impurity region is a low concentration impurity region that does not overlap the gate electrode.Moreover, a plurality of NTFTs on the same substrate should have different second impurity region lengths, respectively, according to difference of the operating voltages. That is, when the operating voltage of the second TFT is higher than the operating voltage of the first TFT, the length of the second impurity region is longer on the second TFT than on the first TFT.
Owner:SEMICON ENERGY LAB CO LTD

Nightlight for phototherapy

A nightlight is provided for providing therapeutic effects on the human body and mind including promoting relaxation, sleep and wakefulness. The nightlight includes a housing, a light source, a central processor, one or more controls, and a power supply. The light source produces at least three modes having various light properties. The light modes include a sleep readiness mode, a sleep help mode and a wake-up mode. The sleep readiness mode produces light at about 40 lumens and preferably includes only light from the blue and yellow portions of the visible light spectrum. The sleep help mode produces monochromatic light in the blue or green spectrum. Preferably, the light undulates at a frequency of one cycle per second to one cycle per minute at a luminosity of between 5 lumens and 25 lumens. Meanwhile, the wake-up mode produces substantially full spectrum light at approximately 1,600 lumens. The processor and controls allow a person to select and control the various light modes. Moreover, the nightlight may include biological sensors for measuring physiological activity of the body.
Owner:SEARFOSS III ROBERT LEE

Temple massaging headband

A system and method that utilizes a massaging apparatus specifically for a person's temples with the expressed purpose of providing relaxation and headache relief, is herein disclosed. The apparatus is configured as a headband with battery-powered massagers at the temples. The apparatus is supported both with minimal elasticity from the headband and with ear supports. Power is supplied to the massagers from a rechargeable battery pack that can be worn about the arm or alternately the waist and is electrically tethered to the headband. Each small disc-shaped temple massager is separately powered by a small motor that produces the massaging effect which is intended to reproduce the sensation of rubbing / massaging the temples.
Owner:RILES CAROL W

Method of treating cellulite

ActiveUS9028469B2Long lastingPreclude additional fatty tissueSurgical instrument detailsLight therapyThermal injuryCuticle
A treatment for subcutaneous fat and / or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.
Owner:CANDELA CORP

Physiological parameter management monitoring system and method based on internet of things

InactiveCN103417195AAccurately grasp the physical condition in real timeAvoid checkingTransmission systemsDiagnostic recording/measuringData centerThe Internet
The invention discloses a physiological parameter management monitoring system and method based on the internet of things. The system comprises a user terminal device worn on a tested object, a data center and a server for achieving physiological parameter management monitoring. The user terminal device is connected with the data center through a bluetooth transmission module in a data communication mode, and the data center is connected with the server through a wireless network in a data communication mode. Physical conditions of the tested object are detected and managed in real time through the internet of things, a physiological parameter sensor collects physiological data periodically and transmits the physiological data to the data center through the bluetooth transmission module, and the data is processed, handled, stored and transmitted to a mobile communication network to be managed and monitored by the server. According to the system and method, the device worn on the tested object is simple and low in cost and power consumption, can monitor the physical conditions of the tested object in real time and is intelligent and good in practicality.
Owner:JIANGSU UNIV

Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction

An implantable device (11) for evaluating autonomic cardiovascular drive in a patient (10) suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead (13) includes helical electrodes (14) configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins (28) electrically connected to the helical electrodes (14). A neurostimulator (12) includes an electrical receptacle (25) into which the connector pins (28) are securely and electrically coupled. The neurostimulator (12) also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes (14) in alternating cycles of stimuli application and stimuli inhibition (90) that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator (12) includes a recordable memory (29) storing a baseline heart rate. The neurostimulator (12) includes an integrated leadless heart rate sensor (31) configured to continually monitor heart rate in light of the baseline heart rate.
Owner:LIVANOVA USA INC

4-METHYL-1-PENTENE/a-OLEFIN COPOLYMER, COMPOSITION COMPRISING THE COPOLYMER AND 4-METHYL-1-PENTENE COPOLYMER COMPOSITION

ActiveUS20120220728A1Preferable in of flexibilityPreferable in of mechanical propertyPolymer scienceStress relaxation
The present invention provides a 4-methyl-1-pentene / α-olefin copolymer being excellent in lightness, stress absorption, stress relaxation, vibration damping properties, scratch resistance, abrasion resistance, toughness, mechanical properties and flexibility, having no stickiness during molding operation and being excellent in the balance among these properties; a composition comprising the polymer; and uses thereof. The 4-methyl-1-pentene / α-olefin copolymer (A) of the present invention satisfies specific requirements, and comprises 5 to 95 mol % of a structural unit (i) derived from 4-methyl-1-pentene, 5 to 95 mol % of a structural unit (ii) derived from at least one kind of α-olefin selected from α-olefins having 2 to 20 carbon atoms excluding 4-methyl-1-pentene and 0 to 10 mol % of a structural unit (iii) derived from a non-conjugated polyene, provided that the total of the structural units (i), (ii), and (iii) is 100 mol %.
Owner:MITSUI CHEM INC

Pillow Device

A pillow device having a pillow portion with a main head support section for supporting the head, and at least one eye mask portion for covering the eyes of the user. For additional comfort, a neck support may be removably attached to the pillow device to provide not only support for the head, but also support for the neck. Because of the overall shape of the pillow device can easily simulate a doll, a skirt with popping out figures may be added to simulate an angel or other favorite figures with open arms to welcome the user. Moreover, the pillow device may function as a computer pad holder and a bag.
Owner:LEE MUNSOO

Shortened Carbon Nanotubes

A shortened carbon nanotube and methods for preparing the same and contrast agents are disclosed. One embodiment includes a shortened carbon nanotube. The shortened carbon nanotube has a length of about 100 nm or less with a cargo. The shortened carbon nanotube is suitable for use in x-ray and MRI imaging as a contrast agent.
Owner:RICE UNIV +1

Industrial robot

A cable drawn from a lower arm of a robot into a first upper arm part of an upper arm is further drawn out to an exterior space of the robot through a first hole of a second upper arm part. The cable is drawn in contact with a sidewall part of the second upper arm part, and is disposed in a wrist arrangement portion through a second hole. A slack part is formed taking account of a length of the cable pulled by a wrist when the wrist pivots in the wrist arrangement portion, and the cable is drawn to a tool through a through hole of the wrist.
Owner:NACHI-FUJIKOSHI
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