The invention discloses a device for quantitative monitoring indicators of a patient with awareness during the general anesthesia operation, which comprises: an EEG signal surface electrode, a filter circuit, an EEG amplification circuit, a brain evoked potential amplifier, an analog-to-digital converter, a computer for calculating the brain 40Hz auditory evoked steady state response index and a sound stimulating circuit. Two brain evoked potential signals and an EEG signal curve which are generated by the computer are stored in a data cache; the sound stimulating circuit comprises: a 40Hz sound modulation circuit and a sound amplification circuit; the computer is synchronous with four sound stimulus, two brain evoked and EEG digital signals are obtained every 100ms and then the data cache is cleared. The device has the following advantages and positive effects: the 40Hz auditory steady state technology is different from other auditory evoked potentials, the major advantage thereof is that the rhythm of the stimulus is synchronous with the position of the wave peak of auditory middle latency, thus forming the resonance effect, improving the signal intensity and regularity, allowing the extraction of the evoked potential to be easier and strengthening the probability of the clinical practical application of the evoked potential technology.