37 results about "Transcranial magnetic stimulation" patented technology

Cantilever electrode apparatuses for wearable neuromodulation devices configured to be worn on a subject's (user's) head or on the subject's head and neck. These cantilever electrodes may mate with the wearable neuromodulation devices to form a neuromodulation system.

A method of eliciting analgesia in a human subject by Transcranial Electrical Stimulation (TCES, herein “TES”) is provided. Electrodes secured to the skin of the subject's head at particular sites provide an electrical current that includes a direct current combined with rectangular AC current pulses delivered at a particular frequency of between 10 and 100 Hz. In an embodiment the total current transmitted, a sum of the DC component and a Mean Absolute Deviation (MAD) of the current pulses, has a value between 0.2 and 20 mA. The method is used to produce analgesia during perioperative period, surgery and the post-operative procedure. It can also be used for treating acute chronic pain and a wide variety of other conditions.

Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.

The present invention provides systems, apparatus and methods for applying electric current to neurons in the brain to treat disorders and to improve motor and / or memory functions in a patient. In a method according to the invention, an electrode is positioned adjacent to and spaced from the skin surface of the patient's head and an electric current is applied through the electrode to a target region in the brain to modulate one or more neurons in the target region. The electrode is housed within an enclosure and spaced from the skin surface so that the electrode does not directly contact the patient's tissue, which reduces the potential for collateral tissue damage or necrosis and shields the electrode from the patient's tissue which substantially inhibits Faradic products (e.g., H+, OH−, H2O2) of the electrode from reaching the target site.

The invention discloses a navigation positioning device for a transcranial magnetic stimulator, and the device comprises a visual positioning module, a computer, a seat, a transcranial magnetic stimulator coil, a mechanical arm, a mechanical arm controller, and a base. The visual positioning module is connected with the computer, and the positioning between the seat and the base and visual positioning module is carried out through a slideway. The transcranial magnetic stimulator coil is disposed at the front end of the mechanical arm, and the mechanical arm is disposed on the base. The mechanical arm is connected with the mechanical arm controller. The mechanical arm controller is connected with the computer. The invention also discloses a positioning method for the device, and the method comprises the steps: building a head model; collecting and processing an image; calculating the coordinates of a target spot; carrying out the coil positioning; carrying out the repeated positioning; carrying out the stimulation treatment; and enabling the coil to return to a standby position after stimulation. The device is characterized in that the device directly detect a human face through employing machine vision, carries out positioning, is high in instantaneity, and enables a patient not to need to wear an auxiliary tool on the head; the device is quick in positioning, is high in repetition precision, and reduces the positioning time and workload; and the device can automatically track the target spot, and guarantees the effectiveness of treatment.

An electromagnetic positioning and navigation device for a transcranial magnetic stimulator is composed of an electromagnetic positioning and navigation module (1), a coil gesture control module (2), a three-dimensional seat (3), an image collection and processing module (4), an electromagnetic calculation module (5), a display module (6) and a transcranial magnetic stimulator coil (7). The electromagnetic positioning and navigation module (1) is connected with the coil gesture control module (2) and the three-dimensional seat (3), and the coil gesture control module (2) is installed on the transcranial magnetic stimulator coil (7). The image collection and processing module (4) can rebuild a three-dimensional head model of a patient in the image space to mark therapeutic targets. The electromagnetic positioning and navigation module (1) records space position and coil gesture of the head (8) of the patient and conducting alignment on head positions in the image space and the sensor space and the position of the transcranial magnetic stimulator coil (7). Induction field distribution of the head of the patient is displayed in the display module (6) by means of calculation of the electromagnetic calculation module (5).

A method includes coupling electrodes to a patient's head and identifying whether any of the electrodes form a functional set, such that a desired therapeutic effect is achieved when the two or more electrodes deliver a total amount of current to the patient regardless of what portion of the total amount of current each respective electrode carries. One or more constant current sources are provided, each having a supply and return terminal, which supply and return equal amounts of current at any given time. The constant current source(s) are coupled to the electrodes in such a manner that each supply terminal and each return terminal is coupled to no more than the electrodes of a single one of the functional sets, if any, or to a single one of the electrodes not included in one of the functional sets.

The invention provides a mental state assessment and regulation system based on transcranial stimulation. The mental state assessment and regulation system is characterized by comprising the followingparts: a physiological signal acquisition module for acquiring a physiological signal of a tested subject; a mental state assessment module used for performing physiological signal preprocessing, feature extraction and mental state analysis to obtain a mental state assessment result; control equipment used for judging the mental state evaluation result and adjusting stimulation parameters according to the mental state evaluation result; and transcranial stimulation equipment used for performing transcranial stimulation on the tested subject according to the stimulation parameters. The mentalstate assessment and regulation system can carry out personalized targeted mental state regulation on the tested subject, has a good mental state adjustment effect, is convenient and effective to use,and has the advantages of noninvasiveness, effectiveness, safety, easiness in operation and the like. The invention further provides a working method of the mental state assessment and regulation system.

The invention relates to a multi-functional transcranial magnetic stimulator. The multi-functional transcranial magnetic stimulator mainly comprises a high-voltage pulse power supply, a myoelectricity acquisition device and a temperature measurement device which are connected to a data acquisition card respectively, wherein the data acquisition card is connected to Labview control software of a microcomputer; and the high-voltage pulse power supply is connected with a stimulation coil. By the multi-functional transcranial magnetic stimulator, a high-voltage pulse generator is controlled to act on the coil through the labview software, so that various kinds of stimulation such as magnetic stimulation single pulse, repetitive pulse, random pulse and train pulse can be realized; the temperature measurement device is combined with the Labview software, so that the temperature of the coil can be acquired and alarm can be controlled; and the Labview software is combined with the myoelectricity acquisition device, so that myoelectricity signals can be acquired. In addition, the multi-functional transcranial magnetic stimulator also has multiple additional functions of database management, report printing, remote control, data communication and the like and can be widely used for diagnosis and treatment in psychiatry departments, neurology departments and laboratories.

The invention discloses a system for transcranial ultrasonic stimulation of mouse and synchronous acquisition of electroencephalogram and electromyogram signals and relates to the field of transcranial ultrasonic stimulation research and synchronous signal acquisition. The system comprises a transcranial ultrasonic stimulation module, a pulse transcranial ultrasonic signal generation module, a brain myoelectric signal acquisition and processing module and a power supply. The device has a series of advantages of stable signal acquisition, strong expansion storage capacity, portability, small size, easiness in operation and the like, and can be effectively applied to real-time synchronous acquisition of electroencephalogram and electromyogram signals of conscious and freely movable mice in transcranial ultrasonic stimulation experiments of various samples. Moreover, the storage module is expanded, and the problems of overlarge storage amount of long-time use data, distortion of wirelesstransmission data and the like are avoided. The system is convenient for subsequent off-line processing of brain myoelectric signals stimulated by transcranial ultrasound, and provides technical support for future mechanism research of transcranial ultrasound stimulation and clinical application of neuromodulation technology.

The invention provides a system for synchronizing transcranial ultrasonic stimulation and electroencephalography recording of the human body, which comprises a computer (110) containing control software, a signal generator (130), a radio frequency amplifier (140), an ultrasonic transducer (150), a synchronization control module (120), a transducer-scalp coupling module (151), an electroencephalography system (160) and a signal receiving terminal (161), and is characterized in that real-time communication between the signal generator (130) and the electroencephalography system (160) can be realized by using the synchronization control module (120), and complete synchronization of ultrasonic stimulation and electroencephalographic signal collection is realized. The system provided by the invention for synchronizing transcranial ultrasonic stimulation and electroencephalography recording of the human body can be applied to basic brain cognitive function research and clinical brain disease intervention treatment research, can realize synchronization of ultrasonic stimulation and electroencephalographic signal recording and solves the technical problems of multi-channel synchronous or asynchronous independent ultrasonic stimulation and corresponding electroencephalographic signal synchronous recording and stimulation marking.

A system for closed-loop pulsed transcranial stimulation for cognitive enhancement. During operation, the system identifies a region of interest (ROI) in a subject's brain and then estimates ROI source activations based on the estimated source of the ROI. It is then determined if a subject is in a bad encoding state based on the ROI source activations. Finally, one or more electrodes are activated to apply a pulsed transcranial stimulation (tPS) therapy when the subject is in a bad encoding state, a predefined external event or behavior occurs, or the subject is in a consolidation state during sleep.

The invention relates to an ultralow frequency transcranial magnetic induction stimulation device, belonging to the technical field of medical instruments. The ultralow frequency transcranial magnetic induction stimulation device comprises a main body and a transcranial magnetic induction acting chair armrest, the main body is provided with a display console, an ultralow frequency magnetic induction delivery spool is arranged on the right side of the main body, the ultralow frequency magnetic induction delivery spool is connected with the transcranial magnetic induction acting chair armrest through an input sleeve opening, a head rest is arranged in back of a leg supporting cushion, a head resting groove is formed in the front of the head rest, meridian massage grooves are formed on the left and right sides of the head resting groove, strip massage protrusions are formed in the meridian massage grooves, a hood lifting adjustor is arranged on the back of the head rest, a scattering channel is formed inside a transcranial magnetic induction acting cover, the scattering channel is provided with an integrated opening, and a delivering straight pipe is arranged below the scattering channel. The device is complete in function and convenient to use, and is time-saving, labor-saving, scientific, convenient, safe and efficient when being used for cerebral magnetic induction stimulation therapy of psychiatric patients, thus relieving the working difficulty of medical staffs.

A magnetic-field focusing coil array used for electric conductivity imaging and functional magnetic stimulation features that 17 unit coils arranged on a semi-spherical surface is divided into 3 layers of 1, 6 and 10 coils for different layers. Their arranging mode and parameters are also disclosed. The magnetic field generated by them can be focused in one or more areas by regulating their exciting currents.

The invention relates to an integrated device of transcranial magnetoacoustic stimulation and electroencephalogram detection, which comprises a signal generator, a power amplifier, an ultrasonic transducer, a microfilament electrode array, a differential amplifier, a signal acquisition card, a computer and magnets, and is characterized in that the output end of the signal generator is connected with the input end of the power amplifier through a coaxial connecting wire, the output end of the power amplifier is connected with the ultrasonic transducer through a coaxial connecting wire, a sample is placed at the bottom part of the ultrasonic transducer, and the magnets are placed at two sides of the test sample respectively; and the output end of a nickel-cadmium microfilament electrode is connected with the input end of the differential amplifier through a coaxial connecting wire, the output end of the differential amplifier is connected with the input end of the signal acquisition card through a coaxial connecting wire, and the output end of the signal acquisition card is connected with the computer through a coaxial connecting wire. The integrated device provided by the invention has the advantages of simple operation, flexible control, accurate stimulation and the like.

The invention provides a transcranial ultrasonic stimulation device and a stimulation method for carrying out nervous tissue orientation and neuromodulation through transcranial ultrasonic stimulation. The transcranial ultrasonic stimulation device comprises an upper computer unit, an ultrasonic pulse transmission unit, an ultrasonic transduction unit and a power circuit. The transcranial ultrasonic stimulation device adopts the integrated circuit mode and further comprises an echo amplification circuit. The focal distance of the ultrasonic transduction unit is 30 mm. The ultrasonic pulse transmission voltage is adjusted by adjusting the power supply voltage, and therefore the transcranial ultrasonic stimulation device is small in size and high in spatial orientation resolution ratio and can achieve system self-inspection. Meanwhile, because the ultrasonic intensity can be adjusted, a low ultrasonic intensity can be selected for carrying out nervous tissue orientation and neuromodulation, a high ultrasonic intensity can be selected for carrying out tissue damage, and the positional information of the stimulation part can be verified.

The invention relates to the field of transcranial magnetic stimulation head model modeling, in particular to an anisotropic conductivity head model modeling method and device combined with cortical excitability. The method includes: establishing an anisotropic conductivity head model based on MRI and DTI images; obtaining an individual cortical excitability comprehensive index through an array target TMS experiment; and constructing an anisotropic conductivity head model containing the cortical excitability according to the anisotropic conductivity head model and the individual cortical excitability comprehensive index. The transcranial magnetic stimulation head model modeling method is combined with functional information on the basis of structural information, reflects the cortical excitability of an individual, is close to a real brain, can further improve the authenticity and reliability of the TMS modeling simulation, has important research significance in simulating the effect of TMS, optimizing TMS coils and stimulation parameters, and has good development and application prospect.

Described is a system for transcranial stimulation to improve cognitive function. During operation, the system generates a customized stimulation pattern based on damaged white matter. Further, data is obtained representing natural brain oscillations of a subject. Finally, while the subject is awake, one or more electrodes are activated in phase with the natural brain oscillations and based on the customized stimulation pattern.

The invention relates to the field of alpha brain waves and provides a control method of transcranial microcurrent stimulation on basis of induction alpha brain waves. Existing transcranial microcurrent stimulation methods have polarization phenomenon easily and the stimulation effect can be weakened obviously. The control method comprises the steps as follows: step 1, obtaining energy ratio deltaalpha of alpha brain waves in user brain waves; step 2, setting a target preset value delta alpha-Thread of the alpha brain waves, determining output parameters of transcranial microcurrent by selecting the working mode of the transcranial microcurrent according to the acquired relation between the energy ratio delta alpha and delta alpha-Thread in the alpha brain waves in the user brain waves, in the state of a mode I, the power of output waveforms of the transcranial microcurrent is kept unchanged, and the frequency of output electric waves of the transcranial microcurrent is continuously adjusted; in the state of a mode II, the frequency of the output electric waves of the transcranial microcurrent is kept unchanged, and the duty ratio of output waveforms of the transcranial microcurrent is adjusted continuously; and step 3, in any work mode, the accumulated release time of the transcranial microcurrent is stopped after reaching preset total output time.

The invention provides a transcranial magnetic stimulator system of a control stimulation coil end. The transcranial magnetic stimulator system comprises a magnetic stimulation module, a control module, a remote regulating module, a remote display module, a signal input module, a motion threshold determination module, and a signal induction module. The motion threshold of a stimulated person can be measured just by one operator. Thus, the transcranial magnetic stimulator system greatly saves manpower, prevents faults possibly generated by cooperative work of multiple people, automatically determines the motion threshold, simplifies a workflow, increases measurement efficiency and measurement speed, improves accuracy of magnetic stimulation effectiveness judgment, and reduces a misjudgment probability of artificial judgment.

The invention provides a tES (transcranial electrical stimulation) electrode falling-off monitoring alarm device and an application thereof. The device comprises a signal acquisition module, a detection judgment module and an alarm module, wherein the signal acquisition module is connected with the detection judgment module, and the detection judgment module is connected with the alarm module. Thedevice is reasonable in design, simple and convenient to prepare, low in cost and capable of detecting whether each electrode falls off in real time and giving an alarm in time under the condition offalling off; the problem about monitoring alarm of electrode falling off of a current transcranial electric stimulator is solved, and safety and convenience of the transcranial electric stimulator inthe using process are improved.

The invention relates to the technical field of multichannel electroencephalogram acquisition, in particular to a whole brain region electroencephalogram cap for transcranial magnetic stimulator treatment, which comprises a cap body and 59 conventional electrode point positions arranged on the cap body and used for covering the whole brain region of the brain, the cap body further covers the cerebellum position of a human body, the cap body is provided with PO9, O9, IZ, O10, PO10, CB1, CBz and CB2 electrode point positions at the cerebellum position of the human body, and the cap body is provided with a plurality of electrode points. The electroencephalogram cap comprises 59 conventional electrode point positions and PO9, O9, IZ, O10, PO10, CB1, CBz and CB2 electrode point positions, C-shaped electrodes are installed on the 59 conventional electrode point positions and the PO9, O9, IZ, O10, PO10, CB1, CBz and CB2 electrode point positions, the other ends of the two extension lines are connected with two patch electrodes respectively, and the C-shaped electrodes are made of silver materials and coated with silver chloride. Meanwhile, when a patient uses the transcranial magnetic therapeutic apparatus for treatment, the phenomena of electrode eddy current and electrode heating caused by the therapeutic apparatus are reduced; the stimulation of the electrode of the electroencephalogram cap on the scalp of a patient and the influence on electroencephalogram signals are relieved.

Described is a system for transcranial stimulation to improve cognitive function. During operation, the system generates a customized stimulation pattern based on damaged white matter. Further, data is obtained representing natural brain oscillations of a subject. Finally, while the subject is awake, one or more electrodes are activated in phase with the natural brain oscillations and based on thecustomized stimulation pattern.

The invention provides a TMES (transcranial magnetic electric stimulation) device. The TMES device comprises at least one pair of internal electrodes inlaid in skull, wherein the internal electrodes are made of a magnetic NdFeB material wrapped with a titanium alloy; a first internal electrode inlaid in left temporal skull and a first external electrode detachably arranged on left temporal scalp of the skull can be electrically connected through the scalp; a second internal electrode inlaid in right temporal skull and a second external electrode detachably arranged on right temporal scalp of the skull can be electrically connected through the scalp; the first external electrode and the second external electrode are connected to an anode and a cathode of a pulse generator through wires respectively. The TMES device is simple, safe, low in cost, convenient to use, good in curative effect and wide in treatment range and has few side effects, craniotomy is avoided for an operation, and abnormal electric activities of brain nerve fibers are changed under physical actions of a magnetic field and an electric field, so that a series of nervous system diseases caused by the abnormal electric activities are treated.

A magnetic resonance navigation device for driving a magnetic stimulator coil to automatically adjust the position, comprising an image workstation (1). The image workstation (1) is connected to a spatial positioning sensor (3), a mechanical arm controller (6) and a physiological signal detection device (9) respectively. The mechanical arm controller (6) is connected to a mechanical arm (5). An end joint of the mechanical arm (5) is connected to a transcranial stimulation coil (2) and a second tracker (7) respectively. The transcranial stimulation coil (2) is connected to a transcranial magnetic stimulator. The spatial positioning sensor (3) is connected to a probe tracker (8). The probe tracker (8) is connected to a first tracker (4). The first tracker (4) is connected to an external marker point (10). This magnetic resonance navigation device enables precise navigation of the RTMS magnetic stimulation probe, visual displaying of the magnetic stimulation position and precise control of the stimulation position, thereby improving the treatment efficiency and reducing side effects.

The invention relates to a monitoring method of a transcranial electrical stimulation device. The monitoring method is implemented by a monitoring device electrically connected with the transcranial electrical stimulation device. The monitoring device receives an input signal, and controls the transcranial electrical stimulation device to generate cranial stimulation current according to the inputsignal; and the monitoring device generates and stores a usage record, wherein the usage record contains a usage time datum and a current datum, wherein the current datum is related to the cranial stimulation current and the usage time datum. Therefore, a user can be facilitated to view the process of the use of the transcranial electrical stimulation device by himself or herself, and physiciansor therapists of medical units can be also assisted to monitor whether the use of the transcranial electrical stimulation device by the user is correct or not.

The invention provides a voice-controlled self-adapting TMS treatment device. The voice-controlled self-adapting TMS treatment device comprises a seat, a sound receiver, an image collector, a base, a mechanical arm, a transcranial magnetic stimulator and a controller, wherein the mechanical arm is arranged above the base; the transcranial magnetic stimulator is arranged at a movable end of the mechanical arm; the controller is electrically connected with the sound receiver, the image collector, the mechanical arm and the transcranial magnetic stimulator separately; and the controller is used for determining a treatment mode of the transcranial magnetic stimulator according to a voice signal, determining a target site of the mechanical arm according to an image signal and the treatment mode, generating an expected moment track of the mechanical arm according to a preset initial site and the target site, controlling the mechanical arm to move according to the expected moment track, and controlling the start and stop of the transcranial magnetic stimulator according to the treatment mode. According to the voice-controlled self-adapting TMS treatment device, positioning of the treatment device can be controlled through voice, treatment in a corresponding mode can be carried out, medical personnel do not need to manually position or set treatment parameters, and the convenience of TMS treatment is greatly improved.

The invention relates to the field of biomedical engineering, and discloses a brain tissue electromagnetic field analysis method based on a transcranial magnetic stimulator, including: placing the 8-shaped coil of the transcranial magnetic stimulator on the top of the brain; The brain tissue below the site has a planar layered structure; according to the current passed into the figure-of-eight coil and the thickness and conductivity of each layer structure in the brain tissue, the electromagnetic field distribution of each layer structure in the brain tissue is analyzed and obtained. The present invention provides a brain structure electromagnetic field analysis method based on a transcranial magnetic stimulator, which establishes a plane layered model of the brain, considers the influence of layered structure eddy currents, and calculates and analyzes the induced current and magnetic field distribution in each tissue , can more accurately understand the distribution of induced current and magnetic field when different layers of the brain are subjected to magnetic stimulation, so as to provide clinical guidance for the location of current action points and improve the clinical use effect of transcranial magnetic stimulators.