696 results about "Neurology" patented technology

Abstract of Disclosure A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is the module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions / disorders / diseases due to mutations or dysregulation of the Wnt pathway and / or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

A system and method for standardizing care in a hospital environment. Information concerning the latest care and practice standards for a given condition is provided to a decision support module. The decision support module comprises decision support algorithms that reflect a standardize guideline of practice for a particular medical condition. The general categories of cardiovascular, endocrinology, general, gastrointestinal, hematology, infectious diseases, neurology, pharmacology, pulmonary, renal, surgery, toxicology, trauma all have guidelines and practice standards associated with them. Patient data and user input are inputted to the decision support algorithm. The user may be prompted for user input, and an assessment is made of the patient so as provide patient care advice for the patient. Examples of patient care advice are a diagnosis, a method of treatment, and a laboratory protocol.

Abstract of Disclosure A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

The invention relates to a navigation transcranial magnetic stimulation treatment system, which mainly comprises a small size nuclear magnetic resonance imaging system, an optical positioning navigation system and a transcranial magnetic stimulation machine, wherein the small size nuclear magnetic resonance imaging system is connected with a microcomputer of the transcranial magnetic stimulation treatment system, the scanned imaging data obtained by the scanning of the small size nuclear magnetic resonance imaging system is transmitted into a microcomputer data base; the optical positioning navigation system arranged in the navigation transcranial magnetic stimulation treatment system calls the imaging date for 3D model reconstruction, registers and stimulates a coil after the reconstruction, and guides the fixing position of the coil to ensure that the stimulated focus of the coil is coincident with an appointed stimulation point; a high-voltage pulse generator of the transcranial magnetic stimulation machine acts on the coil; and the transcranial magnetic stimulation machine and the optical positioning navigation system are both connected to the microcomputer of the transcranialmagnetic stimulation machine, and displayed independently by screens when in working. The invention has the advantages of convenient operation, accurate positioning, stimulation pertinence and strongfunction, and can be widely applied to the departments of psychiatry, neurology and rehabilitation.

Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.

The present invention relates to the field of stem cell biology, in particular the lineage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hESC) in addition to nonembryonic human induced pluripotent stem cells (hiPSC), somatic stem cells, stem cells from patients with a disease, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hESC and / or hiPSC into floor plate midbrain progenitor cells and then further into large populations of midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons using novel culture conditions. The midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons made using the methods of the present invention are further contemplated for various uses including, but not limited to, use in in vitro drug discovery assays, neurology research, and as a therapeutic to reverse disease of, or damage to, a lack of dopamine neurons in a patient. Further, compositions and methods are provided for differentiating midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons from human pluripotent stem cells for use in disease modeling, in particular Parkinson's disease. Additionally, authentic DA neurons are enriched for markers, such as CD142, and A9 type neuronal cells.

The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.

A system and method for standardizing care in a hospital environment. Information concerning the latest care and practice standards for a given condition is provided to a decision support module. The decision support module comprises decision support algorithms that reflect a standardize guideline of practice for a particular medical condition. The general categories of cardiovascular, endocrinology, general, gastrointestinal, hematology, infectious diseases, neurology, pharmacology, pulmonary, renal, surgery, toxicology, trauma all have guidelines and practice standards associated with them. Patient data and user input are inputted to the decision support algorithm. The user may be prompted for user input, and an assessment is made of the patient so as provide patient care advice for the patient. Examples of patient care advice are a diagnosis, a method of treatment, and a laboratory protocol.

The movement of catheters and guide wires for catheters with the aid of magnets is known from the field of cardiology. Conventional magnets are, as a result of their size, not suited to being inserted into the brain of patient, because the vessels there are smaller than the cardiac vessels. To enable the navigation methods proven in cardiology also to be used in neurology, the invention provides a microcatheter having a guide wire, which features magnetic nanoparticles. The magnetic nanoparticles can be provided in the form of a ferrofluid or also as diamond nanoparticles in powder form. This enables navigation of the guide wire and thus ultimately of the catheter in the brain from the outside by way of magnetic fields.

A neurological condition detection unit can include a computer device that is connected to at least two leads that are connectable to a patient for evoking a response from that patient via an electrical current passed through the leads (e.g. a shock) and at plurality of sensors connected to the computer device to sense how the left side and right side of the patient's brain reacts to the evoked event (e.g. the shock). The stroke detection device and / or neurological condition detection unit can be configured to output a warning when one side of the patient's brain is determined to react differently than the opposite side of the patient's brain by at least a pre-selected threshold value. The warning can include an identification of a nearby care facility that may be best suited for providing care to a patient determined to have a neurological condition (e.g. a stroke).

The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising the 21 amino acid sequence GIVEQ CCASV CSLYQ LENYC N (SEQ ID NO:1), and functional analogs thereof are disclosed to modulate neurological activity when administered to a subject. The methods of the invention can be used to prevent or treat neurological disorders as well as improve memory retention and acquisition. The invention includes pharmaceutical compositions comprising a therapeutically or prophylactically effective amount of insulin A-chain peptide or a functional analogs thereof.

The present invention relates to a novel use of opioid compounds for treatment of a neurologic or neurogenic disorder. Such neurologic or neurogenic disorders include lingual, pharyngeal, laryngeal, esophageal, urinary bladder sphincter, lumbar-lumbo-sacral spine, pelvis-pelvic limb paresis or paralysis. The invention provides a unique method of treating the specified disorder or disorder by administering to a subject in need of such a treatment a therapeutically effective amount of a pharmaceutical formulation comprising an opioid compound.

The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and / or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.

The invention discloses a head physiotherapy device for neurology patients and a method for using the same, and belongs to the technical field of medical equipment. The head physiotherapy device comprises a helmet body, a massage ball, and a massage control body. The outer surface of the helmet body is provided with a plurality cylinders corresponding to acupoints of a human head and is also provided with an air inlet channel with a negative ion generator. The massage control body is internally provided with a bevel gear I driven by a micro motor and a cam, the surface of the cam is connectedwith a driving rod, and the lower end of the driving rod is provided with the massage ball; the bevel gear I is in a drive connection with a bevel gear II, a spur gear III, and a spur gear IV successively, and the spur gear IV is fixed to the driving rod. The massage ball comprises a metal net ball body and stone needles and magnets filled in the metal net ball body, the metal net ball body is wrapped with a rubber sleeve, and the rubber sleeve is attached to a cotton layer outside. The head physiotherapy device has the therapeutic effects of far infrared treatment, ultrasonic therapy, magnetic therapy, oxygen absorption therapy, and massage on a patient's head, and has the advantages of high selectivity, strong pertinence, and convenient use.

The invention relates to a neurology nursing moving support and belongs to the technical field of medical instruments. The neurology nursing moving support comprises a moving base and a support body. A guiding supporting leg is arranged on the lower side of the moving base. A driving supporting leg is arranged on the left side of the guiding supporting leg. A power supply box is arranged on the upper side of the moving base. A controller is arranged on the right side of the power supply box. A lifting driving motor is arranged on the right side of the controller. A folding lifting support is arranged on the lower side of the support body. A moving sliding block is arranged on the upper side of the folding lifting support. The moving sliding block is connected with the folding lifting support through a sliding block connecting rotating shaft. A support fixing sliding groove is formed in the moving sliding block. A fixing plate is arranged on the upper side of the support fixing sliding groove. A folding handrail is arranged on the upper side of the fixing plate. An upper body moving plate is arranged on the left side of the fixing plate. A lower limb moving plate is arranged on the right side of the fixing plate. The neurology nursing moving support is simple in structure and convenient to use, when a patient with physical handicaps in neurology gets on and off a bed or moves, operation is easy, time and labor are saved, and great convenience is brought to using of the patient.

The invention relates to a multi-functional transcranial magnetic stimulator. The multi-functional transcranial magnetic stimulator mainly comprises a high-voltage pulse power supply, a myoelectricity acquisition device and a temperature measurement device which are connected to a data acquisition card respectively, wherein the data acquisition card is connected to Labview control software of a microcomputer; and the high-voltage pulse power supply is connected with a stimulation coil. By the multi-functional transcranial magnetic stimulator, a high-voltage pulse generator is controlled to act on the coil through the labview software, so that various kinds of stimulation such as magnetic stimulation single pulse, repetitive pulse, random pulse and train pulse can be realized; the temperature measurement device is combined with the Labview software, so that the temperature of the coil can be acquired and alarm can be controlled; and the Labview software is combined with the myoelectricity acquisition device, so that myoelectricity signals can be acquired. In addition, the multi-functional transcranial magnetic stimulator also has multiple additional functions of database management, report printing, remote control, data communication and the like and can be widely used for diagnosis and treatment in psychiatry departments, neurology departments and laboratories.

The invention relates to a head physiotherapy system used for neurology patients. The head physiotherapy system used for neurology patients comprises a single chip which is connected to a temperature sensor and a heart rate monitor respectively in a wired mode and is used for analyzing and processing the received data; a filter which is connected to the single chip in a wired mode and is used for eliminating interference and noise; a RAM memorizer, a MRAM memorizer and a mass memory which are connected to the single chip in a wired mode and are used for comparing, sampling and querying the information and the physiotherapy schemes of the patients; a cloud server which is connected to the single chip in a wired mode through a GPRS wireless network and is used for conducting data transmission and exchange; a head physiotherapy instrument which is connected to the single chip in a wired mode and is used for the head physiotherapy of the patients; and a heating device which is connected to the single chip in a wired mode and is used for conducting heating on the medicine package inside the head physiotherapy instrument. The head physiotherapy system used for neurology patients is high in intelligent degree, simple to operate, convenient to use and diverse in function, and can adopt different head physiotherapy schemes according to different situations of different people; in addition, the head physiotherapy system used for neurology patients is precise in detecting operating parameters and safe in data storage.

This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and / or treatment of demyelination disorders.

The invention relates to a neurology internal department lower limb care massage device, which belongs to the technical field of medical instruments and comprises ischiadic nerve massage plate, a massage slide rod and a foot part massage box, wherein a slide rod nested head is set at the left side of the ischiadic nerve massage plate; a slide rod two-way rotary motor is set inside the slide rod nested head; a human body cushion is set on the ischiadic nerve massage plate; a heated liquid storage bag is set inside the human body cushion; a liquid heating chip is set inside the heated liquid storage bag; a shank entrance door is set on an upper side of a drive-through type slide massager; the shank entrance door is connected to the drive-through type slide massager through an entrance door rotary shaft; a massage box dustproof door is set at the right upper side of the foot part massage box; and the massage box dustproof door is connected to the foot part massage box through a dustproof door hinge. According to the invention, functions are complete; the use is convenient; the operation is simple when doing exercise and care the lower limbs of a patient in the neurology internal department; the time and the effort are saved; and the work difficulty of a medical worker is reduced.

The invention relates to a neurology department hemiplegia patient lower limb rehabilitation walking aid, and belongs to the field of auxiliary medical apparatuses. The neurology department hemiplegia patient lower limb rehabilitation walking aid is composed of a U-shaped support frame and walking wheels, handles are symmetrically arranged at the two sides of the U-shaped support frame, an adjusting rod is fixedly installed on the U-shaped support frame at the rear end of the handle, and an axilla support is installed at the top of the adjusting rod; a braking rod is installed on the U-shaped support frame, the U-shaped support frame is internally provided with a protection belt, and the protection belt is connected with the braking rod through a lifting belt. The neurology department hemiplegia patient lower limb rehabilitation walking aid effectively lowers the weight force of the lower limbs through the axilla support on the adjusting rod and handles on the U-shaped support frame, the safety in the rehabilitation training process can be improved through the protection belt, and the walking aid can be braked timely through the braking rod and a braking piece between the adjusting rod and the handles to avoid the occurrence of serious results when a patient falls down. The neurology department hemiplegia patient lower limb rehabilitation walking aid has the advantages of being simple in structure, convenient to use and high in safety, and especially suitable for lower limb rehabilitation of hemiplegic patients in neurology department.

This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and / or treatment of demyelination disorders.

The invention discloses a continuous percussion device for the department of neurology, comprising a hammer body, a rotating shaft, an eccentric wheel, a sliding plate, a rolling groove, a sliding block, a sliding chute, a guide rod, a hammerhead body and a main hammerhead, wherein guide blocks are mounted on the right sides of the upper and lower ends of the hammerhead body, guide grooves are formed at the left ends of the upper and lower side walls in the hammer body, a steady plate is also arranged in the hammer body, a through hole for the guide rod to pass through is formed in the steady plate, a spring is arranged between the steady plate and the sliding plate, and the spring is arranged on the guide rod in a sleeved mode. The continuous percussion device is simple and reasonable in structure and convenient in use, and the main hammerhead can have a continuous telescopic function, thereby carrying out percussion on the nerve parts of patients and saving the strength of wrist of a doctor during continuous knocking; the continuous percussion device also can be used like a common percussion hammer for performing original lever knocking according to practical situations; and when not used, the main hammerhead and a subsidiary hammerhead can be contained in the hammer body, thus avoiding damage caused by various conditions, prolonging the service life and being suitable for popularization and use.

The invention relates to an examination device for the department of neurology and belongs to technical field of medical instruments. According to the technical scheme, the examination device for the department of neurology comprises a fixed handle, wherein a controller is arranged on the left side of the fixed handle, a control switch is arranged on the front side of the controller, a work indicating lamp is arranged on the left side of the control switch, a wireless data emitter is arranged on the upper side of the controller, a percussion hammer is arranged on the left side of the controller and connected together with the fixed handle through a hammer body fixed connector, a percussion strength displayer is arranged on the front side of the percussion hammer, and a hammer head sliding limiting connector is arranged on the lower side of the percussion hammer. The examination device integrates multiple medical instruments, is simple in structure, convenient to carry and accurate in examination and can effectively improve the diagnosis work efficiency of a doctor.