48 results about "Neuroplasticity" patented technology

The invention discloses an upper limb rehabilitation intelligent self-adaptive system based on multi-modal fusion and MRD-FES cooperation. The system comprises a multi-modal signal acquisition module, a dynamic intention analysis module, a variable damping precise execution module, a neural remodeling strengthening module and a quantitative effect evaluation module. The tDCS-MRD-FES time sequence cooperation protocol is provided, the cortical excitability is improved through tDCS preprocessing, MRD drives training based on intention, FES closed loop strengthens muscle contraction, and vibration tactile feedback is assisted to strengthen sensory movement integration. And the quantitative effect evaluation module further combines a neuroplasticity index and clinical scale digitalization to realize dynamic optimization of training parameters.

The invention relates to the crossing field of medical rehabilitation and brain-computer interface technology, and particularly discloses a lower limb exoskeleton rehabilitation training system and method based on AR glasses and brain-computer interface control. According to the system, motor imagery electroencephalogram decoding is used as core driving force, lightweight AR visual guidance, lower limb exoskeleton mechanical assistance and functional electrical stimulation feedback are fused, and real-time information interaction among multiple modules is achieved through wireless communication; therefore, a closed-loop rehabilitation system integrating sensing, decoding, execution, multi-mode feedback and self-adaptive adjustment is constructed. Under the framework, the subjective motion intention of the patient not only can directly participate in the exoskeleton control process, but also can continuously adjust training parameters and interaction modes through dynamic monitoring of physiological signals and emotional states, so that a patient-centered lower limb rehabilitation training mode which better conforms to the neuroplastic law is achieved.

The invention provides a virtual reality body rehabilitation system. The virtual reality body rehabilitation system comprises a virtual domain system, a body feeling stimulation system, a body feeling evaluation system, an equipment domain system and a central control module. The virtual domain system specifically induces the sense of ownership, the sense of autonomy and the sense of position by creating a virtual environment of a virtual avatar, real-time action mapping and adaptation rehabilitation tasks; the body feeling stimulation system takes visual stimulation as a core and is matched with linkage of various kinds of sensory stimulation, so that the authenticity of body experience is enhanced; the body feeling evaluation system evaluates real-time body feeling and provides reliable data support for regulation and control. On the basis of the physical cognition theory, the virtual reality technology, the multi-mode sensing technology, the neuroscience and the rehabilitation medicine principle are fused, multi-channel feeling collaborative stimulation such as vision, body feeling and touch feeling is achieved by constructing the immersive virtual environment, a patient is induced to generate physical experience, abnormal body representation is remodeled, nerve plasticity and function recovery are promoted, and the rehabilitation effect of the patient is improved. The patient is helped to return to normal life and society.

The application discloses a kind of cognitive promotion method and system based on multi-modal data.The cognitive promotion method includes: obtaining the first multi-modal data before treatment of patient;Amyloid load grouping is carried out to patient based on the amyloid load in the brain of patient, to obtain the initial cognitive training scheme corresponding;Cognitive training is carried out based on initial cognitive training scheme during the treatment of patient, and the second multi-modal data during treatment is collected;Based on multi-modal data before and after treatment of patient, in combination with brain network group atlas, obtain the multi-modal change data of patient;The multi-modal change data of patient is input into preset model, to output the cognitive promotion scheme that cognitive index of patient is most improved, to push to patient and carry out cognitive training.The method will be integrated by A beta-PET data, functional nuclear magnetic resonance imaging data and event-related potential data, real-time evaluation of the neuroplasticity change of patient, to dynamically generate personalized cognitive promotion scheme.

The invention discloses a herbal medicine composition and application thereof. The herbal medicine composition comprises the following components in percentage by mass: 5%-85% of an extract of Indian ginseng, 5%-85% of an extract of rhodiola rosea, 5%-85% of an extract of melissa officinalis and 5%-85% of an extract of holy basil. The herbal composition is a natural composition that effectively supports mental health while minimizing adverse effects and promoting overall health; in particular, the herbal composition can achieve effects including "coordinated regulation of multiple neurotransmitter systems", "multi-target regulation of an HPA axis", "coordinated enhancement of an antioxidant system", "coordinated promotion of neuronutrition and neuroplasticity", "a synergistic effect of inflammation regulation", and "a synergistic effect of gene expression regulation".

The invention relates to the technical field of medicines, in particular to application of osthole in preparation of a medicine for protecting cognitive function impairment caused by down-regulation of an estrogen receptor. The OST has an improvement effect on the learning and memory ability and pathological damage of 6-month-old female peripheral ERs down-regulated mice and ER alpha- / -mouse models. The mechanism of the OST for improving learning and memory may be related to improvement of neuroplasticity, inhibition of nerve apoptosis and enhancement of neurotransmitter by regulating and controlling an estrogen-cholinergic system by the OST. The OST has a better intervention effect on a 6-month-old female ER alpha- / -mouse model, and possibly is a kidney-tonifying medicine which acts on a related target spot of a peripheral target organ so as to participate in regulation of a cognitive function of a central system.

The application relates to the cross field of biomedical engineering and artificial intelligence, and discloses a personalized brain power development training method based on electroencephalogram signals. The method comprises the following steps: collecting resting state and task state multi-channel electroencephalogram signals of a subject, constructing a functional connection matrix after pretreatment, identifying individualized weak connection target points through difference operation and cluster analysis; matching a neural feedback training protocol from a preset paradigm library based on the target points, and generating a feedback signal by extracting a target point synchronicity feature in real time during training to guide the subject to actively enhance the weak connection; updating the model after each training and dynamically optimizing subsequent parameters to form a closed-loop regulation. The application improves working memory and attention through individualized targeted training, induces neural plasticity, and realizes efficient and accurate brain power development.

This invention belongs to the field of biomedicine and discloses estradiol derivatives or pharmaceutically acceptable salts thereof with the structure shown in Formula I: R is selected from R1, which is selected from F, Cl, Br, and I; L is selected from straight-chain or branched alkyl groups with 2 to 10 carbon atoms. This invention also discloses the use of the estradiol derivatives or pharmaceutically acceptable salts thereof in the preparation of drugs for treating depression and anxiety. Furthermore, this invention discloses the use of the estradiol derivatives or pharmaceutically acceptable salts thereof in the preparation of drugs targeting ERβ / SERT for treating depression and anxiety. The estradiol derivatives of this invention can simultaneously and effectively inhibit SERT and activate ERβ, thereby synergistically enhancing serotonergic neurotransmission and regulating neuroplasticity, and enhancing antidepressant efficacy through multi-target synergistic effects.

This invention provides in some aspects, combinations, compositions and kits comprising a psychedelic drug and an NMD A receptor agonist and applications and uses of same for treating, reducing the incidence of, reducing the severity of or improving a pathology of a subject with a neurologic disease or disorder, a neurocognitive disease or disorder, or a motor disease or disorder, or for enhancing neuroplasticity in a subject with a neurologic disease or disorder, a neurocognitive disease or disorder, or a motor disease or disorder making use of the combinations, compositions and kits of this invention.

The application discloses an evaluation system for an epilepsy electroacupuncture treatment target based on an amygdala nerve response prediction, relates to the technical field of nerve regulation and brain function modeling, and realizes the multi-modal synchronous collection of brain region potentials, blood oxygen and metabolic activities through high-density EEG, electrophysiological sensors, fMRI and PET, and constructs a standardized nerve response dataset and a brain region function mapping matrix. An amygdala prediction response index is calculated and compared with a response threshold, a stimulation response compliance judgment and parameter correction are realized. The nerve response propagation delay, cooperative coupling coefficient and epilepsy wave front tracing time are calculated, a comprehensive target evaluation coefficient is obtained, and effective target points are screened. Based on the treatment scheme implementation of the effective target point set, the nerve feedback data in the continuous treatment cycle is monitored in real time, and a nerve plasticity correction index is calculated, compared with a plasticity stability threshold, an adaptive feedback regulation closed loop is formed, and precise prediction and dynamic optimization control of epilepsy electroacupuncture targets are realized.

The present invention relates to a real-time interactive cognitive guidance system and method using a Magnetic-Sync Engine (MSE) that monitors a user's cognitive state in real time and pre-projects a target trajectory to compensate for the delay in the brain's visual information processing. The MSE of the present invention calculates a virtual gravitational force corresponding to the distance between the user's input point and the target trajectory to pull the user toward the target path like a magnet, and forms a cognitive highway by projecting a visual guide 0.1 to 0.2 seconds earlier than the expected point the user will reach through pre-pulling timing control. By fusing multimodal sensors such as eye tracking and tactile input, the cognitive load is precisely calculated, and accordingly, the size of the virtual gravitational force and the shape of the trajectory can be varied in real time. Upon successful synchronization, neurofeedback is provided through solfège frequency audio and blooming animation to maximize learning efficiency, and the invention can be applied to various fields such as medical rehabilitation, cognitive training, and precision work education.

A digital method of therapeutic brain stimulation is provided. The method comprises presenting to a user in a UI a group of trials by sequentially displaying symbols against a background. The symbols are randomly displayed one at a time against one several contexts in the background to stimulate the user's parietal or frontal lobes or motor cortex. A user response is received for each display of a symbol indicating whether the symbol is the same or different from an immediately prior symbol for the same context, wherein each trial has a maximum allowed response time for the user input after which any response is counted as a false alarm. A user score is generated for the group of trials, wherein the score compares correct identification and incorrect false alarm responses for the group of trials against a user score of a previous group of trials.

The invention discloses a cognitive development matching method and system based on multivariate culture and neuroplasticity. Comprising the following steps: (a) guiding a user to carry out multi-dimensional state evaluation, wherein the evaluation dimension is based on a holographic model containing six dimensions of flexibility, mental intelligence, emotion, body, relationship and environment; (b) on the basis of a multi-level psychosomatic model, an integrated intervention scheme is generated for the user, the multi-level psychosomatic model comprises at least four adjusting levels, and a corresponding adjusting tool is matched for each level. According to the cognitive development matching method and system based on multivariate culture and neuroplasticity provided by the embodiment of the invention, a customized scheme fused with an east-west method can be automatically generated based on scientific evaluation, and a user is guided to complete closed-loop practice from cognitive updating to behavior verification through a prediction processing theory. Meanwhile, the system is combined with ecological niche optimization suggestions and continuous data tracking feedback to help the user to realize stable and measurable cognition and mental and physical state improvement in daily life.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

This invention provides the application of a nutritional composition in the preparation of products that promote neural development and support the improvement of neural function. The research of this invention found that intervention in the body using a nutritional composition comprising *Bifidobacterium animalis* subsp. *lactobacterium* CP-9 and 3'-sialic acid lactose can promote the development of amygdala neuronal structure, improve neural plasticity, and enhance synaptic function, thereby promoting the formation and functional maturation of the normal amygdala structure. As a core brain region regulating emotional responses, social cognition, and stress responses, the normal development of the amygdala plays a crucial role in an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health. Therefore, this invention promotes the structural and functional development of the amygdala through nutritional intervention, ultimately improving an individual's emotional regulation ability, social interaction behavior, cognitive function, and mental health.

The application provides a virtual reality embodiment rehabilitation system, comprising a virtual domain system, an embodiment sense stimulating system, an embodiment sense evaluating system, a device domain system and a central control module. The virtual domain system induces the sense of possession, the sense of autonomy and the sense of location by creating a virtual avatar, a real-time action mapping and a virtual environment suitable for rehabilitation tasks; the embodiment sense stimulating system takes visual stimulation as the core and matches multiple types of sensory stimulation linkage to strengthen the reality of embodiment experience; the embodiment sense evaluating system evaluates real-time embodiment sense to provide reliable data support for regulation and control. The application is based on embodiment cognition theory, combines virtual reality technology, multi-modal sensing technology, neuroscience and rehabilitation medicine principles, builds an immersive virtual environment, realizes multi-channel sensory coordinated stimulation such as vision, proprioception and touch, induces patients to produce embodiment experience, reshapes abnormal body representation, promotes neural plasticity and functional recovery, and helps patients return to normal life and society.

This invention relates to the use of (i) a 5-HT2A agonist (including 5-HT2A agonists that bind to a BDNF receptor, e.g., a 5-HT2A agonist that binds to the TrkB receptor or p75NTR), (ii) a therapeutic agent that promotes neuroplasticity by stimulation of the 5-HT2A receptor, (iii) a therapeutic agent that releases BDNF by stimulation of the 5-HT2A receptor (including those therapeutic agents that stimulate the 5-HT2A receptor and bind to a TrkB receptor or p75NTR), (iv) an AMPA positive allosteric modulator, (v) a therapeutic agent that promotes neuroplasticity by stimulation of the AMPA receptor, (vi) a therapeutic agent that releases BDNF by stimulation of the AMPA receptor, or (vii) an NMDA receptor positive allosteric modulator (such as a stinel compound) in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder (MDD), bipolar disorder, post-traumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms) in select patients who, for instance, have objectively determined cognitive impairment or poor cognition (such as objectively determined impaired learning and / or memory) and / or certain EEG characteristics.

The invention relates to an anti-depression compound 4-methyl-6-methoxy coumarin, and belongs to the technical field of biological medicines. Depression is the most common mental disorder in the world and is also a main reason for disability. The development of a novel anti-depression drug which is based on a nerve plasticity mechanism, takes effect quickly, has a lasting curative effect and is high in safety, and particularly has important clinical requirements and technical necessity for an effective treatment means for refractory depression. Traditional Chinese medicine monomers and a per2- / -zebra fish depression model are adopted for anti-depression drug screening, and finally it is found that 10 mM of 4-methyl-6-methoxycoumarin has the anti-depression characteristic and has the positive treatment effect on the exploration behavior, social interaction and sleep-awakening period of per2- / -zebra fish. The method can effectively rescue and reverse depression-like phenotypes observed in a per2- / -zebra fish circadian rhythmic depression model, and can restore the balance of important gene expression.

This application discloses a facial paralysis rehabilitation training method and system based on facial electromyography (EMG) feedback, belonging to the field of human-computer interaction technology. The method includes: acquiring EMG signals of a target facial region of a user and identifying the current facial expression category based on the EMG signals; retrieving the historical EMG signal time sequence of the current facial expression category and determining the distance parameters between the user and nearby objects; calculating the predicted deformation of the target facial region based on the rising slope of the EMG signals and the historical average peak arrival time in the historical EMG signal time sequence; adjusting the amplitude of the predicted deformation based on the distance parameters to obtain the corrected deformation of the target facial region; and driving the geometric deformation of the target facial region based on the corrected deformation to complete the facial paralysis rehabilitation training. This application creates the necessary behavioral conditions for the reconstruction of neural plasticity.

The present application relates to a multifunctional hydrogel for treating traumatic brain injury and a preparation method and application thereof. The preparation method of the hydrogel comprises the following steps: step 1, dissolving a tetracycline drug in a buffer to prepare a tetracycline drug solution; step 2, adding a multi-arm polyethylene glycol with a double bond end group into the solution prepared in step 1 to form a solution containing the multi-arm polyethylene glycol with a double bond end group and the tetracycline drug; step 3, adding a multi-sulfhydryl compound into the solution prepared in step 1 to form a solution containing the multi-sulfhydryl compound and the tetracycline drug; and step 4, mixing the solutions prepared in steps 2 and 3 to prepare the hydrogel. In the acute phase, the active oxygen rapidly increases to make the hydrogel release more drugs to regulate the inflammatory environment and play a neuroprotective role, and in the chronic phase, the hydrogel continuously releases drugs to continuously regulate the anti-inflammatory polarization of microglia cells, enhance neural plasticity and restore nerve function.

The application discloses application of bupropion hydrochloride tablets (75mg) in preparation of a medicine for treating stroke, and belongs to the technical field of new purposes of medicines. The core verifies the efficacy and safety of the medicine of the specification through systematic animal tests, aims at the problems of post-stroke neural function defect, motor dysfunction and insufficient neural plasticity, adopts a line plug method to prepare a rat focal cerebral ischemia (MCAO) model, sets multiple control tests, and explores the dosing effect of an equivalent dose of the bupropion hydrochloride tablets (75mg). The test results show that the medicine can significantly reduce the neural function defect score of the model animals, improve the motor coordination ability and the limb usage rate, increase the content of brain-derived neurotrophic factor (BDNF) in the brain, promote the repair of neural plasticity, and is safer than a high-dose scheme and has no obvious adverse reactions. Through complete animal test data, the application proves the effectiveness and safety of the bupropion hydrochloride tablets (75mg) in treating stroke, provides solid test basis for clinical conversion and application of the bupropion hydrochloride tablets (75mg), and has important medical application value.

The invention discloses a multi-mode vision correction method based on fertility resonance, and particularly relates to the technical field of vision correction.The multi-mode vision correction method comprises a glasses frame, a fertility resonance chip is installed in the glasses frame, and the fertility resonance chip comprises a receiving and transmitting antenna, a resonance circuit, a processor and an oscillating circuit; according to the invention, a fertility resonance chip is arranged in the intelligent glasses frame, and 9.34 [mu] m far infrared light is emitted. The wave band is matched with the vibration frequency of biomacromolecules of a human body, and acts on mitochondrial cytochrome C oxidase in a targeting manner through a resonance effect, so that the ATP synthesis efficiency is improved, and the microcirculation and oxygenation of eyes are improved; by matching with light-guiding eye-protecting gel, the eye cream is smeared around the eyes, capillary vessels are shrunk through physical cooling, intraocular pressure is reduced, and ciliary muscle spasm is relieved; in combination with Schumann wave (7.83 Hz) vision treatment music, brain waves of the brain are adjusted to be in an alpha / theta state, the visual center reaction capacity is improved, and the neuroplasticity and the visual signal processing efficiency are enhanced; the non-invasive design avoids infection and injury risks.

The utility model discloses a rehabilitation training device for hemiplegic patients, and belongs to the technical field of rehabilitation training devices.The training device comprises a fixing frame and supporting legs installed on the fixing frame, a positioning frame used for being connected with the supporting legs is hinged to the fixing frame, and four sets of fixing bases are arranged on the positioning frame in an array mode; a fixing rod is arranged between every two fixing seats, an adjusting mechanism is arranged on each fixing rod, a transverse push plate used for being arranged on the fixing rods in a sleeving mode is arranged on the positioning frame, grips are symmetrically distributed on the transverse push plate, each adjusting mechanism comprises a spring arranged on the corresponding fixing rod in a sleeving mode, and the springs are arranged on the springs in a sleeving mode. The two ends of the spring are each fixedly provided with an assembly ring used for being arranged on the corresponding fixing rod in a sleeving mode. By the adoption of the replaceable design, the spring with the adaptive rigidity is selected according to the muscle force decline degree of the patient, the paralyzed patient can maximize the neuroplastic potential within the safety range, and the applicability of the whole device is wider.

The invention discloses a training method for improving psychological health level based on body balance training, which comprises the following steps of: combining six types of core actions with a 478 breathing method, implementing three-stage training of 25-35 minutes per time and 1-3 times per week, and activating a synergistic effect of a prefrontal lobe and a self-control brain region. And multi-dimensional evaluations such as plantar pressure, brain wave data, single-foot standing time increment, SDS scale reduction rate and the like are acquired in real time. On the basis of a cognitive theory, a neural pathway is remodeled through ontological sensory feedback, and in combination with endomorphin release and cognitive resource reconfiguration, conversion from body control feeling to psychological stability is realized, finally, cross-domain neuroplastic change is formed, and a stable psychological toughness basis is established.

The application provides a dynamic training optimization system and method based on multi-dimensional biological feedback, and relates to the technical field of intelligent sensing and behavior optimization.The application realizes accurate optimization of the mother-fetus interaction environment by constructing a joint evaluation matrix of physiological data of pregnant women and fetal development indicators, and introduces a regulation technology based on body dynamics and beta wave music cooperation, which significantly reduces the matching deviation of maternal physiological parameters and fetal needs.Meanwhile, by using dynamic nutrition intervention and amniotic fluid dynamics monitoring based on biological rhythm synchronization, the dynamic balance of the intervention during pregnancy and the efficient development of fetal synapses are realized, and combined with multi-dimensional sensory stimulation and neural plasticity enhancement scheme, not only the synaptic density and neural network efficiency of the fetal brain functional area are greatly improved, but also the key problems such as single stimulation, non-systematic intervention and development evaluation lag in the existing fetal education method are effectively solved.

Described herein are neurotrophic and nootropic compositions and methods for treating subjects with such compositions. In one aspect the composition comprises one or more tryptamines in pure form or extracts from psilocybin containing mushrooms, or combinations thereof optionally combined with one or more phenethylamines or amphetamines in pure form or extracts from a plant or mushroom, or combinations thereof, optionally one or more erinacines or hericenones in pure form, extracts from Hericium mushroom species (e.g., H. erinaceus, H. coralloides, H. ramosum) or combinations thereof, optionally one or more cannabinoids in pure form or extracts from Cannabis sativa, Cannabis sativa, Cannabis indica, or Cannabis ruderalis, optionally, one or more adversive compounds, and optionally one or more pharmaceutically acceptable excipients. In another aspect, tryptamine compositions described herein enhance neuroplasticity by promoting neuronal branching through the formation of neurites (i.e., neurite outgrowth) and neurite elongation (i.e., increasing neurite length).

The application discloses a kind of neural regulation self-adapting method and system based on dynamic structure-function coupling monitoring, it is related to neural regulation and medical image analysis technical field, the method first acquires the multimodal magnetic resonance image data of two time points before and after neural regulation stimulation intervention;Second, the structure-function coupling value of each time point target brain area is calculated, the value represents the matching degree of the brain area function connection mode and structure connection mode;Then, calculate early coupling change value;Finally, compare the change value with preset threshold, and generate decision signal accordingly: if greater than threshold, maintain current parameter, if less than or equal to threshold, trigger adaptive adjustment including relocation, parameter adjustment and other strategies.Corresponding system includes data acquisition, processing analysis and decision module.The application realizes neural regulation from static open loop to dynamic closed loop by monitoring the dynamic neural plasticity biomarker in early intervention, improves the accuracy and efficiency of intervention.

Disclosed is a method for providing targeted energy-based neurostimulation treatment of the brain of a patient in need of such treatment, which method involves administering to said patient prior to or simultaneously with administration of said targeted neurostimulation treatment sufficient amount of a dopamine receptor agonist in combination with one or more drugs that modulate or enhance neuroplasticity of the brain of the patient, and repeating said targeted neurostimulation treatment for a time period not exceeding one day. In a preferred embodiment the treatment is for depression, and the targeted neurostimulation treatment involves transcranial magnetic stimulation.

Various embodiments of a platform for providing electromyographic biofeedback are disclosed. The platform includes a sensor device having an IMU and electrodes for simultaneous tracking of IMU and EMG activity. The IMU and EMG data may be generated and leveraged in conjunction with a gaming application provided to a user while engaged to the sensor device to provide biofeedback therapy for rehabilitation.

Systems and methods for monitoring neuroplasticity within at least one region of interest of a brain of a subject are disclosed. The method includes transforming at least one time sequence of signals indicative of neural activity into a summary parameter indicative of plasticity pulses. The method further includes evaluating the summary parameter with respect to one or more threshold values to obtain a determination of neuroplasticity within at least one region of interest of the subject. The method may be used to evaluate the efficacy of a neuroactive therapy, such as a neuroactive medication, a physical therapy, an occupational therapy or a speech therapy. The summary parameter obtained using the disclosed method may be displayed to a subject as a biofeedback during a neurotherapy.