813 results about "Cerebral stroke" patented technology

The present invention provides pyrazine derivatives of formula Iand pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and / or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and / or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and / or prevention of nervous system diseases caused by excessive amount of radicals and / or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

The invention relates to application of a ferulic acid derivative to preparation of drugs for treating and / or preventing neurodegenerative diseases related to nerve cell injury. The neurodegenerative diseases includes but not limited Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, diabetic neuropathy, ischemia stroke and hemorrhagic stroke.

The invention provides an evaluation system and evaluation method for an early noncontrast computed tomography (CT) image of stroke, and a readable storage medium. The evaluation system includes a preprocessing module, a brain blood supply area segmentation module, a segmentation scoring module and a comprehensive scoring module; a brain parenchyma segmentation unit can realize the processing of removing a skull and retaining a brain parenchyma of the noncontrast CT image; the brain blood supply area segmentation module is used to register a brain blood supply area template image to the noncontrast CT image, and map a plurality of segmented blood supply areas marked in the brain blood supply area template image to the noncontrast CT image registered with the areas to obtain a plurality ofsegmented blood supply areas in the noncontrast CT image; and the comprehensive scoring module is used to score the image performance of each segmented blood supply area in the noncontrast CT image toobtain an overall score of the noncontrast CT image. The evaluation system can assist doctors for diagnose in the early diagnosis and treatment of the stroke, reduce the subjective difference of thedoctors, and help improve the diagnosis efficiency and accuracy; and the evaluation method and the readable storage medium have the same advantages.

The invention discloses an intelligent cerebral stroke drug carrier for ROS (reactive oxygen species) response and a preparation method of the drug carrier. The carrier is a nano vesicle, hydrophobic boric acid ester is grafted to hydrophilic glucan framework to form amphiphilic block copolymers, the amphiphilic block copolymers serve as carrier materials to prepare the nano vesicle, and the nano vesicle encapsulates neuroprotective agents NR2B9C. The preparation method includes the steps: performing covalent grafting for the boric acid ester and glucan; preparing a nano vesicle carrier by grafting reaction carrier materials in an automatically filling manner; encapsulating the neuroprotective agents NR2B9C in the nano vesicle carrier. The weight ratio of the boric acid ester and the glucan is 10: (5-25), the carrier easily responds degradation of ROS mediation, so that drugs rapidly release at cerebral ischemia lesion positions, and release in non-lesion areas is decreased, so that the neuroprotective agents are more safely and effectively transmitted in intracerebral target areas.

The invention belongs to the technical field of medical early warning, and discloses an early warning system and method for cerebral apoplexy. The early warning system for cerebral apoplexy comprisesan image collection module, a physiological index collection module, a main control module, an image processing module, a risk evaluation module, a warning module, a data storage module and a displaymodule. According to the system and method, through the image processing module, automatic identification and segmentation of a cerebral ischemia zone in a super-acute stage can be achieved, and the segmentation precision of the ischemia zone is improved; data preprocessing, feature selection and feature optimization are conducted through the risk evaluation module, and obtained data features aremore effective; an XGBoost method is adopted for automatically generating the risk probability that a target group of people suffer from cerebral apoplexy, community health screening can be more efficiently and conveniently conducted, and a doctor can be helped to more simply and quickly evaluate the risk that the target group of people suffer from cerebral apoplexy; health screening can be strongly pushed, so that potential users with cerebral apoplexy are more quickly found, and earlier warning is given, so that earlier and more effective treatment is conducted.

The invention discloses a cerebral stroke hand rehabilitation device. The device comprises a driver, a system controller, multi-cavity soft body drivers, pressure sensors, a myoelectric signal sensorand flexible bending sensors, the driver is connected with the system controller, the driver comprises a glove body, the glove body comprises finger sleeves, the five finger sleevesare arranged and correspond to five fingers of a human body including a thumb finger sleeve, an index finger sleeve, a middle finger sleeve, a ring finger sleeve and a littlefinger sleeve, and the outer upper surfaces of the finger sleevesare provided with cavity sleeves; the multi-cavity soft body driversare disposed inside the cavity sleeves;the pressure sensorsare arranged at the front ends of the finger sleeves;the myoelectric signal sensor is used for collecting a surfacemyoelectric signal, that is,sMEG; the flexible bending sensorsare disposed on the inner surfaces of the cavity sleeves. The device solvesthe problems that a traditional rehabilitation device needs manual operation and is single in action, and a rigid body material device and the fingers are incompatible, which easily causes a secondary injury.

The invention discloses a cerebral arterial thrombosis targeted red cell membrane bionic intellectual drug carrier. The drug carrier is prepared from a nanometer vesica, a red cell membrane and cerebral ischemia homing peptide SHp, wherein the nanometer vesica serves as an inner core and is used for packing NR2B9C, the red cell membrane is arranged on the outer layer, the cerebral ischemia homing peptide SHp is modified on the surface of the cerebral ischemia, and the wrapping fusion between the nanometer vesica serving as the inner core and the red cell membrane on the outer layer is achieved through an ultrasonic fusion technique. The nanometer vesica is prepared from amphiphilic block copolymer (PHB-Dextran) serving as a carrier material, the amphiphilic block copolymer is prepared from hydrophobic borate which is grafted to a hydrophilic glucan framework, the nanometer vesica is used for wrapping a neuroprotective agent NR2B9C, and the amino acid sequence of the neuroprotective agent NR2B9C is KLSSIESDV. The carrier has the characteristics of having biocompatibility, prolonging circulation time in the body and initiatively targeting the focus position of the cerebral arterial thrombosis.

The invention provides a medical image processing system, a model training method and a training device. The medical image processing system comprises an image acquisition unit, a virtual DWI image generation unit and a display unit. After a CTA image obtained by CTA scanning is obtained, the CTA image is converted into a corresponding virtual DWI image through a deep learning model; the virtual DWI image is used for cerebral apoplexy diagnosis. Compared with a CTA image, the virtual DWI image can provide more accurate and comprehensive display of related cerebral apoplexy information; therefore, great convenience is brought to a doctor to diagnose early cerebral apoplexy, a reliable and comprehensive diagnosis basis is provided for controlling and treating cerebral apoplexy, the missed diagnosis and misdiagnosis rate is reduced, a patient can be intervened and treated in time, and medical expenditure can also be saved through fusion of examination modes. The deep learning model in themedical image processing system can be obtained by training through the model training method and device.

The invention discloses a small molecular organic compound with a specific targeting TSPO (Transfer Protein). The structure of the small molecular organic compound comprises a benzene ring, pyrazolo imidazole and a diethyl acetamide structure. The P-toluenesulfonyl on a side chain of a benzene ring is used as a marker site; carrier-free radioactive fluorine-18 is used as a radioactive source; andmild alkaline reaction conditions are designed and utilized. By using a functional GE TRACERlab FX2N synthesizer, a target compound [18F] DPA714 is obtained through a one-step reaction. The method hasthe advantages of mild reaction conditions, simple steps, and automatic labeling; the non-attenuation correction yield reaches 40% or above; the radiochemical purity of the product is higher than 99%, the specific activity is higher than 148GBq / [mu] mol (4Ci / [mu] mol). The invention solves the technical problems of low labeling yield, low specific activity, complex operation and the like in the prior art. A radioactivity molecular probe prepared from the small molecular compound is shown as an imaging evaluation result of a positron emission tomography (PET) in patients (including Alzheimer'sdisease and cerebral apoplexy) with neuroinflammation related diseases, and the radioactivity molecular probe has the characteristics of high sensitivity, high sensitivity, high sensitivity, high sensitivity, high sensitivity, high sensitivity and the like. It is proved that the molecular probe has good specificity, targeting, stability and non-target tissue clearance rate.