828 results about "Cerebral stroke" patented technology

The present invention provides pyrazine derivatives of formula Iand pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and / or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and / or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and / or prevention of nervous system diseases caused by excessive amount of radicals and / or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

The invention discloses a left auricle plugging device and a transport system. The left auricle plugging device comprises a stent and a plugging device body. Firstly, the stent is implanted and fixed on the left auricle inlet position, the double-tray-shaped plugging device body is released on the stent for plugging a left auricle, and therefore the problem of cerebral apoplexy caused by left auricle thrombus because of atrial fibrillation can be solved. The left auricle plugging device is provided with the self-expandable nitinol stent, the stent is firmly fixed on the left auricle inlet position by depending on anchoring thorns, and then the appropriate plugging device body is released on the stent. The transport system transports the left auricle plugging device to the left auricle position. Compared with the prior art, the stent is firstly fixed on the left auricle inlet position, then the double-tray-shaped plugging device body is released on the stent, and therefore release accuracy and implanting stability of the plugging device body are improved, and the plugging device body has selectivity. After release, the stent and the the plugging device body can be recovered to a catheter for relocation or replacement.

The invention relates to the technical field of vegetable-oil soft capsules, in particular to a peony-seed-oil soft capsule and a preparation method thereof. The peony-seed-oil soft capsule is prepared by mixing and gelling of raw materials, capsule pressing and forming, hardening, sizing, scrubbing and drying. The peony-seed-oil soft capsule comprises the following raw materials in parts by weight: 80-95 parts of peony seed oil, 1-3 parts of fucosterol, 1-3 parts of squalene, 1-3 parts of propyl gallate, 0.05-0.25 part of tocopherol, 0.05-0.25 part of soya bean lecithin, 0.15-0.25 part of vitamin C, 5-10 parts of gelatin, 5-10 parts of water, 1.3-2.5 parts of sorbierite, and 2.5-5 parts of glycerol. The peony-seed-oil soft capsule is nutritious and safe, has the obvious effects of reducing blood fat, blood pressure and cholesterol, and can enhance the self immunity, prevent the diabetes, prevent and treat cancers, reduce weight, prevent cerebral stroke and myocardial infarction, clear harmful substances in blood, prevent and treat heart diseases and relieve the climacteric syndrome.

The invention relates to application of a ferulic acid derivative to preparation of drugs for treating and / or preventing neurodegenerative diseases related to nerve cell injury. The neurodegenerative diseases includes but not limited Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, diabetic neuropathy, ischemia stroke and hemorrhagic stroke.

The invention provides an evaluation system and evaluation method for an early noncontrast computed tomography (CT) image of stroke, and a readable storage medium. The evaluation system includes a preprocessing module, a brain blood supply area segmentation module, a segmentation scoring module and a comprehensive scoring module; a brain parenchyma segmentation unit can realize the processing of removing a skull and retaining a brain parenchyma of the noncontrast CT image; the brain blood supply area segmentation module is used to register a brain blood supply area template image to the noncontrast CT image, and map a plurality of segmented blood supply areas marked in the brain blood supply area template image to the noncontrast CT image registered with the areas to obtain a plurality ofsegmented blood supply areas in the noncontrast CT image; and the comprehensive scoring module is used to score the image performance of each segmented blood supply area in the noncontrast CT image toobtain an overall score of the noncontrast CT image. The evaluation system can assist doctors for diagnose in the early diagnosis and treatment of the stroke, reduce the subjective difference of thedoctors, and help improve the diagnosis efficiency and accuracy; and the evaluation method and the readable storage medium have the same advantages.

A rehabilitation training device with anti-convulsant and anti-thrombotic functions for stroke patients comprises a bed frame, a supporting plate and a control mechanism, wherein the supporting plate consists of a fixed part and a rotating part which are hinged to each other; a head and neck support is arranged at one end of the supporting plate; an electrode plate capable of releasing stimulation pulses is arranged on the outer surface of the head and neck support; and the rotating part can be pushed upwards or return downwards. A push-and-pull rod II is arranged at the tail end of the fixed part, and front-back swinging training of a front section of a sole of a patient can be realized. A forearm fixing plate and a shank fixing plate are arranged on the supporting plate, electrode plates are distributed on the surface of the forearm fixing plate and the surface of the shank fixing plate, and the forearm fixing plate and the shank fixing plate can drive the upper limbs or lower limbs of the patient to finish left-right swinging and front-back flexion and extension movements. By the rehabilitation training device, sitting-up and lying-down training, continuous transformation of functional positions of upper affected limbs and lower affected limbs, anti-convulsant training of front-back swinging of soles of both feet and pulse massaging stimulation of the stroke patient can be implemented automatically, muscle spasm and atrophy of the bedridden stroke patient are avoided effectively, and rapid recovery of the stroke patient is promoted.

The invention relates to a method of detecting microRNAs used for diagnosing cerebral stroke form blood. The method includes: adding a sample to be tested and various nucleic acid probes into mixture of various fluorescence-encoded micro-beads to allow for hybridization; adding various single-chain degrading enzymes into the mixture which is hybridized, and allowing for degradation; adding fluorescence-marked streptavidin into the mixture which is degraded, and allowing for conjugation; cleaning the micro-beads which is conjugated; recognizing fluorescence codes of the micro-beads which are cleaned, and detecting fluorescence intensity of the streptavidin on the micro-beads; determining the type of the detected microRNAs according to the fluorescence codes of the micro-beads; determining whether the corresponding types of microRNAs are conjugated to the micro-beads or not according to the fluorescence intensity, and accordingly determining whether the corresponding types of microRNAs exist in the sample to be tested. The method has the advantage that the step of primer synthesis is omitted so that detection is time saving and labor saving.

An object of the present invention is to provide a nerve regenerating drug, an agent for the promotion of neuropoiesis of a neural stem cell, a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis, and a method of the manufacture of the neuron. In order to achieve the object, the invention provides a nerve regenerating drug comprising a substance that inhibits the activity of glycogen synthase kinase-3, as an active ingredient; an agent for the promotion of neuropoiesis of a neural stem cell comprising the substance as an active ingredient; a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis; and a method of the manufacture of the neuron. The medical drug according to the invention is useful as a therapeutic drug for neurological diseases such as Parkinson's disease, Alzheimer's disease, Down's disease, cerebrovascular disorder, cerebral stroke, spinal cord injury, Huntington's chorea, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, anxiety disorder, schizophrenia, depression and manic depressive psychosis.

The invention provides a multi-dimension cerebral stroke prevention screening method based on artificial intelligence. The method includes: S1, transmitting the collected three dimensional data of cerebral stroke to a cloud computing service platform through network to establish a cerebral stroke case database; S2, according to the established cerebral stroke case database, constructing a cerebralstroke prevention screening AI algorithm model, according to the actual incidence status of the cerebral stroke cases, verifying the cerebral stroke prevention screening AI algorithm model; S3, inputting the related data in the three dimensional data of cerebral stroke into a report output device, and according to the prevention screening AI algorithm model, outputting the cerebral stroke prevention screening report. By means of the method, risk control can be carried out on the cerebral stroke prevention screening objects and doctors, thus achieving whole-life-period management on the cerebral stroke prevention. The method has the advantages of preventing future possible risk, reducing the incidence rate of the cerebral stroke and relieving social burden.

The invention discloses HGG (Human Gammaglobulin) polypeptide in combination with the tissue specificity of cerebral arterial thrombosis. The invention relates to a method for obtaining the polypeptide. The method comprises the following steps: carrying out in-vivo selection of a mouse MCAO (Middle Cerebral Artery Occlusion) cerebral arterial thrombosis model by adopting an in-vivo phage display peptide library screening technology so as to obtain phage clones in combination with cerebral arterial thrombosis tissue; and randomly selecting the plurality of phage clones to sequence, and authenticating the in-vivo combination specificity of HGG peptide and coded phage clones HGG-M13 thereof. The invention further relates to application of the polypeptide in preparation of a high-sensitivity imaging molecular probe and a targeting delivery neuroprotective drug for cerebral stroke. The polypeptide can be synthesized through an artificial method; the polypeptide is low in molecular weight, high in activity and penetrating power, good in specificity and low in toxicity, and has good tissue targeting of cerebral arterial thrombosis in vivo; and therefore, the polypeptide is applicable to serving as a carrier of the high-sensitivity imaging molecular probe and the targeting delivery neuroprotective drug.

The invention discloses an intelligent cerebral stroke drug carrier for ROS (reactive oxygen species) response and a preparation method of the drug carrier. The carrier is a nano vesicle, hydrophobic boric acid ester is grafted to hydrophilic glucan framework to form amphiphilic block copolymers, the amphiphilic block copolymers serve as carrier materials to prepare the nano vesicle, and the nano vesicle encapsulates neuroprotective agents NR2B9C. The preparation method includes the steps: performing covalent grafting for the boric acid ester and glucan; preparing a nano vesicle carrier by grafting reaction carrier materials in an automatically filling manner; encapsulating the neuroprotective agents NR2B9C in the nano vesicle carrier. The weight ratio of the boric acid ester and the glucan is 10: (5-25), the carrier easily responds degradation of ROS mediation, so that drugs rapidly release at cerebral ischemia lesion positions, and release in non-lesion areas is decreased, so that the neuroprotective agents are more safely and effectively transmitted in intracerebral target areas.

The invention belongs to the technical field of medical early warning, and discloses an early warning system and method for cerebral apoplexy. The early warning system for cerebral apoplexy comprisesan image collection module, a physiological index collection module, a main control module, an image processing module, a risk evaluation module, a warning module, a data storage module and a displaymodule. According to the system and method, through the image processing module, automatic identification and segmentation of a cerebral ischemia zone in a super-acute stage can be achieved, and the segmentation precision of the ischemia zone is improved; data preprocessing, feature selection and feature optimization are conducted through the risk evaluation module, and obtained data features aremore effective; an XGBoost method is adopted for automatically generating the risk probability that a target group of people suffer from cerebral apoplexy, community health screening can be more efficiently and conveniently conducted, and a doctor can be helped to more simply and quickly evaluate the risk that the target group of people suffer from cerebral apoplexy; health screening can be strongly pushed, so that potential users with cerebral apoplexy are more quickly found, and earlier warning is given, so that earlier and more effective treatment is conducted.

The invention discloses a cerebral stroke hand rehabilitation device. The device comprises a driver, a system controller, multi-cavity soft body drivers, pressure sensors, a myoelectric signal sensorand flexible bending sensors, the driver is connected with the system controller, the driver comprises a glove body, the glove body comprises finger sleeves, the five finger sleevesare arranged and correspond to five fingers of a human body including a thumb finger sleeve, an index finger sleeve, a middle finger sleeve, a ring finger sleeve and a littlefinger sleeve, and the outer upper surfaces of the finger sleevesare provided with cavity sleeves; the multi-cavity soft body driversare disposed inside the cavity sleeves;the pressure sensorsare arranged at the front ends of the finger sleeves;the myoelectric signal sensor is used for collecting a surfacemyoelectric signal, that is,sMEG; the flexible bending sensorsare disposed on the inner surfaces of the cavity sleeves. The device solvesthe problems that a traditional rehabilitation device needs manual operation and is single in action, and a rigid body material device and the fingers are incompatible, which easily causes a secondary injury.

The invention relates to an intelligent cerebral apoplexy risk monitoring system, aims at monitoring cerebral apoplexy risk by utilizing personal information (comprising age, gender, blood pressure, stature, weight, constitutional index and the like) of health examination, physical examination and hospital admission, and blood routine examination and blood biochemistry data, belongs to the application of artificial intelligence and big data in the field of health care, and belongs to the cross technical field of artificial intelligence, big data and health care. The invention mainly aims at providing a simple, practicable and high-correctness cerebral apoplexy risk monitoring system. The intelligent cerebral apoplexy risk monitoring system is established through carrying out over ten thousands of predictions, simulations and analysis assessments on the data of more than five hundred and ninety thousands of normal persons and more than twenty thousands of cerebral apoplexy patients by means of prediction simulation and big data value extraction technologies of artificial intelligence, and is capable of helping users and doctors to carry out cerebral apoplexy risk monitoring so as to provide hope for the users to monitor the cerebral apoplexy risks and finally keep away from cerebral apoplexy.

The invention discloses a cerebral arterial thrombosis targeted red cell membrane bionic intellectual drug carrier. The drug carrier is prepared from a nanometer vesica, a red cell membrane and cerebral ischemia homing peptide SHp, wherein the nanometer vesica serves as an inner core and is used for packing NR2B9C, the red cell membrane is arranged on the outer layer, the cerebral ischemia homing peptide SHp is modified on the surface of the cerebral ischemia, and the wrapping fusion between the nanometer vesica serving as the inner core and the red cell membrane on the outer layer is achieved through an ultrasonic fusion technique. The nanometer vesica is prepared from amphiphilic block copolymer (PHB-Dextran) serving as a carrier material, the amphiphilic block copolymer is prepared from hydrophobic borate which is grafted to a hydrophilic glucan framework, the nanometer vesica is used for wrapping a neuroprotective agent NR2B9C, and the amino acid sequence of the neuroprotective agent NR2B9C is KLSSIESDV. The carrier has the characteristics of having biocompatibility, prolonging circulation time in the body and initiatively targeting the focus position of the cerebral arterial thrombosis.

The present invention refers to a composition comprising uric acid for its use in the treatment of brain stroke in a patient treated by means of mechanical thrombectomy.

The invention discloses a cerebral apoplexy early warning system and method, and relates to the technical field of data processing. The cerebral apoplexy early warning system comprises a cloud side server, a user terminal, a sign monitoring terminal and a medical care terminal. The cloud side server receives the physical sign data and the equipment identifier transmitted by the sign monitoring terminal and then compares the physical sign data with the preset physical sign range and determines user information according to the equipment identifier. When the physical sign data are out of the preset physical sign range, the cerebral apoplexy early warning prompt is transmitted to the user terminal associated with the user information so that the corresponding measures can be timely taken forthe abnormal situation of the user body. Besides, the related medical institutions can acquire the cerebral apoplexy early warning prompt of the user by accessing the cloud side server through the medical care terminal so as to provide the emergency intervention scheme or the first aid service to the user. According to the cerebral apoplexy early warning system and method, accurate early warning for the situation of cerebral apoplexy can be performed for the user so as to guarantee the life safety of the user.

The invention provides a cerebral apoplexy recurrence prediction model establishing method and device. The method comprises the following steps of: obtaining a pathologic data set of each cerebral apoplexy patient in a plurality of cerebral apoplexy patients in a plurality of age groups; screening parameters remarkably associated with cerebral apoplexy recurrence from the pathologic data set of each cerebral apoplexy patient, and determining the parameters remarkably associated with the cerebral apoplexy reoccurrence and an attribute value corresponding to each parameter as pathologic data subsets of each cerebral apoplexy patient; and establishing a first cerebral apoplexy reoccurrence prediction model according to panel data corresponding to the pathologic data subsets. According to the method and device, the cerebral apoplexy reoccurrence prediction model can be established through the parameters of the cerebral apoplexy patients in a plurality of age groups, so that prediction can be carried out to judge whether cerebral apoplexy reoccurs to the patients or not, and then prevention and treatment can be carried out in advance.

The invention provides a new matter glycine-L-cysteine-homotaurine tripeptide and an application of the glycine-L-cysteine-homotaurine tripeptide in the preparation of medicines for treating cerebral apoplexy. The anti-cerebral apoplexy medicines prepared by glycine-L-cysteine-homotaurine tripeptide products have better curative effect. The animal experiment shows that the glycine-L-cysteine-homotaurine tripeptide can improve the behaviors of rats and has the effect on cerebral apoplexy treatment. The effect of the tripeptide is obviously superior to the same dose of homotaurine, taurine and other compounds reported by existing literatures or traditional medicines for clinical use.

The invention discloses miR-106b-5p, a detection primer thereof and application of the antisense nucleotide sequence thereof in the fields of ischemic cerebral stroke diagnosis and treatment, and belongs to the field of application of micro ribonucleic acid. The sequence of a reverse transcription primer in the detection primer of the miR-106b-5p is 5'-CTCAACTGGTGTCGTGGAGTCGGCAATTCAGTTGAGATCTGCAC-3'. The antisense nucleotide sequence of the miR-106b-5p is 5'-AUCUGCACUGUCAGCACUUUA-3'. The miR-106b-5p, the detection primer thereof and the antisense nucleotide sequence thereof are associated with acute ischemic cerebral strokes, the miR-106b-5p can become an auxiliary index of acute ischemic cerebral stroke clinical detection, and a therapeutic target is provided for prevention of the disease. The miR-106b-5p has the advantages of being good in treatment effect, easy to operate, free of toxic and side effects and the like.

A cerebral stroke early-warning and brain blood vessel health management system comprises a cerebral stroke early-warning and brain blood vessel health management system body, wherein the cerebral stroke early-warning and brain blood vessel health management system body comprises a front-end detecting unit, a danger degree assessment unit and a data interface unit, wherein the front-end detecting unit comprises an entering module and an information registration module. The danger degree assessment unit comprises a detection module, a data acquisition module and a calculation and analysis module, the detection module comprises an electrocardiograph detection module, a pressure detection module and an ultrasonic Doppler blood flow speed detection module, the data acquisition module comprises an A / D conversion module and a digital Doppler signal detecting and taking module, the calculation and analysis module comprises software special for brain blood vessel hemodynamics analysis and a main computer, and the ultrasonic Doppler blood flow speed detection module and the digital Doppler signal detecting and taking module are connected with the main computer. The cerebral stroke early-warning and brain blood vessel health management system is simple in operation and short in detection time and has smaller dependence on technologies of operators.

A pharmaceutical composition is an organic salt formed by an organic acid rosuvastatin and an organic base azelnidipine with a molar ratio of 1:1. The pharmaceutical composition can be made into any dosage forms together with a pharmaceutically-acceptable carrier for reducing blood pressure and blood lipid, reducing myocardial infarction and treating cerebral apoplexy. The inventive pharmaceutical composition has the advantages of stable physiochemical indexes, controllable product quality, and convenient administration.

The invention provides a medical image processing system, a model training method and a training device. The medical image processing system comprises an image acquisition unit, a virtual DWI image generation unit and a display unit. After a CTA image obtained by CTA scanning is obtained, the CTA image is converted into a corresponding virtual DWI image through a deep learning model; the virtual DWI image is used for cerebral apoplexy diagnosis. Compared with a CTA image, the virtual DWI image can provide more accurate and comprehensive display of related cerebral apoplexy information; therefore, great convenience is brought to a doctor to diagnose early cerebral apoplexy, a reliable and comprehensive diagnosis basis is provided for controlling and treating cerebral apoplexy, the missed diagnosis and misdiagnosis rate is reduced, a patient can be intervened and treated in time, and medical expenditure can also be saved through fusion of examination modes. The deep learning model in themedical image processing system can be obtained by training through the model training method and device.

The invention discloses novel coumarin compounds and pharmaceutically acceptable salts thereof, the preparation method of the compounds, pharmaceutical compositions containing the compounds, and application of the compounds to preparation of medicaments for prevention or treatment of cerebral diseases, especially prevention or treatment of diseases related to neuron damage and neuroinflammation, and prevention or treatment of Parkinson's disease, dementia, cerebral ischemia, depression and cerebral apoplexy.

The present invention discloses a medicine composition containing rhodiola root extract and ginkgo leaf extract for curing angiocardiopathy and cerebrovascular diseases of cerebral apoplexy, coronary heart disease and angina pectoris, etc. Said medicine composition can be made into oral tablet, capsule, granules and injection preparation.

The compound for treating cardiac and cerebral vascular diseases is triethoxyl quercetin. The preparation process includes the following steps: A. hydrolyzing Troxerutin as material with beteroside hydrolase through stirring at 30-70 deg c for 3-5 days; and B. filtering, water washing the precipitate and drying. Triethoxyl quercetin has pharmacological activity obviously superior to Troxerutin. Different forms of medicine may be prepared with the compound as active component for preventing and treating cardiac and cerebral vascular diseases and cerebral apoplexy.

The invention discloses a lower limb rehabilitation quantitative evaluation method for a patient suffering from cerebral stroke, and relates to a motion capture technology and application thereof in evaluation of limb function rehabilitation, in particular to a lower limb function rehabilitation quantitative evaluation method developed on the basis of the step speed, stride frequency, left and right stride length difference, healthy side and diseased side support comparison value and diseased side and healthy side swing comparison value. A whole body motion capture and display system and the lower limb function rehabilitation quantitative evaluation method are included. Accordingly, a method which evaluates the lower limb rehabilitation degree of the patient in the observation and scale modes and is adopted by traditional rehabilitation medicine is disregarded, the information technology and medicine are combined, gait parameters of double feet movement are analyzed through the whole body motion capture and display system, the healthy side foot of the patient serves as a comparing object, the improvement degree of the lower limb movement function of the patient suffering from the cerebral stroke is quantitatively evaluated in a rating mode, and important significance and value are achieved for human body health restoration and clinical medicine.

The invention is applicable to the technical field of medical treatment, and provides blood vessel wall plaque recognition equipment, system and method and a storage medium. The method comprises the following steps of identifying patches in the MRI image by using a deep learning method. adopting a deep learning method to identify the blood vessel wall plaque. manpower can be greatly reduced, the plaque identification accuracy is improved, the identification efficiency is improved, and the identification accuracy can be ensured. MRI is adopted to carry out comprehensive and accurate image assessment on ischemic stroke related vascular bed plaques, artificial intelligence is utilized to carry out rapid and accurate diagnosis, and the method has very important significance in screening cerebral stroke high-risk groups and exploring pathogenesis to prevent reoccurrence.

The invention provides application of a cerebroside compound (cerebroside A and cerebroside B) extracted and prepared from termitomyces in the preparation of medicaments for treating brain injury after cerebral ischemia. Through pharmacological experiments, the invention confirms that the cerebroside compound has significant therapeutic effect on ischemic brain injury, can permeate blood-brain barriers, reduces the area of cerebral infarction caused by cerebral ischemia, alleviates cerebral edema, reduces neuronal cell death, simultaneously promotes the recovery of motor and cognitive function after stroke, and reduces stroke mortality. The invention develops novel medicament use of the cerebroside compound, and provides a novel therapeutic medicament for treating stroke diseases.

The invention discloses a spectroscopic imaging method for multi-frequency electrical impedance tomography which can be used for early detection of cerebral stroke and belongs to the technical field of electrical impedance tomography. The spectroscopic imaging method includes firstly, using data at all frequency positions in a frequency band for imaging, and reconstructing electrical impedance tomography spectral images reflecting tissue impedance change along with frequencies according to impedance spectral characteristics of tissues; secondly, according to impedance spectral specificity of the tissues, obtaining independent electrical impedance images from the electrical impedance tomography spectral images so as to separate cerebral stroke tissues from normal tissues; finally, selecting the electrical impedance images capable of reflecting the cerebral stroke tissues according to spatial information and position information of the cerebral stroke tissues. The spectroscopic imaging method is capable of detecting focuses of the cerebral stroke from experiments which are based on a real cranium brain structure so as to lay the foundation for applying the multi-frequency electrical impedance tomography to rapid early detection of the cerebral stroke.