36 results about "Nitinol stent" patented technology

The invention relates to a novel percutaneous aortic valve and pulmonary valve exchanger, which is a self-expand support with biological valve, formed by the support in special shape and made from nickel titanium alloy skeleton and the three-blade one-way opening valve formed by pig heart, wherein, the support has fixing and supporting functions, and the pig heart forms three valves fixed in the support. The invention has little hurt, high safety and reduced complication.

A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The added ternary element improves the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same size and strut pattern coated with a thin layer of gold. The nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut / wall thickness for high flexibility.

A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut / wall thickness for high flexibility. Another embodiment includes a balloon expandable stent made from a radiopaque and MRI compatible alloy such as nitinol and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, hafnium, osmium, zirconium, niobium, or molybdenum.

The invention discloses a left auricle plugging device and a transport system. The left auricle plugging device comprises a stent and a plugging device body. Firstly, the stent is implanted and fixed on the left auricle inlet position, the double-tray-shaped plugging device body is released on the stent for plugging a left auricle, and therefore the problem of cerebral apoplexy caused by left auricle thrombus because of atrial fibrillation can be solved. The left auricle plugging device is provided with the self-expandable nitinol stent, the stent is firmly fixed on the left auricle inlet position by depending on anchoring thorns, and then the appropriate plugging device body is released on the stent. The transport system transports the left auricle plugging device to the left auricle position. Compared with the prior art, the stent is firstly fixed on the left auricle inlet position, then the double-tray-shaped plugging device body is released on the stent, and therefore release accuracy and implanting stability of the plugging device body are improved, and the plugging device body has selectivity. After release, the stent and the the plugging device body can be recovered to a catheter for relocation or replacement.

The invention relates to a polyamide 66 membrane covered nickel-titanium alloy intravascular scaffold and a preparation method thereof. The intravascular scaffold comprises a nickel-titanium alloy scaffold and a polyamide 66 membrane, and is provided with a tubular blood vessel shaped structure or a cylindrical blood vessel shaped structure, wherein the surfaces of an inner wall and an outer wallof the scaffold are covered by thin membranes with the thickness between 0.2 and 5 millimeters. The preparation method comprises the following steps of: preparing 1 to 20 percent of polyamide 66 solution by using formic acid as a solvent; coating a layer of the polyamide 66 solution on a glass rod and volatizing the solvent; sleeving a nickel-titanium shape memory alloy expanding scaffold on the glass rod; coating another layer of the polyamide 66 solution on the glass rod and volatizing the solvent; and peeling off the polyamide 66 membrane and the nickel-titanium alloy intravascular scaffold from the glass rod, and performing vacuum drying to obtain the polyamide 66 membrane covered intravascular scaffold. The intravascular scaffold prepared by the method has a stable structure, good mechanical property, transportability and anti-seepage property, overcomes the performance defects of a single material, and has a simple preparation process.

The invention belongs to the medical appliance field, particularly relates to an artificial endovascular stent and method for preparing thereof. The invention adopts tunica vasculosa made from varicosity Teflon and nickel-titanium alloy stent, and makes domestically produced artificial endovascular stents for the intracavity therapy of aneurism. The invention improves the performance of existing artificial endovascular stents, presents a small caliber, fits the windings of arteries, and improves the flexibility and biocompatibility. The stent is nontoxic, nonirritating for tissues, non-pyretogenic, non-sensitizing, non-teratogenic, and does not induce thrombosis in arteriae, thus reduces the direct damages to aorta walls.

The invention provides a new percutaneous aortic valve replacing device which is characterized by the rational designation, convenient usage and low operational danger, which is to solve problems of inconvenient stitching of valve and cradle and high danger of using saccule to expand aortic valve in current aortic valve replacing device, the device is an automatic buckling cradle carrying biological valve, comprising cradle in nickel-tantalum alloy framework and trilobular one-way opening valve composed of pig heart bag. The nickel-tantalum alloy possesses functions of fixing and supporting, the trilobular valve is fixed tightly in the cradle. The product is characterized by the small injury, high safety, reduced complication caused by aortic valve replacement, and wide application prospect.

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a Nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may improve re-endothelialization and / or reduce restenosis when it is used in the treatment of cardiovascular diseases.

The invention provides an electrochemical polishing device and method for a support. The device and method are mainly suitable for electrochemical polishing of the medical metal support. The electrochemical polishing device for the support is characterized by comprising a metal anode, a metal cathode of a cylindrical structure, an electrochemical polishing tank and the like, and in the electrochemical polishing process, the current can be evenly distributed to all the portions of the support. The device is suitable for electrochemical polishing of the metal support such as a nickel-titanium alloy support, a cobalt-chromium alloy support, a stainless steel alloy support and a titanium alloy support and is used for improving the phenomena that pits and protrusions are generated on the inner surface of a support and the inner surface is not smooth and bright in the electrochemical polishing process, and the electrochemical polishing effect of the inner surface of the support is improved, so that both the inner surface and the outer surface of the support can achieve the good mirror surface effect. By the adoption of the device and method, the problem that the removing amount of the head end of the support is large can be solved as well, the polishing evenness of the support is improved, and therefore the metal surface of the support is smooth and bright.

The invention belongs to the technical field of medical instruments and relates to a nanogold film memory alloy esophageal stent with a photo-thermal therapy function. A nanogold film is prepared by conducting in-situ surface chloroauric acid reduction on a high polymer material with a reduction function used for modifying the surface of a memory alloy wire under the alkaline condition. According to the preparing method, a unique nanogold surface coating method is adopted, the nanogold material is safe and free of toxicity, and the coating process is simple and quick; photo-thermal efficiency is high, and repeated use is realized. The method can be applied to nickel-titanium alloy stents in various shapes and types such as a biliary stent, an intestinal tract stent, a urinary tract stent and a tracheal stent.

The invention prepares an interventional cardiac valve prosthesis based on anisotropic polymer fiber composite material valve leaflets. Anisotropic polymer fiber cloth is seamed in a metal stent, so that a self-expanded (such as nickle-titanium alloy stent material) or self-expanded (such as cobalt-chromium alloy stent material) interventional valve stent prosthesis is prepared; and photo-crosslinking or chemical crosslinking polyethylene glycol hydrogel covers the surface of the polymer fiber material. The interventional cardiac valve prosthesis provided by the invention, which is prepared from polymer fiber cloth having anisotropic mechanical performance, such as polyester, polyurethane, polytetrafluoroethylene or a composite material thereof, can simulate a stress distribution state ofa human body aortic valve under a blood flow effect, so that mechanical performance, which is similar to that of human body valve, can be achieved, and subsequently, the fatigue resistance of the valve leaflets can be improved. In addition, by combining the polyethylene glycol hydrogel on the surface, the integration of the valve leaflet material is guaranteed, and moreover, an anti-fouling function is achieved; platelet adhesion and protein adsorption can be relieved; and good bio-compatibility can be achieved.

A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut / wall thickness for high flexibility.

The invention provides a nickel-titanium alloy stent prepared based on a metal additive manufacturing technology and a preparation method thereof, and belongs to the technical field of biological implant materials. According to the preparation method, the shape and size of the stent can be customized according to different patients, so that the stent is more targeted, the size is more appropriate,and the probability of displacement can be reduced; the performance of a formed part can be directly regulated and controlled by adjusting preparation parameters; the nickel-titanium alloy stent is prepared by adopting the metal additive manufacturing technology, so that the forming size precision of the nickel-titanium alloy stent is high; by adjusting the proportion of components in nickel-titanium alloy and technological parameters of the metal additive manufacturing technology, the phase inversion temperature of the prepared nickel-titanium alloy stent is close to the temperature of a human body, and the nickel-titanium alloy stent can be automatically unfolded after entering the human body to space apart the blocking at an affected part; and results of the embodiment show that the nickel-titanium alloy stent prepared through the preparation method can be completely unfolded at the temperature of 37 DEG C after being compressed.

A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut / wall thickness for high flexibility.

The invention belongs to the fields of surface engineering technologies and biomaterials and in particular relates to an ion nitrogen injection method for a vascular stent. In order to solve the technical problem, the invention provides the ion nitrogen injection method for the vascular stent. The ion nitrogen injection method is characterized by adopting the following steps: (1) firstly, sandinga nickel-titanium alloy stent by using waterproof abrasive paper to remove an initial rough state on the surface, and then, cleaning the nickel-titanium alloy stent in acetone and deionized water, andblow-drying the nickel-titanium alloy stent to obtain a bright surface; (2) removing nickel in nickel-titanium alloy by using an anodic oxidation technology; (3) carrying out ion cleaning; and (4) carrying out nitrogen ion implantation. The surface of the nickel-titanium alloy is treated, so that an ultrathin corrosion-resistant coating is formed on the surface; in addition, the coating cannot affect the stent and can be implanted into a body, so that the corrosion resistance of the stent is enhanced, and the Eb value is larger than or equal to 350 mv after potentiodynamic polarization experiments are completed.

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a Nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may improve re-endothelialization and / or reduce restenosis when it is used in the treatment of cardiovascular diseases.

The invention relates to an implantable intravascular arterial intervention valve and discloses a method for manufacturing an aortic intervention valve. The method includes the following steps that 1, iPSCs are directionally induced in vitro to be differentiated into valves VICs and precursor cells VECs; 2, porcine aortic valves are selected, and enzymes and a detergent are used for removing original valve cells; 3, a protein power processing method is applied to build a core-shell structure fiber-state drug control release system; 4, constructing a skin-core structure superfine composite yarn; 5, the cell-valve-free matrix micro-morphology is processed and modified by plasma etching; 6, positioning is conducted through 3D printing cells, and the controlled release of the drug concentration gradient is conducted. By adopting a nickel-titanium alloy wire material weaving and shaping method, a nickel-titanium alloy support is produced. The automatic control performance of the support is achieved, the optimal stress state of aortic valves of the human body is achieved. The enzymes and the detergent are used for removing valve cells attached to the original aortic valves, cell matrixes are completely preserved, and thus the durability and the anti-calcification property of a product are improved.

The invention belongs to the technical field of medical instruments, and relates to a memory alloy esophageal stent with a uniform nano copper sulfide film and an efficient photo-thermal physiotherapy function and a preparation method of the memory alloy esophageal stent. The stent is prepared by reducing dopamine under an alkaline condition to obtain a polydopamine-coated memory alloy stent, and then efficiently adsorbing copper ions through polydopamine under a heating condition to grow copper sulfide in situ. According to the method, a unique method for in-situ growth of nano CuS particles on the surface of the stent is adopted, the nano CuS material is safe and non-toxic, and the growth process is simple and rapid; photo-thermal conversion is efficient, and repeated use can be achieved; the method can be applied to nickel-titanium alloy stents of various shapes and other types, such as biliary tract stents, intestinal tract stents, urinary tract stents and tracheal stents.

A method of a forming a hollow, drug-eluting nitinol stent includes shaping a composite wire into a stent pattern, wherein the composite wire comprises an inner member, a nitinol intermediate member, and an outer member. After the composite wire is shaped into the stent pattern, the composite wire is heat treated to set the nitinol intermediate member in the stent pattern. After heat treatment, the composite wire is processed to remove the outer member and the inner member without adversely affecting the intermediate member. Openings may be provided through the intermediate member and the lumen of the intermediate member may be filled with a substance to be eluted through the openings.

The invention provides a phase-transition temperature tester and a testing method thereof. The phase-transition temperature tester comprises a container, a heating device, an image acquiring device, atemperature sensor and a processor, wherein the container is used for containing a tested sample; the heating device is used for heating the tested sample in the container; the image acquiring deviceis used for acquiring an image of the tested sample; the temperature sensor is connected with the container and is used for detecting the temperature change of the tested sample; and the processor iselectronically connected with the image acquiring device and the temperature sensor and is used for detecting the displacement change, caused by the heating, of the tested sample according to the acquired image and generating a temperature displacement curve of the tested sample according to the detected displacement change, and temperature change. According to the phase-transition temperature tester and the testing method, the non-contact measurement of the phase-transition temperature of nickel-titanium alloy is realized, nickel-titanium alloy brackets of any specification and shape can beaccurately tested, and the applicability is wide.

The invention discloses a suture-free aorta intubation device. The device comprises an outer sleeve, an inner sleeve, a main body and a surgical blade, wherein a cylindrical boss is arranged at the top in the outer sleeve, the inner sleeve is sleeved in a gap between the inner wall of the outer sleeve and the cylindrical boss, the main body is installed in the inner sleeve, the upper end of the main body abuts against the lower end of the cylindrical boss, and the surgical blade is fixedly mounted on the bottom surface of the cylindrical boss and is positioned in the main body; and two symmetrical strip-shaped holes are formed in the upper end of the outer wall of the outer sleeve, a handle is fixedly arranged at the upper end of the outer wall of the inner sleeve, the handle extends out of the strip-shaped holes and is in a U shape, the main body is composed of a nickel-titanium alloy support and a covering film attached to the surface of the nickel-titanium alloy support, and the main body is in a hollow cylinder shape with the upper portion and the lower portion open. According to the intubation device, the operation steps are simplified, the intubation device is operated by a single person, the main body can be mounted on an artery blood vessel only by three operation steps of stabbing, pulling and drawing, the operation is simple, the efficiency is high, and the safety isgood.

The invention belongs to the technical field of medical instrument structures, and particularly discloses a nickel-titanium alloy stent for treating megacolon. The stent is integrally bent into a longitudinal rainbow ring structure in a spiral spring shape or a ring shape from a transverse nickel-titanium alloy in a wave shape, the stent comprises a near-end expansion section and a far-end rectumend, and the diameter of the near-end expansion section is 10-15 mm larger than that of the far-end rectum end. The invention provides the nickel-titanium alloy stent for treating megacolon, the stentis placed at a lesion intestinal segment to expand an intestinal canal, so that intestinal contents smoothly pass through the narrow intestinal canal to be discharged out of the body, and the purposeof non-surgical treatment of the megacolon is achieved. The nickel-titanium alloy stent is used for treating the megacolon, surgical excision of the lesion intestinal canal is not needed, and variousinjuries and complications caused by surgeries are avoided.

The invention belongs to the field of surface engineering technology and biological materials and particularly provides a nickel-titanium alloy support surface treatment method. The nickel-titanium alloy support surface treatment method is characterized by comprising the following steps that (1), a nickel-titanium alloy support is firstly polished using waterproof abrasive paper to remove a surface initial rough state, and then the nickel-titanium alloy support is cleaned in acetone and deionized water and dried by blowing to obtain a bright surface; (2), an anode oxidation technology is adopted to remove nickel in nickel-titanium alloy; and (3), a magnetron sputtering method is adopted, an auxiliary function of an electroacoustic energy conversion device is utilized, and a titanium nitride thin film layer is formed on the surface of the nickel-titanium alloy support by magnetron sputtering. The nickel-titanium alloy support surface treatment method has the beneficial effect that by means of intermittent sound wave control, the adhesion of surface layers attached to metal wires is effectively enhanced.

The invention belongs to the technical field of medical instruments and relates to a nanogold film memory alloy esophageal stent with a photo-thermal therapy function. A nanogold film is prepared by conducting in-situ surface chloroauric acid reduction on a high polymer material with a reduction function used for modifying the surface of a memory alloy wire under the alkaline condition. According to the preparing method, a unique nanogold surface coating method is adopted, the nanogold material is safe and free of toxicity, and the coating process is simple and quick; photo-thermal efficiency is high, and repeated use is realized. The method can be applied to nickel-titanium alloy stents in various shapes and types such as a biliary stent, an intestinal tract stent, a urinary tract stent and a tracheal stent.

An annuloplasty device formed from a Nitinol stent frame that expands into contact with the annulus above the native leaflets. A torus balloon activates barbs along the perimeter to fasten the stent frame to the annulus. A cinch ring is placed under tension to reduce the perimeter of the stent frame. The cinch ring and torus balloon are implanted along with the stent frame.

The invention belongs to the field of surface engineering technology and biomaterials, in particular to a method for treating the surface of a nickel-titanium alloy bracket. A surface treatment method for a nickel-titanium alloy stent, which is characterized in that it includes the following steps: (1) first polish the nickel-titanium alloy stent with water abrasive paper to remove the initial roughness of the surface, then wash it in acetone and deionized water, and dry it to obtain brightness surface; (2) using anodic oxidation technology to remove nickel in nickel-titanium alloy; (3) using magnetron sputtering method, using the auxiliary effect of electroacoustic transducer, on the surface of nickel-titanium alloy bracket, magnetron sputtering nitrogen TiO film layer. The beneficial effects of the present invention: through intermittent sound wave control, the adhesive force on the surface layer of the metal wire can be effectively enhanced.

A method of a forming a hollow, drug-eluting nitinol stent includes shaping a composite wire into a stent pattern, wherein the composite wire comprises an inner member, a nitinol intermediate member, and an outer member. After the composite wire is shaped into the stent pattern, the composite wire is heat treated to set the nitinol intermediate member in the stent pattern. After heat treatment, the composite wire is processed to remove the outer member and the inner member without adversely affecting the intermediate member. Openings may be provided through the intermediate member and the lumen of the intermediate member may be filled with a substance to be eluted through the openings.

The invention discloses a left auricle plugging device and a transport system. The left auricle plugging device comprises a stent and a plugging device body. Firstly, the stent is implanted and fixed on the left auricle inlet position, the double-tray-shaped plugging device body is released on the stent for plugging a left auricle, and therefore the problem of cerebral apoplexy caused by left auricle thrombus because of atrial fibrillation can be solved. The left auricle plugging device is provided with the self-expandable nitinol stent, the stent is firmly fixed on the left auricle inlet position by depending on anchoring thorns, and then the appropriate plugging device body is released on the stent. The transport system transports the left auricle plugging device to the left auricle position. Compared with the prior art, the stent is firstly fixed on the left auricle inlet position, then the double-tray-shaped plugging device body is released on the stent, and therefore release accuracy and implanting stability of the plugging device body are improved, and the plugging device body has selectivity. After release, the stent and the the plugging device body can be recovered to a catheter for relocation or replacement.

The invention relates to a nickel-titanium wire with an anti-adhesion function and a processing method of the nickel-titanium wire. A two-stage micro-nano composite structure is manufactured on the surface of the nickel-titanium wire; the first-stage structure is a micron-stage array protrusion structure; the second-stage structure is a nano-stage protrusion structure; and the second-stage structure is distributed on the surface of the first-stage structure. The micro-nano structure is prepared on the surface of the nickel-titanium alloy wire through a pulse laser processing method, so that the surface of the nickel-titanium alloy wire is endowed with the functions of resisting fibroblast adhesion, resisting protein adhesion and resisting infection, and the problems of blockage and infection after the nickel-titanium alloy stent woven by the nickel-titanium wire is implanted can be effectively solved. And meanwhile, the pulse laser processing technology only relates to physical processing, so that introduction of a chemical coating is avoided.