The invention provides a small-
caliber artificial
blood vessel with a three-layer
composite structure, and a preparation method of the small-
caliber artificial
blood vessel. The small-
caliber artificial
blood vessel comprises a weaving inner layer, an electrostatic
spinning intermediate layer and a
polyurethane outer layer, wherein the electrostatic
spinning intermediate layer is arranged on the outer side of the weaving inner layer; the
polyurethane outer layer is arranged on the outer side of the electrostatic
spinning intermediate layer; the weaving inner layer comprises a first weaving stand
pipe and a second weaving bracket stand
pipe; the second weaving stand
pipe is a weaving stand pipe with axial yarns, and is arranged on the outer side of the first weaving stand pipe. The small-caliber artificial blood vessel adopts a
simulation structure; the weaving stand pipes serve as enhancement
layers and are relatively high in compliance; the electrostatic spinning intermediate layer adopts a precise three-dimensional reticular structure, so that
coated drugs and growth factors are released step by step in the
degradation process,
thrombosis is prevented, and
cell growth is facilitated; the
polyurethane outer layer is relatively high in compliance and adopts a microporous structure, so that
biomass transmission is facilitated; both PDO and PLLA are degradable materials, so that gradient degradation can be realized, the contact between the polyurethane material and blood can be reduced, the foreign-body reactions to the PDO and PLLA materials can be prevented, and the long-term patency rate can be improved.