Preparation method of small-caliber intravascular stent of three-layer structure

A vascular stent and three-layer structure technology, applied in the field of biomedicine, can solve the problems of inability to meet the needs of small-diameter vascular stents, easy to form thrombus, and vascular intimal hyperplasia, and achieve the effect of good cell compatibility and biodegradation performance.

Active Publication Date: 2016-04-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently widely used synthetic vascular stents cannot meet the needs of small-diameter vascular stents
The reason is that when

Method used

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  • Preparation method of small-caliber intravascular stent of three-layer structure
  • Preparation method of small-caliber intravascular stent of three-layer structure
  • Preparation method of small-caliber intravascular stent of three-layer structure

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Experimental program
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Effect test

Embodiment 1

[0044] The present invention uses figure 1 The mold shown is used to prepare vascular stents. The mold includes a first hollow aluminum tube, a second hollow aluminum tube, a third hollow aluminum tube and a base. The first hollow aluminum tube is located in the second hollow aluminum tube, and the second hollow aluminum tube is located in the third hollow aluminum tube. The first hollow aluminum tube, the second hollow aluminum tube and the third hollow aluminum tube are arranged concentrically on the base, and are selected and installed on the base according to requirements.

[0045] The blood vessel stent prepared by the invention has a thickness of 0.5-1 mm and a length of 5-8 mm. Vascular stent simulates and bionics the vascular structure, including inner layer, middle layer, and outer layer; the inner layer is a tubular scaffold composed of fibers prepared by electrospinning, and the middle layer is a tubular scaffold composed of porous structures prepared by freeze-dr...

Embodiment 2

[0057] The present invention specifically comprises the following steps:

[0058] (1) Preparation of inner layer:

[0059] a2. adding thermoplastic polyurethane to dimethylformamide and stirring magnetically at 70° C. for 8 hours to prepare a thermoplastic polyurethane spinning solution with a concentration of 11% by mass;

[0060] b2. Install the thermoplastic polyurethane spinning solution prepared in step a2 on an electrospinning device for spinning, and use the first rotating hollow aluminum tube to collect fibers to prepare a tubular support. The spinning voltage is 15kV and the receiving distance is 16cm. , the flow rate is 0.5ml / h; an inner layer is formed on the outer wall of the first hollow aluminum tube;

[0061] (2) The preparation of the outer layer adopts freeze-drying method:

[0062] c2. forming the first hollow aluminum tube, the second hollow aluminum tube, and the third hollow aluminum tube with an inner layer obtained in step b2 into a concentric hollow c...

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Abstract

The invention relates to a preparation method of a small-caliber intravascular stent of a three-layer structure. The intravascular stent comprises an inner layer, a middle layer and an outer layer which are sequentially arrayed and tightly attached from inside to outside. The inner layer is a tubular support formed by fiber prepared through an electrospinning method, the middle layer is a tubular support formed by a porous structure prepared through a freeze-drying method, and the outer layer is a tubular support prepared through the electrospinning method or the freeze-drying method. The method can be used for preparing the small-caliber intravascular stent; the prepared intravascular stent has high cytocompatibility and biodegradability, can simulate the three-layer structure of natural blood vessels, can be used for repairing cardiovascular and cerebrovascular diseases, and belongs to the biomedical field.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an artificial vascular stent, especially a method for preparing a small-diameter vascular stent with a three-layer structure. Background technique [0002] In recent years, tens of thousands of patients are suffering from cardiovascular and cerebrovascular diseases. The purpose of tissue engineering is to provide regeneration resources for damaged tissues or organs, and to provide reliable treatments for various diseases. The goal of vascular tissue engineering is to prepare functional vascular stents that can be implanted in the body to replace diseased blood vessels, thereby helping the regeneration of new blood vessels. Large-diameter synthetic vascular stents such as Dacron's polyethylene terephthalate (PET) and Gore's expanded polytetrafluoroethylene (ePTFE) have been successfully used in the aorta where blood flows at high speed, such as Thoracic and abdominal aorta. However, ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54A61L27/50A61L27/56D04H1/728
CPCA61L27/18A61L27/50A61L27/54A61L27/56A61L2300/414A61L2430/22D04H1/728C08L75/04C08L69/00
Inventor 经鑫彭响方米皓阳童立生
Owner SOUTH CHINA UNIV OF TECH
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