99 results about "Tubular scaffold" patented technology

Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction. All these results demonstrate its potential application for advanced NGC.

Embodiments hereof relate to a transcatheter valve prosthesis including a tubular fabric body, a first or inflow tubular scaffold attached to a first end portion of the tubular fabric body, and a second or outflow tubular scaffold attached to a second end portion of the tubular fabric body. A prosthetic valve component is disposed within and secured to an intermediate portion of the tubular fabric body that longitudinally extends between the first and second end portions of the tubular fabric body. The intermediate portion is unsupported such that neither of the first and second tubular scaffolds surrounds the intermediate portion of the tubular fabric body. The intermediate portion may include one or more windows for coronary access and may include one or more commissure reinforcement members coupled thereto to provide support for the prosthetic valve component.

A vascular occlusion device for occluding a body cavity. The device includes a tubular scaffold extending from a proximal end to a distal end. The scaffold is formed from a plurality of interconnected and articulated members configured to self-expand into an open configuration. A plurality of barbs extend from the articulated members, each barb including an anchoring end. The anchoring end is disposed radially outward from the scaffold in the open configuration and adapted to embed into the cavity walls. A radially expandable substance is disposed within a device lumen. The substance is configured to promote body tissue growth within the body cavity to occlude the body cavity. In one example, the body cavity includes a patent foramen ovale.

A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.

Disclosed herein are three-dimensional porous tubular scaffolds for cardiovascular, periphery vascular, nerve conduit, intestines, bile conduct, urinary tract, and bone repair/reconstruction applications, and methods and apparatus for making the same.

The invention discloses a construction method of an anticoagulant artificial blood vessel scaffold material. The method includes: taking a rotating stainless steel pipe as a receiver, employing an electrospinning technology to prepare an organic macromolecular polymer, a mixture of a Cu2<+> complex catalyst and the organic macromolecular polymer, and the organic macromolecular polymer successively into a three-layer structured superfine fiber porous tubular scaffold material; and regulating the types and proportion of the Cu2<+> complex catalyst and the organic macromolecular polymer, as well as the electrospinning time of a three-layer electrospinning solution so as to control the release rate of NO. With a three-layer structure, the blood vessel scaffold material formed by the invention not only realizes loading of the Cu2<+> organic complex catalyst, but also improves the phenomenon of NO burst release catalyzed by an ordinary hybrid electrospun structure scaffold material, improves the loading stability of the Cu2<+> complex catalyst, and can leave the biological signal molecule NO to play a better role in inhibiting platelet adhesion, resisting platelet activation and inhibiting smooth muscle cell proliferation so as to improve its anticoagulant property.

The present invention discloses the design and fabrication of highly porous (up to 97%) scaffolds from biodegradable polymers with a novel phase-separation technique to generate controllable parallel array of micro-tubular architecture. The porosity, diameter of the micro-tubes, the tubular morphology and their orientation may be controlled by the polymer concentration, solvent system and temperature gradient. The mechanical properties of these scaffolds are anisotropic. Osteoblastic cells are seeded in these 3-D scaffolds and cultured in vitro. The cell distribution and the neo-tissue organization are guided by the micro-tubular architecture. The method has general applicability to a variety of polymers, therefore the degradation rate, cell-matrix interactions may be controlled by the chemical composition of the polymers and the incorporation of bioactive moieties. These micro-tubular scaffolds may be used to regenerate a variety of tissues with anisotropic architecture and properties.

The invention relates to a preparation method of a porous nano-fiber tubular scaffold, which comprises the steps that (1) PLLA (Poly L Lactic Acid) and other polymers are dissolved in a solvent to get a polymer solution; (2) the polymer solution is injected into a tubular mold and rapidly placed at a low temperature for phase separation, then the polymer solution is taken out, a tubular mold housing is removed, polymer gel after the phase separation and a core mold are immersed in ice water together, then the core mold is taken out, the polymer gel is immersed in deionized ice water to exchange the solvent, and the tubular scaffold is obtained; and (3) finally, the tubular scaffold obtained is frozen and dried for 48-120 hours, and then the porous nano-fiber tubular scaffold is obtained. The preparation method is simple to operate, and requires no additional hole-foaming agent, is suitable for volume production, and is lower in preparation cost; the prepared tubular scaffold has a nano-fiber structure similar to an extracellular matrix of a human tissue, and a porous structure with the diameter and porosity capable of being adjusted, and facilitates growth of cells and reconstruction of a cambium.

The invention provides a silk fibroin tubular support and a preparation method thereof. The tubular stent includes an outer layer, a core layer and an inner layer arranged in sequence, the outer layer and the inner layer are silk fibroin films, and the silk fibroin films include cross-linked silk fibroin and an adhesive; the core layer is Bombyx mori cooked silk thread tubular braid. The bending inner diameter of the tubular stent provided by the present invention is 5mm-7mm. The tubular scaffold provided by the invention has no cytotoxicity and has excellent biomechanical properties.

A beta-type Ti alloy used for the cardiovascular and cerebrovascular scaffold, the tubular scaffold of other organs, and surginal implant contains Zr (0.5-9.5 wt%), Mo (0.5-6.5), Nb (8.5-28.5), C (0-0.03), N (0-0.04), H (0-0.003), O (0-0.12) and Ti (rest). Its advantages are moderate strength, lower modulus of elasticity, high plasticity and low cost.

The invention relates to a tissue engineering tubular scaffold with a multi-stage porous structure. The scaffold comprises at least one channel which is axially arranged, the area of the cross section of the channel is 300 mu m2-300 mm2, the non-channel part of the scaffold has micropores which are interconnected, the volume range of the micropores is 1 mu m3-5000 mu m3, the pore diameter distribution curve of the micropores is serrated, and the microporous wall of the scaffold is a nano-fiber three-dimensional network. Simultaneously, drugs with the function of changing physiological actionsof cells and tissues are contained in the scaffold, the functional drugs are released according to a certain rule to the environment located by the scaffold during the application process, and the types, the loading quantities and the release rate of the drugs can be set according to the actual needs. The tissue engineering scaffold with a fine topological structure and the physiological functionhas broad prospects.

A bifurcation stent system includes a pair of self-expanding stents. Each stent has a C-shaped body section having a generally semicircular cross-section along its length and an O-shaped body section having a circular cross-section along its length. The stents are deployed in vivo such that the edges of the C-shaped body sections abut each other to form a tubular scaffold in a Y-shaped formation that conforms to the bifurcation. In order to connect the stents in vivo, the C-shaped body sections are configured to include a ball and socket connection there between. The C-shaped body sections align and abut to form a tubular scaffold that extends in the main vessel of the bifurcation, while the O-shaped body sections are tubular scaffolds that extend into the respective branch legs of the bifurcation.

An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.

An apparatus and method are shown for detecting leaks in metal roofs which are made up of metal roof panels secured in position to form a roof structure by metal screws. The apparatus includes an elongate tubular stand having a lower extent and an upper extent connected by an internal bore, the lower extent terminating in a bore end opening. A hand operated pump communicates with the internal bore for supplying positive pressure or drawing a vacuum on the internal bore. The bore end opening is sealed by an elastomeric seal which is used to form a pressure tight seal about one of the metal screw to be tested. A pressure gauge on the stand communicates with the internal bore for measuring a change in pressure within the internal bore, such pressure change being indicative of a leak present at the metal screw being tested.

The invention provides a preparation method of a silk fibroin and sulfated silk fibroin composite tubular scaffold. The composite tubular scaffold is characterized in that the composite tubular scaffold is composed of an elastic bonding layer, a fabric reinforcing layer and a compact coating layer, and the fabric reinforcing layer is embedded in the elastic bonding layer, and the outer surface of the compact coating layer is covered with the elastic bonding layer, wherein the compact coating layer and the fabric enhancing layer are made of silk fibroin, and the elastic bonding layer is made a silk fibroin and sulfated silk fibroin mixture. The elastic bonding layer can improve the compliance and the anticoagulation property of the tubular scaffold, the fabric reinforcing layer can improve the mechanical properties of the scaffold, and the compact coating layer can improve the impermeability of the scaffold. The tubular scaffold prepared in the invention has excellent mechanical properties, has good impermeability, cell compatibility and blood compatibility, has a controllable diameter, and can be used for restoring and reconstructing small caliber vessels and constructing a hemodialysis access. The preparation method has the advantages of simple operation, low cost, and commercial production realization.

A medical device is disclosed for joining a first tubular organ (1), such as a blood vessel, to a second tubular organ (2), such as a blood vessel. The kit includes an external tubular scaffold (4) with a removable scaffold handle (7,18,19) and a clip (3). In use, the clip (3) and the external tubular scaffold (4) remain outside of the tubular organs (1,2) being joined. The clip (3) embraces a first longitudinal tubular section (6) of the external tubular scaffold (4) thereby holding together a longitudinal segment of an intima of the first tubular organ (1) and a longitudinal segment of an intima of the second tubular organ (2).

The invention relates to a furniture arch beam arm structure and a preparation method thereof. The preparation method mainly adopts the stamping mode to ensure metal plates are used to separately form different components and connectors; the components and connectors adapt to the curvatures and shapes of different parts of a preset beam arm, wherein each component contains an opening of which width is expanded slantways to one side, the connectors are connected at the openings to form a plurality of sealed hollow tubular scaffolds; and the scaffolds are connected mutually and dressed properly to form a beam arm structure with the preset and complete curvature and shape which is used to connected with other furniture component. The tubular structure formed by metal material is used to replace the original wooden beam arm structure, thus reducing the material cost, simplifying the processing procedure of the arch beam arm structure in the furniture and increasing the overall production efficiency.

Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining populations of smooth muscle cells and neuronal progenitor cells and then seeding the cells together onto a matrix material, followed by culturing the seeded cells to form an innervated smooth muscle cell construct of directionally oriented smooth muscle cells. In one embodiment, the neuronal progenitor cells can be seeded first as neurospheres in a biocompatible solution, e.g., a collagen/laminin solution, and allowed to gel. Next, a second suspension of smooth muscle cells can be deposited as separate layer. Multiple layer structures of alternating muscle or neuron composition can also be formed in this manner. Differentiation of the neuronal progenitor cells can be induced by exposure to a differentiation medium, such as Neurobasal A medium and/or exposure to a differentiating agent, such as B-27 supplement. The innervated muscle structures can be disposed around a tubular scaffold, e.g., a chitosan-containing tube and further cultured to form tubular, bioengineered structures and two or more innervated muscle structures can be joined together to form an elongate composite structure.

A system for treating a body lumen including a first stent configured to be positioned in a body lumen and a second stent configured to be positioned in the lumen of the first stent prior to removing the first stent from the body lumen. The first stent includes a liner disposed radially inward of the tubular scaffold of the first stent to permit tissue ingrowth within a tissue ingrowth region defined between the liner and the tubular scaffold. The retrieval stent is configured to be expanded within the previously implanted first stent to cause tissue to recede from the tissue ingrowth region to facilitate removal of the first stent from the body lumen.