35 results about "Hemodialysis access" patented technology

A hemodialysis port comprising a flexible housing member defining one or more ports. Each port has a selectively-permeable septum member disposed thereon to permit medical devices, for example, Huber needles, sheath and / or dilators to be inserted therein. At the interface between the housing and the septum, a spring member is provided to provide an axial force on the septum which seals the puncture created by the aforementioned medical devices. In one exemplary embodiment, the hemodialysis access port of the present invention is comprised of a plurality of ports designed for multiple hemodialysis treatments over the life of the port. In other exemplary embodiments, the bottom of each port may comprise a needle stop insert formed of, for example, metal, titanium, stainless steel or ceramic.

Implants are associated with a combination of paclitaxel or derivatives and dipyridamole or derivatives in order to inhibit fibrosis that may otherwise occur when the implant is placed within an animal. Exemplary implants include intravascular implants (e.g., coronary and peripheral vascular stents, catheters, balloons), non-vascular stents, pumps and sensors, vascular grafts, perivascular devices, implants for hemodialysis access, vena cava filters, implants for providing an anastomotic connection, electrical devices, intraocular implants, and soft tissue implants and fillers.

A implantable hemodialysis port including a housing and a septum. The housing is formed from a flexible material and includes a plurality of chambers. The chambers are fluidly interconnected with one another by integrated outlet passageways. Each of the chambers include a sidewall portion and a funnel portion tapering from the sidewall portion. The septum encloses each of the chambers.

A method for the treatment of thrombosed hemodialysis access grafts or fistulas defining a shunt positioned between an arterial side and a venous side is achieved by inserting a balloon catheter within the shunt, wherein the balloon catheter includes a distal balloon and at least one infusion aperture located proximally of the distal balloon. Thereafter, the balloon catheter is advanced within an arterial anastomosis at an artery-shunt juncture and the distal balloon is inflated. A thrombolytic agent is then injected through the infusion apertures of the balloon catheter into the shunt to chemically destroy clot material within the shunt, wherein by applying the thrombolytic agent with the distal balloon inflated at the arterial anastomosis the possibility of the clot material moving into the artery is prevented and there is no need to worry about the migration of the clot into the arterial system and the resulting complications. Finally, the inflated distal balloon is pulled toward the venous side, eradicating the arterial plug. A balloon catheter for use in accordance with the present invention is also disclosed.

A treatment assembly is positioned along an AV-fistula and couples therapeutic energy to an adjacent area due to a material response to an applied energy field from a remotely located energy source. The treatment assembly may be delivered into the fistula through a hemodialysis needle, or may be secured to the fistula graft itself and implanted therewith within a patient. A cover provides a shield between an anastomosis area and blood flow. Another AV-fistula includes a valved reservoir that receives a fluid agent from a hemodialysis needle while moving the needle into or from the fistula; the agent leaks from the reservoir into the fistula lumen. Another valved fistula is adjustable between an open condition and closed conditions during and between hemodialysis treatments, respectively. Another AV-fistula has a bladder reservoir coupled to a second refillable fluid reservoir and is adapted to locally deliver a therapeutic agent into the fistula lumen.

A medical blood access system used for hemodialysis treatment to enable blood withdrawal for processing of blood by an external apparatus and return the same blood to a patient, comprising an interfacial fluid conduit between the machine and patient's blood supply which is repeatedly connectable along a guided pathway passing through epidermis and subcutaneous tissue via a naturally formed tissue tract to enter blood space, providing improved patient safely, convenience, effective prophylaxis, without bleeding or tissue trauma or pain, and is executable by the patient to precisely connect and disconnect with minimal disfigurement or life restrictions, and is useable on virtually all patients soon after placement and is robust and safe to high blood flow.

A percutaneous transluminal angioplasty (PTA) catheter may be configured to perform vein expansion and occlusion. A infusion port (132) located proximal to the occlusion feature (162) can be used to inject contract enhancement agent as well as other substances. the catheter can be used espicially advantagrously in vascular regions associated with hemodialysis access.

A medical blood access system used for hemodialysis treatment to enable blood withdrawal for processing of blood by an external apparatus and return the same blood to a patient, comprising an interfacial fluid conduit between the machine and patient's blood supply which is repeatedly connectable along a guided pathway passing through epidermis and subcutaneous tissue via a naturally formed tissue tract to enter blood space, providing improved patient safely, convenience, effective prophylaxis, without bleeding or tissue trauma or pain, and is executable by the patient to precisely connect and disconnect with minimal disfigurement or life restrictions, and is useable on virtually all patients soon after placement and is robust and safe to high blood flow.

A catheter includes a catheter body with a compliant balloon secured at a distal end of the catheter body, the balloon including a proximal end and a distal end, a first lumen in fluid communication with the balloon, a second lumen in fluid communication with at least one infusion aperture directly adjacent the proximal end of the balloon, and a third lumen in fluid communication with a port positioned distally of the balloon. A method for using the catheter is also provided.

A hemodialysis catheter assembly with a flexible catheter lead that can control blood flow at a hemodialysis access site even under high blood pressures encountered at such sites. Flexible tubing extends through the hollow interior of a housing having opposite, open ends. The assembly includes components to alternately occlude or not occlude the lumen of the flexible tubing. In a first embodiment, spring clips press against the tubing, but insertion of a hollow sleeve into the lumen thereof retracts the clips and provides a flow path. In a second embodiment, a pinch bar can be manually moved into and out of engagement with the flexible tubing to occlude or open a flow path. In a third embodiment, the housing has a screw cap. A spring-loaded pinch bar presses against, and occludes the lumen of, the collapsible tubing when the screw cap is screwed into a threaded cutout in the housing, and provides a flow path through the tubing when the screw cap is removed. In a fourth embodiment, the tang portion of a tongue when in an extended position presses against, and occludes the lumen of, the compressible tubing; advancement of a capture ring attached to a sliding button retracts the tang portion and opens a flow path.

An optical sensor includes photoemitter and photodetector elements at multiple spacings (d1, d2) for the purpose of measuring the bulk absorptivity (α) of an area immediately surrounding and including a hemodialysis access site, and the absorptivity (αo) of the tissue itself. At least one photoemitter element and at least one photodetector element are provided, the total number of photoemitter and photodetector elements being at least three. The photoemitter and photodetector elements are collinear and alternatingly arranged, thereby allowing the direct transcutaneous determination of vascular access blood flow.

An optical sensor includes photoemitter and photodetector elements at multiple spacings (d1, d2) for the purpose of measuring the bulk absorptivity (α) of an area immediately surrounding and including a hemodialysis access site, and the absorptivity (αo) of the tissue itself. At least one photoemitter element and at least one photodetector element are provided, the total number of photoemitter and photodetector elements being at least three. The photoemitter and photodetector elements are collinear and alternatingly arranged, thereby allowing the direct transcutaneous determination of vascular access blood flow.

The invention provides a preparation method of a silk fibroin and sulfated silk fibroin composite tubular scaffold. The composite tubular scaffold is characterized in that the composite tubular scaffold is composed of an elastic bonding layer, a fabric reinforcing layer and a compact coating layer, and the fabric reinforcing layer is embedded in the elastic bonding layer, and the outer surface of the compact coating layer is covered with the elastic bonding layer, wherein the compact coating layer and the fabric enhancing layer are made of silk fibroin, and the elastic bonding layer is made a silk fibroin and sulfated silk fibroin mixture. The elastic bonding layer can improve the compliance and the anticoagulation property of the tubular scaffold, the fabric reinforcing layer can improve the mechanical properties of the scaffold, and the compact coating layer can improve the impermeability of the scaffold. The tubular scaffold prepared in the invention has excellent mechanical properties, has good impermeability, cell compatibility and blood compatibility, has a controllable diameter, and can be used for restoring and reconstructing small caliber vessels and constructing a hemodialysis access. The preparation method has the advantages of simple operation, low cost, and commercial production realization.

The invention relates to a sulfated silk fibroin vascular tissue engineering scaffold prepared by using electrostatic spinning and belongs to the field of biological medical materials. The sulfated silk fibroin vascular tissue engineering scaffold is prepared through the following steps of: dissolving a silk fibroin and sulfated silk fibroin sponge in hexafluoroisopropanol, so as to prepare a 7-10% mixed silk fibroin and sulfated silk fibroin solution; filling the solution in an injector, applying a 10-30kV voltage, and receiving fibers by using a rotary metal rod, wherein the receiving distance is 10-25 cm, the diameter of the selected receiving rod is 3-5 mm, the rotating speed is 200-1000 rpm (revolutions per minute), and the propelling speed of the injector is 0.03-0.05 mm / s, so as to obtain a tubular tissue engineering scaffold with the thickness of 0.1-1 mm and the internal diameter of 3-5 mm; then inducing the silk fibroin to convert to a beta laminated structure by using a 90-100% methanol solution to soak the scaffold, so that the tissue engineering scaffold can be prevented from being dissolved in water by virtue of improving mechanical properties. The vascular tissue engineering scaffold prepared by the invention has excellent cell compatibility and long-term and stable anti-blood coagulation property, has controllable caliber, and can be used for maintenance of small-caliber blood vessels and establishment of tissue engineering and hemodialysis access. The preparation method provided by the invention has the advantages of simplicity in operation and low cost, and can be used for realizing commercial production.

A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and / or endothelial cells on at least one surface to yield the functional human hybrid hemodialysis access graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid hemodialysis access graft.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holders where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid graft.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft with a confluent monolayer of endothelial cells by immobilizing a plurality of endothelial cells on the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft and placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the endothelial cells to form a confluent monolayer on the hybrid graft.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid graft with a confluent monolayer of endothelial cells by immobilizing stem cells on a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft, and placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the stem cells to form a confluent monolayer on the hybrid graft and in an environment to promote the stem cells to differentiate into endothelial cells.

The invention discloses a clinical decision-making system for monitoring and evaluating a hemodialysis pathway function. The clinical decision-making system comprises a monitoring module for monitoring a patient and a decision-making module for assisting a doctor in making a judgment, wherein the monitoring module comprises a hemodialysis machine, a plurality of pressure sensors arranged on an extracorporeal circulation blood path and an ultrasonic probe sensor; the decision-making module comprises a decision-making tree algorithm formulated based on a vascular pathway guide and a scoring system matched with the algorithm; and the monitoring module transmits collected data to the decision-making module, and the decision-making module automatically generates a corresponding guidance to assist the doctor in making the judgment. The clinical decision-making system can improve the efficiency of hemodialysis vascular pathway management, improve the accuracy and provide a feasible medical decision. Meanwhile, the current situation that vascular pathway talents are long in cultivation period, high in professionalism and short of supply is solved, and the understanding of existing front-line hemodialysis medical staff on vascular pathway management is helped.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can prepare a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft intended for implantation into a mammal by placing the hybrid graft in a system embodiment according to the invention prior to implantation of the hybrid graft into the mammal.

A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and / or endothelial cells on at least one surface to yield the functional human hybrid hemodialysis access graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid hemodialysis access graft.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.

Methods and apparatus provide therapeutic electromagnetic radiation (EMR) for inactivating infectious agents in, on or around a catheter residing in a patient's body cavity and / or for enhancing healthy cell growth. Transmitting non-ultraviolet therapeutic EMR substantially axially along an optical element in a lumen of the catheter body and / or the catheter body. Through delivery of the therapeutic EMR to particular infected areas and / or areas requiring tissue healing. The inactivation of the major sources of infection in, on, and around catheters and / or enhance healthy cell growth around catheters is accomplished by utilizing controlled relative intensity and / or treatment region specific dosing of the therapeutic EMR emitted radially from the optical element. Specific embodiments of urinary catheters, peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and / or outside a patient's body in, on, and surrounding a catheter and / or a catheter extension to prevent, reduce, and / or eliminate infectious agents in, on, or surrounding the catheter and / or catheter extension. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure / flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure / flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.

An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and / or outside a patient's body in, on, and surrounding a catheter and / or a catheter extension to prevent, reduce, and / or eliminate infectious agents in, on, or surrounding the catheter and / or catheter extension. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.