377 results about "Subcutaneous tissue" patented technology

This disclosure relates to a method of treating a neurological disorder, comprising administering a bupropion, or a combination of a bupropion and a dextromethorphan, to a human being in need thereof, monitoring the human being for Brugada pattern / syndrome, drug reaction with eosinophilia and systemic symptoms, or acute generalized exanthematous pustulosis, and reducing or discontinuing use of the bupropion, or the combination of the bupropion and the dextromethorphan, if the human being develops Brugada pattern / syndrome, subcutaneous tissue disorder, drug reaction with eosinophilia and systemic symptoms (DRESS), or acute generalized exanthematous pustulosis.

The invention discloses a subcutaneous injection site detection and recommendation system based on an intelligent algorithm, and aims to improve the safety of long-term subcutaneous injection and the drug absorption efficiency and reduce the risk of related complications such as subcutaneous hemorrhage, subcutaneous induration and subcutaneous fat hyperplasia at the same time. Comprising a subcutaneous tissue detection module for acquiring subcutaneous vascular distribution, fat layer thickness and induration state of a target part through infrared imaging and ultrasonic technologies and generating subcutaneous tissue characteristic data; the data processing module analyzes the feature data by using an image recognition algorithm, and recognizes a blood vessel dense region, induration and a part where fat hyperplasia has occurred; the injection part recommendation module is used for evaluating an analysis result of the data processing module based on a machine learning algorithm in combination with personalized injection historical data of the patient, and generating an optimal injection part recommendation scheme avoiding a risk area; the intelligent imaging and data analysis technology is utilized, the subcutaneous injection part selection accuracy is improved, and the patient comfort and the treatment effect are improved.

The invention discloses a measurement method, system and related device, the method is applied to first electronic equipment, the first electronic equipment comprises a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; under the condition that a first electrode group and a second electrode group are implanted into subcutaneous tissue, the method comprises the following steps: determining a first physiological parameter through the first electrode group; electrocardiosignals are determined through the first electrode set and the second electrode set. Therefore, the electrocardiosignal of the user can be obtained anytime and anywhere through the first electronic equipment, and one or more other physiological parameters (such as blood glucose, blood ketone, blood lactic acid and uric acid) of the user can be measured at the same time, so that the health monitoring efficiency is improved.

The invention discloses a subcutaneous tunnel establishing device in tunnel type PICC catheterization, and particularly relates to the technical field of subcutaneous tunnel establishing instruments.The subcutaneous tunnel establishing device comprises a puncture needle used for puncturing subcutaneous tissue, a drawing needle is inserted into the puncture needle, and a puncture needle driving part is detachably connected into the drawing needle; a PICC catheter fixing assembly is detachably connected into the drawing needle, when the PICC catheter is drawn, the tail end of the PICC catheter is inserted into the drawing needle and arranged at the tail end of the PICC catheter fixing assembly in a sleeving mode, then air is inflated into the PICC catheter fixing assembly to extrude the tail end of the PICC catheter between the tail end of the PICC catheter fixing assembly and the inner wall of the drawing needle, and fixing of the tail end of the PICC catheter is achieved. According to the drawing needle, the tail end of the PICC can be extruded and fixed in the drawing needle by utilizing the inflated and expanded air bag in the process of drawing the PICC to penetrate through subcutaneous tissue, so that the problem that the PICC falls off from the interior of the drawing needle in the moving process can be solved, and smooth establishment of a subcutaneous tunnel during PICC catheterization is ensured.

The present disclosure provides a new PH20 mutant enzyme which shows significantly enhanced aggregation stability, can be used for the development of drug subcutaneous injection preparations, facilitates the diffusion of drugs in subcutaneous tissues, reduces subcutaneous administration volume limitations, and alleviates swelling or pain caused by large-volume subcutaneous injection.

According to the pressure damage dynamic risk assessment method based on multi-modal sensing, multi-physical field data is collected in real time through an MEMS piezoresistive array, a near infrared spectrum sensor and a flexible capacitance type humidity sensor, and early precise early warning and automatic grading intervention are achieved in combination with an LSTM neural network and dynamic threshold adjustment. According to the method, the early warning time of the stress injury is advanced by 4-6 hours, so that the clinical misjudgment rate is reduced to be less than 15% from 38%, and the problems that in the prior art, poor blood circulation of subcutaneous tissues cannot be accurately identified by traditional visual inspection, the hysteresis of the currently adopted preventive measures and the clinical accurate judgment error rate are relatively high, and the clinical accuracy is relatively low are solved. In order to solve the problem that the occurrence risk and the compression degree of the stress injury cannot be accurately judged due to the fact that the existing tissue ischemia assessment method is based on the three-layer architecture of'multi-modal sensing and dynamic modeling combined with intelligent closed loop ', the transformation from'passive discovery' to'active prevention 'is realized, and a more comprehensive tissue ischemia assessment system is constructed.

The invention relates to the technical field of medical data management and analysis, in particular to a lymphedema treatment monitoring data management method and system. Comprising the following steps: synchronously acquiring bioelectrical impedance, tissue thermodynamic characteristics and subcutaneous tissue morphological data of a patient through multi-modal data acquisition equipment; transmitting the data to a cloud processing platform in a distributed manner, and generating a three-dimensional illness state assessment map containing edema quantitative indexes through a machine learning assessment model; generating a personalized treatment strategy adjustment scheme with a confidence score based on dynamic comparison between the current evaluation map and historical data; feeding back the evaluation map and the adjustment scheme to the medical staff through the interaction terminal, and receiving a clinical correction instruction; according to the method, on the premise of strictly protecting patient data privacy, cross-mechanism multi-modal knowledge sharing can be realized, and the contradiction between a data island and a model effect is solved.

Provided is a vented needle hub assembly for infusion of a liquid into subcutaneous tissue. More specifically, the vented needle hub assembly is provided by a needle hub having an inlet side and an outlet side and a fluid passageway therebetween; an infusion needle in fluid contact with the fluid passageway and extending from the outlet side; a flexible tubing joined to the inlet side in fluid contact with the fluid passageway; at least one vent disposed in a sidewall of the needle hub, the vent in fluid contact with the fluid passageway; and a porous plug disposed within each at least one vent adjacent to the fluid passageway, the porous plug structured and arranged to distinguish gas from liquid, gas permitted to pass from the fluid passageway through the porous plug and out the at least one vent. An associated method of use is provided as well.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention relates to the technical field of medical instruments, and discloses an intelligent dynamic pressure distribution monitoring system based on a sickbed, and the system comprises an image collection module which is used for collecting an image of a patient in the sickbed at a fixed angle according to a fixed time interval; the image processing module is used for comparing the acquired image with the image of the sickbed to obtain a posture profile diagram of the patient in the sickbed; the clustering module is used for clustering the posture profile diagrams of the patients and determining feature postures of the patients; the blood pressure and flow monitoring module is used for optically monitoring the skin of the patient to obtain the blood pressure and flow of the subcutaneous tissue of each part of the patient on different transverse plates; the planning module is used for controlling the height of each transverse plate of the sickbed according to the blood pressure flow of the subcutaneous tissue of each part of the patient on different transverse plates and the posture profile diagram of the patient on the sickbed.

The utility model relates to the technical field of beauty instruments, in particular to an ultrasonic anti-aging system, which comprises an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module and an ultrasonic transducer array module, the switch module is used for switching among different modules; the processing circuit module is used for controlling and monitoring the whole treatment process; and the display module is used for providing real-time visual feedback and displaying imaging results of the skin and the subcutaneous tissue and parameters and effects in the treatment process. According to the utility model, high-frequency sound waves pass through skin and other tissues, energy is focused to a specific position in a body, and the temperature of a focusing point is rapidly increased and can generally reach 65-85 DEG C, so that protein denaturation and cell necrosis of target tissues are caused, and surrounding tissues are hardly influenced.

The utility model relates to the technical field of blood taking needles, and discloses a blood taking needle protection device which comprises a blood taking needle, the blood taking needle is connected with a blood taking device through a hose, the right side of the blood taking needle is fixedly connected with a push piece, the upper side and the lower side of the push piece are both provided with holes, a hollow pipe is arranged on the outer side of the blood taking needle, and the hollow pipe is connected with the blood taking device. An opening is formed in the right side of the hollow pipe, the right side of the push piece penetrates through the opening, fixing columns are fixedly connected to the upper end and the lower end of the right side of the hollow pipe, connecting ropes are fixedly connected to the right ends of the fixing columns, and blocking blocks are fixedly connected to the right ends of the connecting ropes. According to the blood taking device, the sliding blocks are in sliding connection with the corresponding sliding grooves and matched with the pushing pieces to penetrate through the openings to slide, so that the pushing pieces drive the blood taking needles to be inserted into subcutaneous tissue for blood taking, the blocking blocks are matched with the corresponding holes to be clamped, the blood taking needles are protected by the hollow pipe after blood taking, infection caused by pricking of the blood taking needles is avoided, and later classification treatment is facilitated.

The application discloses an analyte detection device mounting unit, a limiting groove is arranged on a shell, and a T-shaped structure sliding block is arranged on a parallel sliding block module correspondingly, the T-shaped structure sliding block is located in the limiting groove, and the T-shaped structure sliding block slides in the limiting groove when a mounting action is implemented. The cooperation of the T-shaped structure sliding block and the limiting groove can limit the parallel sliding block module, avoid deflection of the parallel sliding block module in the shell, guide the parallel sliding block module to slide in the shell, and thus make the sensor pierce into the subcutaneous tissue in a vertical direction, so that the mounting unit is simple in structure and convenient to use.

The utility model discloses a self-heating vomit-stopping ginger acupoint patch, and relates to the technical field of ginger patches, the self-heating vomit-stopping ginger acupoint patch comprises a patch body, the side, used for being attached to the skin, of the patch body is a front side, the side, away from the skin, of the patch body is a back side, a groove is formed in the front side of the patch body, and the area, provided with the groove, of the patch body is defined as an action area; the fresh ginger gel is filled in the groove; the acupoint pressing blocks are arranged in the grooves, the patch body can deform so that the acupoint pressing blocks can move away from the patch body, and therefore the protruding parts can conduct acupoint stimulation on the skin; and the self-heating bag is arranged on the back side of the patch body and covers the action area of the patch body. According to the application, the fresh ginger gel is used for stopping vomiting, the self-heating bag is used for heating, so that the fresh ginger component of the fresh ginger gel can permeate into subcutaneous tissues more easily, the vomiting stopping effect can be enhanced, and meanwhile, the acupoint pressing block is designed, and the vomiting stopping function of acupoint stimulation is achieved.

The application relates to an electroencephalogram monitoring sensor with intradermal needles, comprising an electroencephalogram monitoring sensor body with a plurality of electrode pieces, one or more of the electrode pieces being provided with an intradermal needle, the intradermal needle being fixed to the middle part of the inner side or the outer side of the electrode piece and being electrically connected with the electrode piece; when the electroencephalogram monitoring sensor body is pasted on the forehead of a patient, the intradermal needle penetrates into the subcutaneous tissue; the electroencephalogram monitoring sensor with the intradermal needles can acquire electroencephalogram biological signals in a more direct mode, can better avoid the problem of poor adhesion when the electroencephalogram monitoring sensor is pasted on the forehead of a patient, and has certain application prospect.

The application provides a skin lesion three-dimensional reconstruction system based on a flexible electrode array. The system is characterized by comprising a measuring belt (1), an excitation generator (3), a signal processing module (4), a microprocessor (5) and an imaging module (6). The application can be used for detecting uneven skin lesion areas and constructing three-dimensional shapes of the lesions, and can be widely used in the field of uneven human subcutaneous tissue health detection.

The invention provides a non-invasive tissue fluid lactic acid dynamic monitoring method. The method comprises the following steps: establishing a relation model of epidermal and subcutaneous lactic acid concentrations; steady-state current values under different epidermal lactic acid concentrations are obtained through in-vitro experiments, and then the function relation between the steady-state current values and the epidermal lactic acid concentrations is obtained; net current values under different subcutaneous lactic acid concentrations are obtained through human body experiments, a function relationship between the net current values and the subcutaneous lactic acid concentrations is established, and the function relationship can be used for a subsequent transdermal extraction detection process; substituting the measured epidermal lactic acid concentration into a relation model of epidermal and subcutaneous lactic acid concentrations to obtain an accurate concentration value of tissue fluid lactic acid monitoring; according to the method, in the dynamic real-time monitoring process of the lactic acid concentration of the tissue fluid, the concentration of the lactic acid extracted from the epidermis measured by the lactic acid sensor can be converted into the real-time and accurate lactic acid concentration of the subcutaneous tissue fluid, and rapid, painless, infection-free and continuous monitoring of the lactic acid level of the subcutaneous tissue fluid can be achieved.

The present disclosure relates to a transplantable cell therapy product composition for diabetes mellitus that contains an aggregate of insulin-secreting cells derived from stem cells. In the present disclosure, an NF microwell array membrane was fabricated by applying a molding process to an electrospun, permeable, biodegradable polycaprolactone (PCL) NF membrane and thus allows gases and soluble factors to permeate therethrough. The NF microwell of the present disclosure could provide more nutrients to the iPSC aggregates than conventional impermeable PDMS microwells, thus enhancing survival and differentiation capabilities of the cells. Additionally, the NF membrane was attached singly to the subcutaneous tissue and to the surface of organs such as liver and peritoneum without the need for a fixing material or separate sutures and was integrated with surrounding tissues, resulting in higher insulin secretion than PDMS microwells. Therefore, the present disclosure can be effectively utilized as a composition for the prevention or treatment of diabetes.

Devices, systems, and methods for treating vessel openings are disclosed herein. According to some embodiments, a device for treating a vessel opening comprises a housing configured to be positioned within an opening in subcutaneous tissue proximate the vessel opening. The housing can comprise an inner wall and an outer wall. The inner wall can define a first lumen configured to receive an elongate member therein and the inner and outer walls can define a second lumen configured to receive an adhesive. The outer wall of the housing can define one or more apertures extending radially from the second lumen to an environment external of the housing. The device can comprise an actuator configured to be received within the second lumen. Movement of the actuator can force the adhesive to move through the aperture to the external environment and into an extravascular space within the subcutaneous tissue proximate the vessel opening.

The invention discloses a swelling microneedle patch and a preparation method thereof. The swelling microneedle patch comprises a backing and a swelling microneedle array adhered to the backing, the swelling microneedle array comprises a plurality of microneedles; the microneedle is in the shape of a cone or a rectangular pyramid; the height of the microneedle is 100 to 1000 [mu] m; the diameter of the tip end of the microneedle is 5-30 microns; the diameter of the bottom of the microneedle is 50-500 [mu] m; and the center-to-center distance between every two adjacent microneedles is 50-2000 microns. The swelling microneedle patch provided by the invention can overcome the barrier action of cuticle to penetrate subcutaneously and absorb subcutaneous tissue interstitial fluid, and is simple in preparation process, low in cost and high in universality. The patch is combined with a colloidal gold lateral chromatography test strip, so that the limitations that in-vitro diagnosis of infectious diseases depends on a blood sample, professional medical personnel are needed for operation, the subject compliance is poor and the like can be solved, and the patch is suitable for rapid screening and diagnosis of the infectious diseases.

The invention relates to the technical field of frozen slicing, in particular to a mammal skin embedding method for a spatiomics technology, which comprises the following steps: acquiring an in-vitro skin sample which comprises an epidermal layer, a corium layer and optional subcutaneous tissue; shearing the fat in the skin sample under the condition a to remove the fat in the skin sample, and freezing and embedding the fat-removed skin sample. The mammal skin embedding method provided by the embodiment of the invention provides a standardized overall scheme for sample analysis of mammal skin and hair follicle tissues, is beneficial to obtaining tissue slices with high quality, complete morphology and good cell state, and realizes space omics sequencing with high sample utilization rate.

The application discloses an injectable microsphere gel of controllable performance silk protein and a preparation method thereof, and belongs to the field of biomaterials.The preparation method comprises the following steps: preparing a regenerated silk protein solution, including degumming, dissolving and purifying of mulberry silk, and obtaining a regenerated silk protein solution with a target molecular weight through molecular weight screening; preparing a silk protein microsphere aqueous solution by adding ethanol to the regenerated silk protein solution and performing freezing and thawing; obtaining a silk protein microsphere redispersible powder by drying two solutions prepared in the above steps; and preparing a silk protein microsphere gel by dispersing the silk protein microsphere redispersible powder in a solvent and adding a gel inducer.The whole preparation process does not involve toxic chemical reagents, and thus the excellent mechanical properties, ideal biocompatibility and biodegradability of the material are ensured; the silk protein microsphere gel has thixotropy, can be injected into subcutaneous tissue through a syringe, has a certain self-supporting property after injection, has controllable mechanical properties due to the molecular weight screening, and can be used in different application scenarios.

This utility model discloses a beauty device, relating to the field of medical aesthetics technology. The beauty device includes a shell assembly, an adsorption pump, a circuit assembly, and a first electrode pair. The shell assembly has an adsorption chamber, an air intake, and an action port. The first electrode pair includes a first positive electrode and a first negative electrode located at the action port, which are arranged opposite to each other and electrically connected to the circuit assembly. Both the first positive and first negative electrode include a main body segment and an inclined segment. The main body segment is located on the outer end face of the action port, and the inclined segment extends from the action port to the inner wall of the adsorption chamber. The adsorption pump adsorbs the dermis and subcutaneous tissue of the target treatment area into the adsorption chamber, placing it between the two opposing inclined segments. This utility model improves the structure of the beauty device, significantly increasing the effective depth of action, reaching the deep dermis and even subcutaneous tissue; the effective range of action is also significantly increased; and the effective depth and range of action are adjustable.

This invention discloses a data processing method and system for surface trauma and subcutaneous tissue injury. The method includes: using millimeter-wave radar to perform non-contact signal acquisition of the trauma area to obtain echo signal information; performing two-dimensional data analysis and processing on the echo signal information to obtain target trauma signal information; and performing three-dimensional data analysis and processing on the target trauma signal information to obtain target identification result information.

1. Name of the product in this design: Hook (bent type). 2. Intended use of this design: for subcutaneous tissue surgery. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key features: the front view.

The utility model relates to a removing device for removing subcutaneous tissue in a minimally invasive mode, and belongs to the technical field of medical instruments. Comprising a handle which is provided with a mounting groove; the first end of the connecting assembly is detachably connected with the mounting groove; the planing piece is detachably arranged at the second end of the connecting assembly and used for removing subcutaneous tissue. According to the internal fistula subcutaneous tissue planer, the planing sheet extends into the subcutaneous tissue for planing, part of the subcutaneous tissue is cut off, and the thickness of the internal fistula blood vessel talus is reduced.

The present disclosure relates to a kit. The kit of the present disclosure comprises: a kit body comprising a needle tube and a needle, the first end of the needle being mounted to the needle tube; and a catabolic filling thread comprising a first segment and a second segment connected to each other, at least a part of the first segment being located inside the needle, and at least a part of the second segment being located outside the needle, wherein the catabolic filling thread is a thread made of poly-L-lactic acid. The kit of the present disclosure comprises a catabolic filling thread which can be composed of poly-L-lactic acid, is absorbable, has no residue, and is metabolized into lactic acid in the human body. Such a configuration makes the catabolic filling thread itself not only play a role in filling and tightening when filling surgery is performed using the catabolic filling thread of the present disclosure, but also the lactic acid after its metabolism can still stimulate fibroblasts in the skin and subcutaneous tissue to reconstruct the collagen framework in the human body by using fibroblasts.

It is an object of the present invention to effectively promote growth of granulation tissue at a dermal defect or a subcutaneous tissue defect caused by a severe burn. To achieve this object, burn treatment cells for use in treatment of burns are composed of placenta-derived cells of an animal and promote healing.

This application relates to the field of medical devices and discloses a needle withdrawal system for radiofrequency ablation devices that avoids scarring. Based on a standard radiofrequency ablation device, the system integrates a needle position detection device (real-time monitoring of depth and speed) and a needle tip temperature sensor. During needle withdrawal, the radiofrequency power is dynamically adjusted according to the withdrawal speed (higher power for faster speed); when the needle tip depth is less than a predetermined threshold (close to the body surface), the radiofrequency output is automatically stopped and a prompt to wait for cooling occurs; once the temperature drops below a safe threshold, a prompt indicates that the needle can be completely withdrawn. Through this closed-loop control, the thermal coagulation and end-point cooling processes of the needle track are precisely managed, effectively preventing thermal damage to the skin and subcutaneous tissue and significantly reducing scar formation.

Devices, systems, and methods for treatment of the subcutaneous tissues of various types. Non-invasive ultrasound energy is used for planning, monitoring and treating the adipose tissue, small blood vessels, and benign tumors of the subcutaneous tissue. While high intensity focal ultrasound (HIFU) has been used to treat many areas of the body including cancer lesions typically using ablation / high heat energy, lower intensity volumetric ultrasound (LIVU) techniques are used to denature the subcutaneous layer. Various safety features may be included to further enhance the treatment of the subcutaneous tissue using LIVU techniques.