467 results about "Subcutaneous tissue" patented technology

This disclosure relates to a method of treating a neurological disorder, comprising administering a bupropion, or a combination of a bupropion and a dextromethorphan, to a human being in need thereof, monitoring the human being for Brugada pattern / syndrome, drug reaction with eosinophilia and systemic symptoms, or acute generalized exanthematous pustulosis, and reducing or discontinuing use of the bupropion, or the combination of the bupropion and the dextromethorphan, if the human being develops Brugada pattern / syndrome, subcutaneous tissue disorder, drug reaction with eosinophilia and systemic symptoms (DRESS), or acute generalized exanthematous pustulosis.

The invention discloses a subcutaneous injection site detection and recommendation system based on an intelligent algorithm, and aims to improve the safety of long-term subcutaneous injection and the drug absorption efficiency and reduce the risk of related complications such as subcutaneous hemorrhage, subcutaneous induration and subcutaneous fat hyperplasia at the same time. Comprising a subcutaneous tissue detection module for acquiring subcutaneous vascular distribution, fat layer thickness and induration state of a target part through infrared imaging and ultrasonic technologies and generating subcutaneous tissue characteristic data; the data processing module analyzes the feature data by using an image recognition algorithm, and recognizes a blood vessel dense region, induration and a part where fat hyperplasia has occurred; the injection part recommendation module is used for evaluating an analysis result of the data processing module based on a machine learning algorithm in combination with personalized injection historical data of the patient, and generating an optimal injection part recommendation scheme avoiding a risk area; the intelligent imaging and data analysis technology is utilized, the subcutaneous injection part selection accuracy is improved, and the patient comfort and the treatment effect are improved.

The invention discloses a measurement method, system and related device, the method is applied to first electronic equipment, the first electronic equipment comprises a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; under the condition that a first electrode group and a second electrode group are implanted into subcutaneous tissue, the method comprises the following steps: determining a first physiological parameter through the first electrode group; electrocardiosignals are determined through the first electrode set and the second electrode set. Therefore, the electrocardiosignal of the user can be obtained anytime and anywhere through the first electronic equipment, and one or more other physiological parameters (such as blood glucose, blood ketone, blood lactic acid and uric acid) of the user can be measured at the same time, so that the health monitoring efficiency is improved.

The invention discloses a subcutaneous tunnel establishing device in tunnel type PICC catheterization, and particularly relates to the technical field of subcutaneous tunnel establishing instruments.The subcutaneous tunnel establishing device comprises a puncture needle used for puncturing subcutaneous tissue, a drawing needle is inserted into the puncture needle, and a puncture needle driving part is detachably connected into the drawing needle; a PICC catheter fixing assembly is detachably connected into the drawing needle, when the PICC catheter is drawn, the tail end of the PICC catheter is inserted into the drawing needle and arranged at the tail end of the PICC catheter fixing assembly in a sleeving mode, then air is inflated into the PICC catheter fixing assembly to extrude the tail end of the PICC catheter between the tail end of the PICC catheter fixing assembly and the inner wall of the drawing needle, and fixing of the tail end of the PICC catheter is achieved. According to the drawing needle, the tail end of the PICC can be extruded and fixed in the drawing needle by utilizing the inflated and expanded air bag in the process of drawing the PICC to penetrate through subcutaneous tissue, so that the problem that the PICC falls off from the interior of the drawing needle in the moving process can be solved, and smooth establishment of a subcutaneous tunnel during PICC catheterization is ensured.

The invention discloses an operation lacuna suspension device for breast endoscopic surgery, and belongs to the field of medical instruments, the operation lacuna suspension device comprises a suspension support body, a measuring part is arranged on the lower side of a horizontal part of a connecting frame and the right side of a vertical part of the connecting frame, and the measuring part comprises a first sliding groove formed in the right side of the vertical part of the connecting frame; the movement height of the traction plate can be correspondingly adjusted according to the thickness of the skin and subcutaneous tissue of a patient, so that the traction force can be controlled, and the traction plate is not prone to falling off before the traction plate pulls the incision of the patient. The thickness of the skin and subcutaneous tissue at the incision of a patient can be measured through the distance between the detection plate and the traction plate, and the traction force of the traction plate is correspondingly adjusted according to the skin and subcutaneous tissue of different thicknesses of obese people and thin people. And unnecessary damage caused in the process that the traction plate pulls the knife edge is avoided.

The present disclosure provides a new PH20 mutant enzyme which shows significantly enhanced aggregation stability, can be used for the development of drug subcutaneous injection preparations, facilitates the diffusion of drugs in subcutaneous tissues, reduces subcutaneous administration volume limitations, and alleviates swelling or pain caused by large-volume subcutaneous injection.

The invention relates to the technical field of medical instruments, and provides a radio frequency gold microneedle control system based on subcutaneous impedance identification, and a radio frequency gold microneedle is provided with an electrode array for impedance tomography. Comprising the following steps: an impedance distribution reconstruction module generates reconstructed impedance distribution from a voltage signal of subcutaneous tissue collected by an electrode array through an impedance distribution reconstruction model based on a genetic algorithm; the impedance imaging module generates an impedance distribution image for reflecting subcutaneous tissue impedance distribution from the reconstructed impedance distribution through an impedance rate segmentation model based on a UNet architecture; the depth control module determines the recommended depth of the radio frequency gold microneedle according to the impedance distribution image; and the radio frequency energy control module adjusts control parameters of a control algorithm for controlling the radio frequency energy of the radio frequency gold microneedle according to the plurality of impedance distribution images. Accurate segmentation judgment and better imaging effect on impedance distribution are achieved, and then impedance imaging is applied to depth and energy pulse control of the radio frequency gold microneedle.

The invention discloses an interactive indwelling needle simulation training model which comprises a venipuncture model body and an interactive control system. The venipuncture model main body comprises a simulation skin layer, a simulation blood vessel and a simulation subcutaneous tissue layer; two miniature cameras are arranged close to the proximal end of the venipuncture model main body and can record puncture pictures at the same time, and the puncture angles are interactively output; a puncture inlet of the simulated skin layer is provided with a plurality of first sensors for acquiring a first position of the remaining needle, the periphery of the simulated blood vessel is provided with a plurality of second sensors for acquiring a second position of the remaining needle, and the inner wall of the simulated blood vessel is provided with a plurality of third sensors for acquiring a third position of the remaining needle; the interactive control system compares data of operation training according to standard operation parameters in a preset puncture mode, can feed back the puncture angle and the puncture speed of the operation training to a trainee, and can also provide data of puncture strength and needle insertion depth to the trainee.

According to the pressure damage dynamic risk assessment method based on multi-modal sensing, multi-physical field data is collected in real time through an MEMS piezoresistive array, a near infrared spectrum sensor and a flexible capacitance type humidity sensor, and early precise early warning and automatic grading intervention are achieved in combination with an LSTM neural network and dynamic threshold adjustment. According to the method, the early warning time of the stress injury is advanced by 4-6 hours, so that the clinical misjudgment rate is reduced to be less than 15% from 38%, and the problems that in the prior art, poor blood circulation of subcutaneous tissues cannot be accurately identified by traditional visual inspection, the hysteresis of the currently adopted preventive measures and the clinical accurate judgment error rate are relatively high, and the clinical accuracy is relatively low are solved. In order to solve the problem that the occurrence risk and the compression degree of the stress injury cannot be accurately judged due to the fact that the existing tissue ischemia assessment method is based on the three-layer architecture of'multi-modal sensing and dynamic modeling combined with intelligent closed loop ', the transformation from'passive discovery' to'active prevention 'is realized, and a more comprehensive tissue ischemia assessment system is constructed.

The invention relates to the technical field of medical data management and analysis, in particular to a lymphedema treatment monitoring data management method and system. Comprising the following steps: synchronously acquiring bioelectrical impedance, tissue thermodynamic characteristics and subcutaneous tissue morphological data of a patient through multi-modal data acquisition equipment; transmitting the data to a cloud processing platform in a distributed manner, and generating a three-dimensional illness state assessment map containing edema quantitative indexes through a machine learning assessment model; generating a personalized treatment strategy adjustment scheme with a confidence score based on dynamic comparison between the current evaluation map and historical data; feeding back the evaluation map and the adjustment scheme to the medical staff through the interaction terminal, and receiving a clinical correction instruction; according to the method, on the premise of strictly protecting patient data privacy, cross-mechanism multi-modal knowledge sharing can be realized, and the contradiction between a data island and a model effect is solved.

The invention relates to the technical field of manipulator control, in particular to a livestock grabbing manipulator control method and system. The method comprises the following steps: carrying out stress state collection and struggling force monitoring on livestock in a grabbing state of a manipulator to obtain livestock stress state struggling force monitoring data; according to the livestock stress state struggling force monitoring data, whole body subcutaneous tissue gap shrinkage difference quantification is carried out, livestock needle tube injection fracture risk estimation is carried out, and livestock needle tube injection fracture risk data is obtained; manipulator injection behavior regulation and control are conducted according to the livestock needle tube injection fracture risk data, and manipulator injection behavior regulation and control data are obtained; and manipulator automatic control firmware design is carried out based on the manipulator injection behavior regulation and control data, and manipulator automatic control firmware is obtained. The manipulator control technology is optimized, so that the manipulator control technology is more accurate.

Provided is a vented needle hub assembly for infusion of a liquid into subcutaneous tissue. More specifically, the vented needle hub assembly is provided by a needle hub having an inlet side and an outlet side and a fluid passageway therebetween; an infusion needle in fluid contact with the fluid passageway and extending from the outlet side; a flexible tubing joined to the inlet side in fluid contact with the fluid passageway; at least one vent disposed in a sidewall of the needle hub, the vent in fluid contact with the fluid passageway; and a porous plug disposed within each at least one vent adjacent to the fluid passageway, the porous plug structured and arranged to distinguish gas from liquid, gas permitted to pass from the fluid passageway through the porous plug and out the at least one vent. An associated method of use is provided as well.

The invention relates to the technical field of collagen dressings, in particular to a moisturizing and repairing collagen dressing and a preparation method thereof. The moisturizing and repairing collagen dressing is prepared from the following components in parts by mass: 10 to 30 parts of recombinant human fibronectin, 10 to 20 parts of recombinant collagen, 5 to 15 parts of beta-glucan, 5 to 10 parts of compound hexanediol, 40 to 50 parts of carbomer, 5 to 15 parts of a flavoring agent, 80 to 120 parts of purified water, 10 to 30 parts of a modified recombinant human III type collagen solution and 10 to 20 parts of a modified chitosan solution. The recombinant human fibronectin disclosed by the invention can be deposited at an injured part to form a blood clot, so that the aim of stopping bleeding is fulfilled, and the subcutaneous tissue is protected; the recombinant collagen has high biological activity and can inhibit inflammation and improve the conditions of pachulosis, damage and the like of the skin; the beta-glucan can generate cytokines, promote healing of skin with laser-dependent dermatitis or barrier damage, and realize anti-allergic and anti-inflammatory effects.

The invention provides an EMS pulse fatigue relieving instrument, and relates to the technical field of relieving instruments, the EMS pulse fatigue relieving instrument comprises a relieving instrument, the top of the relieving instrument is provided with a cover plate, both sides of the bottom of the cover plate are fixedly connected with fixing plates, and both sides of the fixing plates are provided with diversion trenches. A pull block is pulled outwards, the pull block drives a pull rod to move outwards, so that a clamping rod is driven by the pull rod to move outwards, the clamping rod moves along a transverse rod, meanwhile, a compression spring is compressed, when the clamping rod is separated from the interior of a clamping groove, a cover plate is opened, and then through the compression spring on the surface of an inclined rod, the inclined rod moves towards the top, so that the cover plate is opened. The lifting plate is pushed to the top, so that the cover plate is jacked up to the top, the cover plate is conveniently and efficiently opened, a 650mm and 850mm double-wave lamp is used, red light has the wavelength of 650mm, irradiates and penetrates through a corium layer, enhances cell activity and relieves muscular soreness, and far infrared light has the wavelength of 850mm, penetrates into subcutaneous tissues of a human body and promotes cell metabolism.

Systems, methods, and devices for treating a subject are described herein. In some embodiments, an applicator for selectively affecting a subject's subcutaneous tissue is provided. The applicator can include: a housing; a treatment cup mounted in the housing, wherein the treatment cup defines a tissue-receiving cavity and includes a temperature-controlled surface; at least one thermal device coupled to the treatment cup and configured to receive energy via a flexible connector coupled to the applicator and to cool the temperature-controlled surface; an at least one vacuum port coupled to the treatment cup and configured to provide a vacuum to draw the subject's tissue into the tissue-receiving cavity and against at least a portion of a treatment area of the temperature-controlled surface to selectively damage and / or reduce the subject's subcutaneous tissue.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention discloses a blood glucose monitoring device and method.The blood glucose monitoring device is characterized in that an interstitial fluid gathering module in the device is connected between a control module and a first sensor and used for gathering subcutaneous tissue fluid under the control of the control module, and the first sensor is used for generating electrochemical reaction with the skin surface of the gathered subcutaneous tissue fluid to output first current; the second sensor is connected with the reference electrode and used for generating electrochemical reaction with the skin surface attached to the reference electrode to output a second current, and the first voltage detection module is connected between the first sensor and the control module and used for monitoring a first voltage value of the first current and sending the first voltage value to the control module; the second voltage detection module is connected between the second sensor and the control module and used for monitoring a second voltage value of the second current and sending the second voltage value to the control module, and the control module is used for obtaining a blood glucose concentration value according to the first voltage value and the second voltage value.

The invention provides a subcutaneous tissue fluid administration device based on air osmotic pressure power, and relates to the technical field of subcutaneous administration equipment.The subcutaneous tissue fluid administration device comprises a base and a microneedle array, a cavity is formed in the inner side of the base, an inner container is installed in the cavity, the microneedle array is installed at the lower end of the inner container, and the lower end of the microneedle array penetrates through the base; a protection assembly is installed below the base, a shell is arranged above the base and connected with the base through a connecting assembly, a solvent cavity is formed in the inner side of the shell, an opening is formed in the lower end of the shell, a semi-permeable membrane is installed on the inner side of the opening, a medicine tablet is installed on the inner side of the inner container, and two sets of silica gel injection nozzles which are symmetrically arranged are installed on the shell. A micro electric valve is mounted on the group of silica gel injection nozzles; a vent hole is formed in the shell; the device is simple in overall structure and convenient to use, a medicine solution is driven to flow through air osmotic pressure difference, and it is ensured that medicine is evenly released subcutaneously.

The invention relates to the technical field of medical instruments, and discloses an intelligent dynamic pressure distribution monitoring system based on a sickbed, and the system comprises an image collection module which is used for collecting an image of a patient in the sickbed at a fixed angle according to a fixed time interval; the image processing module is used for comparing the acquired image with the image of the sickbed to obtain a posture profile diagram of the patient in the sickbed; the clustering module is used for clustering the posture profile diagrams of the patients and determining feature postures of the patients; the blood pressure and flow monitoring module is used for optically monitoring the skin of the patient to obtain the blood pressure and flow of the subcutaneous tissue of each part of the patient on different transverse plates; the planning module is used for controlling the height of each transverse plate of the sickbed according to the blood pressure flow of the subcutaneous tissue of each part of the patient on different transverse plates and the posture profile diagram of the patient on the sickbed.

The utility model relates to the technical field of beauty instruments, in particular to an ultrasonic anti-aging system, which comprises an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module, an ultrasonic transducer array module and an ultrasonic transducer array module, the switch module is used for switching among different modules; the processing circuit module is used for controlling and monitoring the whole treatment process; and the display module is used for providing real-time visual feedback and displaying imaging results of the skin and the subcutaneous tissue and parameters and effects in the treatment process. According to the utility model, high-frequency sound waves pass through skin and other tissues, energy is focused to a specific position in a body, and the temperature of a focusing point is rapidly increased and can generally reach 65-85 DEG C, so that protein denaturation and cell necrosis of target tissues are caused, and surrounding tissues are hardly influenced.

A method and apparatus for degrading a hypodermal tissue scaffold involves exposing the scaffold to a low-intensity focused ultrasonic beam such as to burst gas vesicles trapped in the silk fibroin from which scaffold is constructed. The rate of degradation van be controlled using ultrasonic beams of varying intensities. In one embodiment, the ultrasonic beams are administered trans-dermally to a hypodermal scaffold.

The negative pressure liposuction device comprises a machine shell, a liquid storage pipe and a collecting pipe are installed at the bottom of the side face of the machine shell, a liquid injection opening is formed in the surface of the machine shell, a suction pump is installed at the back end of the machine shell, a connecting pipe is connected between the suction pump and a cover plate at the top end of the collecting pipe, and a top plate slides in the liquid storage pipe. According to the device, through the arrangement of the top plate, the adjusting pipe, the electric push rod and the suction force adjusting mechanism, the suction force in an area with more or less fat is adjusted according to the input amount of the swelling liquid, and fat tissues can be separated and liquefied more effectively by increasing the input amount of the swelling liquid in the area with more fat; the suction process is smoother, fat can be sucked more quickly through large suction force, the operation time is shortened, and the risk of injury to subcutaneous tissue can be reduced by reducing the input amount of swelling liquid and the suction force in an area with the small fat amount.

The utility model relates to the technical field of blood taking needles, and discloses a blood taking needle protection device which comprises a blood taking needle, the blood taking needle is connected with a blood taking device through a hose, the right side of the blood taking needle is fixedly connected with a push piece, the upper side and the lower side of the push piece are both provided with holes, a hollow pipe is arranged on the outer side of the blood taking needle, and the hollow pipe is connected with the blood taking device. An opening is formed in the right side of the hollow pipe, the right side of the push piece penetrates through the opening, fixing columns are fixedly connected to the upper end and the lower end of the right side of the hollow pipe, connecting ropes are fixedly connected to the right ends of the fixing columns, and blocking blocks are fixedly connected to the right ends of the connecting ropes. According to the blood taking device, the sliding blocks are in sliding connection with the corresponding sliding grooves and matched with the pushing pieces to penetrate through the openings to slide, so that the pushing pieces drive the blood taking needles to be inserted into subcutaneous tissue for blood taking, the blocking blocks are matched with the corresponding holes to be clamped, the blood taking needles are protected by the hollow pipe after blood taking, infection caused by pricking of the blood taking needles is avoided, and later classification treatment is facilitated.

The application discloses an analyte detection device mounting unit, a limiting groove is arranged on a shell, and a T-shaped structure sliding block is arranged on a parallel sliding block module correspondingly, the T-shaped structure sliding block is located in the limiting groove, and the T-shaped structure sliding block slides in the limiting groove when a mounting action is implemented. The cooperation of the T-shaped structure sliding block and the limiting groove can limit the parallel sliding block module, avoid deflection of the parallel sliding block module in the shell, guide the parallel sliding block module to slide in the shell, and thus make the sensor pierce into the subcutaneous tissue in a vertical direction, so that the mounting unit is simple in structure and convenient to use.

The utility model discloses a self-heating vomit-stopping ginger acupoint patch, and relates to the technical field of ginger patches, the self-heating vomit-stopping ginger acupoint patch comprises a patch body, the side, used for being attached to the skin, of the patch body is a front side, the side, away from the skin, of the patch body is a back side, a groove is formed in the front side of the patch body, and the area, provided with the groove, of the patch body is defined as an action area; the fresh ginger gel is filled in the groove; the acupoint pressing blocks are arranged in the grooves, the patch body can deform so that the acupoint pressing blocks can move away from the patch body, and therefore the protruding parts can conduct acupoint stimulation on the skin; and the self-heating bag is arranged on the back side of the patch body and covers the action area of the patch body. According to the application, the fresh ginger gel is used for stopping vomiting, the self-heating bag is used for heating, so that the fresh ginger component of the fresh ginger gel can permeate into subcutaneous tissues more easily, the vomiting stopping effect can be enhanced, and meanwhile, the acupoint pressing block is designed, and the vomiting stopping function of acupoint stimulation is achieved.

The application relates to an electroencephalogram monitoring sensor with intradermal needles, comprising an electroencephalogram monitoring sensor body with a plurality of electrode pieces, one or more of the electrode pieces being provided with an intradermal needle, the intradermal needle being fixed to the middle part of the inner side or the outer side of the electrode piece and being electrically connected with the electrode piece; when the electroencephalogram monitoring sensor body is pasted on the forehead of a patient, the intradermal needle penetrates into the subcutaneous tissue; the electroencephalogram monitoring sensor with the intradermal needles can acquire electroencephalogram biological signals in a more direct mode, can better avoid the problem of poor adhesion when the electroencephalogram monitoring sensor is pasted on the forehead of a patient, and has certain application prospect.

The application provides a skin lesion three-dimensional reconstruction system based on a flexible electrode array. The system is characterized by comprising a measuring belt (1), an excitation generator (3), a signal processing module (4), a microprocessor (5) and an imaging module (6). The application can be used for detecting uneven skin lesion areas and constructing three-dimensional shapes of the lesions, and can be widely used in the field of uneven human subcutaneous tissue health detection.

The invention provides a non-invasive tissue fluid lactic acid dynamic monitoring method. The method comprises the following steps: establishing a relation model of epidermal and subcutaneous lactic acid concentrations; steady-state current values under different epidermal lactic acid concentrations are obtained through in-vitro experiments, and then the function relation between the steady-state current values and the epidermal lactic acid concentrations is obtained; net current values under different subcutaneous lactic acid concentrations are obtained through human body experiments, a function relationship between the net current values and the subcutaneous lactic acid concentrations is established, and the function relationship can be used for a subsequent transdermal extraction detection process; substituting the measured epidermal lactic acid concentration into a relation model of epidermal and subcutaneous lactic acid concentrations to obtain an accurate concentration value of tissue fluid lactic acid monitoring; according to the method, in the dynamic real-time monitoring process of the lactic acid concentration of the tissue fluid, the concentration of the lactic acid extracted from the epidermis measured by the lactic acid sensor can be converted into the real-time and accurate lactic acid concentration of the subcutaneous tissue fluid, and rapid, painless, infection-free and continuous monitoring of the lactic acid level of the subcutaneous tissue fluid can be achieved.

The present disclosure relates to a transplantable cell therapy product composition for diabetes mellitus that contains an aggregate of insulin-secreting cells derived from stem cells. In the present disclosure, an NF microwell array membrane was fabricated by applying a molding process to an electrospun, permeable, biodegradable polycaprolactone (PCL) NF membrane and thus allows gases and soluble factors to permeate therethrough. The NF microwell of the present disclosure could provide more nutrients to the iPSC aggregates than conventional impermeable PDMS microwells, thus enhancing survival and differentiation capabilities of the cells. Additionally, the NF membrane was attached singly to the subcutaneous tissue and to the surface of organs such as liver and peritoneum without the need for a fixing material or separate sutures and was integrated with surrounding tissues, resulting in higher insulin secretion than PDMS microwells. Therefore, the present disclosure can be effectively utilized as a composition for the prevention or treatment of diabetes.

Devices, systems, and methods for treating vessel openings are disclosed herein. According to some embodiments, a device for treating a vessel opening comprises a housing configured to be positioned within an opening in subcutaneous tissue proximate the vessel opening. The housing can comprise an inner wall and an outer wall. The inner wall can define a first lumen configured to receive an elongate member therein and the inner and outer walls can define a second lumen configured to receive an adhesive. The outer wall of the housing can define one or more apertures extending radially from the second lumen to an environment external of the housing. The device can comprise an actuator configured to be received within the second lumen. Movement of the actuator can force the adhesive to move through the aperture to the external environment and into an extravascular space within the subcutaneous tissue proximate the vessel opening.