495 results about "Skin tissue" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

The invention provides a composition with oil-controlling, acne-removing, barrier-repairing effects and application thereof, and belongs to the field of cosmetics. The composition is prepared from a baropetalum beetle leaf extract, a roselle flower extract, totarol and a cryptomeria fortunei bud extract. The baropetalum chinense leaf extract has the effects of balancing grease secretion and shrinking pores; the roselle flower extract is rich in organic acid and anthocyanin, and has the effects of dissolving pore keratosuppository, controlling oil, resisting inflammation, smoothing acne skin, preserving moisture and removing redness; as a bacteriostatic agent, totarol has a natural preservative effect on gram-positive bacteria and partial negative bacteria, and has the effects of removing acnes, sterilizing, diminishing inflammation, whitening and the like; the cryptomeria fortunei bud extract can promote skin tissue structure regeneration and strengthen skin barriers. The composition effectively regulates and controls excessive secretion of sebaceous gland grease and pox skin specific protein through the synergistic effect of various components, promotes the health of pox skin, repairs the skin barrier and enhances the self-protection ability of the skin at the same time.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

Systems for producing a cosmetic effect in skin tissue of a patient are provided. The systems include a treatment module and an actuation assembly. The treatment module includes at least one coring element configured to remove a portion of skin tissue when the coring element is inserted into and withdrawn from the skin tissue. The actuation assembly is operably attached to the treatment module and can translate and / or actuate the treatment module in one or more directions relative to a surface of the skin tissue. The system can perform a microcoring procedure that provides a cosmetic effect to the patient. Methods of performing a microcoring procedure are also provided.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention discloses a novel application of bifidobacterium longum subsp. Infantis CCFM1269 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium longum subsp. Infantis CCFM1269 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mast cell infiltration is reduced; (2) reducing the total IgE level of serum; (3) the Treg level of mesenteric lymph nodes and the ILA content of serum are improved; (4) IL-4 and TSLP levels in skin tissues are reduced, IL-10 is improved, and Th1 / Th2 immune balance is recovered; (5) improving AHR and CYP1A1 in the skin tissue; and (4) high yield of ILA.

The invention discloses a chiral alpha alkyl beta hydroxyl phosphate compound as well as a preparation method and application thereof, and belongs to the technical field of chemical synthesis. In the presence of a catalyst, carbonyl of a substrate is reduced into hydroxyl to obtain a chiral alcohol compound, alpha-alkyl beta-ketophosphonate is reduced by an asymmetric catalytic hydrogen transfer method, and a reduced product can be used as a core skeleton of various drug molecules, so that the chiral alcohol compound is prepared. The compound has an obvious promotion effect on migration and repair of keratinocytes, and has great application potential in the aspects of wound healing, skin tissue soothing, repair, aging resistance and the like.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses a composition for regulating scalp micro-ecology and application thereof, and relates to the technical field of daily chemical products. The composition for regulating scalp micro-ecology comprises the following components: emu oil, melaleuca alternifolia leaf oil, Brazil green propolis and hydrogenated castor oil. The invention provides a composition for regulating scalp microecology and application thereof, the composition is prepared by compounding an anti-inflammatory and antibacterial component emu oil with melaleuca alternifolia leaf oil, Brazilian green propolis and hydrogenated castor oil, the composition has synergistic bacteriostasis and anti-inflammation effects, keeps scalp microbe balance, reduces red and swollen skin and itching, and also can promote the regeneration capacity of skin tissue cells.

The invention discloses a glucose-responsive hydrogen sulfide release cascade nano-enzyme as well as a preparation method and application thereof. The cascaded nano-enzyme takes BSA as a growth template and a carrier, and FeS and Au nano-particles are loaded. The FeS-coated Au is synthesized by adopting a biomineralization method, so that the co-loading of FeS and Au is realized, and good biocompatibility is achieved. Meanwhile, by combining the peroxidase-like activity of FeS and the glucose oxidase-like activity of Au, glucose can be catalyzed in a cascade manner to generate toxic hydroxyl free radicals, and drug-resistant bacteria are efficiently killed. In addition, the FeS (at) Au cascade nano-enzyme has a hydrogen sulfide gas release function, and can promote vascular regeneration by up-regulating a hypoxia inducible factor-1 pathway. The cascade nano-enzyme responding to the hyperglycemia microenvironment is combined with a gas treatment mechanism, blood glucose can be effectively consumed, drug-resistant bacterium infection can be eliminated, revascularization can be promoted, and a new strategy is provided for treatment of diabetes wounds infected by drug-resistant bacteria and regeneration of skin tissues.

Method and system for ultrasound treatment. An ultrasound device having at least one tilting ultrasound transducer is deployed onto skin tissue overlying a treatment region of internal tissue of a treated body part. The transducer is induced to transmit ultrasound energy onto skin tissue, such that a body interface implement of the transducer interfaces with the skin tissue surface. A motor-driven oscillator coupled with transducer is oscillated about an oscillation-axis relative to skin tissue surface such that at least one of: a position of the body interface implement, a tilt direction of the body interface implement, and a propagation direction of transmitted ultrasound, oscillates about oscillation-axis. Ultrasound device may be maneuvered to roam over skin tissue along at least one trajectory. Body shape parameters of the treated body part are measured using a measurement assembly including an imaging device, a green screen, and scale markers.

The invention discloses an application of a polypeptide Apelin-13 in a medicine for treating psoriasis, in particular to psoriasis-like skin lesion. In an imiquimod (IMQ) cream induced mouse psoriasis model, intraperitoneal injection of Apelin-13 can significantly reduce scale, erythema and skin thickness, and can inhibit proliferation of epithelial spine cells. HE staining and immunohistochemical staining are carried out on the skin tissue of an experimental mouse, and the result shows that Apelin-13 can reduce the expression of the psoriasis marker protein K17, the thickness of the surface layer of the back side skin of the experimental mouse and the downward extension of a spinous layer. Experimental mouse serum ELISA (enzyme-linked immunosorbent assay) detection results show that the Apelin-13 can be used for down-regulating IL-17A (interleukin-17A) which is highly expressed in psoriasis. The polypeptide Apelin-13 can be used as a medicine for treating psoriasis, especially a medicine for treating psoriasis-like skin lesion.

The invention discloses a multifunctional operation drag hook for animal husbandry and veterinary, and belongs to the field of veterinarians, the multifunctional operation drag hook comprises an operating table, a moving table is assembled on the front side of the operating table, an electric sliding rail is assembled on the top of the moving table, an electric sliding block is assembled on the top of the electric sliding rail, and an electric telescopic rod is fixedly connected to the top of the electric sliding block; the top of the electric telescopic rod is fixedly connected with a drag hook. An extension plate is slidably connected to the inner wall of the drag hook, a sliding groove is formed in the front face of the drag hook, a limiting plate is fixedly connected to the left side of the inner wall of the drag hook, an extrusion block is fixedly connected to the bottom of the extension plate, and a first hydraulic assembly is fixedly connected to the inner wall of the drag hook. Skin tissue can be lifted and opened, the effect of tensioning the skin is achieved, and the operability of an operation area is improved by increasing the contact area of the drag hook and the skin. Particularly, linkage of an air bag, a first hydraulic rod and an extension plate is used, and the stability and the expansion effect of the skin tissue are further ensured through lifting and extrusion.

Disclosed herein is a system for treating skin and / or nails with cold plasma. The system includes a discharge device, which includes a handle and an applicator mounted thereon, and control infrastructure, which includes a waveform generator. The applicator includes an elongated tube housing therein a cathode. The handle includes a flyback amplifier. The waveform generator is configured to induce the flyback amplifier to establish a voltage at the cathode. The voltage produced by the flyback amplifier is configured to generate a self-sustaining Townsend avalanche when a distal end of the tube is positioned sufficiently near a target site on a skin surface or a nail of a subject, such that a cold plasma discharge is produced and directed at the target site and having an average power between about 0.1 μW and about 10 μW, so that the target site is not heated.

The invention relates to the technical field of biological polypeptides, in particular to cyclic pentapeptide-4, a preparation method thereof and a polypeptide cosmetic. The cyclic pentapeptide-4 has a chemical structural formula as shown in a formula I in the specification. Compared with the existing palmitoyl pentapeptide-4, the cyclopentapeptide-4 provided by the invention has good ability to penetrate through an epidermal barrier, so that the cyclopentapeptide-4 can penetrate into skin tissues more deeply, thereby significantly improving the anti-wrinkle and anti-aging ability of the skin. Meanwhile, the expression level of anti-aging genes in human skin fibroblasts can be remarkably improved. Therefore, the cyclic pentapeptide-4 disclosed by the invention can be used for preparing an anti-aging preparation so as to improve the expression level of an anti-aging gene in human skin fibroblasts and further relieve skin aging. # imgabs0 #

The invention relates to a jaw traction device which comprises a support, a lead screw, a fixed traction plate, a movable traction plate and a driving assembly. When an operator presses the button shaft, the ejector rod shaft can be driven to rotate around the axis of the ejector rod shaft through clamping rotation fit between the second clamping part and the first clamping part, then the lead screw is driven to rotate around the axis of the lead screw through meshing transmission between the ejector rod shaft and the lead screw, and therefore the movable traction plate is driven to move along the axis of the lead screw. Furthermore, the distance between the movable traction plate and the fixed traction plate is adjustable, and the movable traction plate and the fixed traction plate can prop open and keep the two ends of the jaw bone by utilizing the screwing self-locking limiting between the screw rod and the movable traction plate; the jaw traction device is designed to be completely implanted into the cheek skin tissue, the operative wound is minimized, accurate traction can be achieved, controllable traction of the jaw is achieved, the living quality of a patient is improved in the traction process, and postoperative nursing difficulty is reduced.

The invention belongs to the crossing field of biomedical engineering, material science and tissue engineering, and discloses multifunctional hydrogel capable of switching mechanical and adhesive properties based on temperature triggering as well as a preparation method and application of the multifunctional hydrogel. The water-based adhesive is prepared from acrylic acid, gelatin, hexadecyl trimethyl ammonium bromide, silver nanoparticle-loaded polydopamine nanoparticles and water. According to the present invention, the good adhesion property and the good mechanical property are provided for the skin tissue, the mechanical property and the adhesion property can be switched, and the adhesion property durability and the adhesion property repeatability are achieved. The temperature-triggered hydrogel prepared by the method has the advantages of simple process, low cost and no introduction of toxic chemical substances, can achieve the effects of tight fitting at body temperature and natural falling at low temperature according to the driving of temperature, still has excellent adhesion performance in a complex environment, and promotes the development of intelligent medical multifunctional wound dressings.

A method of dermocosmetic treatment for skin tissue includes a plurality of treatment laser light sources which are in communication with a rectangular-shaped optical fiber; the optical fiber includes a proximal end to receive laser light from the plurality of treatment laser light sources and a distal end to transmit overlapping laser light to the area of skin tissue to be treated; the plurality of treatment of laser light sources are activated to impinge one or more rectangular-shaped laser light images within one or more rectangular-shaped areas.

The invention relates to the technical field of auxiliary medical treatment, and discloses a cold spraying control method of a radio frequency treatment system and the radio frequency treatment system. The method comprises the following steps: determining a first temperature change rate and a second temperature change rate of skin tissue in a current treatment area; wherein the first temperature change rate represents the temperature response of the skin tissue of the current treatment area to the refrigeration pulse, and the second temperature change rate represents the temperature response of the skin tissue of the current treatment area to the radio frequency pulse; and according to the first temperature change rate and the second temperature change rate, the single-time cold spraying duration of the current refrigeration pulse is determined. According to different responses of the skin tissue to temperature changes, the cold spraying duration is dynamically adjusted, it can be ensured that the temperature of the skin tissue is always kept within a safe and effective range, and it is ensured that the skin tissue in the current treatment area is prevented from being damaged while effective radio frequency treatment is conducted on the skin tissue.

Disclosed are a method for controlling an electrical treatment device with injection function and an electrical treatment device. The method includes: driving ends of a plurality of needle bodies to penetrate at least one target depths of a skin tissue by a actuator, and controlling the plurality of the needle bodies to electrically connect to an electric energy output assembly to release an electric energy at least one target depths of the skin tissue, and / or controlling the plurality of the needle bodies to connect to a liquid storage unit to perform drug injection based on at least one target depths of the skin tissue.

Proposed is an RF electrode cartridge for skin beauty care treatment and a handpiece for skin beauty care treatment provided with the same. While being freely tilted for all ranges of 360 angle degrees around a ball joint part 140 within a radius thereof, the RF electrode body 120 moves in a state of being brought into close contact with the skin during the procedure, thereby preventing an accident that may occur while the RF electrode body 120 is spaced apart from the skin and in which damage to the skin tissue or burns to the skin may be caused. Accordingly, the present disclosure may greatly improve safety during a procedure.

The invention discloses a skin tissue injury repairing composition containing an umbilical cord extract as well as a preparation method and application of the skin tissue injury repairing composition. The composition provided by the invention comprises the umbilical cord extract, the silk fibroin, the gamma-PGA and the antioxidant, has a synergistic effect by accurately controlling the component proportion, can promote cell proliferation and increase collagen secretion, and has a remarkable skin tissue injury repair effect; furthermore, an enzymolysis process of active ingredients of the composition is optimized, so that the yield and the purity of the umbilical cord extract are improved, and the repairing effect of the composition is also improved; meanwhile, by preparing the PLGA nano drug-loaded particles, the stability of the composition is improved, stable delivery and long-acting release of the drug are achieved, efficient transdermal absorption can be achieved, a better skin injury repairing effect is achieved, the advantages of being simple in preparation process, high in stability, remarkable in repairing effect and the like are achieved, and the PLGA nano drug-loaded particles can be used for preparing more efficient drugs; the ointment is suitable for treating various skin injuries such as burns, wounds, ulcers and the like.

The invention relates to the technical field of skin care products. Specifically disclosed is a facial composition containing a hydrolyzed opuntia ficus-indica flower extract. Comprising the following raw materials in percentage by weight: 0.05%-15% of a hydrolyzed opuntia ficus-indica flower extract, 0.1%-20.0% of a humectant, 0.5%-3.0% of grease, 0.8%-4% of an emulsifier, 0.1%-2% of a thickening agent, 0.1%-8% of a functional additive, 0.03%-1.5% of a preservative, 0.01%-1.5% of a pH regulator and the balance of pure water. The functional additive is ceramide NP and a silver ion solution. According to the composition, the adding amount of the silver ions is matched with that of the composition according to the ratio of 1: 10, stimulation of the silver ions is neutralized, stimulation of microorganisms and metabolites to skin tissue is reduced, accordingly, inflammatory response is relieved, repair of damaged skin is facilitated, and the health state of the skin is improved for a long time.

The invention discloses a novel application of bifidobacterium breve CCFM1078 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium breve CCFM1078 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mastocyte infiltration is reduced; (2) the relative expression quantity of mRNA (messenger Ribonucleic Acid) of mouse skin barrier function related genes is increased; (3) reducing the total IgE level of mouse serum; (4) reducing the levels of IL-4, IL-13 and TSLP in mouse skin tissues, improving the levels of IL-10 and IFN-gamma, recovering Th1 / Th2 immune balance, and maintaining immune homeostasis; (5) activating the expression of AHR and CYP1A1 in the skin tissue of the mouse; (6) improving IgA and sIgA secretion of mouse colon tissue; and (7) compared with a representative high-yield ILA strain, the ILA yield is higher.

The invention discloses a microneedle array electrochemical sensor for monitoring a sepsis marker C-reactive protein in skin interstitial fluid. According to the novel-arrangement cactus-like structure microneedle array electrode, the enrichment efficiency of detection liquid is remarkably improved through the design that the structure sequentially extends from the center to the periphery, and good attachment to skin tissue is achieved in combination with a flexible substrate material. Electrode interface construction of the electrochemical sensor is based on electrochemical deposition, a C-reactive protein aptamer is taken as a recognition object, a highly uniform nucleic acid C-reactive protein aptamer probe single layer is formed by combining a freezing-unfreezing method self-assembly technology, and the nucleic acid C-reactive protein aptamer probe single layer has a good linear relationship with a detection electric signal in a C-reactive protein concentration range of 0.5-100 ng / mL; the kit has the properties of high sensitivity, high specificity, rapid response, real-time monitoring, minimally invasive property and the like, is beneficial to rapid detection of C-reactive protein and dynamic monitoring of sepsis course change, and also provides technical support for development of biosensors for biomarker detection in complex media.

The invention discloses a speed-related puncture characteristic modeling method for an SMA flexible drive puncture device, and the method comprises the following steps: researching the characteristics of the SMA flexible drive puncture device in a skin tissue puncture process, firstly controlling a puncture needle to puncture skin tissues at different speeds, and obtaining puncture force data and input voltage and puncture displacement data; according to the puncture process, puncture force is divided into rigid force, shear force and friction force, and a speed-related puncture force equation is designed to describe speed-related characteristics of the rigid force and the friction force; a kinetic equation of the SMA flexible driving puncture device is established, a modulation GPI algorithm is used for describing the driving force of an SMA wire, and a puncture force equation related to the speed is combined into the kinetic equation; and performing parameter identification on the speed-related puncture force equation and the kinetic equation by using a least square algorithm to obtain an actual speed-related puncture characteristic model of the SMA flexible driving puncture device.

The invention relates to a dressing for promoting healing of diabetic wounds. Chitosan is dissolved in a hydrochloric acid solution at room temperature to obtain a chitosan solution; the preparation method comprises the following steps: dissolving loxoprofen in ethanol activated by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / N-hydroxysuccinimide, dropwise adding into a chitosan solution, adding ethanol while stirring at a high speed by using a magnetic rod to form a transparent solution, and stirring at a low speed in the dark; air-drying the solution in a drying oven to form a solid film, and thoroughly washing the solid film in ethanol to obtain a chitosan-loxoprofen conjugate; the preparation method comprises the following steps: adding chitosan-loxoprofen into a phosphate buffer solution to form a chitosan-loxoprofen solution; dissolving genipin in a phosphate buffer solution to obtain a genipin solution, stirring and mixing the chitosan-loxoprofen solution and the genipin solution at a high speed, cross-linking, and freezing in a refrigerator to obtain the chitosan-loxoprofen / genipin sponge bracket. The dressing disclosed by the invention can effectively relieve chronic inflammation, remarkably improve skin tissue regeneration and stimulate angiogenesis.

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning, and / or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

Method and system for ultrasound treatment. An ultrasound device having at least one tilting ultrasound transducer is deployed onto skin tissue overlying a treatment region of internal tissue of a treated body part. The transducer is induced to transmit ultrasound energy onto skin tissue, such that a body interface implement of the transducer interfaces with the skin tissue surface. A motor-driven oscillator coupled with transducer is oscillated about an oscillation-axis relative to skin tissue surface such that at least one of: a position of the body interface implement, a tilt direction of the body interface implement, and a propagation direction of transmitted ultrasound, oscillates about oscillation-axis. Ultrasound device may be maneuvered to roam over skin tissue along at least one trajectory. Body shape parameters of the treated body part are measured using a measurement assembly including an imaging device, a green screen, and scale markers.