361 results about "Skin tissue" patented technology

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

Systems for producing a cosmetic effect in skin tissue of a patient are provided. The systems include a treatment module and an actuation assembly. The treatment module includes at least one coring element configured to remove a portion of skin tissue when the coring element is inserted into and withdrawn from the skin tissue. The actuation assembly is operably attached to the treatment module and can translate and / or actuate the treatment module in one or more directions relative to a surface of the skin tissue. The system can perform a microcoring procedure that provides a cosmetic effect to the patient. Methods of performing a microcoring procedure are also provided.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention discloses a novel application of bifidobacterium longum subsp. Infantis CCFM1269 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium longum subsp. Infantis CCFM1269 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mast cell infiltration is reduced; (2) reducing the total IgE level of serum; (3) the Treg level of mesenteric lymph nodes and the ILA content of serum are improved; (4) IL-4 and TSLP levels in skin tissues are reduced, IL-10 is improved, and Th1 / Th2 immune balance is recovered; (5) improving AHR and CYP1A1 in the skin tissue; and (4) high yield of ILA.

The invention discloses a chiral alpha alkyl beta hydroxyl phosphate compound as well as a preparation method and application thereof, and belongs to the technical field of chemical synthesis. In the presence of a catalyst, carbonyl of a substrate is reduced into hydroxyl to obtain a chiral alcohol compound, alpha-alkyl beta-ketophosphonate is reduced by an asymmetric catalytic hydrogen transfer method, and a reduced product can be used as a core skeleton of various drug molecules, so that the chiral alcohol compound is prepared. The compound has an obvious promotion effect on migration and repair of keratinocytes, and has great application potential in the aspects of wound healing, skin tissue soothing, repair, aging resistance and the like.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses a composition for regulating scalp micro-ecology and application thereof, and relates to the technical field of daily chemical products. The composition for regulating scalp micro-ecology comprises the following components: emu oil, melaleuca alternifolia leaf oil, Brazil green propolis and hydrogenated castor oil. The invention provides a composition for regulating scalp microecology and application thereof, the composition is prepared by compounding an anti-inflammatory and antibacterial component emu oil with melaleuca alternifolia leaf oil, Brazilian green propolis and hydrogenated castor oil, the composition has synergistic bacteriostasis and anti-inflammation effects, keeps scalp microbe balance, reduces red and swollen skin and itching, and also can promote the regeneration capacity of skin tissue cells.

Method and system for ultrasound treatment. An ultrasound device having at least one tilting ultrasound transducer is deployed onto skin tissue overlying a treatment region of internal tissue of a treated body part. The transducer is induced to transmit ultrasound energy onto skin tissue, such that a body interface implement of the transducer interfaces with the skin tissue surface. A motor-driven oscillator coupled with transducer is oscillated about an oscillation-axis relative to skin tissue surface such that at least one of: a position of the body interface implement, a tilt direction of the body interface implement, and a propagation direction of transmitted ultrasound, oscillates about oscillation-axis. Ultrasound device may be maneuvered to roam over skin tissue along at least one trajectory. Body shape parameters of the treated body part are measured using a measurement assembly including an imaging device, a green screen, and scale markers.

The invention relates to a jaw traction device which comprises a support, a lead screw, a fixed traction plate, a movable traction plate and a driving assembly. When an operator presses the button shaft, the ejector rod shaft can be driven to rotate around the axis of the ejector rod shaft through clamping rotation fit between the second clamping part and the first clamping part, then the lead screw is driven to rotate around the axis of the lead screw through meshing transmission between the ejector rod shaft and the lead screw, and therefore the movable traction plate is driven to move along the axis of the lead screw. Furthermore, the distance between the movable traction plate and the fixed traction plate is adjustable, and the movable traction plate and the fixed traction plate can prop open and keep the two ends of the jaw bone by utilizing the screwing self-locking limiting between the screw rod and the movable traction plate; the jaw traction device is designed to be completely implanted into the cheek skin tissue, the operative wound is minimized, accurate traction can be achieved, controllable traction of the jaw is achieved, the living quality of a patient is improved in the traction process, and postoperative nursing difficulty is reduced.

A method of dermocosmetic treatment for skin tissue includes a plurality of treatment laser light sources which are in communication with a rectangular-shaped optical fiber; the optical fiber includes a proximal end to receive laser light from the plurality of treatment laser light sources and a distal end to transmit overlapping laser light to the area of skin tissue to be treated; the plurality of treatment of laser light sources are activated to impinge one or more rectangular-shaped laser light images within one or more rectangular-shaped areas.

Disclosed are a method for controlling an electrical treatment device with injection function and an electrical treatment device. The method includes: driving ends of a plurality of needle bodies to penetrate at least one target depths of a skin tissue by a actuator, and controlling the plurality of the needle bodies to electrically connect to an electric energy output assembly to release an electric energy at least one target depths of the skin tissue, and / or controlling the plurality of the needle bodies to connect to a liquid storage unit to perform drug injection based on at least one target depths of the skin tissue.

Proposed is an RF electrode cartridge for skin beauty care treatment and a handpiece for skin beauty care treatment provided with the same. While being freely tilted for all ranges of 360 angle degrees around a ball joint part 140 within a radius thereof, the RF electrode body 120 moves in a state of being brought into close contact with the skin during the procedure, thereby preventing an accident that may occur while the RF electrode body 120 is spaced apart from the skin and in which damage to the skin tissue or burns to the skin may be caused. Accordingly, the present disclosure may greatly improve safety during a procedure.

The invention discloses a novel application of bifidobacterium breve CCFM1078 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium breve CCFM1078 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mastocyte infiltration is reduced; (2) the relative expression quantity of mRNA (messenger Ribonucleic Acid) of mouse skin barrier function related genes is increased; (3) reducing the total IgE level of mouse serum; (4) reducing the levels of IL-4, IL-13 and TSLP in mouse skin tissues, improving the levels of IL-10 and IFN-gamma, recovering Th1 / Th2 immune balance, and maintaining immune homeostasis; (5) activating the expression of AHR and CYP1A1 in the skin tissue of the mouse; (6) improving IgA and sIgA secretion of mouse colon tissue; and (7) compared with a representative high-yield ILA strain, the ILA yield is higher.

The invention relates to a dressing for promoting healing of diabetic wounds. Chitosan is dissolved in a hydrochloric acid solution at room temperature to obtain a chitosan solution; the preparation method comprises the following steps: dissolving loxoprofen in ethanol activated by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / N-hydroxysuccinimide, dropwise adding into a chitosan solution, adding ethanol while stirring at a high speed by using a magnetic rod to form a transparent solution, and stirring at a low speed in the dark; air-drying the solution in a drying oven to form a solid film, and thoroughly washing the solid film in ethanol to obtain a chitosan-loxoprofen conjugate; the preparation method comprises the following steps: adding chitosan-loxoprofen into a phosphate buffer solution to form a chitosan-loxoprofen solution; dissolving genipin in a phosphate buffer solution to obtain a genipin solution, stirring and mixing the chitosan-loxoprofen solution and the genipin solution at a high speed, cross-linking, and freezing in a refrigerator to obtain the chitosan-loxoprofen / genipin sponge bracket. The dressing disclosed by the invention can effectively relieve chronic inflammation, remarkably improve skin tissue regeneration and stimulate angiogenesis.

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning, and / or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

The invention relates to the technical field of image processing, and discloses a facial health state assessment method and system based on layered optical modeling. The objective of the invention is to solve the problems of poor face health state evaluation precision and robustness caused by rough optical modeling, mixed reflection components, weak environmental adaptability and insufficient multi-dimensional health index fusion capability in the prior art. The method comprises the following steps: synchronously acquiring a user face video sequence comprising at least two different spectral bands through a multispectral imaging device; constructing a multilayer optical transmission model of the skin tissue, and separating a specular reflection component and a diffuse reflection component from the face video sequence; extracting a physiological time sequence signal related to subcutaneous blood flow activity from the separated diffuse reflection component, and calculating heart rate, heart rate variability and blood oxygen saturation parameters; and fusing the physiological parameters and expression and micro-expression features extracted from the facial video sequence, and outputting quantitative evaluation results of fatigue degree, pressure level and emotional state through a pre-trained deep neural network model. The system comprises a multispectral image acquisition module, a layered optical modeling module, a reflection component separation module, a physiological parameter inversion module and a health state evaluation module. According to the technical scheme, the signal-to-noise ratio and stability of physiological signal extraction in a complex illumination environment can be remarkably improved, the adaptability to individuals with different skin colors and dynamic illumination conditions is enhanced, and more accurate and more robust judgment of the high-order health state is achieved.

The present invention relates to a method for producing a skin tissue model, comprising: (a) isolating and culturing fibroblasts and keratinocytes from skin tissue; (b) preparing a bioink composition for a dermal layer and a bioink composition for an epidermal layer, the bioink composition containing the isolated cells; and (c) producing a skin tissue model using the bioink composition for a dermal layer and the bioink composition for an epidermal layer.

The utility model discloses an anastomat anastomosis nail independent gasket which comprises nail foot fixing pieces, foot connecting pieces, a ring piece and a fixing sleeve, a plurality of foot connecting pieces are distributed on the edge of the ring piece, the outer end of each foot connecting piece is integrally connected with the nail foot fixing piece, each nail foot fixing piece is provided with a suturing nail, and the nail foot fixing pieces are fixedly connected with the fixing sleeve. The nail foot fixing pieces are mutually independent, and one side of the ring piece is integrally connected with a fixing sleeve. The nail foot fixing device is reasonable in design, each nail foot fixing piece distributed on the ring piece is a nailing part of a suturing nail, the pain intensity caused by interlocking connection and dragging between the nail foot fixing pieces in the dismounting process is effectively reduced, meanwhile, the width of the foot connecting pieces located between the nail foot fixing pieces and the ring piece is small, and the nail foot fixing pieces are not prone to falling off. And the time required for decomposition and separation is relatively shortened, and the adhesion surface with the skin tissue is reduced.

The application provides a Guizhou Rhamnus skin wound healing ointment and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. The ointment comprises Guizhou Rhamnus concentrated extract and base excipients. The ointment has the functions of promoting skin wound healing, preventing swelling and pain, preventing infection and scar, reducing swelling and pain, removing blood stasis and promoting tissue regeneration, dredging channels and activating collaterals, and healthy skin tissue. The active ingredients of traditional Chinese medicine have the advantages of rapid healing and repair, obvious swelling and pain relief, delicate ointment texture, easy absorption by the skin, high safety, good stability, wide source of raw materials, easy collection, simple preparation process, batch processing, no toxic side effects on the health of production personnel, and no adverse effects on the environment.

The skin treatment device of the present invention comprises: a radio frequency (RF) generator for generating RF energy; an electrode for transmitting the RF energy to a skin tissue of a user; a measurement unit for measuring a forward RF voltage caused by the RF energy and a reverse RF voltage caused by the RF energy reflected to the RF generator; and a controller for calculating a skin impedance and an RF energy efficiency of the user based on the measured forward RF voltage and the reverse RF voltage, and controlling an output of the RF generator based on the calculated skin impedance and the RF energy efficiency.

The invention discloses an electrode pad and a non-invasive high-frequency output device, and relates to the technical field of skin improvement through electric energy, the electrode pad is used for being electrically connected with a radio frequency energy output device so as to convey radio frequency energy to skin tissue, and the electrode pad comprises a plurality of radio frequency energy areas which are electrically connected with at least one radio frequency energy output device; the electrode pad is provided with a treatment surface, the multiple radio frequency energy areas are arranged on the treatment surface, the treatment surface is provided with a central part and an edge part, and the multiple radio frequency energy areas surround the central part in an annular path mode and are sequentially arranged in the direction from the central part to the edge part; wherein the impedances of the plurality of radio frequency energy regions are sequentially increased along the direction from the central part to the edge part; the invention aims to solve the problem that the energy of the noninvasive high-frequency output equipment is concentrated at the edge part of the electrode pad due to the influence of the edge part effect.

The invention relates to the technical field of biomedical materials, in particular to hydrogel as well as a preparation method and application thereof. The hydrogel is obtained by crosslinking a polymer framework material, a functional additive and a shielding agent, the polymer framework material comprises any one or more of gelatin, carboxymethyl chitosan, hyaluronic acid, chitosan, collagen, polyvinyl alcohol, sodium carboxymethyl cellulose and sodium alginate; the functional additive comprises any one or more of tannic acid, tea polyphenol, vitamin C and procyanidine; the shielding agent comprises any one or more of barium sulfate, bismuth simple substance and bismuth-containing compound. The hydrogel provided by the invention can effectively isolate radiotherapy rays, reduce oxidative stress reaction, provide a protective barrier for normal tissues in a radiotherapy process and reduce radiation damage, has excellent tissue repair promotion capability, is safe in components, fast in metabolism and adjustable in flowability and adhesion, and is more beneficial to adaptation in rectum or skin tissues.

The application provides a chemical luminescence substrate with high chemical luminescence intensity, long wavelength and good stability, and a preparation method and application thereof. The chemical luminescence substrate has a structure shown in formula I. In addition, the application provides spontaneous fluorescence wavelength and intensity of the chemical luminescence probe in a physiological environment, and application of the chemical luminescence probe in in-vivo imaging. Test results show that the chemical luminescence probe provided in the application has long-wavelength spontaneous fluorescence (600 nm), can effectively penetrate skin tissue, has high spontaneous fluorescence intensity (> 10 7 p / s / cm 2 / sr), excellent thermal stability (without 1,2-dioxetane structure) and diversified detection groups (suitable for different detection models).

The application provides an anti-urticaria traditional Chinese medicine composition, a medicine preparation and a preparation method and application, and belongs to the field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is composed of the following raw materials: 12-18 parts of Fructus Mume, 8-12 parts of Glycyrrhiza, 12-18 parts of Imperata Cylindra, 8-12 parts of Smilax Glabra, 8-12 parts of Coix Lachryma-jobi, 8-12 parts of Radix Angelicae Dahuricae, 5-7 parts of Mentha, 5-7 parts of Astragalus, 8-12 parts of Pericarpium Citri Reticulatae, and 8-12 parts of Momordica Grosvenorii. The composition follows the compatibility principle of monarch, minister, assistant and messenger, has mild medicinal properties, can significantly improve the histopathological damage of skin tissues, reduce the infiltration of mast cells, reduce the serum IgE level, correct the Th1 / Th2 immune deviation by up-regulating the Th1-type cytokine IFN-gamma and down-regulating the Th2-type cytokines IL-4, IL-5 and IL-13, and reconstruct the local immune homeostasis of skin, and has significant advantages in relieving the symptoms of urticaria and reducing the recurrence.

This invention belongs to the interdisciplinary field of biomedical engineering, materials science, and tissue engineering, and discloses a multifunctional hydrogel with switchable mechanical and adhesive properties based on temperature triggering, its preparation method, and applications. The invention consists of acrylic acid, gelatin, hexadecyltrimethylammonium bromide, polydopamine nanoparticles loaded with silver nanoparticles, and water. This invention not only exhibits excellent adhesion and mechanical properties to skin tissue but also possesses switchable mechanical and adhesive properties, achieving durable and repeatable adhesion. The temperature-triggered hydrogel prepared by this invention is simple to process, low in cost, and introduces no toxic chemicals. It can achieve a close fit at body temperature and natural detachment at low temperatures, driven by temperature, and maintains excellent adhesion properties even in complex environments, thus promoting the development of intelligent medical multifunctional wound dressings.

The present application relates to the field of biological materials, and particularly relates to a ROS / pH dual-response modified type XVII collagen microneedle patch loaded with bioactive substances and application, the microneedle patch is composed of boric acid modified type XVII collagen, bioactive substances and polymer substrate.Boric acid modified type XVII collagen and polyvinyl alcohol are double-crosslinked through physical and chemical levels to form collagen hydrogel, then load bioactive substance insulin-like growth factor, and form ROS / pH dual-response collagen microneedle patch loaded with bioactive substances with polymer substrate.When applied to the skin, the microneedle tip reaches the area where hair follicle stem cells exist in a painless and minimally invasive manner, and due to the change of active oxygen and pH environment in the skin tissue, the borate ester bond in the collagen hydrogel can be broken, thereby removing active oxygen and releasing the wrapped IGF-1 into the hair follicle stem cells.

The invention relates to a veterinary hoof disease prevention and treatment composition as well as a preparation method and application thereof, and aims to solve the technical problems that existing commercial hoof bath lotion is limited in sterilization effect and relatively strong in local irritation, and a safe and efficient treatment medicament for treating cow hoof warts is lacked and the like. The invention provides a veterinary composition which comprises the following active ingredients: a glycyrrhizic acid compound, didecyl methyl ammonium bromide and polyhexamethylene guanidine salt, and the three components are combined, so that the composition has an antibacterial effect and an effect of promoting skin tissue repair at the same time. A series of tests prove that the traditional Chinese medicine composition can effectively inhibit animal pathogenic bacteria, prevent and / or treat animal limb and foot diseases and promote healing and repairing of ulcer injury. The medicament disclosed by the invention is suitable for preventing and treating limb and hoof diseases in a large-scale pasture, has the characteristics of high sterilization efficiency, good safety and effective treatment, and can improve the animal hoof health management level.

The present invention relates to a gelatin-coated acellular dermal tissue and a use thereof. More specifically, the present invention relates to: an acellular dermal tissue in which gelatin derived from human skin tissue is crosslinked on the surface of the acellular dermal tissue; and a use thereof for treating skin damage. The gelatin-coated acellular dermal tissue according to the present invention has predetermined physical properties so as to provide ease of handling, and also eliminates toxicity and transplant rejection responses, and thus can be effectively used for treating patients with skin tissue damage.

The application belongs to the technical field of chemical synthesis, and specifically provides a chiral hydroxyphosphonate, a preparation method and application thereof. The chiral hydroxyphosphonate has a structure as shown in formula II: each R is independently H, an alkyl group, an alkenyl group, an alkynyl group or a halogenated alkyl group; Ar is an aromatic ring or a heteroaromatic ring; X is a bond, -O-, -N(R 1 )- 2 q , -S(=O) m -; the chiral hydroxyphosphonate is obtained by reducing an alpha phosphonate substituted benzocycloalkanone compound through an asymmetric hydrogenation method, has two chiral centers, and has a yield of up to 99% and an enantiomeric selectivity of up to 99%. The chiral hydroxyphosphonate has wide application potential and value in skin tissue soothing, repairing, anti-aging and the like.​

The present invention relates to the field of auxiliary medical technology, and discloses a cold spray control method for a radio frequency treatment system and a radio frequency treatment system. The method comprises: determining a first temperature change rate and a second temperature change rate of the skin tissue in the current treatment area; wherein the first temperature change rate characterizes the temperature response of the skin tissue in the current treatment area to the cooling pulse, and the second temperature change rate characterizes the temperature response of the skin tissue in the current treatment area to the radio frequency pulse; and determining the duration of a single cold spray of the current cooling pulse based on the first temperature change rate and the second temperature change rate. The present invention dynamically adjusts the cold spray duration based on the different responses of the skin tissue to temperature changes, thereby ensuring that the temperature of the skin tissue is always maintained within a safe and effective range, ensuring that while the skin tissue is effectively treated with radio frequency, damage to the skin tissue in the current treatment area is avoided.