652 results about "Skin tissue" patented technology

According to some embodiments, a device for treating a skin surface comprises a handpiece with an opening configured to receive a container containing a concentrated treatment fluid, a skin interface portion, configured to contact the skin surface, and a treatment fluid mixing zone within the handpiece. The mixing zone can receive concentrated treatment material from the container secured to the handpiece and dilution fluid from a dilution fluid conduit, and mix the two or more input fluids / materials to create a diluted treatment fluid to be delivered to the interface portion during use. The handpiece can include a waste fluid connection in fluid communication with the interface portion of the device and a vacuum source to draw the mixed treatment fluid to the interface portion and skin tissue, and to draw spent treatment material from the interface portion during use.

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

The invention discloses a laser heat effect evaluation method and device, and belongs to the technical field of biology. The method comprises the following steps: acquiring an original laser speckle blood flow image sequence, and analyzing an original laser speckle image by adopting a time contrast analysis algorithm to obtain a laser speckle contrast image; and converting the laser speckle contrast image to obtain a laser speckle blood flow image. Calculating the full width at half maximum of the blood vessel in the laser speckle blood flow image as the width of the blood vessel; subtraction is conducted on the blood flow image obtained after laser irradiation and the blood flow image obtained before laser irradiation, and a difference image is obtained; blood vessels with blood flow changes due to laser irradiation are obtained according to the difference image, then a region of interest is selected, the blood flow mean value of the blood vessels before and after laser irradiation is obtained, and therefore the final laser treatment effect is evaluated. The mouse spine window 108 is irradiated from the complete skin side of the mouse spine window 108, and the blood flow change is monitored in real time on the opposite exposed blood vessel side by adopting technologies such as laser speckle blood flow imaging and the like. The influence of the upper skin tissue is considered, the blood flow change is monitored in real time, and accurate evaluation of the blood vessel laser heat effect is achieved.

The invention provides a composition with oil-controlling, acne-removing, barrier-repairing effects and application thereof, and belongs to the field of cosmetics. The composition is prepared from a baropetalum beetle leaf extract, a roselle flower extract, totarol and a cryptomeria fortunei bud extract. The baropetalum chinense leaf extract has the effects of balancing grease secretion and shrinking pores; the roselle flower extract is rich in organic acid and anthocyanin, and has the effects of dissolving pore keratosuppository, controlling oil, resisting inflammation, smoothing acne skin, preserving moisture and removing redness; as a bacteriostatic agent, totarol has a natural preservative effect on gram-positive bacteria and partial negative bacteria, and has the effects of removing acnes, sterilizing, diminishing inflammation, whitening and the like; the cryptomeria fortunei bud extract can promote skin tissue structure regeneration and strengthen skin barriers. The composition effectively regulates and controls excessive secretion of sebaceous gland grease and pox skin specific protein through the synergistic effect of various components, promotes the health of pox skin, repairs the skin barrier and enhances the self-protection ability of the skin at the same time.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

The present disclosure provides a method and system for estimating the distance between an optical fiber end and a target. Treatments using laser and optical fiber technology require high precision to ensure that the laser is aimed at the correct target (stone, tissue, tumor, etc.) to achieve clinical objectives such as tissue ablation, coagulation, stone fragmentation, dust removal, etc. Therefore, it is important to know the distance between the target and the optical fiber end (distal end) from which the laser light is emitted, because laser treatment parameters such as energy, pulse width, laser power modulation, and / or repetition rate are often determined based on the distance from the tip of the optical fiber to the target.

Systems for producing a cosmetic effect in skin tissue of a patient are provided. The systems include a treatment module and an actuation assembly. The treatment module includes at least one coring element configured to remove a portion of skin tissue when the coring element is inserted into and withdrawn from the skin tissue. The actuation assembly is operably attached to the treatment module and can translate and / or actuate the treatment module in one or more directions relative to a surface of the skin tissue. The system can perform a microcoring procedure that provides a cosmetic effect to the patient. Methods of performing a microcoring procedure are also provided.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention discloses a novel application of bifidobacterium longum subsp. Infantis CCFM1269 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium longum subsp. Infantis CCFM1269 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mast cell infiltration is reduced; (2) reducing the total IgE level of serum; (3) the Treg level of mesenteric lymph nodes and the ILA content of serum are improved; (4) IL-4 and TSLP levels in skin tissues are reduced, IL-10 is improved, and Th1 / Th2 immune balance is recovered; (5) improving AHR and CYP1A1 in the skin tissue; and (4) high yield of ILA.

The invention discloses a chiral alpha alkyl beta hydroxyl phosphate compound as well as a preparation method and application thereof, and belongs to the technical field of chemical synthesis. In the presence of a catalyst, carbonyl of a substrate is reduced into hydroxyl to obtain a chiral alcohol compound, alpha-alkyl beta-ketophosphonate is reduced by an asymmetric catalytic hydrogen transfer method, and a reduced product can be used as a core skeleton of various drug molecules, so that the chiral alcohol compound is prepared. The compound has an obvious promotion effect on migration and repair of keratinocytes, and has great application potential in the aspects of wound healing, skin tissue soothing, repair, aging resistance and the like.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses a composition for regulating scalp micro-ecology and application thereof, and relates to the technical field of daily chemical products. The composition for regulating scalp micro-ecology comprises the following components: emu oil, melaleuca alternifolia leaf oil, Brazil green propolis and hydrogenated castor oil. The invention provides a composition for regulating scalp microecology and application thereof, the composition is prepared by compounding an anti-inflammatory and antibacterial component emu oil with melaleuca alternifolia leaf oil, Brazilian green propolis and hydrogenated castor oil, the composition has synergistic bacteriostasis and anti-inflammation effects, keeps scalp microbe balance, reduces red and swollen skin and itching, and also can promote the regeneration capacity of skin tissue cells.

The invention discloses a medical cosmetology method and device based on a photoacoustic effect. Existing skin anti-wrinkle and anti-aging photoelectric equipment such as radio frequency and ultrasound has the problems of pain, discomfort, limited application depth, unstable flash type light source energy output and the like. According to the method, pulse laser with a specific wave band and pulse duration is utilized to irradiate the skin to generate a photoacoustic effect, 400-700nm of the pulse laser acts on a surface layer, 700-1300nm of the pulse laser can reach a deep layer of 50mm, collagen regeneration and wrinkle resistance are promoted, and the method is painless and radiation-free. The device comprises a laser generating part, a light splitting part, a combined lens part and the like, a controller coordinates all the parts to work, a steering engine adjusts a reflector to control the laser depth, and an ultrasonic sensor assists. The system has the advantages that energy is accurately controlled, the system is suitable for skin tissues of all layers, the defects in the prior art are effectively overcome, and a safer and more efficient new scheme is provided for the field of medical cosmetology.

The invention relates to the field of biological materials, in particular to a thioketal bond modified 17-type collagen dopamine drug-loaded nanoparticle composite microneedle patch and a preparation method and application thereof, and the microneedle patch is composed of dopamine drug-loaded nanoparticles, thioketal bond modified recombinant 17-type collagen and a polymer substrate. The thioketal bond modified 17-type collagen and polyvinyl alcohol are subjected to physical and chemical double-crosslinking to form hydrogel, then the hydrogel is loaded with drug-loaded nanoparticles, and the hydrogel and a polymer substrate form the ROS and pH value microenvironment double-response collagen microneedle patch loaded with bioactive substances. When the collagen hydrogel is applied to the skin, the tip of the microneedle reaches the area where the hair follicle stem cells exist in a painless and minimally invasive mode, and due to the change of microenvironment molecules in the skin tissue, the breakage of thioketal bonds in the collagen hydrogel can be promoted, so that active oxygen is removed, and the wrapped IGF-1 is released into the hair follicle stem cells; and a potential treatment strategy is provided for androgenetic alopecia.

The invention relates to application of VBIT-4 or pharmaceutically acceptable salt thereof in preparation of drugs for preventing or treating vitiligo and complications thereof. A large number of modern pharmacological scientific researches and in-vivo pharmacodynamic tests prove that VBIT-4 has a treatment effect on a leucoderma mouse model and inhibits synthesis of inflammatory factors and chemotactic factors in a leucoderma mouse skin lesion area. The mechanism of the invention is that VBIT-4 inhibits the expression of inflammatory factors and chemotactic factors in skin tissues so as to treat leucoderma, compared with the existing treatment means, VBIT-4 can promote the compound color of pigments in a skin lesion region on the back of a leucoderma mouse, has no obvious toxicity, and reduces the expression level of inflammatory factors (IL-1beta, IL-6 and IFN-alpha) and chemotactic factors (CXCL9 and CXCL10). In conclusion, the VBIT-4 is clear in action mechanism, remarkable in effect and free of obvious side effects, and has remarkable advantages and progress compared with existing drugs.

The invention discloses a glucose-responsive hydrogen sulfide release cascade nano-enzyme as well as a preparation method and application thereof. The cascaded nano-enzyme takes BSA as a growth template and a carrier, and FeS and Au nano-particles are loaded. The FeS-coated Au is synthesized by adopting a biomineralization method, so that the co-loading of FeS and Au is realized, and good biocompatibility is achieved. Meanwhile, by combining the peroxidase-like activity of FeS and the glucose oxidase-like activity of Au, glucose can be catalyzed in a cascade manner to generate toxic hydroxyl free radicals, and drug-resistant bacteria are efficiently killed. In addition, the FeS (at) Au cascade nano-enzyme has a hydrogen sulfide gas release function, and can promote vascular regeneration by up-regulating a hypoxia inducible factor-1 pathway. The cascade nano-enzyme responding to the hyperglycemia microenvironment is combined with a gas treatment mechanism, blood glucose can be effectively consumed, drug-resistant bacterium infection can be eliminated, revascularization can be promoted, and a new strategy is provided for treatment of diabetes wounds infected by drug-resistant bacteria and regeneration of skin tissues.

Method and system for ultrasound treatment. An ultrasound device having at least one tilting ultrasound transducer is deployed onto skin tissue overlying a treatment region of internal tissue of a treated body part. The transducer is induced to transmit ultrasound energy onto skin tissue, such that a body interface implement of the transducer interfaces with the skin tissue surface. A motor-driven oscillator coupled with transducer is oscillated about an oscillation-axis relative to skin tissue surface such that at least one of: a position of the body interface implement, a tilt direction of the body interface implement, and a propagation direction of transmitted ultrasound, oscillates about oscillation-axis. Ultrasound device may be maneuvered to roam over skin tissue along at least one trajectory. Body shape parameters of the treated body part are measured using a measurement assembly including an imaging device, a green screen, and scale markers.

The invention discloses an application of a polypeptide Apelin-13 in a medicine for treating psoriasis, in particular to psoriasis-like skin lesion. In an imiquimod (IMQ) cream induced mouse psoriasis model, intraperitoneal injection of Apelin-13 can significantly reduce scale, erythema and skin thickness, and can inhibit proliferation of epithelial spine cells. HE staining and immunohistochemical staining are carried out on the skin tissue of an experimental mouse, and the result shows that Apelin-13 can reduce the expression of the psoriasis marker protein K17, the thickness of the surface layer of the back side skin of the experimental mouse and the downward extension of a spinous layer. Experimental mouse serum ELISA (enzyme-linked immunosorbent assay) detection results show that the Apelin-13 can be used for down-regulating IL-17A (interleukin-17A) which is highly expressed in psoriasis. The polypeptide Apelin-13 can be used as a medicine for treating psoriasis, especially a medicine for treating psoriasis-like skin lesion.

The invention discloses a multifunctional operation drag hook for animal husbandry and veterinary, and belongs to the field of veterinarians, the multifunctional operation drag hook comprises an operating table, a moving table is assembled on the front side of the operating table, an electric sliding rail is assembled on the top of the moving table, an electric sliding block is assembled on the top of the electric sliding rail, and an electric telescopic rod is fixedly connected to the top of the electric sliding block; the top of the electric telescopic rod is fixedly connected with a drag hook. An extension plate is slidably connected to the inner wall of the drag hook, a sliding groove is formed in the front face of the drag hook, a limiting plate is fixedly connected to the left side of the inner wall of the drag hook, an extrusion block is fixedly connected to the bottom of the extension plate, and a first hydraulic assembly is fixedly connected to the inner wall of the drag hook. Skin tissue can be lifted and opened, the effect of tensioning the skin is achieved, and the operability of an operation area is improved by increasing the contact area of the drag hook and the skin. Particularly, linkage of an air bag, a first hydraulic rod and an extension plate is used, and the stability and the expansion effect of the skin tissue are further ensured through lifting and extrusion.

Disclosed herein is a system for treating skin and / or nails with cold plasma. The system includes a discharge device, which includes a handle and an applicator mounted thereon, and control infrastructure, which includes a waveform generator. The applicator includes an elongated tube housing therein a cathode. The handle includes a flyback amplifier. The waveform generator is configured to induce the flyback amplifier to establish a voltage at the cathode. The voltage produced by the flyback amplifier is configured to generate a self-sustaining Townsend avalanche when a distal end of the tube is positioned sufficiently near a target site on a skin surface or a nail of a subject, such that a cold plasma discharge is produced and directed at the target site and having an average power between about 0.1 μW and about 10 μW, so that the target site is not heated.

The invention firstly discloses application of portulaca oleracea polysaccharide in preparation of the medicine for treating psoriasis, the medicine for treating psoriasis can improve psoriasis-like skin injury and reduce skin tissue inflammation, and the portulaca oleracea polysaccharide is single-component pure polysaccharide extracted from portulaca oleracea and purified. The monosaccharide composition is composed of all or several monosaccharides of rhamnose, arabinose, galactose, glucose, xylose and galacturonic acid, and the molecular weight of the monosaccharide composition is 80-200 kDa. The invention further discloses application of the purslane polysaccharide in preparation of drugs for treating psoriasis and application of the purslane polysaccharide in preparation of cosmetics and medical auxiliary materials for relieving psoriasis-like skin injury. The purslane polysaccharide disclosed by the invention is high in purity, clear in structure and high in safety, has a good psoriasis treatment effect, is superior to dexamethasone in curative effect, can be used as a skin external medicine, a cosmetic, a medical instrument and a medical auxiliary material, and has various potential application values.

The invention relates to the technical field of biological polypeptides, in particular to cyclic pentapeptide-4, a preparation method thereof and a polypeptide cosmetic. The cyclic pentapeptide-4 has a chemical structural formula as shown in a formula I in the specification. Compared with the existing palmitoyl pentapeptide-4, the cyclopentapeptide-4 provided by the invention has good ability to penetrate through an epidermal barrier, so that the cyclopentapeptide-4 can penetrate into skin tissues more deeply, thereby significantly improving the anti-wrinkle and anti-aging ability of the skin. Meanwhile, the expression level of anti-aging genes in human skin fibroblasts can be remarkably improved. Therefore, the cyclic pentapeptide-4 disclosed by the invention can be used for preparing an anti-aging preparation so as to improve the expression level of an anti-aging gene in human skin fibroblasts and further relieve skin aging. # imgabs0 #

The invention relates to a jaw traction device which comprises a support, a lead screw, a fixed traction plate, a movable traction plate and a driving assembly. When an operator presses the button shaft, the ejector rod shaft can be driven to rotate around the axis of the ejector rod shaft through clamping rotation fit between the second clamping part and the first clamping part, then the lead screw is driven to rotate around the axis of the lead screw through meshing transmission between the ejector rod shaft and the lead screw, and therefore the movable traction plate is driven to move along the axis of the lead screw. Furthermore, the distance between the movable traction plate and the fixed traction plate is adjustable, and the movable traction plate and the fixed traction plate can prop open and keep the two ends of the jaw bone by utilizing the screwing self-locking limiting between the screw rod and the movable traction plate; the jaw traction device is designed to be completely implanted into the cheek skin tissue, the operative wound is minimized, accurate traction can be achieved, controllable traction of the jaw is achieved, the living quality of a patient is improved in the traction process, and postoperative nursing difficulty is reduced.

The invention belongs to the crossing field of biomedical engineering, material science and tissue engineering, and discloses multifunctional hydrogel capable of switching mechanical and adhesive properties based on temperature triggering as well as a preparation method and application of the multifunctional hydrogel. The water-based adhesive is prepared from acrylic acid, gelatin, hexadecyl trimethyl ammonium bromide, silver nanoparticle-loaded polydopamine nanoparticles and water. According to the present invention, the good adhesion property and the good mechanical property are provided for the skin tissue, the mechanical property and the adhesion property can be switched, and the adhesion property durability and the adhesion property repeatability are achieved. The temperature-triggered hydrogel prepared by the method has the advantages of simple process, low cost and no introduction of toxic chemical substances, can achieve the effects of tight fitting at body temperature and natural falling at low temperature according to the driving of temperature, still has excellent adhesion performance in a complex environment, and promotes the development of intelligent medical multifunctional wound dressings.

A method of dermocosmetic treatment for skin tissue includes a plurality of treatment laser light sources which are in communication with a rectangular-shaped optical fiber; the optical fiber includes a proximal end to receive laser light from the plurality of treatment laser light sources and a distal end to transmit overlapping laser light to the area of skin tissue to be treated; the plurality of treatment of laser light sources are activated to impinge one or more rectangular-shaped laser light images within one or more rectangular-shaped areas.

The invention relates to the technical field of auxiliary medical treatment, and discloses a cold spraying control method of a radio frequency treatment system and the radio frequency treatment system. The method comprises the following steps: determining a first temperature change rate and a second temperature change rate of skin tissue in a current treatment area; wherein the first temperature change rate represents the temperature response of the skin tissue of the current treatment area to the refrigeration pulse, and the second temperature change rate represents the temperature response of the skin tissue of the current treatment area to the radio frequency pulse; and according to the first temperature change rate and the second temperature change rate, the single-time cold spraying duration of the current refrigeration pulse is determined. According to different responses of the skin tissue to temperature changes, the cold spraying duration is dynamically adjusted, it can be ensured that the temperature of the skin tissue is always kept within a safe and effective range, and it is ensured that the skin tissue in the current treatment area is prevented from being damaged while effective radio frequency treatment is conducted on the skin tissue.

The present invention relates to a method for culturing skin-derived stem cells and uses thereof, and to a method for culturing skin-derived stem cells; skin-derived stem cells produced by the method; a pharmaceutical composition for skin regeneration or wound treatment comprising the skin-derived stem cells produced by the method, a culture thereof, or cells differentiated from the skin-derived stem cells as an active ingredient; a quasi-drug composition; and a cosmetic composition. According to the culture method of the present invention, stem cells can be effectively isolated and obtained from skin tissue. The obtained skin-derived stem cells have excellent pluripotency and self-renewal ability, and have excellent skin regeneration and wound treatment effects, and can therefore be usefully used for skin regeneration and wound treatment or improvement applications.

The invention provides a wound sealing and repairing hydrogel patch and a preparation method thereof. The hydrogel patch is provided with an independent adhesion layer and an adhesion layer and anti-adhesion layer combination. The adhesive layer is prepared from gelatin, N-acryloylated amino acid, acrylic acid-N-succinimide ester, 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone and water through ultraviolet light crosslinking; the anti-adhesion layer is prepared from methacryloyl ethyl sulphobetaine, polyethylene glycol diacrylate, 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone and water through ultraviolet light crosslinking. The hydrogel patch can be used for sealing and repairing wounds of various tissues (such as skin tissues, liver tissues and stomach tissues), the healing time is shortened, the healing effect is improved, the healing time of a skin incision can be shortened from 14 days to 10 days, the hydrogel patch is superior to other treatment modes according to macroscopic photos and related slices, and the hydrogel patch has a good application prospect. And no-injury healing can be realized.

Disclosed are a method for controlling an electrical treatment device with injection function and an electrical treatment device. The method includes: driving ends of a plurality of needle bodies to penetrate at least one target depths of a skin tissue by a actuator, and controlling the plurality of the needle bodies to electrically connect to an electric energy output assembly to release an electric energy at least one target depths of the skin tissue, and / or controlling the plurality of the needle bodies to connect to a liquid storage unit to perform drug injection based on at least one target depths of the skin tissue.