59 results about "Skin tissue" patented technology

The present invention relates to a method for producing a skin tissue model, comprising: (a) isolating and culturing fibroblasts and keratinocytes from skin tissue; (b) preparing a bioink composition for a dermal layer and a bioink composition for an epidermal layer, the bioink composition containing the isolated cells; and (c) producing a skin tissue model using the bioink composition for a dermal layer and the bioink composition for an epidermal layer.

The application provides a kind of simulated human tissue fluid and its preparation method and application, it relates to wireless communication technical field, the simulated human tissue fluid includes: water, 55wt%~75wt% by mass percentage;Ionic inorganic salt, 2wt%~5wt%;Albumin, 10wt%~18wt%;Lipid, 12wt%~20wt%;Non-ionic surfactant, 2wt%~4wt%;Preservative, 0.2wt%~1wt%.Therefore, by water, ionic inorganic salt, albumin, lipid, non-ionic surfactant and preservative cooperate to simulate the skin of human body, so as to be able to carry out APD test in the frequency range of 10GHz~30GHz, and the stability of simulated skin tissue fluid is good, and the cost is lower.

The present application relates to the field of biotechnology, in particular to the application of Radix Rabdosiae Rubescens derived exosomes in the preparation of a drug for promoting wound healing, wherein the prepared Radix Rabdosiae Rubescens derived exosomes are uniform in size, good in appearance, can promote cell proliferation, have good effects of promoting fibroblast migration and reducing scar formation; and a scar-free wound healing hydrogel containing Radix Rabdosiae Rubescens derived exosomes is also provided, wherein the hydrogel can encapsulate rEVs or ORI, can effectively increase the proportion of type III collagen in the new skin tissue, effectively reduce the formation of scars, effectively promote the healing of deep second-degree burn wounds, and effectively inhibit the MMT process of macrophages in the wound healing process, and has a wide application prospect in the field of scar prevention and treatment.

The present disclosure relates to an apparatus (1) for fractional treatment of skin tissue of a patient. The apparatus (1) comprises a handpiece with a housing, at least one first electrode (11) and at least one second electrode (15) located on a distal end of the handpiece and an energy source, which is connected to said at least one first (11) and said at least one second (15) electrode. The apparatus (1) is adapted for applying radio frequency (RF) energy to the tissue. The at least one second electrode (15) is arranged on a base plate (13) and the at least one first electrode (11) is or comprises a pin or a needle (11), in particular a microneedle, which penetrates the base plate (13) through a through hole (17). The apparatus (1) further comprises a vacuum chamber (9) behind the base plate (13) and inside of the housing of the handpiece, which is in fluid communication with the at least one through hole (17) provided in the base plate (13) for exerting attraction onto a surface (33) of the skin tissue towards the at least one first electrode (11) and towards the at least one second electrode (15), when the first electrode (11) and the at least one second electrode (15) is placed in proximity of or is touching the surface (33) of the tissue.

This invention discloses the application of *Lactobacillus animalis* ATCC35046 in the preparation of anti-aging drugs. The *Lactobacillus animalis* ATCC35046 involved in this invention is colonized in dental plaque of primates and in the intestines of dogs and mice. It can significantly reduce the expression of P16 or P21 in brain, bone, muscle, and skin tissues, significantly downregulate the level of aging-related secretory phenotypes in serum, and improve spatial memory, motor function, and muscle function. This provides a theoretical reference and guidance for the development of multi-target, multifunctional anti-aging probiotic preparations.

This disclosure provides a needle-free injector and its assembly and control methods. The needle-free injector includes a nozzle, a drug chamber, a driving fluid chamber, and a housing. The housing includes a guide groove; the driving fluid chamber includes a first side boss corresponding to the guide groove; the drug chamber includes a second side boss corresponding to the guide groove; the nozzle is disposed inside the housing; the driving fluid chamber is disposed inside the housing along the guide groove via the first side boss; the drug chamber is disposed inside the housing along the guide groove via the second side boss; the drug chamber stores the drug to be injected; the driving fluid chamber stores the driving fluid to provide pressure for the needle-free injector; the nozzle sprays the drug from the drug chamber into the patient's skin tissue. This disclosure, through a simple mechanical structure, reduces the number of fixing screws and uses the interlocking of components for fixation, thus reducing the cost of using the needle-free injector as a consumable, thereby reducing the patient's treatment costs.

This product is a medical thread inserted into the skin, such as the face, and used for cosmetic lifting or suturing of skin tissue. The main body is provided with a mesh section and a cog section, which can enhance the lifting or suturing effect.

This invention relates to the medical field, specifically to a cell digestion solution, a method for isolating γδT cells, and its application. The cell digestion solution comprises: collagenase, mammalian serum, antibiotics, a buffer, and a cell culture medium; wherein the collagenase content is 1-4 mg / ml, the mammalian serum content is 5 vol%-15 vol%, the antibiotic content is 0.5 vol%-2 vol%, and the buffer content is 5-15 mM / L. Through the synergistic effect and optimized content of components such as collagenase, mammalian serum, and buffer, the cell digestion solution effectively protects cell viability and surface antigen integrity while efficiently dissociating skin tissue, providing a high-quality cell source for subsequent isolation of rare immune cells.

This product is a medical thread inserted into the skin, such as the face, and used for cosmetic lifting or suturing of skin tissue. The main body is provided with a mesh section and a cog section, which can enhance the lifting or suturing effect.

This application relates to the field of pharmaceutical technology, and in particular to a topical ointment formulation and its preparation method. The formulation uses Sonicate as the active ingredient, combined with petrolatum, liquid paraffin, a solubilizing and penetration-enhancing system, and emulsifiers as excipients, to form an O / W type cream, an oil-based or water-soluble ointment. The preparation process employs a low-temperature dosing method at 40°C to ensure drug activity and inhibit crystallization. This application achieves high-concentration retention in local skin tissue through topical administration, significantly reducing radiation damage scores and pathological damage, while resulting in extremely low systemic plasma exposure, avoiding the systemic toxicity of oral administration, and providing a safe and efficient means for the clinical prevention and treatment of radiation-induced skin damage.

The present disclosure provides an isolated skin tissue comprising an epidermis, a basement membrane, and a dermis, wherein the epidermis is attached to one surface of the basement membrane, and the dermis is attached to the other surface of the basement membrane; and the epidermis comprises first cells, and the dermis comprises second cells, wherein the second cells have no ability to differentiate into mature epidermal cells.

This invention relates to the field of skin tissue repair material manufacturing, and particularly to a porous polyurethane dermal scaffold and its preparation method. The preparation method of the porous polyurethane dermal scaffold includes the following steps: adding dibutyltin dilaurate, triethylenediamine, butanediol, and silicone oil sequentially to polyethylene glycol and mixing thoroughly to obtain a mixed solution; adding lysine diisocyanate and ultrapure water to the mixed solution and mixing thoroughly to obtain a mixture; placing the mixture in a mold and allowing it to foam and solidify, then curing, demolding, washing, and drying to obtain the porous polyurethane dermal scaffold. The preparation method of this invention is simple, the material has a pore size of 30-200 μm, a porosity > 95%, a tensile strength of 10-12 N / cm, an elongation at break > 50%, is non-toxic and non-immunogenic, and meets the biocompatibility requirements of standards such as GB / T 16886, showing great application potential in wound dressings and skin tissue engineering.

The present disclosure provides a needleless injector, which comprises a drug liquid chamber, a first one-way valve and a nozzle; the first one-way valve is arranged outside the outlet of the drug liquid chamber and in the inner cavity of the nozzle; the drug liquid chamber is used for storing the drug to be injected; the first one-way valve is used for allowing the drug to flow from the drug liquid chamber to the nozzle in one direction; and the nozzle is used for spraying the drug liquid into the skin tissue of a patient. The present disclosure realizes the one-way flow of the drug through the first one-way valve and the second one-way valve. The drug is allowed to flow only from the drug feeder to the drug liquid chamber and only from the drug liquid chamber to the nozzle. The backflow of the drug is prevented, the injection efficiency is increased, and the accurate control of the injection amount of the drug is promoted.

The application of bazedoxifene as an active ingredient in the preparation of a drug for blocking the differentiation of fibroblasts of the IL-6 family / gp130 signal axis. It has been verified that in the microenvironment of skin tissue, the early or very early appearance of pro-fibrotic stimulating factors (such as IL-11 and / or IL-6) can significantly inhibit the initiation of the pro-fibrotic molecular program, avoid the abnormal activation of myofibroblasts, thereby inhibiting the differentiation of fibroblasts into myofibroblasts, and can effectively inhibit the fibroblast migration of skin fibroblasts induced by pro-fibrotic stimulating factors (especially IL-11), effectively prevent skin fibrosis, and thereby prevent the formation of keloid.

The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of skin cells and skin tissues, for preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism, in skin cells. Finally, the invention relates to a nontherapeutic cosmetic process for caring for keratin materials comprising the topical application of such a composition.

This invention discloses a near-infrared photoresponsive hydrogel, its preparation method, and its application in wound repair. The method includes the following steps: S1, modifying chitosan with 1,3-propanesulfonate lactone to prepare sulfonated chitosan; S2, mixing sulfonated chitosan solution, chitosan solution, genipin solution, and NaOH solution to prepare a hydrogel solution; S3, blending MXene, MOF, and the hydrogel solution to prepare a near-infrared photoresponsive hydrogel. The composite hydrogel provided by this invention utilizes the biomimetic structure and good biocompatibility of sulfonated chitosan, combined with the photothermal properties of MXene and the catalytic and ion-release characteristics of MOF, to achieve a dual function of broad-spectrum and highly effective antibacterial activity and multi-pathway promotion of skin tissue regeneration. This provides a novel integrated solution for the treatment of infected wounds, combining anti-infection, promotion of vascularization, and re-epithelialization.

The application provides a film structure, a screen body, a light therapy device and a wearable device. The film structure is suitable for a light therapy device and a wristband device, and is arranged on the side of the light therapy device and the wristband device in contact with the skin tissue. The film structure comprises a hydrophobic layer, a flow guide layer and a hydrophilic layer arranged in order from weak to strong in terms of hydrophilicity. The hydrophilic layer is arranged close to the side of the light therapy device and the wristband device. The hydrophobic layer, the flow guide layer and the hydrophilic layer are made of a light-transmitting material or a light-transmitting composite material. The application can enable sweat to spontaneously move from the hydrophobic layer to the hydrophilic layer side, guide the sweat from the layer close to the skin to the layer far from the skin, and achieve the effects of moisture absorption, sweat removal and air permeation. In addition, the layers of the film structure are made of a light-transmitting material or a light-transmitting composite material, which can avoid affecting the treatment and detection effects of the light therapy device and the portable wearable device.

This disclosure provides a laser therapy device and its control method. The laser therapy device includes: a beam transmission module, a handpiece, and a needle-free injector; one end of the handpiece is threadedly connected to the light outlet of the beam transmission module; the other end of the handpiece is threadedly connected to the needle-free injector; the handpiece is used to receive a first laser beam emitted from the beam transmission module, to shape and focus the first laser beam, and to change the optical parameters of the first laser beam; the needle-free injector is used to receive a second laser beam emitted from the handpiece to drive the injection of a drug solution into the patient's skin tissue. This disclosure achieves a rotary connection by threading the beam transmission module, handpiece, and needle-free injector, resulting in a simple structure and minimalist appearance for the laser therapy device, making it convenient for the operator to use.

The application provides a high-axial-support expansion catheter, relates to the technical field of medical devices, and comprises a luer joint; an expansion tube section connected with the luer joint; the expansion tube section comprises a first tube section, a second tube section and a third tube section arranged in sequence in the direction away from the luer joint; the second tube section comprises an inner layer and an outer layer wrapped outside the inner layer; the outer layer is provided with an elastomer, and the hardness of the elastomer is lower than the hardness of the inner layer, the first tube section and the third tube section. When the expansion catheter is used in cooperation with an outer sheath with a complex bending shape, the corresponding bending position of the expansion catheter has high axial strength and sufficient flexibility, so that the expansion catheter can smoothly pass through skin tissue or an atrial septum and the like, the influence of the angle change of the outer sheath is small when the outer sheath is withdrawn, and the sheath can be ensured to be left in a predetermined position.

The application discloses a kind of for tissue adhesion and repair mussel biomimetic flexible sustained-release gel film, including flexible sustained-release gel film matrix and active ingredient loaded in the matrix.The flexible sustained-release gel film matrix is composed of mussel extraction protein, silk fibroin, collagen, crosslinking agent, gold yellow chamomile vesicle-phospholipid complex, deionized water;The active ingredient is composed of sandalwood essential oil, tea tree essential oil, ekdoine, dextran.The application adopts mussel extraction protein, silk fibroin and collagen compound as matrix, adopts gold yellow chamomile vesicle-phospholipid complex as carrier material, and is prepared by specific crosslinking agent, and the gel film obtained has excellent wet-state adhesive property, good mechanical property and biocompatibility, can realize the sustained slow release of active ingredient, effectively promote the repair and regeneration of skin tissue, and can be widely applied in wound dressing, medical instrument coating, tissue engineering scaffold and other fields.

The present invention relates to a gel composition for wound dressing comprising alloferon as an active ingredient, wherein the composition comprises alloferon having excellent anti-inflammatory activity, and further comprises additional components capable of forming a physical barrier on damaged skin tissue to protect a wound site and to provide and retain moisture. The composition of the present invention protects a wound site vulnerable to ultraviolet radiation, alleviates inflammation, and prevents destruction of elastic fibers in the skin and epidermal hyperplasia. Accordingly, the composition can be advantageously utilized as a gel composition for wound dressing to prevent, ameliorate, alleviate, or treat skin inflammation induced by ultraviolet radiation.

The present application relates to a kind of jaw traction device, including jaw tractor and magnetic control handle, jaw tractor is used to be implanted completely into buccal skin tissue, jaw tractor includes support, screw rod, fixed traction plate, movable traction plate, magnetic drive assembly and transmission assembly, fixed traction plate is set on support;Screw rod is rotationally arranged on support, movable traction plate is screwed on screw rod;Magnetic drive assembly is connected with one end of screw rod by transmission assembly;Magnetic control handle is located outside the buccal skin tissue, when magnetic control handle is close to magnetic drive assembly, magnetic drive assembly can autorotation under the magnetic force traction of magnetic control handle, to drive screw rod rotates around its axis by transmission assembly, to drive movable traction plate moves along the axis of the screw rod;Transmission assembly is used to realize the storage and release of the energy output by magnetic drive assembly.

This invention belongs to the field of magnetic materials technology, and relates to an injectable multifunctional magnetic hydrogel, its preparation method, and its applications. The injectable multifunctional magnetic hydrogel comprises the following components: aldehyde-modified Prönnicke F127; carboxymethyl chitosan; ε-polylysine-modified iron(III) oxide; and phosphate buffer. The aldehyde-modified Prönnicke F127 can undergo a Schiff base reaction with amino groups in skin tissue, endowing the hydrogel with excellent tissue adhesion. The ε-polylysine-modified iron(III) oxide not only has the ability to rapidly scavenge reactive oxygen species, but also acts as a small molecule crosslinking agent to accelerate the hydrogeling process, and binds to negatively charged plasma proteins and platelets in the blood through electrostatic interactions. The prepared magnetic hydrogel exhibits rapid gelation, good rheological properties, adhesive properties, hemostatic properties, and excellent biocompatibility, and can synergistically promote wound healing and angiogenesis under external magnetic field stimulation.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

The application relates to the technical field of gel patches, in particular to a hydrogel patch and a preparation method thereof, which comprises a gel layer, and the material of the gel layer comprises, according to mass fraction ratio, 10-20 mass fractions of sodium polyacrylate, 1-3 mass fractions of glycoxy aluminum, 40-70 mass fractions of a moisturizing agent, 8-15 mass fractions of a tackifier, 10-20 mass fractions of propylene glycol, 1-5 mass fractions of an antibacterial agent and 1-2 mass fractions of kaolin, wherein the antibacterial agent comprises nano-zinc oxide or / and nano-silver. The hydrogel patch provided in the application has an effective time of up to 48 hours or more than 48 hours, and has a long effective time. The hydrogel patch provided in the application has a bacteriostatic function, can reduce the proliferation of anaerobic bacteria, can reduce the stimulation to skin tissues and can reduce the risk of inflammation or infection.

The present application provides a kind of human umbilical cord mesenchymal stem cell freeze-dried powder and its preparation method and application.The freeze-dried powder is prepared by stem cell and a composite protective agent containing trehalose, human serum albumin and recombinant Oligosarcus microlepidotus III type antifreeze protein mutant (rZaAFPIII-M) by specific programmed freeze-drying process. Among them, the rZaAFPIII-M is obtained by site-directed amino acid replacement, with improved stability and solubility. The technical scheme makes the obtained freeze-dried stem cells not only have high cell survival rate after recovery, but also can significantly maintain the ability of key paracrine repair factors and the biological activity to skin target cells, and the comprehensive effect is comparable to traditional cryopreservation. The product has good storage stability under refrigerated conditions, can be conveniently used in the preparation of skin tissue repair drugs or cosmetics with anti-aging and moisturizing effects, and provides a new solution for the standardization and industrialization of stem cell preparations.

The present application relates to the technical field of biological materials, and particularly relates to a collagen microneedle transdermal patch and a preparation method thereof.The collagen microneedle transdermal patch comprises a substrate and a microneedle array perpendicular to the substrate, and the microneedle array is made of microneedle slurry dried and solidified; the microneedle slurry comprises the following raw materials: collagen 4-8 mg / mL, high molecular weight sodium hyaluronate 2-4 mg / mL, nano-keramite 0.3-0.5 mg / mL, and alkyl glucoside 0.001-0.002 mg / mL; the particle size of the nano-keramite is 20-80 nm; and the solvent of the microneedle slurry is water.The present application uses the adsorption, softening and dehydration hardening characteristics of nano-keramite to strengthen the microneedle, control the release of collagen, and realize the functional repair and regeneration of skin tissue.Alkyl glucoside as a dispersing agent can uniformly disperse nano-keramite in the microneedle slurry containing collagen and high molecular weight sodium hyaluronate, and improve the mechanical strength of the microneedle on the microneedle transdermal patch.

The application discloses a therapeutic instrument and a control method and storage medium thereof, and belongs to the field of electronic devices. The therapeutic instrument comprises a signal generator, a probe, multiple groups of electrodes, a switching circuit and a control unit. The multiple groups of electrodes are located on the probe. The switching circuit is connected between the signal generator and the multiple groups of electrodes. The control unit controls the on-off of the switching circuit, so that the signal generator is in communication with at least one group of electrodes in the multiple groups of electrodes, and a treatment signal is output. Through the therapeutic instrument, energy can be output to only a local area, the surface of skin tissue in a narrow space can be attached, and the skin tissue in the narrow space can be treated. Meanwhile, when only part of the electrodes are in communication with the signal generator, the output power of the signal generator can be concentrated on the part of the electrodes that need to output the treatment signal, so that the treatment efficiency of the therapeutic instrument is improved, and energy waste is avoided.

The application discloses ALDH1A1 The application discloses a gene and a protein in application of promoting hair follicle cell proliferation, and belongs to the technical field of functional gene application. ALDH1A1 The application discloses that overexpression of the gene can significantly promote hair follicle cell proliferation, and the ALDH1A1 protein is expected to be used for preparing a product for promoting hair follicle cell proliferation or damage repair, thereby providing a new and safe candidate preparation for improving the problem of hair loss. ALDH1A1 The application discloses that the expression amount of the gene in skin tissue is significantly higher than that in other tissues; compared with hair follicles in a regression period and a resting period, the expression amount of the gene in hair follicles in a growth period is the highest; and the structural and composition analysis results of the ALDH1A1 protein are provided.