20 results about "Skin function" patented technology

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning, and / or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

The invention belongs to the technical field of polyacrylamide hydrogel, and discloses rapid temperature-sensitive response polyacrylamide composite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving N-isopropylacrylamide NIPAM, acrylic acid AA, [2-(methylacryloyloxy)-ethyl] dimethyl-(3-sulfopropyl) SBMA, an initiator and a chemical cross-linking agent in an amphiphilic cellulose acetate WSCA solution, mixing and stirring until a uniform and transparent hydrogel precursor solution is formed, and carrying out cross-linking polymerization on the obtained hydrogel precursor solution to obtain the hydrogel. Finally, the polyacrylamide composite hydrogel with rapid temperature-sensitive response is generated, and the polyacrylamide composite hydrogel is marked as the WSCA-PNSA composite temperature-sensitive hydrogel. The composite thermosensitive hydrogel provided by the invention has a phospholipid-like characteristic, so that the PNIPAM hydrogel has high thermosensitive driving force while realizing rapid thermal shrinkage, skin functional recovery can be promoted, and rapid and scar-free wound healing is realized.

The present invention aims to provide a skin function improving agent, a neurotrophic factor production promoting agent, and a CXCL1 production inhibitor containing peony extract and rose water. [Solution] The present invention provides a skin function improving agent, a neurotrophic factor production promoting agent, and a CXCL1 production inhibitor containing peony extract and rose water.

The invention discloses application of R-1, 3-butanediol in preparation of anti-aging cosmetics or medicines, and relates to the technical field of cosmetics. According to the embodiment of the invention, the R-1, 3-butanediol is applied to the skin, and the R-1, 3-butanediol is explored and proved to be capable of exceeding the traditional physical and chemical functions of R-1, 3-butanediol, being utilized by cells, participating in the energy metabolism process of the skin cells, regulating the energy metabolism of mitochondria and regulating the expression of AMPK protein in the skin cells; the skin function is improved from the fundamental level of cell energy supply, and the skin aging problem caused by cell metabolism decline is resisted. The positioning and action mechanism is different from all known traditional applications, and represents a brand-new application mode of the component in cosmetics based on cytobiology. The functional skin care product is expected to be promoted to be upgraded to the direction of cellular metabolism regulation, and is popularized and applied.

The present invention relates to a composition for improving skin function, containing Lactobacillus plantarum as an active ingredient and, specifically, to a composition having the effects of activating primary cilia, improving skin barrier function, soothing skin, reducing skin wrinkles, whitening skin, and inhibiting melanin production, the composition containing a Lactobacillus plantarum beLP1 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or dead cells thereof as an active ingredient.

The application belongs to the technical field of protein engineering, and discloses a humanized collagen type ⅩⅦ polypeptide and a preparation method and application thereof. The amino acid sequence of the humanized collagen type ⅩⅦ polypeptide is shown as SEQ ID NO. 1, and the polynucleotide sequence encoding the humanized collagen type ⅩⅦ polypeptide is shown as SEQ ID NO. 2. The application also provides application of the polypeptide in preparation of a protein product with the functions of preventing hair loss, repairing, anti-wrinkle and skin tightening. The efficacy detection at the cell level proves that the prepared humanized collagen type ⅩⅦ polypeptide can promote the proliferation of hair papilla cells, keratinocytes and fibroblasts, and promote the up-regulation of the expression of the β-Catenin signal pathway protein closely related to hair growth in the hair papilla cells, thereby proving that the humanized collagen type ⅩⅦ polypeptide has the efficacy of preventing hair loss and / or repairing, anti-wrinkle and skin tightening.

The application discloses a nanofiber membrane material with temperature-sensitive controlled release, and preparation and application thereof. In the application, the nanofiber membrane material comprises a shell layer and a core layer formed by using a coaxial electrospinning technology; the shell layer comprises a polymer material with temperature-sensitive response; the core layer is a skin function material for producing various effects on the skin in the shell layer; and the polymer material with temperature-sensitive response is dissolved or swelled at 35-40 DEG C to release the core layer. Through the special shell-core structure, the active factor can be completely wrapped in the oxygen-light shielding shell layer material before use; when used, the shell layer material is rapidly dissolved or swelled to release the active factor, and the effects of moisturizing, whitening, wrinkle removing and anti-allergy are achieved; and the problems of unstable active ingredient, preservative or stabilizer harmful to the skin in traditional masks can be effectively solved, so the application has a wide application prospect.

The present disclosure provides use of a device for applying negative pressure to the whole body of an individual in the manufacture of a device for treating diseases, resisting aging, promoting skin functions, and / or achieving non-therapeutic cosmetic purposes. Provided is a method for treating diseases, resisting aging, promoting skin functions, and / or achieving non-therapeutic cosmetic purposes for an individual, which comprises applying negative pressure to the whole body of the individual.

This invention belongs to the field of tissue engineering and regenerative medicine technology, specifically a multi-layered biomimetic skin structure and its synchronous bio-3D printing preparation method and system, comprising a sequentially combined epidermal layer and dermal layer. This invention highly mimics natural skin through a multi-layered structure. A micropillar array in the dermal layer provides a strong mechanical anchor between the epidermis and dermis, while embedded PLGA microspheres can sustainably release VEGF and EGF for 3-4 weeks, continuously promoting repair. Integrated vascular network channels and nerve guidance structures address the challenges of nutrient delivery and the lack of neural perception function, respectively, filling the functional gaps in traditional biomimetic skin. The synchronous bio-3D printing process enables integrated fabrication of the multi-layered structure. Combined with a four-channel printhead and a multi-physics coupling module, along with a visual positioning and pressure feedback system, printing accuracy and stability are ensured, preventing filament breakage or ink overflow. An intelligent cultivation system simulates the physiological environment, further enhancing skin maturity. This invention is applicable to the repair of skin defects such as burns and chronic ulcers.

The invention relates to an anti-initial-aging face cream composition with a liquid crystal emulsification effect and a preparation method of the anti-initial-aging face cream composition. The composition comprises an emulsifier (such as polyglycerol-10 stearate and / or polyglycerol-5 oleate and 7-dehydrocholesterol), a thickening agent, grease, a solvent, a preservative and a plurality of natural effective components (such as a calendula extract, a raspberry leaf extract, DNA sodium and the like). A stable and ordered liquid crystal structure is formed through preparation by a PI T phase transformation method, and the effective existence time exceeds 6 months. The face cream can help cells to resist irritation, repair cell damage and coordinate skin functions, achieves the effects of resisting wrinkles, preserving moisture, resisting oxidation, brightening skin color and the like, meanwhile reduces irritation, improves skin feeling and is suitable for being used for a long time. The preparation method is simple, the addition amount of glycerin is small, the face cream is fresh and non-sticky in texture, and the active ingredients have a strong synergistic effect.

A formulation for use as a medicament for the prevention and / or treatment of skin dysfunction in humans, comprising or consisting of (a) a hydroxypinacolone retinoate (I), and optionally (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) at least one antioxidant.

The invention discloses a biological active element, and belongs to the technical field of biological active elements, and the biological active element is prepared by the following steps: S1, selecting 30 herbal raw materials, screening at the same time, and crushing the herbal raw materials; s2, respectively putting three parts of 30 herbal raw materials into three parts of cellulase solutions to form a first enzymatic hydrolysate, a second enzymatic hydrolysate and a third enzymatic hydrolysate for later use; according to the invention, 30 natural herbal raw materials including pseudo-ginseng, ginseng, American ginseng, gastrodia elata, stigma croci, ganoderma lucidum, cordyceps sinensis and other traditional Chinese medicinal materials with the effects of promoting blood circulation to remove blood stasis, benefiting qi, nourishing blood, tonifying kidney, invigorating spleen, resisting oxidation and the like are selected, and aloe, purslane, collagen and other functional components are supplemented, so that the health of the body can be maintained through scientific proportioning; the body skin function is improved to be in the best physiological state, the biological vitality element activated cells can protect and repair the injured skin to the maximum extent without forming scar vitality, the skin is kept safe and young, and the whole life process of skin aging is delayed.

The invention relates to application of Antarctic red in preparation of a composition with a skin tightening function, and belongs to the technical field of biology, the Antarctic red is derived from a fungus Geomyces sp.wnf-18C or a fermentation product of Geomyces sp.wnf-15A, the preservation number of the Geomyces sp.wnf-18C is CCTCC NO: M2019086, and the preservation number of the Geomyces sp.wnf-15A is CCTCC NO: M2012255. The Antarctic red has no toxicity to cells when the concentration is not higher than 250g / mL, and the Antarctic red can significantly improve the cell viability of human-derived fibroblasts and has the effect of increasing skin compactness.

The invention provides a skin grafting device which comprises a skin taking structure and a driving part, the skin taking structure comprises a plurality of skin taking parts, each skin taking part comprises a tool bit and a first connecting part, the first connecting parts extend in the first direction, and the tool bits are connected to the ends, in the first direction, of the first connecting parts; the other end, in the first direction, of the first connecting part is rotatably connected to the driving part, the multiple skin taking parts are arranged at intervals in the direction perpendicular to the first direction, and the driving part is used for driving the skin taking parts to rotate around the axis parallel to the first direction. The multiple skin taking parts take skin at the same time, the skin taking efficiency is remarkably improved, in the rotation process of the skin taking parts, the tool bit extracts skin tissue, tiny autologous skin extracted by the skin taking parts carries hair follicles, sweat glands, melanocytes and the like, and the multiple skin taking parts carry the autologous skin to be implanted into allogeneic skin or artificial skin at the same time, so that a complete skin function reconstruction basis is provided, and the skin taking efficiency is improved. Therefore, the skin transplantation effect and the skin transplantation efficiency are improved, and meanwhile, a smaller wound is generated on a skin tissue donor region.

The invention discloses a composition for benefiting qi, nourishing blood, maintaining beauty and keeping young and a preparation method thereof, and belongs to the technical field of compositions for maintaining beauty and keeping young. Comprising codonopsis pilosula, bighead atractylodes rhizome, Chinese yam, white hyacinth bean, fructus amomi, poria cocos, amomum cardamomum, curculigo orchioides, angelica sinensis, prepared rehmannia root, white paeony root, ligusticum wallichii, donkey-hide gelatin, red dates, ginseng, longan, astragalus membranaceus, Sinkiang alkanet powder, yarrow leaf powder, broom photinia root powder, pork liver powder and codonopsis lanceolata root powder. The traditional Chinese medicine formula of codonopsis pilosula, angelica sinensis and the like solves the internal root of deficiency of spleen and stomach qi and deficiency of qi and blood caused by endocrine dyscrasia, and builds a firm foundation for skin health; meanwhile, by relying on herbal extracts such as yarrow herb and blue-ear grass, external problems such as skin oxidation, inflammation and barrier injury are solved, the yarrow herb and the blue-ear grass form positive circulation of internal nutrition supply, skin function enhancement and surface layer repair enlargement, and finally the synergistic effects of benefiting qi, nourishing blood and maintaining beauty and keeping young are achieved.

This invention relates to a multi-effect skincare essence for improving skin function and its preparation method. The invention supplements essential lipids and phospholipid precursors for the skin by adding linoleic acid and ethanolamine, strengthening the stratum corneum barrier and cell membrane structure integrity. It also adds serum albumin to address the poor water solubility and easy oxidation of linoleic acid and ethanolamine, improving the stability and skin affinity of the active ingredients. Simultaneously, it adds stable inorganic salts of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum to enhance the skin's anti-aging, repair, and firming abilities. Furthermore, it adds transferrin, which, on the one hand, blocks iron-mediated Fenton reactions and free radical generation, reducing photoaging and oxidative stress damage; on the other hand, transferrin prevents oxidative inactivation of linoleic acid, vitamins, selenium, tin, and other components under iron ion catalysis, reducing oxidative loss and protecting the formula's activity. Thus, it synergistically achieves effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone.

The application belongs to the technical field of scarless skin lesion repair, and particularly relates to a magnetic particle-protein fiber dressing as well as a preparation method and application thereof. The magnetic nanoparticles are coated to obtain coated magnetic nanoparticles, the coated magnetic nanoparticles are mixed with a water-soluble copper salt and water to load copper ions, the coated magnetic nanoparticles loaded with copper ions are mixed with functional proteins and a buffer solution to be incubated, the obtained magnetic microsphere-protein composite solution is placed in an external magnetic field to be magnetically attracted, and then directional assembly is carried out in the external magnetic field to obtain a magnetic particle-protein fiber assembly. The magnetic particle-protein fiber assembly and the medical dressing coated with the magnetic particle-protein fiber provided by the application can realize rapid scarless repair of a wound and restore the integrity of skin function, and the preparation method is simple, and the application has important clinical application value and market prospect.

The application belongs to the technical field of protein engineering, and discloses a humanized collagen type VII polypeptide and a preparation method and application thereof. The amino acid sequence of the humanized collagen type VII polypeptide is shown as SEQ ID NO. 1, and the polynucleotide sequence encoding the same is shown as SEQ ID NO. 2. The application also provides application of the polypeptide in preparation of a protein product with the functions of preventing hair loss, and / or repairing, anti-wrinkle and skin tightening. The application proves that the humanized collagen type VII polypeptide can promote proliferation of hair papilla cells, keratinocytes and fibroblasts, promote up-regulation of expression of β-Catenin signal pathway protein in hair papilla cells which is closely related to hair growth, and promote up-regulation of expression of collagen type III, collagen type IV, collagen type VII, fibronectin and elastin in fibroblasts, thereby proving that the polypeptide has the functions of preventing hair loss, and / or repairing, anti-wrinkle and skin tightening.

The present disclosure discloses a mesh body data synchronization method and device, a storage medium and an electronic device. The method comprises: determining a first mesh body configured with a skin function and a skin parameter; determining a second mesh body which is not configured with a skin function and corresponding skin parameter; synchronizing the skin function corresponding to the first mesh body to the second mesh body, so that the instruction area corresponding to the second mesh body includes the skin function; in response to the skin function not being at the target position of the instruction area, resetting the instruction area in the second mesh body, so that the skin function is at the target position in the instruction area of the second mesh body; and in response to the skin function being at the target position in the instruction area of the second mesh body, synchronizing the skin parameter corresponding to the first mesh body to the skin function corresponding to the second mesh body. The present disclosure solves the technical problem of low synchronization efficiency in the prior art when synchronizing the skin parameter of the mesh body.