38 results about "Skin function" patented technology

The invention belongs to the technical field of tissue engineering, and particularly discloses a preparation method of a 3D full-thickness skin model. The preparation method provided by the invention comprises the following steps: constructing a corium layer, constructing an inner epidermal layer through first epidermal inoculation, constructing an epidermal layer through second epidermal inoculation and obtaining a complete 3D full-thickness skin model through co-culture. The 3D full-thickness skin model obtained through the preparation method is distinct in gradation, uniform in thickness, free of shrinkage and stable in quality, the epidermal layer and the corium layer are uniformly fused, and the 3D full-thickness skin model is suitable for skin function research and sample evaluation. Meanwhile, the preparation method provided by the invention is simple in process and convenient to operate, does not need additional reagents or anti-shrinkage tools, can meet the requirements of large-scale industrial production, and has good production feasibility and market application prospects.

The invention provides an elastin peptide-containing composition as well as a preparation method and application thereof. The elastin peptide-containing composition comprises elastin peptide, camel milk active small molecule peptide and water lily oligopeptide in a mass ratio of 1: (1-3): (1.8-2.5). The elastin peptide, the camel milk active small molecule peptide and the water lily oligopeptide which are obtained through a specific treatment mode are compounded according to a specific proportion, synthesis of aquaporin AQP3 can be promoted, the content of sodium hyaluronate is increased, and the free radical scavenging activity is improved. The composition containing the elastin peptide can quickly and efficiently improve the skin state, repair the skin, delay the skin aging, enhance the skin function and recover the elasticity. The composition containing elastin peptide can promote the proliferation and growth of fibroblasts, improve the cell viability and promote the healing of skin wounds, and is non-toxic to cells.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The utility model discloses a negative pressure cabin for providing negative pressure for individuals, mainly relates to the field of medical facilities, in particular to a negative pressure cabin with an oxygen delivery device, and provides a negative pressure cabin which comprises a cabin body, a negative pressure device arranged on the cabin body and an oxygen delivery device arranged on or in the cabin body. Such a negative pressure compartment may be used for treating disease, resisting aging, promoting skin function, and / or beautifying for non-therapeutic purposes.

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning, and / or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

The invention belongs to the technical field of polyacrylamide hydrogel, and discloses rapid temperature-sensitive response polyacrylamide composite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving N-isopropylacrylamide NIPAM, acrylic acid AA, [2-(methylacryloyloxy)-ethyl] dimethyl-(3-sulfopropyl) SBMA, an initiator and a chemical cross-linking agent in an amphiphilic cellulose acetate WSCA solution, mixing and stirring until a uniform and transparent hydrogel precursor solution is formed, and carrying out cross-linking polymerization on the obtained hydrogel precursor solution to obtain the hydrogel. Finally, the polyacrylamide composite hydrogel with rapid temperature-sensitive response is generated, and the polyacrylamide composite hydrogel is marked as the WSCA-PNSA composite temperature-sensitive hydrogel. The composite thermosensitive hydrogel provided by the invention has a phospholipid-like characteristic, so that the PNIPAM hydrogel has high thermosensitive driving force while realizing rapid thermal shrinkage, skin functional recovery can be promoted, and rapid and scar-free wound healing is realized.

Provided is an oral composition containing β-nicotinamide mononucleotide (β-NMN) and a proteoglycan as active ingredients. The composition can be used for improving joint function as well as skin function.

The invention belongs to the technical field of protein engineering, and discloses a humanized collagen XVII type polypeptide as well as a preparation method and application thereof. The amino acid sequence of the humanized collagen XVII type polypeptide is as shown in SEQ ID NO.1, and the polynucleotide sequence for coding the humanized collagen XVII type polypeptide is as shown in SEQ ID NO.2. The invention also provides application of the polypeptide in preparation of a protein product with functions of preventing hair loss and growing hair and / or repairing, resisting wrinkles and tightening skin. The application proves that the humanized collagen XVII type polypeptide can promote proliferation of hair papilla cells, keratinocytes and fibroblasts and promote up-regulation of expression of beta-Catenin signal channel protein closely related to hair growth in the hair papilla cells; the up-regulation expression of fibroblast type III collagen, type IV collagen, type VII collagen, fibronectin and elastin is promoted, so that the polypeptide is proved to have the effects of preventing hair loss and growing hair and / or repairing, resisting wrinkles and tightening skin.

The present invention aims to provide a skin function improving agent, a neurotrophic factor production promoting agent, and a CXCL1 production inhibitor containing peony extract and rose water. [Solution] The present invention provides a skin function improving agent, a neurotrophic factor production promoting agent, and a CXCL1 production inhibitor containing peony extract and rose water.

The invention discloses a double-bionic wound dressing with seepage management and self-power generation functions as well as a preparation method and application of the double-bionic wound dressing. The double-bionic wound dressing comprises a first electrode layer, a blocking layer, a moisture absorption power generation layer, a diffusion antibacterial layer, an evaporation power generation layer and a second electrode layer which are sequentially stacked from bottom to top. The electrostatic spinning fiber membrane with high biocompatibility is adopted, a liquid transport mechanism of plant transpiration and an ion active transport principle of electric ray power generation cells are combined through bionic design, the triple functions of wound surface antibiosis, efficient seepage management and stable power generation are achieved, the wound surface microenvironment is regulated and controlled, and the wound surface antibacterial effect is achieved. Excessive inflammation caused by seepage accumulation is effectively avoided, fibroblast migration, angiogenesis and skin appendage regeneration are remarkably promoted, wound healing is accelerated, skin function recovery is facilitated, and a new treatment mode is provided for burn wound repair.

The invention discloses application of R-1, 3-butanediol in preparation of anti-aging cosmetics or medicines, and relates to the technical field of cosmetics. According to the embodiment of the invention, the R-1, 3-butanediol is applied to the skin, and the R-1, 3-butanediol is explored and proved to be capable of exceeding the traditional physical and chemical functions of R-1, 3-butanediol, being utilized by cells, participating in the energy metabolism process of the skin cells, regulating the energy metabolism of mitochondria and regulating the expression of AMPK protein in the skin cells; the skin function is improved from the fundamental level of cell energy supply, and the skin aging problem caused by cell metabolism decline is resisted. The positioning and action mechanism is different from all known traditional applications, and represents a brand-new application mode of the component in cosmetics based on cytobiology. The functional skin care product is expected to be promoted to be upgraded to the direction of cellular metabolism regulation, and is popularized and applied.

The present invention relates to a composition for improving skin function, containing Lactobacillus plantarum as an active ingredient and, specifically, to a composition having the effects of activating primary cilia, improving skin barrier function, soothing skin, reducing skin wrinkles, whitening skin, and inhibiting melanin production, the composition containing a Lactobacillus plantarum beLP1 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or dead cells thereof as an active ingredient.

The application belongs to the technical field of protein engineering, and discloses a humanized collagen type ⅩⅦ polypeptide and a preparation method and application thereof. The amino acid sequence of the humanized collagen type ⅩⅦ polypeptide is shown as SEQ ID NO. 1, and the polynucleotide sequence encoding the humanized collagen type ⅩⅦ polypeptide is shown as SEQ ID NO. 2. The application also provides application of the polypeptide in preparation of a protein product with the functions of preventing hair loss, repairing, anti-wrinkle and skin tightening. The efficacy detection at the cell level proves that the prepared humanized collagen type ⅩⅦ polypeptide can promote the proliferation of hair papilla cells, keratinocytes and fibroblasts, and promote the up-regulation of the expression of the β-Catenin signal pathway protein closely related to hair growth in the hair papilla cells, thereby proving that the humanized collagen type ⅩⅦ polypeptide has the efficacy of preventing hair loss and / or repairing, anti-wrinkle and skin tightening.

The invention is suitable for the technical field of temperature-sensitive hydrogel, and provides a temperature-sensitive hydrogel capable of promoting wound healing and a preparation method and application thereof, the temperature-sensitive hydrogel comprises the following raw materials: hydroxybutyl chitosan, oxidized bletilla striata polysaccharide, an alkannin cerium complex and an injection aqueous solution; wherein in the hydrogel, the concentration of the hydroxybutyl chitosan is 1 to 200 mg / mL, the concentration of the oxidized bletilla striata polysaccharide is 1 to 200 mg / mL, and the concentration of the alkannin cerium complex is 1 to 50 mg / mL. According to the present invention, the strong wound healing promoting effect can be provided through the synergistic multiple effects of wound microenvironment adjustment, bacteriostasis, active oxygen removal and the like, and the temperature-sensitive wound healing promoting agent further has characteristics of temperature sensitivity and good wound fitting and sealing property, can be widely used in the preparation of the wound healing promoting drug, and further has advantages of wide application prospect and wide application prospect. The wound area is reduced, and the skin function recovery at the wound is promoted.

The application discloses a nanofiber membrane material with temperature-sensitive controlled release, and preparation and application thereof. In the application, the nanofiber membrane material comprises a shell layer and a core layer formed by using a coaxial electrospinning technology; the shell layer comprises a polymer material with temperature-sensitive response; the core layer is a skin function material for producing various effects on the skin in the shell layer; and the polymer material with temperature-sensitive response is dissolved or swelled at 35-40 DEG C to release the core layer. Through the special shell-core structure, the active factor can be completely wrapped in the oxygen-light shielding shell layer material before use; when used, the shell layer material is rapidly dissolved or swelled to release the active factor, and the effects of moisturizing, whitening, wrinkle removing and anti-allergy are achieved; and the problems of unstable active ingredient, preservative or stabilizer harmful to the skin in traditional masks can be effectively solved, so the application has a wide application prospect.

The present disclosure provides use of a device for applying negative pressure to the whole body of an individual in the manufacture of a device for treating diseases, resisting aging, promoting skin functions, and / or achieving non-therapeutic cosmetic purposes. Provided is a method for treating diseases, resisting aging, promoting skin functions, and / or achieving non-therapeutic cosmetic purposes for an individual, which comprises applying negative pressure to the whole body of the individual.

The invention belongs to the technical field of protein engineering, and discloses a humanized collagen XVII type polypeptide as well as a preparation method and application thereof. The amino acid sequence of the humanized collagen XVII type polypeptide is as shown in SEQ ID NO.1, and the polynucleotide sequence for coding the humanized collagen XVII type polypeptide is as shown in SEQ ID NO.2. The invention also provides application of the polypeptide in preparation of protein products with functions of preventing hair loss, growing hair, repairing, resisting wrinkles and tightening skin. The cell level efficacy detection proves that the prepared humanized collagen XVII type polypeptide can promote the proliferation of hair papilla cells, keratinocytes and fibroblasts, and promote the up-regulation of the expression of beta-Catenin signaling pathway protein closely related to hair growth in the hair papilla cells; therefore, the humanized collagen XVII type polypeptide is proved to have the effects of preventing hair loss, growing hair and / or repairing, and resisting wrinkles and tightening.

This invention belongs to the field of tissue engineering and regenerative medicine technology, specifically a multi-layered biomimetic skin structure and its synchronous bio-3D printing preparation method and system, comprising a sequentially combined epidermal layer and dermal layer. This invention highly mimics natural skin through a multi-layered structure. A micropillar array in the dermal layer provides a strong mechanical anchor between the epidermis and dermis, while embedded PLGA microspheres can sustainably release VEGF and EGF for 3-4 weeks, continuously promoting repair. Integrated vascular network channels and nerve guidance structures address the challenges of nutrient delivery and the lack of neural perception function, respectively, filling the functional gaps in traditional biomimetic skin. The synchronous bio-3D printing process enables integrated fabrication of the multi-layered structure. Combined with a four-channel printhead and a multi-physics coupling module, along with a visual positioning and pressure feedback system, printing accuracy and stability are ensured, preventing filament breakage or ink overflow. An intelligent cultivation system simulates the physiological environment, further enhancing skin maturity. This invention is applicable to the repair of skin defects such as burns and chronic ulcers.

The application discloses a kind of liquid management and spontaneous power generation dual bionic wound dressing and preparation method and application.The dual bionic wound dressing includes first electrode layer, barrier layer, hygroscopic power generation layer, diffusion antibacterial layer, evaporation power generation layer and second electrode layer stacked in order from bottom to top;The application adopts high biocompatibility electrostatic spinning fiber membrane, realizes the triple function of wound antibacterial, seepage efficient management and stable power generation by combining the liquid transport mechanism of plant transpiration with the ion active transport principle of electric ray power generation cell through bionic design, regulates wound microenvironment, effectively avoids excessive inflammation caused by seepage accumulation, significantly promotes fibroblast migration, angiogenesis and skin appendage regeneration, accelerates wound healing, and is beneficial to restore skin function, provides a new treatment for burn wound repair.

The present invention is applicable to the field of thermosensitive hydrogel technology, and provides a thermosensitive hydrogel and its preparation method and application that can promote wound healing, including the following raw materials: hydroxybutyl chitosan, oxidized bletilla striata polysaccharide, shikonin cerium complex and injection aqueous solution; wherein, the concentration of hydroxybutyl chitosan in the hydrogel is 1 200 mg / mL, the concentration of oxidized bletilla striata polysaccharide is 1 200 mg / mL, and the concentration of shikonin cerium complex is 1 50 mg / mL. The present invention can play a stronger wound healing effect by regulating the wound microenvironment, inhibiting bacteria, removing reactive oxygen species and other synergistic multiple effects. At the same time, it also has thermosensitive properties, has better conformability and closure to the wound, can be widely used in the preparation of drugs that promote wound healing, and is conducive to promoting the reduction of wound area and promoting the recovery of skin function at the wound.

The invention relates to an anti-initial-aging face cream composition with a liquid crystal emulsification effect and a preparation method of the anti-initial-aging face cream composition. The composition comprises an emulsifier (such as polyglycerol-10 stearate and / or polyglycerol-5 oleate and 7-dehydrocholesterol), a thickening agent, grease, a solvent, a preservative and a plurality of natural effective components (such as a calendula extract, a raspberry leaf extract, DNA sodium and the like). A stable and ordered liquid crystal structure is formed through preparation by a PI T phase transformation method, and the effective existence time exceeds 6 months. The face cream can help cells to resist irritation, repair cell damage and coordinate skin functions, achieves the effects of resisting wrinkles, preserving moisture, resisting oxidation, brightening skin color and the like, meanwhile reduces irritation, improves skin feeling and is suitable for being used for a long time. The preparation method is simple, the addition amount of glycerin is small, the face cream is fresh and non-sticky in texture, and the active ingredients have a strong synergistic effect.

A formulation for use as a medicament for the prevention and / or treatment of skin dysfunction in humans, comprising or consisting of (a) a hydroxypinacolone retinoate (I), and optionally (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) at least one antioxidant.

The invention discloses a biological active element, and belongs to the technical field of biological active elements, and the biological active element is prepared by the following steps: S1, selecting 30 herbal raw materials, screening at the same time, and crushing the herbal raw materials; s2, respectively putting three parts of 30 herbal raw materials into three parts of cellulase solutions to form a first enzymatic hydrolysate, a second enzymatic hydrolysate and a third enzymatic hydrolysate for later use; according to the invention, 30 natural herbal raw materials including pseudo-ginseng, ginseng, American ginseng, gastrodia elata, stigma croci, ganoderma lucidum, cordyceps sinensis and other traditional Chinese medicinal materials with the effects of promoting blood circulation to remove blood stasis, benefiting qi, nourishing blood, tonifying kidney, invigorating spleen, resisting oxidation and the like are selected, and aloe, purslane, collagen and other functional components are supplemented, so that the health of the body can be maintained through scientific proportioning; the body skin function is improved to be in the best physiological state, the biological vitality element activated cells can protect and repair the injured skin to the maximum extent without forming scar vitality, the skin is kept safe and young, and the whole life process of skin aging is delayed.

To provide a novel and useful skin function improving agent, and a topical preparation for skin, a cosmetic, and a skin function improving agent composition each containing the skin function improving agent.SOLUTION: A skin function improving agent, a topical preparation for skin, a cosmetic, and a skin function improving agent composition according to the present invention contain an extract from red bayberry as an active ingredient.SELECTED DRAWING: Figure 1

The invention discloses a skin function unit transplantation device and method for optimizing a donor-receptor area, and the transplantation device is an independent modular operation terminal or a cooperative execution terminal embedded in a surgical robot. The transplantation device is provided with an equipment shell, a skin attaching support, a skin function unit extracting mechanism, a skin taking depth limiting mechanism and a skin tension maintaining mechanism, and the equipment shell is an integrated shell internally integrated with a power management module, a main control chip set and a wireless communication module; a display control panel used for real-time parameter adjustment, state visualization and emergency braking is arranged on the outer side of the equipment shell. The skin attaching support is arranged on the edge of the bottom side of the equipment shell and attached to the surface of the donor area skin, and the skin attaching support is used for covering, supporting and protecting the donor area skin. The skin taking depth can be accurately controlled, small skin function units with complete epidermis, dermis and accessory structures can be accurately extracted, and excessive damage caused by large-area skin cutting to a donor area is avoided.

The invention relates to application of Antarctic red in preparation of a composition with a skin tightening function, and belongs to the technical field of biology, the Antarctic red is derived from a fungus Geomyces sp.wnf-18C or a fermentation product of Geomyces sp.wnf-15A, the preservation number of the Geomyces sp.wnf-18C is CCTCC NO: M2019086, and the preservation number of the Geomyces sp.wnf-15A is CCTCC NO: M2012255. The Antarctic red has no toxicity to cells when the concentration is not higher than 250g / mL, and the Antarctic red can significantly improve the cell viability of human-derived fibroblasts and has the effect of increasing skin compactness.

The invention provides a skin grafting device which comprises a skin taking structure and a driving part, the skin taking structure comprises a plurality of skin taking parts, each skin taking part comprises a tool bit and a first connecting part, the first connecting parts extend in the first direction, and the tool bits are connected to the ends, in the first direction, of the first connecting parts; the other end, in the first direction, of the first connecting part is rotatably connected to the driving part, the multiple skin taking parts are arranged at intervals in the direction perpendicular to the first direction, and the driving part is used for driving the skin taking parts to rotate around the axis parallel to the first direction. The multiple skin taking parts take skin at the same time, the skin taking efficiency is remarkably improved, in the rotation process of the skin taking parts, the tool bit extracts skin tissue, tiny autologous skin extracted by the skin taking parts carries hair follicles, sweat glands, melanocytes and the like, and the multiple skin taking parts carry the autologous skin to be implanted into allogeneic skin or artificial skin at the same time, so that a complete skin function reconstruction basis is provided, and the skin taking efficiency is improved. Therefore, the skin transplantation effect and the skin transplantation efficiency are improved, and meanwhile, a smaller wound is generated on a skin tissue donor region.

The invention discloses a composition for benefiting qi, nourishing blood, maintaining beauty and keeping young and a preparation method thereof, and belongs to the technical field of compositions for maintaining beauty and keeping young. Comprising codonopsis pilosula, bighead atractylodes rhizome, Chinese yam, white hyacinth bean, fructus amomi, poria cocos, amomum cardamomum, curculigo orchioides, angelica sinensis, prepared rehmannia root, white paeony root, ligusticum wallichii, donkey-hide gelatin, red dates, ginseng, longan, astragalus membranaceus, Sinkiang alkanet powder, yarrow leaf powder, broom photinia root powder, pork liver powder and codonopsis lanceolata root powder. The traditional Chinese medicine formula of codonopsis pilosula, angelica sinensis and the like solves the internal root of deficiency of spleen and stomach qi and deficiency of qi and blood caused by endocrine dyscrasia, and builds a firm foundation for skin health; meanwhile, by relying on herbal extracts such as yarrow herb and blue-ear grass, external problems such as skin oxidation, inflammation and barrier injury are solved, the yarrow herb and the blue-ear grass form positive circulation of internal nutrition supply, skin function enhancement and surface layer repair enlargement, and finally the synergistic effects of benefiting qi, nourishing blood and maintaining beauty and keeping young are achieved.

This invention relates to a multi-effect skincare essence for improving skin function and its preparation method. The invention supplements essential lipids and phospholipid precursors for the skin by adding linoleic acid and ethanolamine, strengthening the stratum corneum barrier and cell membrane structure integrity. It also adds serum albumin to address the poor water solubility and easy oxidation of linoleic acid and ethanolamine, improving the stability and skin affinity of the active ingredients. Simultaneously, it adds stable inorganic salts of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum to enhance the skin's anti-aging, repair, and firming abilities. Furthermore, it adds transferrin, which, on the one hand, blocks iron-mediated Fenton reactions and free radical generation, reducing photoaging and oxidative stress damage; on the other hand, transferrin prevents oxidative inactivation of linoleic acid, vitamins, selenium, tin, and other components under iron ion catalysis, reducing oxidative loss and protecting the formula's activity. Thus, it synergistically achieves effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone.

The present invention relates to a composition for improving skin function, containing Enterococcus faecalis as an active ingredient and, particularly, to a composition for skin whitening, skin barrier amelioration, skin wrinkle amelioration and skin elasticity enhancement, or skin soothing, containing, as an active ingredient, an Enterococcus faecalis EF -2001 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or a dead cell thereof.