170 results about "Cellular energy" patented technology

Helmet (1) comprising: a shell (2): one or more inserts (3) of a cellular energy-absorbing material: one or more retainers (4) crossing the one or more inserts (3) from side to side and fixed to the shell (2) at opposing sides of each insert (3) for constraining it to the shell (2), the one or more retainers (4) are shaped so laterally and inwardly trap the one or more inserts (3).

The invention discloses an anti-aging composition containing ergothioneine, glutathione and fish collagen, relates to the technical field of anti-aging compositions, and aims to solve the technical problems that a traditional anti-aging composition lacks attention to the aspects of cell energy metabolism, barrier repair and the like, and the overall skin improvement effect is not obvious. The ergothioneine is used as a natural antioxidant, and the content of the ergothioneine is 0.01-5wt%; the ergothioneine participates in a synergistic effect of an intracellular antioxidant enzyme system, so that tyrosinase activity is effectively inhibited, melanogenesis is reduced, and DNA and protein are protected from oxidation damage; in a simulated strong ultraviolet environment, compared with skin cells not using the ergothioneine-containing product, the content of free radicals in the cells is reduced by 30% after the ergothioneine-containing product is used; the ergothioneine can also regulate a cell signal channel, promote cell metabolism and maintain normal growth of cells. The mask has the advantages of accelerating skin metabolism and improving the self-repairing ability of the skin.

The current invention provides a biocompatible energy recharge system to normalize body functions for a mammal. Both stationary and circulatory scalar wave energy was produced and utilized to enable the entire body of a mammal to increase the energy potential of any cell in the body, to promote cell growth, to facilitate cell repair, and to reduce cell destruction, hence the cells, organs, systems and the entire body of a mammal become healthy, and to treat a disease or disorder. The invention is a combination of the generators of the three-dimensional bio-waves in the stationary and in the circulationary formats for empowering the cells in all parts of a mammal, and a method of using the 3D bio-waves uniformly to empower each organ of a mammal to restore and maintain the normal body health and function.

The invention discloses a pharmaceutical composition for promoting aTreg cell differentiation and application thereof, and relates to the field of biological medicine, and the pharmaceutical composition comprises zinc salt, a basic cell culture medium, fetal calf serum, antibiotic, L-glutamine and a pH buffer agent. According to the application, the basic cell culture medium is used for providing basic nutrition required by cell growth for lymphocytes, the fetal calf serum is used for providing growth factors, hormones, adhesion proteins and nutrient substances required by cell growth for the lymphocytes, and the antibiotics are used for preventing bacterial infection; l-glutamine provides key amino acid for cell energy metabolism and participates in synthesis of protein and nucleic acid, zinc salt provides zinc ions, and under the comprehensive action, the proportion of Treg cells and aTreg cells differentiated from lymphocytes in peripheral blood mononuclear cells is increased.

Provided are methods for regulating cellular energy metabolism by lipoate protein ligase, wherein cell growth or production of molecules of interest in a cell is improved by overexpressing a lipoate protein ligase in the cell.

The invention provides a method for evaluating cell population heterogeneity based on an energy index, and belongs to the technical field of biological recognition, and the method comprises the following steps: S1, preprocessing single cell transcriptome data; s2, carrying out feature selection on the preprocessed data, and defining a cell state; s3, constructing a gene local network based on a Hupfield neural network; s4, calculating gene local network energy and cell energy, and carrying out normalization processing on the cell energy; s5, introducing a Gaussian mixture model, identifying the potential state of the cells by analyzing the energy distribution difference of the cells, and clustering the cells in the same differentiation potential state; and step S6, evaluating the heterogeneity of the cell population. By adopting the method for evaluating the heterogeneity of the cell population based on the energy index, the complexity and the difference in the cell population can be disclosed more accurately.

The invention discloses a silverweed cinquefoil root composition with an anti-hypoxia function and a preparation method thereof, and belongs to the technical field of medical compositions.The silverweed cinquefoil root composition comprises silverweed cinquefoil root polysaccharide, silverweed cinquefoil root polyphenol and silverweed cinquefoil root glycoside compounds according to the mass ratio of (0.6-0.8): (0.2-0.4): (0-0.05), and the silverweed cinquefoil root glycoside compounds comprise roxburgh rose glycoside and multiflora rose glycoside according to the mass ratio of (0.05-0.45): 1. The compounding of the potentilla anserine polysaccharide and the potentilla anserine polyphenol can provide a comprehensive free radical scavenging effect, maintain the dynamic balance of generation and scavenging of oxygen free radicals in an organism, coordinate cell energy metabolism and help the organism to better utilize limited oxygen resources. The silverweed cinquefoil root glycoside compound is used as an additional antioxidant, oxidative stress reaction and side reaction can be reduced, and the obtained silverweed cinquefoil root composition can well improve the anti-hypoxia capacity of an organism.

The invention discloses a gelatin microcarrier lysate as well as a preparation method and application thereof. The gelatin microcarrier lysis buffer comprises lyase, a cell protective agent, a cell energy metabolism protective agent, an antioxidant, a buffer solution and a chelating agent. The gelatin microcarrier lysate has extremely strong protectiveness to cells, abandons damaging trypsin and EDTA, and innovatively adds a cell protection combination of a cell protective agent L-arginine, a cell energy metabolism protective agent sodium pyruvate and an antioxidant vitamin C, so that the cell survival rate (gt; 98%) and the retention rate (gt; the method is high in cell yield, good in safety and wide in range.

The invention relates to a nerve repair guide catheter, a preparation method and application, an electrostatic spinning technology is adopted to construct a nanofiber membrane which is directionally and orderly arranged so as to guide nerve axons to directionally grow, and cell energy metabolism is promoted and tissue repair and regeneration are accelerated through metabolism and conversion of degradation products. Therefore, the nerve injury repairing effect better than that of traditional matrix materials without biological activity, such as PCL, is achieved. According to the invention, a novel solution is provided for solving the problem of insufficient biological activity of a traditional nerve conduit material by constructing a degradable high polymer material with biological activity. Therefore, the regeneration efficiency of peripheral nerve injury repair is improved, and the application prospect of the bioactive material in the fields of tissue engineering and regenerative medicine is expanded.

Disclosed are therapeutic "brain boost" combinations of agents and pharmaceutical kits and compositions thereof, such as combinations of serotonergic (5-HT 2A receptor agonist) psychedelics, with mitochondrial energy enhancers, such as metabolic cofactors and metabolic coenzymes, in some embodiments together with antioxidants and glucose regulators. In some embodiments, the combinations are used in methods of enhancing energy, such as increasing cellular energy production or metabolism, and for optimizing glucose levels and protecting cells from oxidative damage. In some embodiments, the combinations have applications as longevity treatments, for end-of-life care, for the treatment and prevention of mental health conditions, and for the betterment of mental functioning and overall health and wellbeing, such as by heightening consciousness and enhancing cognitive function.

The invention relates to the technical field of cosmetics, in particular to a preparation method of a cell energy activator containing nicotinamide, VC ethyl ether and a bacillus fermentation product and application of the cell energy activator in skin oxidation resistance. The preparation method comprises the following steps: preparing a fermentation culture medium containing golden camellia powder and glucose powder, activating bacillus, and inoculating the bacillus into the fermentation culture medium to prepare a first component; inoculating the activated bacillus into a culture medium to prepare a second component; mixing the first component with the second component, and then adding nicotinamide and VC ethyl ether to prepare the cell energy activator. The cell energy activator disclosed by the invention can play a synergistic role, effectively improve the antioxidant activity of the skin and improve the skin barrier.

Compositions comprising a nettle concentrate are provided. The compositions can be administered to an individual in need thereof for (i) improving a physiological state linked to metabolic fatigue in one or more cells, and / or (ii) increasing mitochondrial energy and mitochondrial calcium uptake in one or more cells, and / or (iii) enhancing mitochondrial function, and / or (iv) treating or preventing a calcium deficiency / depletion disorder in an individual. Additionally or alternatively, the compositions can be administered for treating or preventing a mitochondria-related disease or a condition associated with altered mitochondrial function in an individual in need thereof or at risk thereof.

The invention belongs to the technical field of cosmetics, and particularly relates to a cell energy activation composition with an anti-aging effect and a preparation method thereof, the cell energy activation composition with the anti-aging effect and the preparation method thereof are characterized in that the cell energy activation composition with the anti-aging effect comprises the following components: 3-10 parts of thiotaurine and 0.01-0.5 part of a metal ion compound, the composition is prepared from the following raw materials in parts by weight: 0.05-0.5 part of an antioxidant, 0.005-0.05 part of redox regulatory protein, 0.1-6 parts of a raw grass-containing extract, 0.01-1 part of 4-tert-butyl cyclohexanol and 0.05-3 parts of a lipidosome delivery system, according to the invention, multi-channel energy activation is carried out: thiotaurine participates in energy metabolism, metal ions promote enzyme activity, thioredoxin maintains redox balance, and mitochondrial functions are comprehensively improved; liposomal delivery enhances absorption: the transdermal ability of active matters is improved, the stability is enhanced, and the utilization rate is increased; multiple anti-aging mechanisms are as follows: oxidation resistance, saccharification resistance and cell repair.

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

Described is an anti-cancer formulation comprising a dry liquid dispersible composition of a cellular energy inhibitor in combination with a reactive ingredient and a pharmaceutically acceptable carrier wherein the cellular energy inhibitor has the structure according to Formula I; wherein R is selected from one of OR ', N (R '') 2, C (0) R''', C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, C6-C12 heteroaryl, H or alkali metal, where R 'is selected from one of H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C (0) R ''', where R'' is selected from one of H, C1-C6 alkyl or C6-C12 aryl, and where R '''is selected from one of H, C1-C20 alkyl or C6-C12 aryl.

The invention discloses a multi-system function regeneration factor composition as well as a preparation method and application thereof. The multi-system function regeneration factor composition is prepared from the following components in parts by mass: 0.8 to 2.4 parts of melatonin, 84 to 126 parts of nicotinamide ribose and 42 to 84 parts of resveratrol. According to the multi-system functional regeneration factor composition disclosed by the invention, through scientific proportioning and synergistic effect of melatonin, nicotinamide ribose and resveratrol, the functions of stem cells are strongly activated, proliferation of the stem cells is remarkably promoted, the stemness maintaining capability of the stem cells is improved, osteogenesis and adipogenesis differentiation potential is enhanced, and the regeneration effect of the stem cells is improved. Meanwhile, an NAD < + > metabolic pathway is activated so as to strengthen cell energy and anti-aging capability. The capsule adopts the design of combining quick-release pellets and sustained-release pellets, the quick-release part can quickly release melatonin, the local drug concentration can be increased in a short time, and stem cell activation signals can be quickly started; and the sustained release part slowly releases nicotinamide ribose and resveratrol to maintain the long-acting stability of the drug concentration, so that the effect taking speed is ensured, the action time is prolonged, and the bioavailability is greatly improved.

A composition is provided that comprises a combination of fisetin or a derivative thereof and quercetin or a derivative thereof. The composition can be an oral nutritional composition, such as a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purposes (FSMP). The composition can be administered to an individual in need thereof for (i) improving a physiological state associated with metabolic fatigue in one or more cells, (ii) increasing mitochondrial energy and mitochondrial calcium uptake in one or more cells, and (iii) enhancing antioxidant capacity, reducing oxidative stress and / or enhancing mitochondrial function, (iv) treating or preventing calcium deficiency / depletion disorders in an individual. Additionally or alternatively, by the present method, mitochondrial-related diseases or conditions associated with changes in mitochondrial function can be treated or prevented in individuals in need of such treatment or at risk thereof.

The invention belongs to the technical field of formula foods for special medical purposes, and particularly relates to a fat component for treating Alzheimer's disease and a preparation method of the fat component. The fat component is prepared from the following raw materials in parts by weight: medium-chain triglyceride, starch sugar, silicon dioxide, sodium caseinate, starch sodium octenylsuccinate, mono-glycerol fatty acid ester, diglycerol fatty acid ester and potassium hydroxide. And a neuroprotective nutrient combination. According to the invention, the medium-chain triglyceride capable of supplying energy quickly is creatively combined with the nerve protection nutrient with a specific mechanism. The medium-chain triglyceride provides efficient ketone energy; magnesium citrate stabilizes the excitability of neurons; the nicotinamide ribose supports cell energy metabolism; the omega-3 fatty acid plays roles in resisting inflammation and repairing nerve cell membranes. The four components provide protection from energy supply, neuron stabilization, metabolism support and structure repair, and bring better neurological function prognosis while controlling the Alzheimer's disease.

The invention discloses a method and a device for detecting the energy metabolism level of cells and organoids. According to the detection method disclosed by the invention, the acidification rate and the oxygen consumption rate of the extracellular microenvironment are obtained through signal response of hydrogen ions and the dissolved oxygen sensing electrode, and meanwhile, a dynamic detection microcavity is constructed by utilizing a metabolism detection device, so that the sensitivity and the accuracy of measurement are improved. By adopting different drug intervention schemes, the energy metabolism pathway of the cells can be regulated and controlled, so that the evaluation of the two energy metabolism pathways of glycolysis and aerobic respiration of the cells is realized. The in-situ and high-sensitivity cell energy metabolism detection method and device are provided by detecting the concentration change of the specific analyte of the extracellular microenvironment, the method has the universality of two-dimensional and three-dimensional cell models, a brand new platform is provided for scientific research and drug effect screening based on an in-vitro model, and the application prospect is wide.

According to the self-energized biological 3D printing bio-ink, the 3D printing bioactive scaffold and the preparation method of the self-energized biological 3D printing bio-ink, the controllable-release self-energized biological 3D printing bio-ink is prepared by mixing the organic high-molecular polymers with different molecular weights and the energy metabolism promoting substances, and the ink is good in biocompatibility; by changing the content of energy supply substances, the ink can be designed to'provide 'and'accept' different cell metabolism regulation clues in an adjustable time regulation manner, better migration and adhesion of cells are realized, and functions are exerted, and meanwhile, the ink has controllable slow release of energy metabolism promoting substances and generates micro-nano pores when being used for constructing a three-dimensional bracket through 3D printing, so that the energy metabolism promoting effect is improved. The hydrophilicity of the scaffold is improved, the biological energy metabolism activity of the composite material is enhanced, the energy metabolism promoting substance can provide a sufficient nutrition environment for cell growth, the cell energy metabolism process is regulated and controlled, and adhesion, growth, proliferation and functionalization of cells are facilitated.

The application discloses a method for inducing T cell reprogramming into NK-like cells, comprising the following steps: (1) culturing the T cells in a culture system to obtain activated T cells; (2) adding small molecule inducers twice to the activated T cells to obtain NK-like cells; wherein the culture system in step (1) contains 1-10 v / v % serum substitute and / or platelet lysate, and does not contain fetal bovine serum. By optimizing the culture process and precisely adding drugs twice, the small molecule accumulation toxicity caused by multiple drug additions is avoided, the damage to the structure and function of the mitochondrial membrane is reduced, the mitochondrial membrane potential is significantly improved, the energy metabolism capacity of the mitochondria is enhanced, sufficient energy support is provided for the long-term survival and function maintenance of the cITNK cells, and the physiological activity of the cells is ensured from the energy metabolism level.

The invention relates to the technical field of biology, and discloses application of ascaroside in anti-aging, and the ascaroside can be widely applied to the fields of anti-aging foods, nutritional supplements and medicines. The invention reveals that ascaroside asc-C9 can play a cross-species conservative anti-aging effect from insects to mammals to a fermentation system for the first time, and the mechanism of ascaroside asc-C9 comprises promotion of mitochondrial function, enhancement of fat browning, improvement of antioxidant level and maintenance of cell energy steady state; the invention provides an anti-aging active molecule which is natural in source and clear in effect and a fermentation preparation approach thereof.

The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and / or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

The application discloses a hierarchical cellular energy-absorbing structure with spatial staggered hierarchical bearing, which is formed by a plurality of thin-walled hierarchical cells connected by common walls or connecting walls around a central hole cavity to form a continuous closed annular hierarchical topology. The bottom ends of the cells are coplanar, and the top ends are provided with at least three discrete axial height levels, and the circumferentially adjacent cells have different heights to form non-coplanar spatial staggered hierarchical contact end faces. When axially compressed, the highest height level is first contacted and bears, and the remaining height levels are sequentially involved in crushing with compression displacement, thereby reducing the initial simultaneous bearing area. Simulation results show that, compared with a common full-height structure with the same parameters, the mass of the structure is reduced by about 39.1%, the initial peak force is reduced by about 72.7%, and the specific energy absorption is increased by about 45.6%. The application can be widely applied to vehicle cushioning, protective sandwich and lightweight impact-resistant devices.

The present application provides a kind of fluorine boron compound, the fluorine boron compound contains anthraquinone group, can generate strong oxidizing anion radical after photoexcitation efficiently, thus has lower half inhibitory concentration, stronger inhibitory effect, has stronger phototoxicity, can kill cancer cells in shorter time;Meanwhile, the superoxide anion radical generated can specifically oxidize FADH2 coenzyme in mitochondrial electron transport chain, by oxidizing its isoalloxazine ring structure to cause coenzyme inactivation, then mitochondrial electron transport process, and inhibit cancer cell energy metabolism, so as to effectively inhibit the proliferation activity of cancer cells.

The invention discloses a composition with a tumor mitochondrial dual regulation effect, temperature-sensitive hydrogel and application, and belongs to the technical field of biological medicine, the composition is composed of a peroxide initiator and a mitochondrial autophagy inhibitor, the peroxide initiator is used for causing mitochondrial damage, and the mitochondrial autophagy inhibitor is used for causing mitochondrial autophagy. The mitochondrial autophagy inhibitor is used for inhibiting mitochondrial The peroxide initiator is indocyanine green, chlorin, iron oxide nanoparticles or Fe-MOFs (Metal-Organic Frameworks); the mitochondrial autophagy inhibitor is chloroquine, 3-methyladenosine or bajulomycin A1; the tumor is specifically melanoma; the combination of the peroxide initiator and the mitochondrial autophagy inhibitor can better inhibit the energy metabolism of tumor cells and inhibit the occurrence and development of tumors, and after the composition is delivered through the temperature-sensitive hydrogel carrier, the treatment effect of the composition on tumors is further improved.

1. Name of the product in this design: Physiotherapy Chamber. 2. Purpose of this design: A 360° internal heat-transmitting cell energy chamber for use during physiotherapy. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design key points: Combined state reference diagram.

The invention discloses application of R-1, 3-butanediol in preparation of anti-aging cosmetics or medicines, and relates to the technical field of cosmetics. According to the embodiment of the invention, the R-1, 3-butanediol is applied to the skin, and the R-1, 3-butanediol is explored and proved to be capable of exceeding the traditional physical and chemical functions of R-1, 3-butanediol, being utilized by cells, participating in the energy metabolism process of the skin cells, regulating the energy metabolism of mitochondria and regulating the expression of AMPK protein in the skin cells; the skin function is improved from the fundamental level of cell energy supply, and the skin aging problem caused by cell metabolism decline is resisted. The positioning and action mechanism is different from all known traditional applications, and represents a brand-new application mode of the component in cosmetics based on cytobiology. The functional skin care product is expected to be promoted to be upgraded to the direction of cellular metabolism regulation, and is popularized and applied.

The invention discloses an organic acid-containing anti-hair-loss composition based on a cacumen biotae extract, which comprises the cacumen biotae extract and an organic acid as anti-hair-loss active components, and the acid is succinic acid or malic acid or a combination of the succinic acid and the malic acid. The invention also provides application of the anti-hair loss composition in regulating hair follicle energy metabolism and preventing hair loss. The composition containing the cacumen biotae extract, the succinic acid and the malic acid can promote the activity of hair papilla cells, enhance the energy metabolism of the cells, recover the function of hair follicles damaged by oxidation and recover the energy metabolism of the hair follicles damaged by oxidation, so that the composition has a good effect of preventing and treating alopecia, stimulates hair growth and has few toxic and side effects.

The invention discloses a cell energy cabin with an in-cabin body position fixing structure, and relates to the technical field of cell energy cabins, the cell energy cabin comprises a physiotherapy table assembly and adjustable limiting frames, the adjustable limiting frames are horizontally installed on the middle surfaces of the left side and the right side of the physiotherapy table assembly, and a far infrared component is erected at one end of the physiotherapy table assembly; and the left and right ends of the bottom of the far infrared component are horizontally connected with the structure adjusting components. According to the cell energy cabin with the in-cabin body position fixing structure, through the use of the adjustable limiting frame, flexible adjustment and accurate positioning can be carried out according to the body shape characteristics of different users, it is ensured that the users keep stable and comfortable body positions in the cabin, the situation that the physical therapy effect is affected due to body position changes is effectively avoided, and the physical therapy effect is improved. Through the arrangement of the far infrared component, the cell energy cabin can utilize the far infrared generation plate to generate far infrared rays to irradiate a user in all directions, blood circulation is promoted, cell viability is enhanced, and the physical therapy effect is further improved.