10 results about "Cellular energy" patented technology

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

The application discloses a method for inducing T cell reprogramming into NK-like cells, comprising the following steps: (1) culturing the T cells in a culture system to obtain activated T cells; (2) adding small molecule inducers twice to the activated T cells to obtain NK-like cells; wherein the culture system in step (1) contains 1-10 v / v % serum substitute and / or platelet lysate, and does not contain fetal bovine serum. By optimizing the culture process and precisely adding drugs twice, the small molecule accumulation toxicity caused by multiple drug additions is avoided, the damage to the structure and function of the mitochondrial membrane is reduced, the mitochondrial membrane potential is significantly improved, the energy metabolism capacity of the mitochondria is enhanced, sufficient energy support is provided for the long-term survival and function maintenance of the cITNK cells, and the physiological activity of the cells is ensured from the energy metabolism level.

The application discloses a three-layer time sequence regulation type inflammation targeting composite repair system for repairing endometrial injury and a preparation method and application thereof. The system is a three-layer composite structure, which comprises, from outside to inside, (1) an outer ROS response hydrogel layer loaded with anti-inflammatory drugs, which can respond to early high expression of active oxygen to rapidly degrade the drugs, so that acute inflammation is inhibited; (2) a middle layer of targeted delivery and metabolic repair, which is a M1 macrophage membrane pseudo-loaded drug liposome (NMN@M-Lipo), which is exposed after the degradation of the outer hydrogel, actively targets the inflammation lesion through the M1 membrane, and slowly releases nicotinamide mononucleotide (NMN) to restore cell energy metabolism; and (3) an inner layer of cell recruitment and regeneration, which is a decellularized matrix scaffold loaded with SDF-1 alpha, which continuously releases SDF-1 alpha to recruit endogenous stem cells in the later repair stage, and promotes functional regeneration of the endometrium. The application utilizes the time sequence microenvironment changes of endometrial repair, and realizes the cascade regulation of 'anti-inflammation first, metabolic repair second, and regeneration promotion third'. Animal experiments show that the system can significantly restore the reproductive function of the injured endometrium and improve the number of offspring.

The application relates to the field of pet anti-aging and antioxidant medicines, in particular to a pet anti-aging and antioxidant special nutrient supplement and a preparation method thereof. The pet anti-aging and antioxidant special nutrient supplement comprises the following components in parts by weight: NMN 25-35 parts, manganese ascorbate 3-5 parts, coenzyme Q10 30-40 parts, hydrolyzed tannin 5-8 parts, Omega-3 fatty acid 180-220 parts, ergothioneine 2-3 parts, L-carnitine 20-40 parts, betaine 3-5 parts and vitamin E 5-8 parts. The various substances in the formula realize the pet anti-aging and antioxidant functions through a multi-pathway synergistic mechanism, which respectively are direct free radical scavenging, construction of an antioxidant defense network, repair of mitochondrial function, improvement of cell energy metabolism efficiency, blockage of inflammation and metabolic disorder and cutting off of an aging associated pathway.

A composition comprising nettle concentrate is provided. The composition can be administered to an individual in need for (i) improvement of a physiological condition associated with metabolic fatigue in one or more cells, and / or (ii) increased mitochondrial energy and increased mitochondrial calcium uptake in one or more cells, and / or (iii) enhancement of mitochondrial function, and / or (iv) treatment or prevention of calcium deficiency / depletion disorders in the individual. Additionally or alternatively, the composition can be administered for the treatment or prevention of the above in an individual in need of or at risk of treatment or prevention of mitochondrial-related diseases or conditions associated with altered mitochondrial function.

The application belongs to the technical field of energy-absorbing materials, and discloses a unit cell energy-absorbing structure, a metamaterial and an energy-absorbing device. The unit cell energy-absorbing structure comprises a connecting frame part and a flexible embedded part, and the connecting frame part and the flexible embedded part are both concave hexagons. The connecting frame part is made of a thermoplastic polymer, and the flexible embedded part is fixedly connected to the inside of the connecting frame part and is made of an elastic material. The Young's modulus of the connecting frame part is greater than that of the flexible embedded part. The flexible embedded part and the connecting frame part can deform cooperatively to adjust the lateral deformation response of the unit cell energy-absorbing structure under pressure, so that the unit cell energy-absorbing structure can exhibit zero Poisson's ratio characteristics, and the energy-absorbing effect, compression stability and buckling resistance of the unit cell energy-absorbing structure are improved. The unit cell energy-absorbing structure also has temperature responsiveness. The metamaterial and the energy-absorbing device realize zero Poisson's ratio characteristics and also have temperature responsiveness by applying the unit cell energy-absorbing structure.

A helmet (1) comprising: a shell (2); a head receiving system (3); at least one cellular energy absorbing structure (4) comprising a plurality of open cells (9) interconnected configured to absorb energy during an impact on the shell (2) by deforming; at least one clamping device (5) comprising a base (6) and an opposite base (7) connected to each other by means of an extendable elongated body (8) to form an integral piece sized to pass through at least one open cell (9) of the cellular energy absorbing structure (4), wherein the extendable elongated body (8) is configured to significantly and reversibly elongate with respect to its initial length when subjected to a pulling.

The application discloses a synergistic anti-oxidation ergothioneine composition and application thereof in anti-fatigue beverages. In the application, a multi-level anti-oxidation defense system is constructed by the combination of ergothioneine and pyrroloquinoline quinone, from free radical scavenging to cell energy metabolism to form a complete protection chain. Ergothioneine can directly capture and neutralize active oxygen free radicals in cells, protect cell membranes, proteins and DNA from oxidative damage, and reduce the generation of hydroxyl radicals by chelating metal ions. Pyrroloquinoline quinone can activate the mitochondrial biosynthesis pathway, improve the cell energy metabolism efficiency, and enhance the activity of the cell's own antioxidant enzyme system, thereby reducing the generation of free radicals from the root. The synergistic effect of the two can not only quickly remove the formed free radicals, but also enhance the cell's anti-oxidation repair capacity.

This invention discloses an engineered stem cell membrane biomimetic formulation, its preparation method, and its applications. The biomimetic formulation of this invention consists of core-shell structured drug-loaded nanoparticles. The core is a lipid polymer hybrid nanoparticle loaded with a drug for reprogramming microglia metabolism; the outer shell is an engineered stem cell membrane on which ligands that specifically target microglia are highly expressed. The engineered stem cell membrane-coated biomimetic formulation provided by this invention has a simple preparation process and features high drug loading capacity, controlled release, high blood-brain barrier penetration, and precise microglia targeting capability. It can achieve synergistic therapeutic effects through microglia energy metabolism reprogramming and has high clinical research value in the treatment of neurodegenerative diseases.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a pharmaceutical composition for treating simple obesity of spleen deficiency and dampness retention type and its application. This pharmaceutical composition is prepared based on seven traditional Chinese medicines listed in the Food and Drug Catalogue: Codonopsis pilosula, Poria cocos, Coix lacryma-jobi, Dioscorea opposita, Nelumbo nucifera, Lilium brownii, and Ziziphus jujuba. The pharmaceutical composition provided by this invention improves the condition of swollen, pale, and white-coated tongue in rats with simple obesity of spleen deficiency and dampness retention type, and improves abnormal lipid metabolism; it can effectively regulate abnormalities in serum BUN, UA, MTL, VIP, and other indicators in rats with simple obesity of spleen deficiency and dampness retention type, improve gastrointestinal emptying, enhance gastrointestinal motility, and increase the calcium content of myocardial cell membranes. 2+ -ATPase, Na + -K + - It increases ATPase activity, improves cellular energy metabolism, and reduces the risk of cardiovascular disease caused by obesity; it inhibits the expression levels of BUN and UA, which can treat obesity-induced hyperuricemia and improve renal metabolism. It also exerts a therapeutic effect on simple obese rats with spleen deficiency and dampness retention.