The present invention discloses anti-
cancer compositions, and associated methods, including an anti-
cancer composition comprising: a 
cellular energy inhibitor having the structure according to formula Iwherein X is selected from the group consisting of: a nitro, an 
imidazole, a 
halide, 
sulfonate, a 
carboxylate, an 
alkoxide, and 
amine oxide; and R is selected from the group consisting of: OR′, N(R″)2, C(O)R′″, C1-C6 
alkyl, C6-C12 
aryl, C1-C6 heteroalkyl, a C6-C12 heteroaryl, H, and an 
alkali metal; where R′ represents H, 
alkali metal, C1-C6 
alkyl, C6-C12 
aryl or C(O)R′″, R″ represents H, C1-C6 
alkyl, or C6-C12 
aryl, and R′″ represents H, C1-C20 alkyl or C6-C12 aryl. The anti-
cancer composition can additionally comprise at least one 
sugar, which stabilizes the 
cellular energy inhibitor by substantially preventing the inhibitor from hydrolyzing. Also, the anti-cancer composition can comprise a 
glycolysis inhibitor. Further, the anti-cancer composition can comprise a biological buffer that is present in an amount sufficient to at least partially deacidify the 
cellular energy inhibitor and neutralize metabolic by-products of the cellular energy inhibitor.