The present invention discloses anti-
cancer compositions, and associated methods, including an anti-
cancer composition comprising: a
cellular energy inhibitor having the structure according to formula Iwherein X is selected from the group consisting of: a nitro, an
imidazole, a
halide,
sulfonate, a
carboxylate, an
alkoxide, and
amine oxide; and R is selected from the group consisting of: OR′, N(R″)2, C(O)R′″, C1-C6
alkyl, C6-C12
aryl, C1-C6 heteroalkyl, a C6-C12 heteroaryl, H, and an
alkali metal; where R′ represents H,
alkali metal, C1-C6
alkyl, C6-C12
aryl or C(O)R′″, R″ represents H, C1-C6
alkyl, or C6-C12
aryl, and R′″ represents H, C1-C20 alkyl or C6-C12 aryl. The anti-
cancer composition can additionally comprise at least one
sugar, which stabilizes the
cellular energy inhibitor by substantially preventing the inhibitor from hydrolyzing. Also, the anti-cancer composition can comprise a
glycolysis inhibitor. Further, the anti-cancer composition can comprise a biological buffer that is present in an amount sufficient to at least partially deacidify the
cellular energy inhibitor and neutralize metabolic by-products of the cellular energy inhibitor.