235 results about "Islet" patented technology

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Specifically, methods of treating internal hard and soft tissues, such as but not limited to organs, bones, muscles, tendons, ligaments, vessels and nerves, with such EMR-treated islets are described. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Methods of treatment of tissue with electromagnetic radiation (“EMR”) to produce lattices of photoselective islets and other energy selective islets in tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

The invention provides an isolated island operation detection method of photovoltaic grid-connected generation system which includes: a control device detects voltage frequency of grid-connected point, judges voltage frequency of grid-connected point whether reaching frequency protection threshold, if yes, a start anti-isolated island protection signal is outputted; if not, frequency signal of grid-connected current instruction is calculated by using double positive feedback active frequency deflection method, and the frequency signal is outputted; the double positive feedback active frequency deflection method is that obtained grid-connected point voltage frequency deflection relative to average frequency is used as first positive feedback, and change trend of frequency deflection is used as second positive feedback, feedback magnification factor of first positive feedback is adjusted. The method realizes isolated island detection rapidly, simulation and experimental result, isolated island detection time is shorten in 0.10s, 0.13s, grid-connected current harmonic distortion THD are 2.06%, 2.97% respectively, and has advantage over traditional method in isolated island detection speed and reducing interference to power network.

Devices and methods of treatment of tissue, such as skin tissue, with electromagnetic radiation (EMR) are disclosed that employ local deformation of tissue in small areas. Devices and methods employing local deformation are used to produce fractional lattices of EMR-treated islets in tissue for application including hair growth management.

Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (DpG and GpD) are provided to target the CpG islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position. Methods for synthesizing these oligonucleotide analogues and for modulating nucleic acid methylation are provided. Also provided are phosphoramidite building blocks for synthesizing the oligonucleotide analogues, methods for synthesizing, formulating and administering these compounds or compositions to treat conditions, such as cancer and hematological disorders.

A microfluidic system and method for sorting cell clusters, and for the continuous and automated encapsulation of the clusters, once sorted, in capsules of sizes suitable for those of these sorted clusters is provided. The microfluidic system comprises a substrate in which a microchannel array comprising a cell sorting unit is etched and around which a protective cover is bonded, and the sorting unit comprises deflection means capable of separating, during the flow thereof, relatively noncohesive cell clusters, each of size ranging from 20 μm to 500 μm and of 20 to 10 000 cells approximately, such as islets of Langerhans, at least two sorting microchannels arranged in parallel at the outlet of said unit being respectively designed so as to transport as many categories of sorted clusters continuously to a unit for encapsulation of the latter, also formed in said array.

The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.

Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (DpG and GpD) are provided to target the CpG islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position. Methods for synthesizing these oligonucleotide analogues and for modulating nucleic acid methylation are provided. Also provided are phosphoramidite building blocks for synthesizing the oligonucleotide analogues, methods for synthesizing, formulating and administering these compounds or compositions to treat conditions, such as cancer and hematological disorders.

The invention provides compounds and methods useful for the diagnosis, prediction, therapy, or prophylaxis of type 1 diabetes. The compounds of the invention include peptides derived from IAPP (islet amyloid polypeptide) precursor, proinsulin, insulin, IGRP, IA-1 or phogrin peptides.

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared form 46 kinds of raw material medicines of fructus corni, wolfberry, mulberry, radix polygoni multiflori preparata, black sesame, ligustrum lucidum, prepared rehmannia root, herba epimedii, black ants, eucommia and the like. The traditional Chinese medicine composition starts with liver nourishing and kidney tonifying, and focuses on effecting a permanent cure. The traditional Chinese medicine composition removes heat, cools blood, adjusts human body, corrects glucose and lipid metabolism disorder, improves microcirculation, acts on pancreas islet directly, strengthens internal organs, activates pancreas cells in body, repairs and promotes pancreas islet functions, controls and eliminates complications rapidly, decreases blood sugar steadily until human body keeps balance of yin and yang, and eradicates diabetes thoroughly. The invention also provides a preparation method for the traditional Chinese medicine composition for treating diabetes.

The invention provides an acquisition method for exosomes derived from human urinary cells. The acquisition method includes the steps that firstly, human urine source cells are separately cultured, a culture medium is collected, the culture medium of the human urine source cells is filtered through a 0.22-micrometer filter membrane, and then large cell fragments and other impurities are removed; then an organelle is centrifugally removed, and supernatant is reserved; a membrane capable of intercepting 100KD molecular weight is used, the exosomes in the supernatant are centrifugally intercepted, after interception, PBS is used for eluting the membrane, and an exosome concentrated solution is obtained. The exosomes can be used for preparing medicine with the effects of resisting apoptosis, promoting angiogenesis, restoring ischemia damage and promoting cell growth and used for treating skin defects, skin ulcers, pressure sores, bone defects, bone ununion, femoral head necrosis, renal injury, ischemic injury, spinal cord injury, islet damage, diabetes, complications of diabetes, Alzheimer's diseases and the like.

The invention provides an MEMS sensor low stress package and a package system. An islet structure and a stress isolation groove are arranged inside the bottom of the package. The bottom of the package is provided with the islet structure and the stress isolation groove. The stress isolation groove is applied to isolate the effect which is imposed on a MEMS chip by the package deformation and to ensure the stability of a paster area of the MEMS chip. The location and area of the dispensing islet are changed according to different chips. The texture of the package is aluminum nitride. Because a hooked pin has the effect of supporting and delivering electrical signal, the hooked pin is capable of isolating the effect on the package caused by self-deformation of a circuit board and is capable of isolating the package and the circuit board. When the temperature is changed, the package and the circuit board are not contacted with each other to produce the stress. On one hand, the stress isolation groove isolates the stress from the package and makes the stress not conducted to MEMS chip. On the other hand, because of making most area of the MEMS chip not contacted with the package, the stress produced by thermal expansion mismatch is avoided.

The invention discloses an islet microgrid unified SoC balancing control method. The method comprises the steps of obtaining state of charge (SOC) rectifying information of each distributed energy storage unit, using the state of charge (SOC) rectifying information based on the condition of low bandwidth distributed communication to adjust a drooping coefficient of each distributed energy storage unit, adjusting an angular frequency reference value of each distributed energy storage unit by adjusting the drooping coefficient of each distributed energy storage unit so that charge-discharge power of each distributed energy storage unit can be in an optimal state, and equipartition of load power and the balance of the state of charge (SOC) of each distributed energy storage unit can be finally achieved. In this way, the purpose is achieved that one control strategy is applicable to SOC balance control in the charging state and SOC balance control in the discharging state simultaneously, thus the control strategy of the charging and discharging mode is unified, and the shortcoming that the system is unstable caused by conversion of control strategies in the charging and discharging process is overcome.

Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells. In certain embodiments, the population of cells produced by the methods is further enriched for islet-like cells.

The invention discloses a process of afloat ship twin-islet jointing. The process is characterized by comprising the flowing steps of: a, dividing a whole ship into two islets, building the two islets at the same time in a dock; b, performing ballast trimming on adjacent butt joint sections so that the afloat condition and draught of the two butt joint sections are consistent; c, centering, gathering and positioning the two sections; d, draining the dock so that the two islets fall down at specified docking blocks; e, draining a jointing partition; and f, performing assembling and jointing operation so as to complete the overall jointing work of a built object. The process has the advantages that the traditional concept that the construction contract is based on underwater facilities is broken through, and the construction capacity is improved on the basis of the advance of the process technology. The process is adapted to product market, and a large number of investment risks can be avoided, therefore the process is a positive construction method.

The invention belongs to the technical field of biomedical detection, and relates to a method for extracting a microwave detection breast model based on medical magnetic resonance imaging. The method includes the steps: acquiring a T1 weighted magnetic resonance image of a breast portion; enhancing a boundary; performing gray discrete processing; calculating the water content of a tissue corresponding to each pixel for a thoracic gland portion in the magnetic resonance image by the aid of an image gray value; comparing the water content of the tissue corresponding to each pixel with typical water content data of each tissue of a normal human body, determining tissue information of each pixel and defining the pixel as an islet if the tissue information of the pixel cannot be determined; giving the same gray value to the pixels with the determined tissue information and belonging to the same tissue, and normalizing the gray of the magnetic resonance image according to the tissue information; corroding small discrete islets; building the breast model. A breast structure can be really simulated by the method.

The invention provides a peptoid inhibitor as well as a preparation method and application thereof, relates to the technical field of biomedicine and specifically relates to a peptoid, in particular to a polypeptide-aggregated peptoid inhibitor capable of inhibiting Abeta1-42. The peptoid inhibitor is prepared from Npip, Nmba, Nlys and Nleu subunits. The peptoid inhibitor API 1 is an inhibitor which is high in water solubility, low in cytotoxicity and high in associative property with beta-islet amyloid polypeptide, thereby providing a new selection for researching medicaments for treating Alzheimer's disease.

The invention discloses a steady-state operation strategy for a wind and light contained diesel storage isolated microgrid. The strategy is subdivided into five kinds of operation modes. Firstly, an energy storage SOC (system on chip) is divided into four operation intervals, and the energy storage SOC is taken as a starting condition for dividing the operation strategy so as to decide the charging and discharging state selection boundary for the energy storage equipment; then the starting and stopping states and the unoperated areas of a diesel engine are determined by the energy storage SOC and the charging and discharging states thereof; a main power supply of the microgrid is determined by the energy storage SOC, the charging and discharging states and the state of the diesel engine; and finally the operation mode and the mode switching time sequence are determined by the microgrid. The isolated microgrid disclosed by the invention comprises an isolated-type microgrid which is not electrically connected with a main grid completely or a parallel-type microgrid at the islet operation mode. According to the invention, the refined operation of the microgrid can be improved by fully utilizing the energy storage equipment, and the system spared level, the operation stability, the power supplying reliability and recycled energy source utilization ratio are improved.

The invention provides a yoghurt capable of reducing blood sugar, wherein the yoghurt comprises the following components by weight: 80-120 parts of milk, 10-20 parts of astragalus mongholicus, 10-20 parts of smoked plum, 5-15 parts of medlar, 5-15 parts of root of red-rooted salvia and 5-15 parts of green tea, and further comprises 10<6>-10<9>cfu / ml probiotics. The invention further provides a preparation method of the yoghurt. The yoghurt capable of reducing blood sugar is rich in nutrition and common in raw materials; by using the combination of astragalus mongholicus, red-rooted salvia, medlar, smoked plum, and green tea, the yoghurt has the function of reducing blood sugar after being taken for a long time. The yoghurt capable of reducing blood sugar is scientific in compatibility of medicines, and has the effects of protecting pancreas islet function, improving glycometabolism, reducing sugar absorption, and the like, so that the yoghurt has a significant blood sugar reducing effect.

The invention, which belongs to the field of the power grid technology, discloses a processing method for electric energy quality data. The method comprises the following steps: obtaining real-time monitoring data of the electric energy from electric energy monitoring equipment; generating the real-time monitoring data of the electric energy into target electric energy quality data according to a preset electric energy monitoring model; and analyzing the electric energy quality according to the target electric energy quality data. According to the invention, the electric energy real-time monitoring data obtained by the electric energy monitoring equipment are generated into the target electric energy quality data with the unified format and specification based on the preset electric energy monitoring model, so that a phenomenon of an electric energy quality data information islet due to mutual incompatibility of data formats and thus the utilization and processing cost of the electric energy quality data can be substantially lowered.

Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells. In certain embodiments, the population of cells produced by the methods is further enriched for islet-like cells.

The invention discloses a blood glucose reducing particle and a preparation method thereof. The blood glucose reducing particle is prepared from the following raw material medicines in parts by weight: 200-300 parts of hippophae thamnoides L., 200-300 parts of pueraria lobata, 180-220 parts of polygonatum sibiricum, 130-170 parts of equus asinus L., 130-170 parts of platycodon grandiflorum, 80-120 parts of gardenia jasminoides ellis, 180-220 parts of dioscorea opposita Thunb., 80-120 parts of lycium barbarum L., 180-220 parts of siraitia grosvenorii, 130-170 parts of dry slice of momordica charantia L., 130-170 parts of dry slice of psidium guajava L. and 80-120 parts of leaf of morus alba L.. The blood glucose reducing particle has the efficacy of reducing blood glucose, reducing lipid, promoting the secretion of saliva or body fluid, quenching thirst, enriching yin, nourishing kidney and the like, can obviously improve symptoms of hyperlipemia, polydipsia, diuresis, polyphagia, emaciation, fatigue and lack of strength, deficiency of spleen and stomach and the like together with high blood glucose for patients, and repairs the pancreas islet function. The raw material medicines are all taken from varieties and food with homology of medicine and food, and the blood glucose reducing particle is safe to use.

The invention provides compounds and methods useful for the diagnosis, prediction, therapy, or prophylaxis of type 1 diabetes. The compounds of the invention include peptides derived from IAPP (islet amyloid polypeptide) precursor peptides.

The invention provides a diet yogurt. The diet yogurt comprises the following components in part by weight: 80 to 120 parts of skimmed milk, 15 to 25 parts of cassia occidentalis, 5 to 15 parts of smoked plum, 5 to 15 parts of plantain seed, 5 to 15 parts of lotus leaf, and 5 to 15 parts of hawthorn. The diet yogurt also comprises 10<6> to 10<9> cfu / ml of probiotics. The invention also provides a preparation method for the yogurt. The diet yogurt is rich in nutrition, raw materials are common, and by combination of the cassia occidentalis, the lotus leaf, the plantain seed, the smoked plum and the hawthorn, the diet yogurt has the effect of reducing blood sugar if the yogurt is drunk for a long time. The diet yogurt has a scientific formulation, has the effect of protecting pancreas islet, improving glycome metabolism and reducing sugar absorption, and therefore has the remarkable effect of reducing blood sugar.