7 results about "Islet" patented technology

The utility model discloses an adjustable skin stitching instrument which comprises an attachment plate, two symmetrically-arranged mounting plates are arranged on one side of the attachment plate, and the first mode is that the mounting plate on one side is provided with a plurality of single-body lock catches or double-body lock catches, and the mounting plate on the other side is provided with a plurality of double-body bases or single-body bases; according to the second mode, the mounting plates on the two sides are provided with a plurality of single lock catches or double-body lock catches and the double-body base or the single base in a crossed mode; the base is connected with a pull rod, a plurality of locking rings are arranged on the side wall of the pull rod, a cavity is formed in the lock catch, and a locking block is arranged in the cavity. According to the coral island lagoon face traction device, the combined structure of the double-body lock catch or the single-body lock catch, the single-body base or the double-body base, the mounting plate, the pull rod and the like is arranged, so that a coral island reef'ring reef lagoon face '-shaped combined traction range can be formed at the wound of a patient, and a U-shaped traction range is formed between the double-body lock catch or the double-body base; stress can be reduced during transverse closing and longitudinal extending of the incision, and healing of the incision is promoted.

The invention discloses a blood island organoid polar structure culture device, a blood island organoid culture device and a culture method thereof, and relates to the technical field of stem cell and organoid engineering. According to the method, the problems that stable, directional and controllable fluid shear force cannot be provided, and the organ cannot be accurately positioned, so that the stress of the organ is non-uniform, and a physiological correlation polar structure is difficult to form in an existing blood island organ in-vitro culture technology are solved. According to the device disclosed by the invention, the magnetic rotor rotates to generate a directional vortex in the hole, and a double-screen structure is combined to carry out accurate positioning and physical isolation on blood island organs, so that continuous, stable, consistent-direction and controllable-strength fluid shearing force is provided for the blood island organs. The in-vivo blood island development mechanical microenvironment is effectively simulated. The blood island organ can be efficiently induced to form a polar structure and the hematopoietic function maturation is promoted. The system is compatible with a standard porous plate system, supports high-throughput culture, and provides an advanced platform for blood island development mechanism research and drug screening.

Compounds comprising a rhodanine scaffold, compositions comprising same, method of using such compounds find compositions to inhibit tubulin-associated unit (tau) protein aggregation or alpha-synuclein (α-syn) protein aggregation in a subject having, or at risk for, tau protein aggregation or α-syn protein aggregation, respectively; and methods of using such compounds and compositions to inhibit islet amyloid polypeptide (LAPP) fibril formation and to detect LAPP fibrils.

The present invention provides synthetic peptides, pharmaceutical compositions containing synthetic peptides, and the use of synthetic peptides for the treatment of amyloidosis. [Solution] The synthetic peptide of the present invention has the effect of preventing the formation of β-amyloid aggregation and preventing the folding and aggregation of β-amyloid (amyloidβ, Aβ), tau protein, α-synuclein (α-synuclein, α-Syn), islet amyloid polypeptide (IAPP), or transthyretin (TTR), thereby treating amyloidosis.

The disclosed concept includes the preparation and use of biocompatible bioinks, as well as techniques and methods therein for bioprinting, preparing and 3D printing primary cells and patient-specific cells and forming functional soft tissue in a three-dimensional construct form that incorporates the cells and mimics native tissues. The biocompatible bioinks include alginate, methylcellulose, and primary or iPSC-derived cells in the form of single cells or aggregates. The bioprinted 3D construct includes one or more of the iPSC organoids, human islets, as well as TEPCs.

Provided herein are endocrine progenitor cells and organoids derived from adult islets in vitro, as well as methods for making and using the same. The compositions are useful for treating or preventing diabetes, other diseases or disorders characterized by impaired islet function, and symptoms thereof.