4 results about "Cystatin" patented technology

The invention discloses a clonorchis sinensis recombinant protease inhibitor Cystatin-2 and a polarization effect of the clonorchis sinensis recombinant protease inhibitor Cystatin-2 on macrophages. The protease inhibitor Cystatin-2 is derived from clonorchis sinensis, can remarkably promote polarization of macrophages, and is an immunomodulatory molecule with application prospects.

This invention discloses the application of a Trichinella spiralis cysteine ​​protease inhibitor in acute myocardial infarction and subsequent ventricular remodeling, belonging to the field of medicinal chemistry. This invention provides a drug that can prevent, alleviate, and / or treat acute myocardial infarction and subsequent ventricular remodeling. The active ingredient of this drug is the Trichinella spiralis cysteine ​​protease inhibitor cystatin, abbreviated as rTs-Cys. rTs-Cys can effectively delay acute myocardial infarction and inflammatory response in mice, reduce the infarct area, improve cardiac function deterioration, and reverse organ pathological damage, providing a new approach for the clinical treatment of acute myocardial infarction and subsequent ventricular remodeling.

The present application relates to a kind of detection methods for identifying urinary retention pet kidney function damage, comprising: collecting the blood sample of urinary retention pet and pretreatment, obtain test sample;The test sample is added to the fluorescent immunochromatography triplex test reagent card prepared in advance, obtain test card, and the test card is sent into fluorescent immunoassay instrument, and the quantitative result of creatinine, symmetric dimethylarginine and cystatin C index is obtained, wherein, index quantitative result includes concentration value, and the concentration value corresponding negative index and positive index;Urinary retention pet kidney function damage condition is judged based on the index quantitative result: if creatinine, symmetric dimethylarginine and cystatin C are all positive index, judge urinary retention pet kidney function damage;If creatinine and symmetric dimethylarginine are positive index, and cystatin C is negative index, judge urinary retention pet kidney function is not damaged or early kidney function damage;Other index quantitative result, then not used to judge urinary retention pet kidney function damage condition.The present application can quickly judge whether urinary retention pet is kidney function damage, accuracy is high, and simplify detection operation process, greatly improve detection efficiency.

The application discloses a nasal secretion biomarker composition for diagnosing type 2 chronic rhinosinusitis with nasal polyps and application thereof, relates to the technical field of biological medicine, and the nasal secretion biomarker composition comprises glial cell-derived neurotrophic factor, cystatin 5, transforming growth factor beta 1 and monocyte chemoattractant protein 4. When the nasal secretion biomarker composition is used for diagnosing CRSwNP intrinsic type, nasal secretion is used as a detection sample, polyp biopsy is not needed, the nasal secretion biomarker composition is non-invasive, simple, convenient, has high sensitivity and specificity, can classify CRSwNP patients before operation without damaging mucosa, can predict the disease intrinsic type of the CRSwNP patient in advance and accurately, and is an ideal non-invasive method.