34 results about "Nasal secretion" patented technology

This invention relates to the field of nasal aspirator technology, and more specifically, to a nasal aspirator and its method, comprising: a nasal plug suction head unit and a negative pressure suction unit. The nasal plug suction head unit includes: a suction head body, which has an suction port for inserting into the nasal cavity to aspirate nasal secretions and an exhaust port for connecting to the negative pressure suction unit. The nasal aspirator and its method of this invention adjust the suction force of the suction head body through the negative pressure suction unit, making it easier to control the speed or force of aspirating nasal secretions, reducing discomfort inside the nasal cavity. Compared to oral nasal aspirators, this invention provides better suction and reduces the risk of infection. The structural design of the nasal plug suction head unit in this invention effectively prevents the backflow of nasal secretions, preventing secondary infection caused by backflow, and reducing discomfort caused by irritation to the nasal cavity or throat.

The invention provides a device for collecting a nasal secretion sample. The device includes a sample collection member comprising a material for collecting a predetermined volume of a nasal secretion sample. The device further includes a handle and an elongated support member extending between the handle and the sample collection member and for supporting the sample collection member. The device is adapted for a user holding the handle to locate the sample collection member in contact with tissue at a target location inside the nasal cavity where the sample collection member collects a predetermined volume of a nasal secretion sample.

A nasal secretion smear diagnosis method and system based on deep learning. The method comprises: reading, in chunks by means of a sliding window, a nasal secretion smear to be subjected to diagnosis; performing a preprocessing operation on a read window image and inputting same into a trained cell detection model; performing a series of feature extractions on the input image, then enhancing a pyramid feature map by means of bottom-up and top-down feature fusion, finally obtaining coordinates and a score of a rectangular box of a detected target on the basis of a feature map of each scale, and on the basis of a set score threshold value, filtering out rectangular boxes, the scores of which are lower than the threshold value, so as to obtain a set R of rectangular boxes; on the basis of the coordinates of each rectangular box in R, cropping a corresponding image from the original window image and performing a preprocessing operation, inputting the processed image into a trained cell classification model, and outputting a cell category of the corresponding image; and performing post-processing, so as to obtain a cell category of the original nasal secretion smear to be subjected to diagnosis.

The utility model provides an aspirator for ear and nose secretion cleaning, which comprises a cabinet, an operating table is fixedly mounted at the top of the cabinet, a first guide cavity and a second guide cavity are respectively arranged in the operating table, a guide chamber and a collection chamber are respectively arranged in the cabinet, and the first guide cavity and the second guide cavity are communicated with each other. A saline water barrel and a collecting assembly are arranged in the collecting chamber, a flow dividing assembly is fixedly installed in the guiding and conveying chamber, the output end of the flow dividing assembly penetrates through the first guiding and conveying cavity and is provided with an injection head in a butt joint mode, and the input end of the flow dividing assembly is connected with the saline water barrel; the input end of the collecting assembly is in butt joint with a recoil assembly. According to the utility model, normal saline in the saline water barrel is extracted through the back flushing assembly, so that the suction operation can be realized, meanwhile, the saline water can be fed into the suction pipeline, not only can sucked foreign matters be discharged in an auxiliary manner, but also the interior of the suction pipe can be continuously flushed, and the inner wall of the suction pipe is prevented from being bonded and blocked.

1. The name of the design product: electric nose aspirator. 2. The use of the design product: the nose aspirator for automatically removing nasal secretions. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: immune chromatography analyzer. 2. The use of the design product: for animal clinical test, specifically used with the adapter, can detect and analyze animal serum, feces, eye and nose secretions, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

This invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for sinusitis. The composition is characterized by being prepared from ephedra (processed with honey), bitter almond, perilla seed, prepared pinellia, licorice, scutellaria, angelica, belamcanda, coltsfoot flower, mulberry bark, cicada slough, silkworm, and earthworm. The composition of this invention improves sinusitis symptoms, reduces inflammation levels, and regulates the pH of nasal secretions in a sinusitis model prepared by Staphylococcus aureus, suggesting that this traditional Chinese medicine composition has a good therapeutic effect on sinusitis.

The utility model belongs to the technical field of medical auxiliary instruments, particularly relates to a portable quantitative collection device for nasal secretions, and aims to solve the problems that an existing device adopts a negative pressure extraction mode, extraction pressure is not easy to control, nasal mucosa can be damaged when nasal secretions are directly sucked, and bleeding can be accompanied, and the portable quantitative collection device for the nasal secretions comprises a centrifugal tube, a built-in tube is arranged in the centrifugal tube; the utility model has the beneficial effects that the filter paper automatically adsorbs nasal secretions to simulate the natural discharge state of the secretions, so that the secretions at different parts in the nasal cavity can be more comprehensively and uniformly collected without generating any additional pressure impact, thereby protecting the integrity of the mucous membrane of the nasal cavity to the greatest extent, reducing the risk of mucous membrane damage and improving the safety of the nasal cavity. Due to the fact that the nasal cavity cannot be strongly stimulated due to adsorption of the filter paper, discomfort feelings such as pain and soreness caused by negative pressure cannot occur to a patient in the collection process, and the whole collection process is more comfortable.

The present invention provides an apparatus for collecting nasal secretion samples. 【Solution means】 The apparatus includes a sample collection member having a material for collecting a predetermined amount of nasal secretion samples. The apparatus further includes a handle and an elongated support member that extends between the handle and the sample collection member and supports the sample collection member. The apparatus is configured such that a user holding the handle contacts the sample collection member with the tissue at a target position within the nasal cavity, and the sample collection member collects a predetermined amount of nasal secretion samples at the target position.

The utility model relates to the technical field of slaughtering and quarantine, in particular to a pre-slaughtering living body inspection and quarantine device, which is characterized in that fixing clamping plates are arranged on two sides inside a box body, when the device is used, a worker opens a box door, enables livestock to enter the box body from a guide block, then closes the box door and adjusts a rotating hand wheel, and then the livestock can enter the box body from the guide block. Meanwhile, a positioning ring matched with the livestock is selected to be fixed to the through groove, the head of the livestock penetrates through the positioning ring so that the head of the livestock can be limited, and therefore quarantine personnel can conveniently collect samples of visible mucous membranes of the livestock, the head of the livestock extends out of the box body through the sampling opening, and the livestock can be conveniently taken out. And quarantine personnel can conveniently collect samples of oral mucosa and mouth and nose secretions of livestock.

Methods for identifying and optionally treating subjects, e.g., subjects who have Chronic Rhinosinusitis (CRS), based on the detection of elevated levels of soluble P-glycoprotein in nasal secretions. The methods of treatment can include administration of a therapeutically effective amount of a P-glycoprotein inhibitor.

This invention relates to the field of biomedical technology and proposes a biomarker for reflecting the efficacy of hormone therapy for allergic rhinitis and its application. The biomarker includes one or more combinations of IFNGR1, Furin, and CSF1R. The biomarkers IFNGR1, Furin, and CSF1R of this invention can all differentiate between hormone-sensitive and hormone-insensitive rhinitis. Their expression levels in the nasal secretions of patients with hormone-insensitive allergic rhinitis are significantly lower than those of patients with hormone-sensitive allergic rhinitis, thus reflecting the efficacy of hormone therapy for allergic rhinitis. Furthermore, compared with a single biomarker, the combination of the three biomarkers has better discriminative ability and better efficacy, providing important evidence for subsequent treatment of allergic rhinitis.

The utility model provides a nasal secretion collection device, and belongs to the technical field of nasal secretion collection. Comprising a bag body, a transparent bag is arranged on the side face of the bag body, a partition layer is arranged in the middle of the interior of the bag body, two limiting holes are formed in the partition layer, two sampling pipes are clamped in the limiting holes in a sliding mode, and pipe covers are movably installed on the two sampling pipes in a threaded mode. According to the nasal secretion collection device, through the arrangement of the bag body, the separation layer and the limiting holes, the sampling tubes are limited, and the sampling tubes are prevented from being mixed together to directly collide, so that tube covers of the sampling tubes are prevented from loosening, samples in the sampling tubes are prevented from being polluted, and the accuracy of a detection result is ensured.

1. The name of this design product: Electric nasal aspirator. 2. Purpose of this design product: used to aspirate nasal secretions. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention belongs to the field of pharmaceutical technology and specifically relates to a pharmaceutical composition containing pyruvate, its preparation method, and its use. The pharmaceutical composition comprises the following raw materials, by mass percentage: 0.05-0.1% Compound I, 0.1-0.2% sodium pyruvate, 0.05-0.1% sodium dihydrogen phosphate, 0.05-0.1% sodium dihydrogen phosphate, 3-5% glycerol, and the balance being saline. The structural formula of Compound I is shown below, #imgabs0#. This pharmaceutical composition alleviates the symptoms of stress-induced rhinitis by reducing nasal secretions, downregulating the expression of TE4, IgE, and IL-4, and lowering the number of eosinophils.

The utility model relates to the technical field of nasal cavity washing devices, in particular to a nasal cavity washing device which comprises a nasal inflating pipe, a handle and a piston are connected in the inflating pipe in a sliding mode, a first pipe and a breather pipe are fixedly installed on the bottom face of the inflating pipe, and a second pipe is fixedly installed on the surface of the inflating pipe. A water tank and a third pipe are fixedly mounted at the top of the inflating pipe, a liquid outlet cavity and a liquid inlet cavity are formed in the water tank, and a water outlet pipe and a water inlet pipe are slidably connected to the surface of the water tank. By arranging a pull ring and a fixing rod, a user can pull a sliding block through the pull ring, so that a limiting block is separated from a water inlet pipe and a water outlet pipe, and the pull ring is matched with the fixing rod, so that the user can fix the position of the first sliding block, and the user can quickly take down the water inlet pipe and the water outlet pipe and clean the water inlet pipe and the water outlet pipe; and bacteria breeding caused by substances such as residual cleaning liquid and nasal secretions in the water outlet pipe and the water inlet pipe is avoided, and the risk of nasal infection is reduced.

1. Name of the Design Product: Main Unit of Infant Electric Nasal Aspirator. 2. Use of the Design Product: Main unit of a nasal aspirator for clearing nasal secretions. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective View 1.

1. Name of the Design Product: Drainage Tube. 2. Use of the Design Product: This design product is mainly used for draining and sucking blood, waste liquid, etc. during and after surgery, as well as sucking nasal secretions after being matched with appropriate equipment. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective View.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition added with pyruvate as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials in percentage by mass: 0.05 to 0.1 percent of a compound I, 0.1 to 0.2 percent of sodium pyruvate, 0.05 to 0.1 percent of sodium dihydrogen phosphate, 0.05 to 0.1 percent of disodium hydrogen phosphate, 3 to 5 percent of glycerol and the balance of normal saline, the structural formula of the compound I is as shown in the specification, # imgabs0 #. The pharmaceutical composition relieves the symptom of strain rhinitis by reducing the amount of nasal secretions, down-regulating the expression of TE4, IgE and IL-4 and reducing the number of eosinophilic cells.

The invention discloses a recombinant feline herpesvirus as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention aims to provide a cat herpesvirus vaccine or multi-combined vaccine with a good immune effect. The invention provides a recombinant feline herpesvirus, which is obtained by taking an FHV-1CH-B strain of the recombinant feline herpesvirus as a parent strain and replacing gI and gE proteins with a fusion protein of a VP1 protein and an LTB protein. When the recombinant feline herpesvirus is used as a vaccine, the clinical symptoms of cats are obviously relieved, the viral load of eye and nose secretions is obviously reduced, the pathological injury is obviously relieved, and the recombinant feline herpesvirus can effectively resist FHV-1 and FCV virulent virus attack.

The utility model relates to the technical field of secretion extraction, and discloses a newborn oral cavity and nasal cavity secretion extraction device which comprises a shell, a partition plate is fixedly installed on the middle section of the shell, a top cover is connected to the top of the shell in a clamped mode, and a bottom cover is installed at the bottom of the shell in a sliding mode. A storage pipe is arranged in the shell and located below the partition plate in a penetrating mode, the bottom of the storage pipe is in threaded connection with a sealing cover, and a suction pipe is embedded in the side face of the storage pipe. The sealing plug and the intubation tube are firstly taken out from the shell, the intubation tube can be separated from the suction tube, the bottom cover is opened in a sliding mode at the bottom of the shell through the sliding groove and the sliding strip, then the storage tube is drawn out from the two lower protection plates, the sealing cover is spirally opened from the bottom of the storage tube, and secreta in the storage tube can be poured out. Therefore, the purpose of conveniently dismounting and cleaning the storage pipe is achieved, and water can be prevented from entering the shell to damage electronic devices.

The invention discloses application of Der p sIgE and / or Der f sIgE in nasal secretion in preparation of a kit or a detection platform for diagnosing local allergic rhinitis, and relates to the technical field of in vitro diagnosis and immunoassay. The invention relates to application of Der p sIgE and / or Der f sIgE in nasal secretion in preparation of a kit or a detection platform for diagnosing local allergic rhinitis. The invention proposes and verifies that the dust mite sIgE in the nasal secretion can be used as an effective biomarker for diagnosing LAR for the first time, and solves the technical problem of difficulty in typing serum sIgE negative rhinitis patients clinically. Detection can be completed only by collecting nasal secretions, operation is easy and convenient, safety is high, and clinical popularization is easy. According to the method, diagnosis is objective and accurate, a diagnosis critical value is scientifically established through research on healthy people, a quantitative objective diagnosis standard is provided, it is verified through the cell factor level that the diagnosis result is highly consistent with the intrinsic biological mechanism of allergic inflammation, and the accuracy is high.

1. Name of the product in this design: Nose hair scraper. 2. Purpose of this design: For cleaning nasal hairs and nasal secretions. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of the design product: nose wax stick. 2. The use of the design product: for cleaning the nose hair and nasal secretions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The utility model relates to the technical field of tracheostomy patient collecting devices, in particular to a mouth and nose secretion collecting device for tracheostomy patients with dysphagia, which is characterized in that two nasal liquid tubes are mounted at the bottom of one side of a protective mask in a penetrating manner, a nose support is mounted on the outer side of the top end of each nasal liquid tube, and a collecting piece is arranged at the top of each nasal liquid tube; a mounting plate is mounted on one side in the protective mask, rotating parts are mounted on two sides of the saliva tube, the nose support extends into the nasal cavity, and then the nasal tube is matched to drive the blocking ball to move into the nose support, so that the diameter of the nose support is expanded, supporting force is provided for the interior of the nasal cavity, liquid in the nasal cavity can flow out more smoothly, and the safety of the nasal cavity is improved. Oral secretions flow into the other side of the liquid collecting bottle along the saliva tube, the oral secretions of a patient can be conveniently collected, the cleaning process is simpler and more convenient, and meanwhile, the saliva tube and the expansion sponge are made of soft materials, so that the patient does not have foreign body sensation in the process of wearing and using the device.

The invention discloses a tissue engineering lacrimal passage with supporting, elasticity-rich and anti-reflux functions, and belongs to the technical field of tissue engineering and regenerative medicine. The tissue engineering lacrimal passage comprises a lacrimal passage tube main body made of an acellular tracheal matrix material, the outer surface of the lacrimal passage tube main body is coated with an outer spiral reinforcing layer, and the surface of the outer spiral reinforcing layer is coated with a biological amniotic membrane; a plurality of Tesla valve structures are arranged in the middle of the lacrimal duct body, and an anti-backflow valve is arranged at the bottom. The tissue engineering lacrimal passage is constructed by adopting the decellularized trachea, the biological amniotic membrane and the 3D printing polyurethane as the stent, and the Tesla valve structure and the anti-reflux valve are applied to the tissue engineering lacrimal passage, so that the elasticity of the lacrimal duct is kept, and the reflux of tear, nasal secretions and gas is prevented.

The present invention discloses a method for preparing a solution for detecting allergen activity, an analytical method, and its application, relating to the field of immunoassay technology. A solution for detecting serum and nasal secretion IgE levels is prepared, and the correlation between seasonal pollen concentrations, serum IgE and nasal secretion IgE levels, and SAR allergy symptoms and CSMS is analyzed. The present invention also discloses the application of the method in preparing reagents, kits, test strips, or chips to assist in screening patients for seasonal allergic rhinitis treatment, providing support for new treatment strategies and drug development.

The application discloses a nasal secretion biomarker composition for diagnosing type 2 chronic rhinosinusitis with nasal polyps and application thereof, relates to the technical field of biological medicine, and the nasal secretion biomarker composition comprises glial cell-derived neurotrophic factor, cystatin 5, transforming growth factor beta 1 and monocyte chemoattractant protein 4. When the nasal secretion biomarker composition is used for diagnosing CRSwNP intrinsic type, nasal secretion is used as a detection sample, polyp biopsy is not needed, the nasal secretion biomarker composition is non-invasive, simple, convenient, has high sensitivity and specificity, can classify CRSwNP patients before operation without damaging mucosa, can predict the disease intrinsic type of the CRSwNP patient in advance and accurately, and is an ideal non-invasive method.

The utility model relates to the field of medical instruments, in particular to a nasal postoperative nursing device which comprises two bottom plates, annular columns are arranged at the tops of the two bottom plates, contact pads sleeve the surfaces of the annular columns, a nasal mask is hinged to the back faces of the bottom plates, and fixing belts are arranged on the two sides of the nasal mask. The other ends of the two fixing bands are detachably connected to form a closed ring, and the contact pad is made of a liquid absorbing material; after the nursing device is taken out from a cool position in advance, the surface of the annular column is sleeved with the contact pad, then the annular column drives the contact pad to be inserted into the nostrils, then the nose cover is bent till the nose cover makes contact with the face skin, the fixing belts on the two sides are wound to the back of the brain to be connected, and nasal secretions can be adsorbed by the contact pad; and the nasal mask is combined, so that the outflow of nasal secretions can be effectively reduced.

The invention relates to the field of biological medicine, and particularly provides application of LCN2 as a biomarker of non-eosinophilic chronic disease nasosinusitis with nasal polyp. The LCN2 provided by the invention is derived from nasal secretion, and by detecting a nasal secretion sample which is easy to collect, the wound, pain and potential complication risk caused by traditional nasal polyp tissue biopsy are completely avoided, and the detection compliance and acceptability of a patient are remarkably improved. The collection process of the nasal secretions is simple, and the technical requirements on operators are not high. The LCN2 detection method is relatively mature, is controllable in cost, is convenient to popularize and apply in medical institutions at all levels, and is suitable for screening large-scale crowds. The LCN2 level in nasal secretions has high sensitivity and specificity for distinguishing neCRSwNP from eCRSwNP and healthy people, and the ROC area under the curve (AUC) of the LCN2 level shows good diagnostic value.