49 results about "Nasal secretion" patented technology

This invention relates to the field of nasal aspirator technology, and more specifically, to a nasal aspirator and its method, comprising: a nasal plug suction head unit and a negative pressure suction unit. The nasal plug suction head unit includes: a suction head body, which has an suction port for inserting into the nasal cavity to aspirate nasal secretions and an exhaust port for connecting to the negative pressure suction unit. The nasal aspirator and its method of this invention adjust the suction force of the suction head body through the negative pressure suction unit, making it easier to control the speed or force of aspirating nasal secretions, reducing discomfort inside the nasal cavity. Compared to oral nasal aspirators, this invention provides better suction and reduces the risk of infection. The structural design of the nasal plug suction head unit in this invention effectively prevents the backflow of nasal secretions, preventing secondary infection caused by backflow, and reducing discomfort caused by irritation to the nasal cavity or throat.

The invention discloses a method for predicting the clinical outcome of treatment of a CRSwNP patient by omphizumab according to the baseline expression level of cytokines in nasal secretions and application of the method. 48 cytokines in the nasal secretions of the patient are detected before treatment by omphizumab; the clinical outcome of nasal polyp improvement of a CRSwNP patient treated by omaszumab can be noninvasively predicted by virtue of the baseline expression level of any one of seven cell factors including Eotaxin, GM-CSF, CXCL-1, IP-10, IL-1a, MPO and IgE in nasal secretions of the patient, wherein the NPS improvement of the treatment improvement group and the poor treatment group is greater than that of the treatment improvement group and the poor treatment group is found for the first time. The clinical outcome of the nasal polyp improvement of the CRSwNP patient treated by omaszumab can be noninvasively predicted.

The invention provides a device for collecting a nasal secretion sample. The device includes a sample collection member comprising a material for collecting a predetermined volume of a nasal secretion sample. The device further includes a handle and an elongated support member extending between the handle and the sample collection member and for supporting the sample collection member. The device is adapted for a user holding the handle to locate the sample collection member in contact with tissue at a target location inside the nasal cavity where the sample collection member collects a predetermined volume of a nasal secretion sample.

The present invention discloses a nasal secretion smear diagnosis method and system based on deep learning, including: reading the nasal secretion smear to be diagnosed in blocks in a sliding window manner; performing a preprocessing operation on the read window image and inputting it into a trained cell detection model, performing a series of feature extraction on the input image, enhancing the pyramid feature map by bottom-up and top-down feature fusion, and finally obtaining the coordinates and score of the rectangular frame of the detected target according to the feature map of each scale, filtering out the rectangular frames below the threshold according to a set score threshold, and obtaining a rectangular frame set R; according to the coordinates of the rectangular frames in R, cutting the corresponding image from the original window image and performing a preprocessing operation, inputting it into a trained cell classification model, outputting the cell category of the corresponding image and performing post-processing, and obtaining the cell category of the original nasal secretion smear to be diagnosed. The present invention can diagnose nasal secretion smears efficiently and accurately.

A nasal secretion smear diagnosis method and system based on deep learning. The method comprises: reading, in chunks by means of a sliding window, a nasal secretion smear to be subjected to diagnosis; performing a preprocessing operation on a read window image and inputting same into a trained cell detection model; performing a series of feature extractions on the input image, then enhancing a pyramid feature map by means of bottom-up and top-down feature fusion, finally obtaining coordinates and a score of a rectangular box of a detected target on the basis of a feature map of each scale, and on the basis of a set score threshold value, filtering out rectangular boxes, the scores of which are lower than the threshold value, so as to obtain a set R of rectangular boxes; on the basis of the coordinates of each rectangular box in R, cropping a corresponding image from the original window image and performing a preprocessing operation, inputting the processed image into a trained cell classification model, and outputting a cell category of the corresponding image; and performing post-processing, so as to obtain a cell category of the original nasal secretion smear to be subjected to diagnosis.

The utility model provides an aspirator for ear and nose secretion cleaning, which comprises a cabinet, an operating table is fixedly mounted at the top of the cabinet, a first guide cavity and a second guide cavity are respectively arranged in the operating table, a guide chamber and a collection chamber are respectively arranged in the cabinet, and the first guide cavity and the second guide cavity are communicated with each other. A saline water barrel and a collecting assembly are arranged in the collecting chamber, a flow dividing assembly is fixedly installed in the guiding and conveying chamber, the output end of the flow dividing assembly penetrates through the first guiding and conveying cavity and is provided with an injection head in a butt joint mode, and the input end of the flow dividing assembly is connected with the saline water barrel; the input end of the collecting assembly is in butt joint with a recoil assembly. According to the utility model, normal saline in the saline water barrel is extracted through the back flushing assembly, so that the suction operation can be realized, meanwhile, the saline water can be fed into the suction pipeline, not only can sucked foreign matters be discharged in an auxiliary manner, but also the interior of the suction pipe can be continuously flushed, and the inner wall of the suction pipe is prevented from being bonded and blocked.

1. The name of the design product: electric nose aspirator. 2. The use of the design product: the nose aspirator for automatically removing nasal secretions. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: immune chromatography analyzer. 2. The use of the design product: for animal clinical test, specifically used with the adapter, can detect and analyze animal serum, feces, eye and nose secretions, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

This invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for sinusitis. The composition is characterized by being prepared from ephedra (processed with honey), bitter almond, perilla seed, prepared pinellia, licorice, scutellaria, angelica, belamcanda, coltsfoot flower, mulberry bark, cicada slough, silkworm, and earthworm. The composition of this invention improves sinusitis symptoms, reduces inflammation levels, and regulates the pH of nasal secretions in a sinusitis model prepared by Staphylococcus aureus, suggesting that this traditional Chinese medicine composition has a good therapeutic effect on sinusitis.

The utility model belongs to the technical field of medical auxiliary instruments, particularly relates to a portable quantitative collection device for nasal secretions, and aims to solve the problems that an existing device adopts a negative pressure extraction mode, extraction pressure is not easy to control, nasal mucosa can be damaged when nasal secretions are directly sucked, and bleeding can be accompanied, and the portable quantitative collection device for the nasal secretions comprises a centrifugal tube, a built-in tube is arranged in the centrifugal tube; the utility model has the beneficial effects that the filter paper automatically adsorbs nasal secretions to simulate the natural discharge state of the secretions, so that the secretions at different parts in the nasal cavity can be more comprehensively and uniformly collected without generating any additional pressure impact, thereby protecting the integrity of the mucous membrane of the nasal cavity to the greatest extent, reducing the risk of mucous membrane damage and improving the safety of the nasal cavity. Due to the fact that the nasal cavity cannot be strongly stimulated due to adsorption of the filter paper, discomfort feelings such as pain and soreness caused by negative pressure cannot occur to a patient in the collection process, and the whole collection process is more comfortable.

The present invention provides an apparatus for collecting nasal secretion samples. 【Solution means】 The apparatus includes a sample collection member having a material for collecting a predetermined amount of nasal secretion samples. The apparatus further includes a handle and an elongated support member that extends between the handle and the sample collection member and supports the sample collection member. The apparatus is configured such that a user holding the handle contacts the sample collection member with the tissue at a target position within the nasal cavity, and the sample collection member collects a predetermined amount of nasal secretion samples at the target position.

The utility model relates to the technical field of slaughtering and quarantine, in particular to a pre-slaughtering living body inspection and quarantine device, which is characterized in that fixing clamping plates are arranged on two sides inside a box body, when the device is used, a worker opens a box door, enables livestock to enter the box body from a guide block, then closes the box door and adjusts a rotating hand wheel, and then the livestock can enter the box body from the guide block. Meanwhile, a positioning ring matched with the livestock is selected to be fixed to the through groove, the head of the livestock penetrates through the positioning ring so that the head of the livestock can be limited, and therefore quarantine personnel can conveniently collect samples of visible mucous membranes of the livestock, the head of the livestock extends out of the box body through the sampling opening, and the livestock can be conveniently taken out. And quarantine personnel can conveniently collect samples of oral mucosa and mouth and nose secretions of livestock.

Methods for identifying and optionally treating subjects, e.g., subjects who have Chronic Rhinosinusitis (CRS), based on the detection of elevated levels of soluble P-glycoprotein in nasal secretions. The methods of treatment can include administration of a therapeutically effective amount of a P-glycoprotein inhibitor.

This invention relates to the field of biomedical technology and proposes a biomarker for reflecting the efficacy of hormone therapy for allergic rhinitis and its application. The biomarker includes one or more combinations of IFNGR1, Furin, and CSF1R. The biomarkers IFNGR1, Furin, and CSF1R of this invention can all differentiate between hormone-sensitive and hormone-insensitive rhinitis. Their expression levels in the nasal secretions of patients with hormone-insensitive allergic rhinitis are significantly lower than those of patients with hormone-sensitive allergic rhinitis, thus reflecting the efficacy of hormone therapy for allergic rhinitis. Furthermore, compared with a single biomarker, the combination of the three biomarkers has better discriminative ability and better efficacy, providing important evidence for subsequent treatment of allergic rhinitis.

1. The name of the product under this design: detection pen. 2. Purpose of the product of this design: for a medical device used for the detection of various antigens, haptens, antibodies, nasal secretions, blood, urine, saliva, hormones, enzymes, fatty acids, vitamins and drugs, etc. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

The utility model provides a nasal secretion collection device, and belongs to the technical field of nasal secretion collection. Comprising a bag body, a transparent bag is arranged on the side face of the bag body, a partition layer is arranged in the middle of the interior of the bag body, two limiting holes are formed in the partition layer, two sampling pipes are clamped in the limiting holes in a sliding mode, and pipe covers are movably installed on the two sampling pipes in a threaded mode. According to the nasal secretion collection device, through the arrangement of the bag body, the separation layer and the limiting holes, the sampling tubes are limited, and the sampling tubes are prevented from being mixed together to directly collide, so that tube covers of the sampling tubes are prevented from loosening, samples in the sampling tubes are prevented from being polluted, and the accuracy of a detection result is ensured.

The utility model discloses a nostril cleaner, and belongs to the field of personal hygiene care. Comprising a screwing-out shell, a nostril cleaning rod and a nostril cleaning cap. A first containing cavity is formed in the screwing-out shell, the nostril cleaning rod is arranged in the first containing cavity, the inner wall of the screwing-out shell is slidably connected with the bottom of the nostril cleaning rod, and the pushing component of the screwing-out shell is rotated to drive the base of the nostril cleaning rod to slide up and down. In this way, the nostril cleaning rod can be well connected with the screwing-out shell and is driven by the rotating shell to clean the nostrils. And the nostril cleaning cap is sleeved at the end of the nostril cleaning rod, so that the nostril cleaning cap is convenient to replace and clean and is convenient and sanitary. The outer surface of the nostril cleaning cap is provided with thorn-shaped protrusions used for increasing friction force, and nasal secretion can be conveniently cleaned. Thus, after a user cleans nostrils through the nostril cleaning cap in the nostril cleaner, the user can conveniently and quickly keep the nostril cleaner in a clean and sanitary state by replacing the nostril cleaning cap.

1. The name of this design product: Electric nasal aspirator. 2. Purpose of this design product: used to aspirate nasal secretions. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention belongs to the field of pharmaceutical technology and specifically relates to a pharmaceutical composition containing pyruvate, its preparation method, and its use. The pharmaceutical composition comprises the following raw materials, by mass percentage: 0.05-0.1% Compound I, 0.1-0.2% sodium pyruvate, 0.05-0.1% sodium dihydrogen phosphate, 0.05-0.1% sodium dihydrogen phosphate, 3-5% glycerol, and the balance being saline. The structural formula of Compound I is shown below, #imgabs0#. This pharmaceutical composition alleviates the symptoms of stress-induced rhinitis by reducing nasal secretions, downregulating the expression of TE4, IgE, and IL-4, and lowering the number of eosinophils.

The disclosure relates to an application device (100) applicable for positioning an AM-element (10) within a cavity of a human or animal body, the application device (100) comprising: a storage and release tube (101) configured to store and release an AM-element (10); the AM-element (10) being stored within an inner space (102) of the tube (101); a release element (106) being slidably supported with respect to the tube (101) along a longitudinal axis (L) of the tube (101); at least one deflection means (110) capable to bend the AM-element (10) away from the longitudinal axis (L) of the tube (101) when the AM-element (10) is released from the tube (101). The disclosure further relates to a collection kit comprising the application device (100). The disclosure further relates to the use of the application device (100) or the collection kit for collecting nasal secretion.

The utility model relates to the technical field of nasal cavity washing devices, in particular to a nasal cavity washing device which comprises a nasal inflating pipe, a handle and a piston are connected in the inflating pipe in a sliding mode, a first pipe and a breather pipe are fixedly installed on the bottom face of the inflating pipe, and a second pipe is fixedly installed on the surface of the inflating pipe. A water tank and a third pipe are fixedly mounted at the top of the inflating pipe, a liquid outlet cavity and a liquid inlet cavity are formed in the water tank, and a water outlet pipe and a water inlet pipe are slidably connected to the surface of the water tank. By arranging a pull ring and a fixing rod, a user can pull a sliding block through the pull ring, so that a limiting block is separated from a water inlet pipe and a water outlet pipe, and the pull ring is matched with the fixing rod, so that the user can fix the position of the first sliding block, and the user can quickly take down the water inlet pipe and the water outlet pipe and clean the water inlet pipe and the water outlet pipe; and bacteria breeding caused by substances such as residual cleaning liquid and nasal secretions in the water outlet pipe and the water inlet pipe is avoided, and the risk of nasal infection is reduced.

1. Name of the Design Product: Main Unit of Infant Electric Nasal Aspirator. 2. Use of the Design Product: Main unit of a nasal aspirator for clearing nasal secretions. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective View 1.

1. Name of the Design Product: Drainage Tube. 2. Use of the Design Product: This design product is mainly used for draining and sucking blood, waste liquid, etc. during and after surgery, as well as sucking nasal secretions after being matched with appropriate equipment. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective View.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition added with pyruvate as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials in percentage by mass: 0.05 to 0.1 percent of a compound I, 0.1 to 0.2 percent of sodium pyruvate, 0.05 to 0.1 percent of sodium dihydrogen phosphate, 0.05 to 0.1 percent of disodium hydrogen phosphate, 3 to 5 percent of glycerol and the balance of normal saline, the structural formula of the compound I is as shown in the specification, # imgabs0 #. The pharmaceutical composition relieves the symptom of strain rhinitis by reducing the amount of nasal secretions, down-regulating the expression of TE4, IgE and IL-4 and reducing the number of eosinophilic cells.

The invention provides a device for collecting a nasal secretion sample. The device comprises a sample collection member comprising a material for collecting a predetermined volume of a nasal secretion sample. The device also includes a handle and an elongate support member extending between the handle and the sample collection member for supporting the sample collection member. The device is adapted for a user to hold the handle to position the sample collection member in contact with the tissue at a target location within the nasal cavity at which the sample collection member collects a predetermined volume of a nasal secretion sample.

The invention discloses a recombinant feline herpesvirus as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention aims to provide a cat herpesvirus vaccine or multi-combined vaccine with a good immune effect. The invention provides a recombinant feline herpesvirus, which is obtained by taking an FHV-1CH-B strain of the recombinant feline herpesvirus as a parent strain and replacing gI and gE proteins with a fusion protein of a VP1 protein and an LTB protein. When the recombinant feline herpesvirus is used as a vaccine, the clinical symptoms of cats are obviously relieved, the viral load of eye and nose secretions is obviously reduced, the pathological injury is obviously relieved, and the recombinant feline herpesvirus can effectively resist FHV-1 and FCV virulent virus attack.

The utility model relates to the technical field of secretion extraction, and discloses a newborn oral cavity and nasal cavity secretion extraction device which comprises a shell, a partition plate is fixedly installed on the middle section of the shell, a top cover is connected to the top of the shell in a clamped mode, and a bottom cover is installed at the bottom of the shell in a sliding mode. A storage pipe is arranged in the shell and located below the partition plate in a penetrating mode, the bottom of the storage pipe is in threaded connection with a sealing cover, and a suction pipe is embedded in the side face of the storage pipe. The sealing plug and the intubation tube are firstly taken out from the shell, the intubation tube can be separated from the suction tube, the bottom cover is opened in a sliding mode at the bottom of the shell through the sliding groove and the sliding strip, then the storage tube is drawn out from the two lower protection plates, the sealing cover is spirally opened from the bottom of the storage tube, and secreta in the storage tube can be poured out. Therefore, the purpose of conveniently dismounting and cleaning the storage pipe is achieved, and water can be prevented from entering the shell to damage electronic devices.

The suction head of the nasal aspirator comprises a suction end head, a suction nozzle and a suction nozzle, a cavity is formed in the suction head shell, and the suction head shell comprises a first opening and a second opening; the air bag body comprises an air bag and an air bag body mounting part; the suction head bottom cover is provided with a mounting seat and a second channel, the air bag can be fixed in the cavity through the air bag body mounting part, and the cavity is divided into a storage cavity and an air bag cavity; the first channel is communicated with the storage cavity, and the second channel is communicated with the air bag cavity. Due to the fact that the air bag can be installed in the cavity of the suction head shell through the air bag body installation part arranged at one end of the air bag, installation is easy and convenient, due to the fact that the cavity is divided into the containing cavity and the air bag cavity through the air bag, the inflated air bag releases air instantly so that normal atmospheric pressure in the containing cavity can be converted into negative pressure instantly, and the suction head is convenient to use. According to the nasal aspirator, the inhaled nasal secretions such as snot are stored in the containing cavity, the structure of the nasal aspirator is simplified, meanwhile, the nasal secretions such as snot can be rapidly sucked, and the user experience is improved.

The invention discloses application of Der p sIgE and / or Der f sIgE in nasal secretion in preparation of a kit or a detection platform for diagnosing local allergic rhinitis, and relates to the technical field of in vitro diagnosis and immunoassay. The invention relates to application of Der p sIgE and / or Der f sIgE in nasal secretion in preparation of a kit or a detection platform for diagnosing local allergic rhinitis. The invention proposes and verifies that the dust mite sIgE in the nasal secretion can be used as an effective biomarker for diagnosing LAR for the first time, and solves the technical problem of difficulty in typing serum sIgE negative rhinitis patients clinically. Detection can be completed only by collecting nasal secretions, operation is easy and convenient, safety is high, and clinical popularization is easy. According to the method, diagnosis is objective and accurate, a diagnosis critical value is scientifically established through research on healthy people, a quantitative objective diagnosis standard is provided, it is verified through the cell factor level that the diagnosis result is highly consistent with the intrinsic biological mechanism of allergic inflammation, and the accuracy is high.

The utility model relates to the technical field of newborn oxygen catheters, in particular to a two-section type newborn oxygen catheter, and solves the technical problems that an existing oxygen catheter adopts an integrated design, when the oxygen catheter is blocked by nasal secretions of a newborn, the whole oxygen catheter needs to be replaced, and resources are wasted. According to the technical scheme, the two-section type newborn oxygen catheter comprises a first oxygen catheter body, a humidifying bottle, a second oxygen catheter body, a winding assembly, a limiting assembly and a fixing assembly; an original whole oxygen catheter for the newborn is designed into the two-section oxygen catheter, when the oxygen catheter is blocked by secretions in the nasal cavity of the newborn, the portion, close to the nasal cavity of the newborn, of the second oxygen catheter is replaced, and compared with traditional replacement of the whole oxygen catheter, the two-section oxygen catheter is economical and more resource-saving, and solves the problems that an existing oxygen catheter is integrally designed, and the oxygen catheter is inconvenient to use. When the oxygen catheter is blocked by nasal secretions of the newborn, the whole oxygen catheter needs to be replaced, and resources are wasted.