34 results about "Chronic rhinosinusitis" patented technology

Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.

Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a percutaneous coronary transluminal angioplasty, vascular atherosclerosis, hemorrhagic apoplexy, acute myocardial infarction, chronic heart failure, aneurysm, lung cancer metastasis, adult respiratory distress syndrome, asthma, interstitial pulmonary fibrosis, chronic rhinosinusitis, bronchitis or chronic obstructive pulmonary disease (COPD).

The present invention relates generally to the use of recombinant human CC10 (rhCC10), also known as recombinant human uteroglobin, for use as a therapeutic in the treatment of nasal rhinitis, nasal sinusitis, chronic rhinosinusitis, and nasal polyposis. More particularly, the invention provides methods, including broadly the critical dosage ranges of rhCC10 and intranasal route of administration, which may be administered to safely and effectively treat the aforementioned conditions. The invention further provides a composition useful in administering rhCC10 to humans.

The invention discloses a Chinese medicinal preparation for treating chronic rhinosinusitis, which is characterized by being prepared from the following raw Chinese medicinal herbs in percentage by weight, 6.7-10.2 % of magnolia flower, 6.7-10.2 % of dark plum, 3.4-6.8 % of dahurian angelica root, 6.7-10.2 % of siberian cocklour fruit, 15.3-18.6 % of astragalus root, 6.7-10.2 % of chrysanthemum, 6.7-10.2 % of Chinese thorowax root, 3.4-6.8 % of cicada slough, 3.4-6.8 % of honey-fried Chinese ephedra, 6.8-10.2 % of honey-fried licorice root, 6.8-10.2 % of paniculate swallowwort root and 6.8-10.2 % of India madder root. The Chinese medicinal preparation for treating chronic rhinosinusitis has the advantages of reasonable formulation, convenience for taking, no toxic or side effects, has the functions of increasing immunity, shortening the curing time for chronic rhinosinusitis and improving a therapeutic effect, and can be widely used for treating the chronic rhinosinusitis.

The invention discloses a Chinese medicinal preparation for treating chronic rhinosinusitis and a preparation method thereof. The preparation comprises the following raw materials in part by weight: 1 to 2 parts of heartleaf houttuynia herb, 1 to 2 parts of baical skullcap root and 1 to 2 parts of chilly. The preparation method comprises the following steps of: mixing the Chinese medicinal raw materials in proportion; extracting fat-soluble components in the Chinese medicinal materials; and then preparing the Chinese medicinal materials into required Chinese medicinal formulations by a conventional method. Convention is broken through; a spicy medicament, namely the chilly is creatively introduced and has scientific compatibility with other Chinese medicinal medicaments; and the preparation has good curative effect and small side effects.

The invention relates to a medicament, in particular to a medicament for treating chronic rhinosinusitis, which is prepared from many traditional Chinese medicines serving as raw materials. The invention mainly solves the problems of serious side effects, susceptibility to causing medicament resistance, undesirable treatment effect, incapability of suppressing relapse and the like of the conventional medicaments for treating chronic rhinosinusitis. The medicament of the invention is prepared by proportioning Chinese ligusticum rhizome, biond magnolia flower, thunberg fritillary bulb, pseudo-ginseng, dendrobe, coasiaI gIehnia root, bunge cherry seed, scrophularia ningpoensis, dwarf lilyturf tuber, fragrant solomonseal rhizome, the root of Chinese thorowax, indigowoad leaf, scaphium scaphigerum, Scutellaria baicalensis, rough gentian, indigo naturalis, liquoric root, talcum powder, asiatic moonseed rhizome, blackberry lily, Platycodon grandiflorum, mint, hawthorn, bombyx batryticatus, great burdock achene, mongolian snakegourd root, Chinese date and ginger. In the invention, the traditional Chinese medicines are used for treatment and conditioning, so the side effects are fewer, medicament resistance is not generated in a taking process, both the symptoms and root causes are address, the treatment effect is remarkable, the cure rate is high, surgery is not needed, and extra injury to the patient is avoided.

Method for treating chronic rhinosinusitis in a human patient. In the method a photosensitizing agent such as indocyanine green can be applied to color a nasal or sinal treatment site harboring infectious microorganisms. The photosensitizing agent can have an energy absorption peak in a near infrared wavelength region of the electromagnetic spectrum. The method can also include applying light energy from a laser source at a near infrared red wavelength or wavelengths to the colored treatment site, for a duration sufficient to control the microorganisms. Apparatus for performing the method is also disclosed.

The present invention is directed to compositions, devices, and methods for non-irritatively treating and preventing mucositis, such as chronic rhinosinusitis (CRS). Some aspects of the invention concern compositions comprising or consisting essentially of sodium phosphate buffer (e.g., sodium phosphate dibasic and sodium phosphate monobasic) and calcium carbonate; mucoadministration devices and kits containing such compositions; and methods for treating or preventing mucositis conditions such as CRS, comprising mucoadministering a composition of the invention to a subject in need thereof.

Disclosed herein are ionic aqueous compositions useful as nasal passage washes to aid in the resorption of edema of the respiratory mucosa, e.g., the nasal mucosa, for the treatment of respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis, sinusitis, allergic rhinitis and nasal polyps. The composition includes an ionic aqueous solution and algae-derived constituents, such as branched, sulfated polysaccharides having an average molecular weight greater than 4 kDa and comprising L-fucose and sulfate ester groups or extracts from brown algae. Also disclosed are methods and pharmaceutical compositions for treating respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis.

The invention discloses a traditional Chinese medicine drug for treating rhinitis and a processing method thereof. The formula comprises 5-10 parts of biond magnolia flowers, 5-10 parts of fineleaf schizonepeta herb, 5-10 parts of siberian cocklebur fruits, 3-10 parts of dahurian angelica roots, 3-10 parts of Chinese gentian, 3-10 parts of forsythia fruits, 5-10 parts of honeysuckles, 1-5 parts ofSichuan lovage rhizomes, 3-10 parts of winkled gianthyssop herb, 1-5 parts of divaricate saposhnikovia roots, 3-10 parts of incised notopterygium rhizomes, 1-3 parts of manchurian wildginger, 2-3 parts of Yunnan poria cocos, 5-10 parts of scorched largehead atractylodes rhizomes, 3-10 parts of mint, 1-5 parts of Chinese honeylocust fruits and 1-6 parts of an excipient. The processing method comprises the following steps: step 1, selection of raw materials; step 2, pretreatment of the raw materials; step 3, grinding of the raw materials; step 4, preparation of watered pills; and step 5, inspecting and packaging. According to the traditional Chinese medicine drug for treating rhinitis and the processing method thereof, the drug can effectively treat common cold complications such as variousrhinosinusitis, chronic rhinosinusitis and frontal sinusitis, and has the advantages of mild drug effect, obvious response, high cure rate and low recurrence rate.

The invention provides a method of treating chronic rhinosinusitis such as allergic fungal sinusitis comprising daily oral administration of a composition from more than 500 mg to about 800 mg, preferably about 625 mg or 725 mg terbinafine base equivalent as hydrochloride, or a molar equivalent in other acid addition salt or free base form, for a duration effective to reduce the symptoms of, or eliminate chronic rhinosinusitis; it further concerns the use of terbinafine in the manufacture of a corresponding medicament, and packs containing a plurality of corresponding compositions and medicaments.

The invention relates to the field of molecular biological detection, in particular to application of Cystatin SN in forecast of sensitivity of a chronic rhinosinusitis with polyposis patient on glucocorticoid. A sample collection method of a forecast method is safe and non-invasive, is good in tolerance, simple and rapid in detection method and favorable in forecast performance and has favorable clinical application prospect.

The invention discloses a traditional Chinese medicine nasal drop for treating chronic nasosinusitis and a preparation method thereof. The traditional Chinese medicine nasal drop comprises: biond magnolia flower-bud, dahurian angelica roots, herba houttuyniae, loofah sponge, spina gleditsiae, centipeda minima, rhizoma chuanxiong, herba ephedrae, radix scutellariae, menthol and frankincense. The preparation method comprises the following steps: soaking the biond magnolia flower-bud, the dahurian angelica roots, the herba houttuyniae, the loofah sponge, the spina gleditsiae, the centipeda minima, the rhizoma chuanxiong, the herba ephedrae and the radix scutellariae in sesame oil, performing heating with slow fire, fishing out the medicinal materials when the medicinal materials are fried toyellowish-brown, performing standing and filtering, co-grinding the menthol and the frankincense, adding liquid paraffin, performing uniform stirring and filtering, and uniformly mixing the filtered material with sesame oil. The nasal drop is prepared from pure traditional Chinese medicines, has scientific and reasonable compatibility of components, and has the effects of dispelling wind and clearing heat, inducing diuresis to alleviate edema, inducing resuscitation with fragrance and promoting blood circulation to arrest pain; and the preparation method is simple, small in side effect, low inprice and remarkable in curative effect, and has a clinical cure rate up tp 89%.

The present invention provides methods of treating chronic rhinosinusitis that comprise administering a formulation of boric acid to the nasal and paranasal cavities of a patient in need. The present invention also provides for the use of a formulation comprising boric acid for the treatment of chronic rhinosinusitis.