739results about "Veterinary instruments" patented technology

A bioenergy generator to increase the life force of a biological system is provided. The bioenergy generator includes fine pieces of natural stone, fine pieces of natural sand, fine pieces of metal, water and a supporting material operable to hold the natural sand, the natural stone, the metal, and the water together. Uses of the bioenergy generator are also provided, in particular, to enhance stem cell production.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention belongs to the technical field of biotechnology and animal models, and discloses a double-person-derived mouse model for simulating a tumor immune microenvironment and a construction method and application thereof. The method comprises the following steps: firstly, pretreating NSG immunodeficient mice by adopting low-dose whole-body irradiation in combination with double-antibody targeted bone marrow depletion, and transplanting CD34 + hematopoietic stem cells from the same human donor to complete human immune system reconstruction; separating tumor primary cells, tumor-related fibroblasts and tumor vascular endothelial cells of the same donor, performing three-dimensional co-culture to obtain homologous human tumor organs, and performing in-situ inoculation to immune reconstruction mice to obtain a target model. The core defects of MHC mismatching, low immune reconstruction efficiency, poor tumor immune microenvironment simulation degree, low clinical consistency and the like of an existing model are overcome, and the method can be used for tumor immune treatment drug screening, microenvironment mechanism research and personalized tumor treatment scheme verification.

The invention discloses a humanized osteoporosis mouse model and a construction method thereof, and belongs to the technical field of biotechnology and animal models. The invention aims at the core defects of large species difference, insufficient humanization degree, low pathological simulation degree, unstable phenotype and the like of the existing osteoporosis model. The humanized osteoporosis mouse model is constructed through five core steps of experimental animal pretreatment, collagen-nano hydroxyapatite bionic scaffold preparation and cell pre-implantation, immune-bone metabolism double-derived system construction, progressive osteoporosis induction and model identification and verification. According to the method, double-person origination of immune and bone metabolism systems is realized for the first time, the colonization rate and survival time of human cells are greatly improved, the pathological process of clinical postmenopausal osteoporosis is accurately simulated, the phenotype of the model is stable and uniform, the reactivity matching degree with clinical drugs is high, and the method can be widely applied to research and development of anti-osteoporosis drugs and research of pathological mechanisms.

The invention discloses wearable pet multifunctional physical therapy health equipment and a use method thereof. The wearable pet multifunctional physical therapy health equipment comprises a biocompatible flexible substrate and wearing system, an intelligent moxibustion warm physical therapy module, a multifunctional phototherapy module, a bionic micro-vibration massage module, a vital sign real-time monitoring system, an intelligent control and energy system and an omnibearing safety protection system. A biocompatible flexible substrate and a wearable system are adopted as carriers, multiple modules such as intelligent moxibustion warm physical therapy, multifunctional phototherapy, bionic micro-vibration massage and vital sign real-time monitoring are integrated, cooperative operation is achieved through intelligent control and an energy system, and meanwhile an all-around safety protection system runs through all the time. The integrated design breaks through the limitation that traditional pet physiotherapy equipment is single in function. The device has the core advantages that the accuracy of cross-species treatment is improved, the concealment of the treatment process is guaranteed, and human-pet-medical collaborative management is realized.

The invention relates to the technical field of medical instruments, in particular to an electromagnetic needleless injector which comprises a shell, a nozzle assembly, a liquid storage assembly, a driving assembly and an intelligent control system. Firstly, a series excitation linear motor is adopted to replace a traditional needleless injector driven by a spring, and the problems that driving force is limited and elasticity is attenuated due to the spring are effectively solved. According to the series excitation linear motor, through excitation magnetic field coupling between the stator coil and the rotor coil in the motor, the rotor directly drives the plunger rod to do linear motion in the axial direction so as to complete injection, the structure is simpler, the direct drive type connection structure is adopted, the stability is higher, and force transmission is more accurate. In addition, an intelligent control system integrated in the needleless injector enables the needleless injector to be more intelligent, control precision is higher, operation is more convenient, the needleless injector can be wirelessly connected with a breeding cloud management system, rapid, accurate and painless injection of live pigs and other animals can be achieved, and breeding efficiency and injection safety are improved.

A variable sensor system for non-contact vital sign monitoring of animals is described. Non-contact vital sign monitoring may involve correcting measured signals for reflectance and variations in distance between measurements. Non-contact vital sign detection may include temperature detection, and / or measuring cardiovascular and respiratory information. Embodiments are described using a non-contact variable sensor integrated with a weight scale, integrated with a drone, having a pan-tilt monitoring feature, integrated with a kennel, integrated with an automatic pass-fail interface, and including a medication dispensing control module.

The invention relates to the technical field of veterinary epidemic disease detection, and discloses a veterinary epidemic disease remote monitoring and intelligent diagnosis system, which comprises a multi-mode biosensor array including an implantable miniature biochip, a wearable flexible physiological monitoring patch and an environment sensing sensor cluster, the implantable miniature biochip is used for being implanted into a key tissue organ area in an animal body and collecting microscopic physiological data such as cellular metabolism signals and local immune reaction marker concentration in real time, and the wearable flexible physiological monitoring patch is used for being attached to the body surface of the animal. By means of the multi-mode biosensor array and the edge intelligent preprocessing unit, animal physiology and environment data are accurately monitored in real time. The multi-modal biosensor array covers the implantable miniature biochip, the wearable flexible physiological monitoring patch and the environment sensing sensor cluster, and can comprehensively collect in-vivo microscopic physiological data, body surface macroscopic physiological parameters and feeding environment information of animals.

The invention discloses a construction method and application of a preeclampsia animal model based on an RASA3 target, and belongs to the technical field of biomedicine.The preeclampsia animal model is constructed by injecting Ad-RASA3 into a pregnant mouse and monitoring pathological indexes, related to preeclampsia, of the pregnant mouse. According to the method, the animal model with preeclampsia-like clinical symptoms can be stably induced, the abnormal change of the uterine spiral artery remodeling process can be systematically monitored, the method is high in operation controllability and model stability, and an effective tool can be provided for deeply researching the pathogenesis of preeclampsia and developing a novel diagnosis and treatment strategy.

The invention is a smart crate that includes a variety of improved features to promote safety and peace for both the pet and owner. Specifically, the disclosed crate includes smart technology with a remote monitoring system that allows a user to view, hear, and / or communicate with an animal positioned within the crate. Accordingly, pet and owner anxiety is thereby reduced or eliminated. The crate also includes improved safety features, such as an automatic locking element that allows a user to remotely open and close the crate door. In this way, the animal is allowed to exit the crate interior, such as in the case of an emergency.

A device for dispensing a fluid drop-by-drop can include a fluid connector to supply the fluid to be dispensed, a pump which is fluidically connected to the fluid connector, an outlet nozzle which is fluidically connected to the pump, an actuating element, and a control unit. When the actuating element is actuated, the control unit activates the pump which pumps the supplied fluid to the outlet nozzle for dispensing drop-by-drop. The outlet nozzle has an outlet opening and a fluid channel which extends as far as the outlet opening and which, in the direction of the fluid from the pump as far as the outlet opening, has a first channel portion with a first cross-sectional surface and a second channel portion with a second cross-sectional surface adjoining the first channel portion. The second cross-sectional surface can be smaller than the first cross-sectional surface.

The utility model discloses a disinfection spraying device for animal husbandry veterinarians, which belongs to the technical field of animal husbandry disinfection and comprises a disinfection aisle, an inner cooling arc shell is arranged on the inner side of the disinfection aisle, door curtains for shielding are arranged at channel openings on two sides of the disinfection aisle, and the disinfection aisle is arranged above the ground of an installation position. The device comprises a disinfection aisle, a disinfectant box is arranged below the disinfection aisle, at least one spraying plate is arranged on the inner side of the disinfection aisle, the spraying plate is designed to be hollow, a plurality of nozzles are installed on one side of the spraying plate, a filter plate is embedded and clamped in the disinfectant box, a pressure sensitive switch is arranged at the top of the filter plate, and a bearing plate is arranged at the inner bottom of the disinfection aisle. Pressing columns are fixed to the positions, corresponding to the pressure-sensitive switches, of the bottom of the bearing plate. The disinfection spraying device for animal husbandry and veterinary medicine can be automatically started, automatic disinfection of animal husbandry is achieved, manpower is reduced, meanwhile, convenience is greatly improved, and disinfectant can be recycled.

The embodiment of the invention discloses a method and system for emission computed tomography for animal imaging. The method comprises the steps that a plurality of imaging animals are placed on a plurality of trays in preset placement postures, each tray is configured to place one imaging animal, each tray comprises a body part fixing part, and the body part fixing parts are configured to fix the preset placement postures of the imaging animals placed on the body part fixing parts; placing a plurality of trays on the supporting part of the multi-imaging animal fixing device; the multi-imaging-animal fixing device is placed in an animal cabin of scanning equipment, and emission computed tomography is carried out on multiple imaging animals at the same time.

The invention relates to the technical field of medical instruments, in particular to a veterinary venous indwelling needle fixing and protecting system and an anti-falling application method.The veterinary venous indwelling needle fixing and protecting system comprises a first neck sleeve, a second neck sleeve and a flexible sleeve fixedly connected between the first neck sleeve and the second neck sleeve, a gap is formed in the top end of the flexible sleeve, and a notch is formed in the inner end, close to the gap, of the flexible sleeve; a notch is formed in the outer wall of the flexible sleeve, an indwelling groove is formed in the position, close to the notch, of the outer wall of the flexible sleeve in a penetrating mode, a connecting belt is fixedly connected to the position, close to the indwelling groove, of the outer wall of the flexible sleeve, a pawl is fixedly connected to an inner belt of the connecting belt, a hook-and-loop fastener belt is fixedly connected to one end of the connecting belt, and fifth hook-and-loop fasteners distributed on the flexible sleeve adhere to the hook-and-loop fastener belt; according to the pet indwelling needle, the pawls of the connecting belt are meshed with the pawl grooves, secondary reinforcement is achieved in cooperation with the hook-and-loop fastener belt, and the breathable film sticker is matched for limiting, so that the indwelling needle is effectively prevented from shifting and falling off due to movement of a pet.

The utility model relates to the technical field of veterinary medicine feeding, and discloses an anti-bite animal husbandry veterinary medicine feeding device which comprises a bite assembly, the bite assembly comprises a bite block, a bite elastic column is arranged in the bite block, and an extending pipe is arranged in the bite block in a penetrating mode. The needle tube assembly comprises a needle tube body, a piston rod cover piece used for pushing liquid medicine is arranged on the needle tube body, one end, close to the piston rod cover piece, of the needle tube body is fixedly connected with a clamping plate, and one end, far away from the piston rod cover piece, of the needle tube body is in threaded connection with an installation nut. According to the utility model, through the arrangement of the occlusion assembly, the occlusion block can be placed in the mouth of an animal to be bitten by the animal, so that the needle tube body is prevented from being bitten and damaged, and medicine feeding can be carried out smoothly; through the arrangement of the needle tube assembly and the placing assembly, the piston rod can be automatically pushed, manual pushing of the piston rod is not needed, labor and time are saved in use, various kinds of liquid medicine can be contained, and use is convenient and practical.

This disclosure features tissue storage, irrigation, and infusion media compositions, and methods of using such compositions, for example, the temporary storage of cells and tissues prior to implantation or re-implantation, or for wound irrigation, wound packing, surgical site irrigation, or intravenous infusion. The tissue storage, irrigation, and infusion media compositions disclosed herein are useful in a healthcare or veterinary setting.

The utility model discloses a special continuous drenching device for animal husbandry and veterinary surgeons, and relates to the technical field of livestock equipment. The continuous drenching device special for the animal husbandry veterinarian comprises a drenching gun body and a drenching stirring assembly, the surface of the drenching gun body is in threaded connection with a drenching gun gallipot, and a handle is installed at the lower end of a handle; the drenching and stirring assembly is arranged in the drenching gun body and comprises a rotating shaft, an auger, a first sealing ring, a first push plate, a second sealing ring and a second push plate, the first sealing ring slides in the drenching gun body, and the auger is fixedly connected to a drenching gun tank in a sleeving mode. The auger can enter the medicine tank of the drenching gun to rotate to mix clear water and medicine, so that the medicine in the medicine tank of the drenching gun can be fully and uniformly mixed, and the problem that the medicine is not uniform enough, so that the medical prevention and other effects of animal husbandry are poor is avoided.

The utility model relates to the technical field of animal administration devices, in particular to a rodent wound administration auxiliary device which comprises an annular fixing ring used for being fixed to the outer side of a rodent wound, an annular silicon rubber sleeve wrapping the outer side of the annular fixing ring and at least one fixing belt connected to the side face of the annular silicon rubber sleeve. A bonding layer is attached to the bottom of the annular silica gel sleeve, a medicine feeding opening is formed in the inner side of the annular fixing ring, and a protective cover used for covering the medicine feeding opening is installed on the annular fixing ring. According to the rodent wound administration auxiliary device, the outer side of the annular fixing ring is wrapped with the annular silicon rubber sleeve, so that the rodent wound administration auxiliary device makes contact with the skin of a rodent more comfortably, the annular fixing ring can be more firmly fixed to the body of the rodent through the pasting layer and the fixing belt, and the protection cover covering the administration opening is adopted, so that the rodent wound administration auxiliary device is more convenient to use. The medicine is separated from the outside, rodents can be prevented from dropping the medicine in the moving process, the medicine can be repeatedly administered, the cost is reduced, the structure is simple, and the use is convenient.

The invention belongs to the technical field of construction methods of disease animal models, and particularly relates to a construction method and application of a renal syndrome hemorrhagic fever mouse model. According to the HTNV infected mouse model established by the method disclosed by the invention, the symptom of the experimental mouse is close to the clinical symptom of a severe hemorrhagic fever with renal syndrome after challenge, the complete lethality and repeatability are high, and the HTNV infected mouse model has the advantages of simple operation, low cost and high efficiency. The method can be used for research on the HTNV pathogenic mechanism and immune mechanism and research and development of antiviral drugs and vaccines, and has great application value for perfecting an HTNV full-chain prevention and control system.

The invention belongs to the technical field of biomedicine, and particularly relates to an animal model and a modeling method thereof. According to the method, the northwest dryness syndrome type sub-health animal model is successfully constructed, an open model evaluation mode is adopted, and the established model is evaluated through goodness of fit; furthermore, autumn pear syrup is used for indicating that the prescription corresponds to the syndrome. The northwest dryness syndrome type sub-health target model established by the invention can provide a stable and reliable research model for external dryness syndrome essence exploration, arid region sub-health prevention and treatment, drug effect and pharmacological mechanism research of traditional Chinese medicines, prescriptions and the like with body resistance strengthening and dryness moistening effects, health product research and development and the like. An open model evaluation mode is adopted, and the higher the goodness of fit is, the closer the model to the northwest dryness syndrome type sub-health target model is. The northwest dryness syndrome type square domain dryness evil sub-health rat model is more suitable for arid region sub-health status research, and the northwest dryness syndrome type autumn cause dryness evil sub-health rat model is more suitable for autumn moistening health care research.

An apparatus, a system and a method for euthanizing laboratory animals, in particular rodents and lagomorphs, housed in a laboratory cage, the cage having a tub shaped body and an upper rim, wherein the apparatus comprises two sidewalls being arranged parallel to each other, a top panel, a leverage mechanism, and a gas unit for administering a euthanizing gas, wherein the top panel is positioned in between the two sidewalls, and connects the two sidewalls with each other, the top panel comprises at least one gas inlet and one gas outlet, the gas inlet and the gas outlet being connected to the gas unit.

This utility model relates to the field of medical equipment technology, and in particular to an animal vaccine injection booster device, comprising a first air chamber, a second air chamber, a piston assembly, and a gun body; the gun body has a first air chamber and a second air chamber, the first air chamber having a gas source inlet, a gas outlet, and a gas delivery outlet, the gas delivery outlet communicating with the second air chamber, and a control valve also being provided in the first air chamber; when the trigger of the gun body presses the control valve, the control valve blocks the connection between the gas delivery outlet and the gas outlet; when the trigger of the gun body is released, the control valve blocks the connection between the gas delivery outlet and the gas source inlet; the second air chamber has a piston assembly, the piston assembly including a piston and a firing pin, the firing pin being disposed on the piston, and an elastic element being provided between the piston and the firing pin output end of the second air chamber; the trigger is disposed on the grip part of the gun body, the grip part having a grip groove on the side near the trigger, and a thumb groove on the top side of the grip part away from the trigger. This utility model is easy to operate and has a good grip feel.

The adjustable drencher comprises a functional block, a metering pump is fixedly installed on the left side of the functional block, a drenching pipe is fixedly installed at the left end of the metering pump, a spray head is fixedly installed at the left end of the drenching pipe, a supporting assembly is arranged in the functional block, and the supporting assembly comprises a square block. The square block is fixedly installed in the functional block, and an electric push rod is fixedly installed in the square block. According to the adjustable drencher for the animal husbandry veterinarian, by arranging the supporting assembly, when the adjustable drencher is used, an electric push rod is started, the electric push rod drives a sliding strip to contract, the sliding strip drives two fixing blocks to move upwards, and the two fixing blocks drive two first hinge rods to rotate towards the outer side of a square block through connecting blocks; the two first hinge rods are matched with the second hinge rods to drive the two supporting blocks to stretch out of the functional block to support the oral cavity of the livestock, and through the arrangement, the oral cavity of the livestock can be supported without manpower.

The utility model discloses an electric needleless injector for livestock. The electric needleless injector comprises a shell, a battery, a nozzle assembly, a liquid inlet pipe assembly, a liquid storage cavity, an adapter block, a motor, a rotating worm, a worm position measuring plate, a compression spring, a spring connecting rod, a piston fixing rod, a transmission bearing, a spring pressing plate, a buffering rubber mat, a liquid medicine push rod and a Hall sensor. The utility model provides three more optimized functional structures: (1) the trigger device is simpler and more practical: the trigger device can be triggered by only pressing the head, the trigger device can be pressed on an animal body when in use, and liquid flying caused by the fact that the trigger device is not attached to the epidermis can be prevented; (2) the liquid medicine, the medicine bottle and the like are more convenient to replace: the Luer taper of the medicine bag is directly sleeved during use, or the medicine tube is directly sleeved on the Luer taper when the self-made medicine bottle and the medicine cylinder are used; and (3) the power structure is more stable and simpler: the motor drives the worm to rotate and then drives the straight connecting rod to operate.

The utility model relates to a capsule dosing device for rhesus monkeys, which comprises a thick tube and a thin tube, the thin tube is movably mounted in the thick tube in a penetrating manner, and a claw-shaped clamp is arranged at the bottom of the thick tube; the claw-shaped clamp comprises mounting blocks, the mounting blocks are fixedly mounted on the left inner wall and the right inner wall of the thick pipe correspondingly, first springs are fixedly mounted at the bottoms of the two mounting blocks correspondingly, a movable block is fixedly mounted between the bottoms of the two first springs, and a connecting rod is movably mounted at the bottom of the movable block; and adjusting plates are movably mounted at the bottoms of the connecting rods. The capsule administration device for the rhesus monkey can prevent the rhesus monkey from crushing the capsule to influence the accuracy of the administration amount and the drug absorption, so that the success rate of capsule administration can reach 100%, the test quality is ensured, and effective reference is provided for clinical medication; and moreover, the possibility that the teeth of the rhesus monkey hurt people during capsule administration can be effectively avoided, and the safety of people is guaranteed to the greatest extent.

The mouse intestinal tumor cell injector comprises a handle, an injection device installed in the handle, and a radially telescopic support ring structure connected with the handle, tumor cells can be discharged from a first injection needle by operating a first push rod, and antibiotics can be discharged from a second injection needle by operating a second push rod; when the support ring structure is in a contracted state, the first injection needle and the second injection needle are located in the support ring structure; when the support ring structure is in an expanded support state, the needle heads of the first injection needle and the second injection needle can both extend to the outside of the outer edge of the support ring structure and are inserted into the mouse intestinal wall. The present application supports the mouse intestine by the support ring structure, supports the insertion of the first injection needle and the second injection needle into the mouse intestinal wall, ensures that only the mouse intestinal endothelium is punctured and the mouse intestinal canal is not punctured, ensures that tumor cells are injected into the mouse intestinal wall, and when the tumor cells are injected, antibiotics are also injected for anti-inflammatory treatment, which is beneficial to the recovery of the mouse intestinal puncture point.

The invention relates to the technical field of medicine feeding, in particular to a quantitative medicine feeding device for mouse experiments, which comprises a gun-shaped main body, a medicine storage bottle is arranged on the main body, the medicine storage bottle is communicated with a quantitative cylinder arranged at the end part of the main body through a communication component, and the quantitative cylinder is communicated with a medicine feeding pipe; a sealing assembly is arranged on the medicine storage bottle and is in transmission connection with the communicating assembly; a piston in transmission connection with the communication assembly is slidably arranged in the quantitative cylinder, and the piston feeds a mouse with liquid medicine through a medicine feeding pipe; an adjusting assembly corresponding to the piston is arranged at the end of the quantifying cylinder and is in transmission connection with the piston to adjust the position of the piston. The device is compact in structure, convenient to operate and capable of flexibly and conveniently feeding mice with medicine, and the experiment precision is improved; and meanwhile, during administration, continuous supplement of the liquid medicine can be realized, so that continuous operation is realized, the workload is reduced, and the risk that the medicine is polluted is reduced.

By applying an alternating electric field to the brain for a period of time, certain substances (e.g., macromolecules) that would normally be unable to cross the blood-brain barrier can be introduced into the brain, where the frequency of the alternating electric field is chosen such that application of the alternating electric field increases the permeability of the blood-brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood-brain barrier is increased, the substance is able to cross the blood-brain barrier.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.