2 results about "Memory formation" patented technology

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of a traditional Chinese medicine composition in the preparation of drugs for improving cognitive impairment. By weight, the traditional Chinese medicine composition comprises: 225-300 parts rhubarb, 50-75 parts pig bile powder, 90-120 parts aster, 360-480 parts scrophularia, 180-240 parts immature bitter orange peel, and 180-240 parts areca nut. This invention is the first to demonstrate that a composition of six traditional Chinese medicines, including scrophularia, rhubarb, and areca nut, significantly improves memory acquisition (induced by scopolamine), consolidation (induced by sodium nitrite), and retrieval impairments, covering the entire process of memory formation, encoding, storage, and retrieval, thus overcoming the limitations of existing drugs that only target a single memory stage.

The present invention relates to a ferritin nanocage-integrated vaccine comprising a flagellin immunoadjuvant, and a preparation method therefor. The present invention enables multivalent presentation of an antigen and a flagellin immunoadjuvant on the surface of a ferritin nanocage using a SpyTag–SpyCatcher system, thereby increasing efficiency of vaccine formulations, enhancing B cell maturation and memory formation, elevating T cell activation, and providing improved protective efficacy.