3 results about "Memory formation" patented technology

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of a traditional Chinese medicine composition in the preparation of drugs for improving cognitive impairment. By weight, the traditional Chinese medicine composition comprises: 225-300 parts rhubarb, 50-75 parts pig bile powder, 90-120 parts aster, 360-480 parts scrophularia, 180-240 parts immature bitter orange peel, and 180-240 parts areca nut. This invention is the first to demonstrate that a composition of six traditional Chinese medicines, including scrophularia, rhubarb, and areca nut, significantly improves memory acquisition (induced by scopolamine), consolidation (induced by sodium nitrite), and retrieval impairments, covering the entire process of memory formation, encoding, storage, and retrieval, thus overcoming the limitations of existing drugs that only target a single memory stage.

The present invention relates to a ferritin nanocage-integrated vaccine comprising a flagellin immunoadjuvant, and a preparation method therefor. The present invention enables multivalent presentation of an antigen and a flagellin immunoadjuvant on the surface of a ferritin nanocage using a SpyTag–SpyCatcher system, thereby increasing efficiency of vaccine formulations, enhancing B cell maturation and memory formation, elevating T cell activation, and providing improved protective efficacy.

The invention belongs to the technical field of neurobiology, and particularly relates to a targeted NPTX1-Kv7.2 signal axis for inhibiting neuronal hyperexcitation and improving memory impairment formed by aging. According to the invention, a scene fear memory mouse behavior model is adopted, experimental research is carried out by combining in-vitro brain slice patch clamp recording, single-molecule fluorescence in situ hybridization, immunohistochemistry and other methods, and the result shows that NPTX1 can be used as a cognitive disorder molecular marker, and neuronal hyperactivity caused by aging can be rescued by specifically supplementing NPTX1 in a DG brain region; the activation of DG neurons during scene fear experience is improved, and neuronal activation damage and dysmnesia caused by aging are improved; the retigabine serving as an agonist of the NPTX1 interaction protein Kv7.2 is injected in the intraperitoneal cavity, so that neuron activation damage and dysmnesia caused by senescence can also be effectively improved. The invention discloses the effect of the NPTX1-Kv7.2 signal axis in improving the memory impairment of an aging individual, and provides a new thought and target spot for treating the memory impairment caused by aging.