5 results about "Memory formation" patented technology

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of a traditional Chinese medicine composition in the preparation of drugs for improving cognitive impairment. By weight, the traditional Chinese medicine composition comprises: 225-300 parts rhubarb, 50-75 parts pig bile powder, 90-120 parts aster, 360-480 parts scrophularia, 180-240 parts immature bitter orange peel, and 180-240 parts areca nut. This invention is the first to demonstrate that a composition of six traditional Chinese medicines, including scrophularia, rhubarb, and areca nut, significantly improves memory acquisition (induced by scopolamine), consolidation (induced by sodium nitrite), and retrieval impairments, covering the entire process of memory formation, encoding, storage, and retrieval, thus overcoming the limitations of existing drugs that only target a single memory stage.

The invention discloses a mouse working memory implantation behavior device and method based on an Arduino open source hardware platform. According to the invention, cooperative regulation and control of multi-modal stimulation parameters are realized on an Arduino IDE platform; building a specific signal control circuit by means of an Arduino development board; and then a closed-loop control module and a multi-channel signal generation circuit which are independently researched and developed are integrated, and an intelligent experiment device with parameters capable of being adjusted in real time is constructed. And finally, completing a mouse working memory implantation experiment through a training and verification two-stage experiment process. According to the invention, a plurality of difficulties of insufficient stimulation time sequence synchronism, limited parameter adjustability and the like in the traditional memory implantation research are overcome, high-precision programmable control of memory implantation related stimulation signals is realized, rapid reconstruction of stimulation mode combination is realized through modular design, and the system has a wide application prospect. And an efficient new tool is expected to be provided for deeply exploring a memory formation, storage and extraction mechanism in the field of neuroscience.

The present invention relates to a ferritin nanocage-integrated vaccine comprising a flagellin immunoadjuvant, and a preparation method therefor. The present invention enables multivalent presentation of an antigen and a flagellin immunoadjuvant on the surface of a ferritin nanocage using a SpyTag–SpyCatcher system, thereby increasing efficiency of vaccine formulations, enhancing B cell maturation and memory formation, elevating T cell activation, and providing improved protective efficacy.

The invention belongs to the technical field of neurobiology, and particularly relates to a targeted NPTX1-Kv7.2 signal axis for inhibiting neuronal hyperexcitation and improving memory impairment formed by aging. According to the invention, a scene fear memory mouse behavior model is adopted, experimental research is carried out by combining in-vitro brain slice patch clamp recording, single-molecule fluorescence in situ hybridization, immunohistochemistry and other methods, and the result shows that NPTX1 can be used as a cognitive disorder molecular marker, and neuronal hyperactivity caused by aging can be rescued by specifically supplementing NPTX1 in a DG brain region; the activation of DG neurons during scene fear experience is improved, and neuronal activation damage and dysmnesia caused by aging are improved; the retigabine serving as an agonist of the NPTX1 interaction protein Kv7.2 is injected in the intraperitoneal cavity, so that neuron activation damage and dysmnesia caused by senescence can also be effectively improved. The invention discloses the effect of the NPTX1-Kv7.2 signal axis in improving the memory impairment of an aging individual, and provides a new thought and target spot for treating the memory impairment caused by aging.

The invention discloses a memristor neural network circuit for simulating memory forgetting characteristics of different age stages. Three input modules in the circuit convert different input signal ends into pulse electric signals respectively; the three input modules are respectively connected to the voltage selection module, and signals are selected from three paths of pulse voltages to drive the memristor; the output of the voltage selection module is connected to the memristor synapse module, and the signal transmission function of the biological synapse is simulated through the resistance change of the memristor; the output of the memristive synapse module is connected to the memristive learning module, adjusts the weight based on the synapse signal, and outputs a memory to form a signal output end. The bionic memristive synapse array is established, the dynamic change process of neural synapses of children, young and old age groups during memory formation is quantitatively represented, and a new thought is provided for application of the memristive device in neuroscience and brain-like research.